| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-97 |
DRI_Background |
denotes |
Basal ganglia local field potential activity: character and functional significance in the human. |
| T2 |
98-324 |
DRI_Approach |
denotes |
Functional neurosurgery in patients with movement disorders has provided a unique opportunity to record directly form the human basal ganglia (BG) and to thereby further our understanding of these 'dark basements of the mind.' |
| T3 |
325-571 |
DRI_Approach |
denotes |
Two possibilities exist: either single unit and local field potential (LFP) recordings can be made intra-operatively through microelectrodes, or LFPs may be recorded directly from the deep brain stimulation electrode in the peri-operative period. |
| T4 |
572-726 |
DRI_Approach |
denotes |
The LFPs so recorded in the BG of patients are pleomorphic, oscillatory, focal and the product of synchronised current changes in local neuronal elements. |
| T5 |
727-967 |
DRI_Approach |
denotes |
They are presently most simply classified by frequency into activities at <8, 8-30 and >60 Hz, although such a schema is unlikely to capture the full complexity of rhythmic synchronisation with respect to behavioural and disease dependency. |
| T6 |
968-1036 |
DRI_Background |
denotes |
The best characterised group of LFP oscillations is that at 8-30 Hz. |
| T7 |
1037-1181 |
DRI_Background |
denotes |
This activity is prominent in the subthalamic nucleus and globus pallidus of Parkinsonian patients withdrawn from their dopaminergic medication. |
| T8 |
1182-1273 |
DRI_Background |
denotes |
Dopaminergic treatments, behaviourally relevant stimuli and voluntary movement suppress it. |
| T9 |
1274-1413 |
DRI_Outcome |
denotes |
The available evidence points to the 8-30 Hz activity being essentially antikinetic in character and inversely related to motor processing. |
| T10 |
1414-1499 |
DRI_Challenge |
denotes |
Its exaggeration may therefore contribute to the bradykinesia of Parkinson's disease. |
