PubMed:15987957 / 921-1192 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"15987957_0","span":{"begin":140,"end":145},"obj":"ProteinMutation"},{"id":"15987957_1","span":{"begin":166,"end":171},"obj":"ProteinMutation"},{"id":"15987957_2","span":{"begin":173,"end":178},"obj":"ProteinMutation"}],"attributes":[{"id":"15987957_0_ProteinMutation","pred":"proteinmutation","subj":"15987957_0","obj":"rs779694939"},{"id":"15987957_1_ProteinMutation","pred":"proteinmutation","subj":"15987957_1","obj":"rs62541771"},{"id":"15987957_2_ProteinMutation","pred":"proteinmutation","subj":"15987957_2","obj":"rs28937594"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T5","span":{"begin":0,"end":271},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":271},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":271},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"GlycoBiology-GDGDB","denotations":[{"id":"_T11","span":{"begin":45,"end":48},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00385"},{"id":"_T12","span":{"begin":45,"end":48},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00386"},{"id":"_T13","span":{"begin":128,"end":131},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00385"},{"id":"_T14","span":{"begin":128,"end":131},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00386"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"uniprot-human","denotations":[{"id":"T9","span":{"begin":45,"end":48},"obj":"http://www.uniprot.org/uniprot/F5H499"},{"id":"T10","span":{"begin":128,"end":131},"obj":"http://www.uniprot.org/uniprot/F5H499"},{"id":"T17","span":{"begin":53,"end":56},"obj":"http://www.uniprot.org/uniprot/Q04656"},{"id":"T18","span":{"begin":161,"end":164},"obj":"http://www.uniprot.org/uniprot/Q04656"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"GO-BP","denotations":[{"id":"T8","span":{"begin":212,"end":227},"obj":"http://purl.obolibrary.org/obo/GO_0003824"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"GO-CC","denotations":[{"id":"T3","span":{"begin":5,"end":9},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"EDAM-topics","denotations":[{"id":"T11","span":{"begin":90,"end":99},"obj":"http://edamontology.org/topic_0199"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"EDAM-DFO","denotations":[{"id":"T3","span":{"begin":26,"end":35},"obj":"http://edamontology.org/operation_2428"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}

{"project":"mondo_disease","denotations":[{"id":"T10","span":{"begin":53,"end":56},"obj":"Disease"},{"id":"T11","span":{"begin":161,"end":164},"obj":"Disease"}],"attributes":[{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0010651"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0010651"}],"text":"This cell-free system was validated for both GNE and MNK activities, and it revealed that mutations in one enzymatic domain (in GNE, G135V, V216A, and R246W; in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain."}