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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and nimesulide associated or not with common non-steroidal anti-inflammatory drugs.
T2 175-186 Sentence denotes BACKGROUND:
T3 187-299 Sentence denotes Acetaminophen (paracetamol--P) and Nimesulide (N) are widely used analgesic-antipyretic/anti-inflammatory drugs.
T4 300-380 Sentence denotes The rate of adverse hypersensitivity reactions to these agents is generally low.
T5 381-484 Sentence denotes On the contrary non-steroidal anti-inflammatory drugs (NSAIDs) are commonly involved in such reactions.
T6 485-569 Sentence denotes Celecoxib (CE) is a novel drug, with high selectivity and affinity for COX-2 enzyme.
T7 570-580 Sentence denotes OBJECTIVE:
T8 581-742 Sentence denotes We evaluated the tolerability of CE in a group of patients with documented history of adverse cutaneous reactions to P and N associated or not to classic NSAIDs.
T9 743-751 Sentence denotes METHODS:
T10 752-862 Sentence denotes We studied 9 patients with hypersensitivity to P and N with or without associated reactions to classic NSAIDs.
T11 863-939 Sentence denotes The diagnosis of P and N-induced skin reactions was based in vivo challenge.
T12 940-1012 Sentence denotes The placebo was blindly administered at the beginning of each challenge.
T13 1013-1097 Sentence denotes After three days, a cumulative dosage of 200 mg of CE in refracted doses were given.
T14 1098-1155 Sentence denotes After 2-3 days, a single dose of 200 mg was administered.
T15 1156-1282 Sentence denotes All patients were observed for 6 hours after each challenge, and controlled again after 24 hours to exclude delayed reactions.
T16 1283-1402 Sentence denotes The challenge was considered positive if one or more of the following appeared: erythema, rush or urticaria-angioedema.
T17 1403-1411 Sentence denotes RESULTS:
T18 1412-1490 Sentence denotes No reaction was observed with placebo and eight patients (88.8%) tolerated CE.
T19 1491-1552 Sentence denotes Only one patient developed a moderate angioedema of the lips.
T20 1553-1564 Sentence denotes CONCLUSION:
T21 1565-1671 Sentence denotes Only one hypersensitivity reaction to CE was documented among 9 P and N-highly NSAIDs intolerant patients.
T22 1672-1782 Sentence denotes Thus, we conclude that CE is a reasonably safe alternative to be used in subjects who do not tolerate P and N.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1812 10-19 ChemicalEntity denotes celecoxib MESH:C105934
1813 45-59 DiseaseOrPhenotypicFeature denotes skin reactions MESH:D003875
1814 63-76 ChemicalEntity denotes acetaminophen MESH:D000082
1815 78-89 ChemicalEntity denotes paracetamol MESH:D000082
1816 95-105 ChemicalEntity denotes nimesulide MESH:C012655
1817 136-173 ChemicalEntity denotes non-steroidal anti-inflammatory drugs MESH:D000894
1818 187-200 ChemicalEntity denotes Acetaminophen MESH:D000082
1819 202-213 ChemicalEntity denotes paracetamol MESH:D000082
1820 215-216 ChemicalEntity denotes P MESH:D000082
1821 222-232 ChemicalEntity denotes Nimesulide MESH:C012655
1822 234-235 ChemicalEntity denotes N MESH:C012655
1823 263-274 ChemicalEntity denotes antipyretic MESH:D058633
1824 275-298 ChemicalEntity denotes anti-inflammatory drugs MESH:D000893
1825 320-336 DiseaseOrPhenotypicFeature denotes hypersensitivity MESH:D004342
1826 397-434 ChemicalEntity denotes non-steroidal anti-inflammatory drugs MESH:D000894
1827 436-442 ChemicalEntity denotes NSAIDs MESH:D000894
1828 485-494 ChemicalEntity denotes Celecoxib MESH:C105934
1829 496-498 ChemicalEntity denotes CE MESH:C105934
1830 556-561 GeneOrGeneProduct denotes COX-2 NCBIGene:4513
1831 614-616 ChemicalEntity denotes CE MESH:C105934
1832 675-694 DiseaseOrPhenotypicFeature denotes cutaneous reactions MESH:D003875
1833 698-699 ChemicalEntity denotes P MESH:D000082
1834 704-705 ChemicalEntity denotes N MESH:C012655
1835 735-741 ChemicalEntity denotes NSAIDs MESH:D000894
1836 779-795 DiseaseOrPhenotypicFeature denotes hypersensitivity MESH:D004342
1837 799-800 ChemicalEntity denotes P MESH:D000082
1838 805-806 ChemicalEntity denotes N MESH:C012655
1839 855-861 ChemicalEntity denotes NSAIDs MESH:D000894
1840 880-881 ChemicalEntity denotes P MESH:D000082
1841 886-887 ChemicalEntity denotes N MESH:C012655
1842 896-910 DiseaseOrPhenotypicFeature denotes skin reactions MESH:D003875
1843 1064-1066 ChemicalEntity denotes CE MESH:C105934
1844 1363-1371 DiseaseOrPhenotypicFeature denotes erythema MESH:D004890
1845 1381-1390 DiseaseOrPhenotypicFeature denotes urticaria MESH:D014581
1846 1391-1401 DiseaseOrPhenotypicFeature denotes angioedema MESH:D000799
1847 1487-1489 ChemicalEntity denotes CE MESH:C105934
1848 1529-1539 DiseaseOrPhenotypicFeature denotes angioedema MESH:D000799
1849 1574-1590 DiseaseOrPhenotypicFeature denotes hypersensitivity MESH:D004342
1850 1603-1605 ChemicalEntity denotes CE MESH:C105934
1851 1629-1630 ChemicalEntity denotes P MESH:D000082
1852 1635-1636 ChemicalEntity denotes N MESH:C012655
1853 1644-1650 ChemicalEntity denotes NSAIDs MESH:D000894
1854 1695-1697 ChemicalEntity denotes CE MESH:C105934
1855 1774-1775 ChemicalEntity denotes P MESH:D000082
1856 1780-1781 ChemicalEntity denotes N MESH:C012655

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 1381-1390 DiseaseOrPhenotypicFeature denotes urticaria 0005492
T2 1391-1401 DiseaseOrPhenotypicFeature denotes angioedema 0010481
T3 1529-1539 DiseaseOrPhenotypicFeature denotes angioedema 0010481

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 45-49 GeneOrGeneProduct denotes skin
T2 320-336 GeneOrGeneProduct denotes hypersensitivity
T3 505-510 GeneOrGeneProduct denotes novel
T4 522-526 GeneOrGeneProduct denotes high
T5 556-561 GeneOrGeneProduct denotes COX-2
T6 562-568 GeneOrGeneProduct denotes enzyme
T7 598-610 GeneOrGeneProduct denotes tolerability
T8 617-621 GeneOrGeneProduct denotes in a
T9 743-750 GeneOrGeneProduct denotes METHODS
T10 779-795 GeneOrGeneProduct denotes hypersensitivity
T11 888-895 GeneOrGeneProduct denotes induced
T12 896-900 GeneOrGeneProduct denotes skin
T13 915-920 GeneOrGeneProduct denotes based
T14 956-963 GeneOrGeneProduct denotes blindly
T15 984-993 GeneOrGeneProduct denotes beginning
T16 1058-1060 GeneOrGeneProduct denotes mg
T17 1135-1137 GeneOrGeneProduct denotes mg
T18 1156-1159 GeneOrGeneProduct denotes All
T19 1373-1377 GeneOrGeneProduct denotes rush
T20 1477-1486 GeneOrGeneProduct denotes tolerated
T21 1547-1551 GeneOrGeneProduct denotes lips
T22 1574-1590 GeneOrGeneProduct denotes hypersensitivity
T23 1637-1643 GeneOrGeneProduct denotes highly
T24 1765-1773 GeneOrGeneProduct denotes tolerate

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 505-510 GeneOrGeneProduct denotes novel
T2 522-526 GeneOrGeneProduct denotes high
T3 556-561 GeneOrGeneProduct denotes COX-2
T4 562-568 GeneOrGeneProduct denotes enzyme
T5 1373-1377 GeneOrGeneProduct denotes rush
T6 1547-1551 GeneOrGeneProduct denotes lips

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 155-167 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T2 280-292 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T3 320-336 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T4 416-428 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T5 779-795 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T6 1363-1371 DiseaseOrPhenotypicFeature denotes erythema D004890
T7 1381-1390 DiseaseOrPhenotypicFeature denotes urticaria D014581
T8 1391-1401 DiseaseOrPhenotypicFeature denotes angioedema D000799
T9 1529-1539 DiseaseOrPhenotypicFeature denotes angioedema D000799
T10 1574-1590 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 556-561 GeneOrGeneProduct denotes COX-2
T2 1373-1377 GeneOrGeneProduct denotes rush
T3 1547-1551 GeneOrGeneProduct denotes lips

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 45-49 DiseaseOrPhenotypicFeature denotes skin 0002531
T2 320-336 DiseaseOrPhenotypicFeature denotes hypersensitivity 0000605
T3 779-795 DiseaseOrPhenotypicFeature denotes hypersensitivity 0005271|0000605
T5 896-900 DiseaseOrPhenotypicFeature denotes skin 0002531
T6 1381-1390 DiseaseOrPhenotypicFeature denotes urticaria 0005492
T7 1391-1401 DiseaseOrPhenotypicFeature denotes angioedema 0010481
T8 1529-1539 DiseaseOrPhenotypicFeature denotes angioedema 0010481
T9 1574-1599 DiseaseOrPhenotypicFeature denotes hypersensitivity reaction 0000605

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 45-59 DiseaseOrPhenotypicFeature denotes skin reactions DISEASE
T2 155-167 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T3 280-292 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T4 320-336 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T5 416-428 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T6 675-694 DiseaseOrPhenotypicFeature denotes cutaneous reactions DISEASE
T7 779-795 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T8 896-910 DiseaseOrPhenotypicFeature denotes skin reactions DISEASE
T9 1363-1371 DiseaseOrPhenotypicFeature denotes erythema D004890
T10 1381-1390 DiseaseOrPhenotypicFeature denotes urticaria D014581
T11 1391-1401 DiseaseOrPhenotypicFeature denotes angioedema D000799
T12 1529-1539 DiseaseOrPhenotypicFeature denotes angioedema D000799
T13 1574-1590 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 45-59 DiseaseOrPhenotypicFeature denotes skin reactions DISEASE
T2 320-336 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T3 675-694 DiseaseOrPhenotypicFeature denotes cutaneous reactions DISEASE
T4 779-795 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T5 896-910 DiseaseOrPhenotypicFeature denotes skin reactions DISEASE
T6 1363-1371 DiseaseOrPhenotypicFeature denotes erythema D004890
T7 1381-1390 DiseaseOrPhenotypicFeature denotes urticaria D014581
T8 1391-1401 DiseaseOrPhenotypicFeature denotes angioedema D000799
T9 1529-1539 DiseaseOrPhenotypicFeature denotes angioedema D000799
T10 1574-1590 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 10-19 ChemicalEntity denotes celecoxib D000068579|http://purl.obolibrary.org/obo/CHEBI_41423
T3 63-76 ChemicalEntity denotes acetaminophen D000082
T4 78-89 ChemicalEntity denotes paracetamol D000082|http://purl.obolibrary.org/obo/CHEBI_46195
T6 95-105 ChemicalEntity denotes nimesulide C012655|http://purl.obolibrary.org/obo/CHEBI_44445
T8 136-173 ChemicalEntity denotes non-steroidal anti-inflammatory drugs ChemicalEntity
T9 187-200 ChemicalEntity denotes Acetaminophen http://purl.obolibrary.org/obo/CHEBI_46195
T10 202-213 ChemicalEntity denotes paracetamol D000082|http://purl.obolibrary.org/obo/CHEBI_46195
T12 222-232 ChemicalEntity denotes Nimesulide http://purl.obolibrary.org/obo/CHEBI_44445
T13 263-274 ChemicalEntity denotes antipyretic ChemicalEntity
T14 275-298 ChemicalEntity denotes anti-inflammatory drugs ChemicalEntity
T15 397-434 ChemicalEntity denotes non-steroidal anti-inflammatory drugs ChemicalEntity
T16 436-442 ChemicalEntity denotes NSAIDs ChemicalEntity
T17 485-494 ChemicalEntity denotes Celecoxib http://purl.obolibrary.org/obo/CHEBI_41423
T18 496-498 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T19 614-616 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T20 735-741 ChemicalEntity denotes NSAIDs ChemicalEntity
T21 855-861 ChemicalEntity denotes NSAIDs ChemicalEntity
T22 1064-1066 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T23 1487-1489 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T24 1603-1605 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T25 1644-1650 ChemicalEntity denotes NSAIDs ChemicalEntity
T26 1695-1697 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 23-31 OrganismTaxon denotes patients
T2 631-639 OrganismTaxon denotes patients
T3 765-773 OrganismTaxon denotes patients
T4 1160-1168 OrganismTaxon denotes patients
T5 1460-1468 OrganismTaxon denotes patients
T6 1500-1507 OrganismTaxon denotes patient
T7 1662-1670 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T26 1695-1697 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T25 1644-1650 ChemicalEntity denotes NSAIDs ChemicalEntity
T24 1603-1605 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T23 1487-1489 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T22 1064-1066 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T21 855-861 ChemicalEntity denotes NSAIDs ChemicalEntity
T20 735-741 ChemicalEntity denotes NSAIDs ChemicalEntity
T19 614-616 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T18 496-498 ChemicalEntity denotes CE http://purl.obolibrary.org/obo/CHEBI_41423
T17 485-494 ChemicalEntity denotes Celecoxib http://purl.obolibrary.org/obo/CHEBI_41423
T16 436-442 ChemicalEntity denotes NSAIDs ChemicalEntity
T15 397-434 ChemicalEntity denotes non-steroidal anti-inflammatory drugs ChemicalEntity
T14 275-298 ChemicalEntity denotes anti-inflammatory drugs ChemicalEntity
T13 263-274 ChemicalEntity denotes antipyretic ChemicalEntity
T12 222-232 ChemicalEntity denotes Nimesulide http://purl.obolibrary.org/obo/CHEBI_44445
T10 202-213 ChemicalEntity denotes paracetamol http://purl.obolibrary.org/obo/CHEBI_46195|D000082
T9 187-200 ChemicalEntity denotes Acetaminophen http://purl.obolibrary.org/obo/CHEBI_46195
T8 136-173 ChemicalEntity denotes non-steroidal anti-inflammatory drugs ChemicalEntity
T6 95-105 ChemicalEntity denotes nimesulide http://purl.obolibrary.org/obo/CHEBI_44445|C012655
T4 78-89 ChemicalEntity denotes paracetamol http://purl.obolibrary.org/obo/CHEBI_46195|D000082
T3 63-76 ChemicalEntity denotes acetaminophen D000082
T1 10-19 ChemicalEntity denotes celecoxib http://purl.obolibrary.org/obo/CHEBI_41423|D000068579
T43394 1547-1551 GeneOrGeneProduct denotes lips
T2 1373-1377 GeneOrGeneProduct denotes rush
T62506 556-561 GeneOrGeneProduct denotes COX-2
T81773 1574-1590 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T1796 1529-1539 DiseaseOrPhenotypicFeature denotes angioedema D000799
T60160 1391-1401 DiseaseOrPhenotypicFeature denotes angioedema D000799
T7 1381-1390 DiseaseOrPhenotypicFeature denotes urticaria D014581
T45126 1363-1371 DiseaseOrPhenotypicFeature denotes erythema D004890
T5 896-910 DiseaseOrPhenotypicFeature denotes skin reactions DISEASE
T44986 779-795 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T67354 675-694 DiseaseOrPhenotypicFeature denotes cutaneous reactions DISEASE
T59891 320-336 DiseaseOrPhenotypicFeature denotes hypersensitivity D006967
T16483 45-59 DiseaseOrPhenotypicFeature denotes skin reactions DISEASE
T98322 1662-1670 OrganismTaxon denotes patients
T30054 1500-1507 OrganismTaxon denotes patient
T78444 1460-1468 OrganismTaxon denotes patients
T61683 1160-1168 OrganismTaxon denotes patients
T14302 765-773 OrganismTaxon denotes patients
T56732 631-639 OrganismTaxon denotes patients
T24676 23-31 OrganismTaxon denotes patients