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PubMed:15851554 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 873-878 gene:654231 denotes OCM-1
T1 847-861 disease:C0220633 denotes uveal melanoma
T2 1432-1437 gene:654231 denotes OCM-1
T3 1345-1362 disease:C0178874 denotes Tumor progression
R1 T0 T1 associated_with OCM-1,uveal melanoma
R2 T2 T3 associated_with OCM-1,Tumor progression

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15851554-5#60#65#gene654231 873-878 gene654231 denotes OCM-1
15851554-5#66#69#gene2321 879-882 gene2321 denotes FRT
15851554-5#34#48#diseaseC0220633 847-861 diseaseC0220633 denotes uveal melanoma
15851554-9#87#92#gene654231 1432-1437 gene654231 denotes OCM-1
15851554-9#93#96#gene2321 1438-1441 gene2321 denotes FRT
15851554-9#0#17#diseaseC0178874 1345-1362 diseaseC0178874 denotes Tumor progression
60#65#gene65423134#48#diseaseC0220633 15851554-5#60#65#gene654231 15851554-5#34#48#diseaseC0220633 associated_with OCM-1,uveal melanoma
66#69#gene232134#48#diseaseC0220633 15851554-5#66#69#gene2321 15851554-5#34#48#diseaseC0220633 associated_with FRT,uveal melanoma
87#92#gene6542310#17#diseaseC0178874 15851554-9#87#92#gene654231 15851554-9#0#17#diseaseC0178874 associated_with OCM-1,Tumor progression
93#96#gene23210#17#diseaseC0178874 15851554-9#93#96#gene2321 15851554-9#0#17#diseaseC0178874 associated_with FRT,Tumor progression

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 126-803 OBJECTIVE denotes Human uveal melanoma develops in one of the most capillary-rich tissues of the body and has a pure hematogenous dissemination. Radiodiagnostic examinations, such as ultrasonic diagnostic resonance imaging and chest radiographs plus liver enzyme studies in blood, are methods used to detect liver and other distant metastases in patients. Nevertheless, the mortality rate is high, because of the frequent occurrence of metastases and the lack of systemic therapy. Therefore, the development of novel anticancer strategies is urgent, and more sensitive and less invasive methods of detecting and monitoring in vivo tumor growth and metastatic disease in cancer models are needed.
T2 813-1204 METHODS denotes A luciferase (Luc)-positive human uveal melanoma cell line (OCM-1 FRT/luc) was established. Tumor cells were inoculated into the anterior chamber of murine eyes for induction of orthotopic growth or into the left heart ventricle to mimic hematogenous micrometastatic spread. Development of metastases and tumor growth was monitored weekly by whole-body bioluminescent reporter imaging (BLI).
T3 1214-1826 RESULTS denotes Injection of cancer cells into the anterior chamber of the eye of mice closely mimicked orthotopic tumor growth of uveal melanoma. Tumor progression could be quantitatively monitored 3 weeks after inoculation of 10(5) OCM-1 FRT/luc cells. Of the mice injected, 83% exhibited a detectable tumor within 5 weeks. Intracardiac injection of tumor cells resulted in metastatic growth, especially in bone. Mice had bone (maxillofacial region and femora) and visceral (lung and mediastinum) metastases after 4 to 6 weeks. OCM-1 FRT/luc cells may also have a propensity to colonize the eye after intracardiac inoculation.
T4 1840-2072 CONCLUSIONS denotes BLI enables continuous quantitative monitoring in the same animal of growth kinetics for each tumor and its metastases. This model will accelerate the understanding of the pathogenesis and treatment of uveal melanoma and metastasis.