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PubMed:15821891 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15821891-2#200#216#gene64006 464-480 gene64006 denotes envelope protein
15821891-2#200#216#gene30816 464-480 gene30816 denotes envelope protein
15821891-2#174#178#gene7433 438-442 gene7433 denotes HVR1
15821891-2#196#199#diseaseC0019196 460-463 diseaseC0019196 denotes HCV
15821891-2#196#199#diseaseC0019196 460-463 diseaseC0019196 denotes HCV
15821891-4#228#231#gene309 822-825 gene309 denotes p70
15821891-4#228#231#gene84959 822-825 gene84959 denotes p70
15821891-4#236#241#gene3600 830-835 gene3600 denotes IL-15
15821891-4#38#41#diseaseC0019196 632-635 diseaseC0019196 denotes HCV
15821891-4#38#41#diseaseC0019196 632-635 diseaseC0019196 denotes HCV
200#216#gene64006196#199#diseaseC0019196 15821891-2#200#216#gene64006 15821891-2#196#199#diseaseC0019196 associated_with envelope protein,HCV
200#216#gene64006196#199#diseaseC0019196 15821891-2#200#216#gene64006 15821891-2#196#199#diseaseC0019196 associated_with envelope protein,HCV
200#216#gene30816196#199#diseaseC0019196 15821891-2#200#216#gene30816 15821891-2#196#199#diseaseC0019196 associated_with envelope protein,HCV
200#216#gene30816196#199#diseaseC0019196 15821891-2#200#216#gene30816 15821891-2#196#199#diseaseC0019196 associated_with envelope protein,HCV
174#178#gene7433196#199#diseaseC0019196 15821891-2#174#178#gene7433 15821891-2#196#199#diseaseC0019196 associated_with HVR1,HCV
174#178#gene7433196#199#diseaseC0019196 15821891-2#174#178#gene7433 15821891-2#196#199#diseaseC0019196 associated_with HVR1,HCV
228#231#gene30938#41#diseaseC0019196 15821891-4#228#231#gene309 15821891-4#38#41#diseaseC0019196 associated_with p70,HCV
228#231#gene30938#41#diseaseC0019196 15821891-4#228#231#gene309 15821891-4#38#41#diseaseC0019196 associated_with p70,HCV
228#231#gene8495938#41#diseaseC0019196 15821891-4#228#231#gene84959 15821891-4#38#41#diseaseC0019196 associated_with p70,HCV
228#231#gene8495938#41#diseaseC0019196 15821891-4#228#231#gene84959 15821891-4#38#41#diseaseC0019196 associated_with p70,HCV
236#241#gene360038#41#diseaseC0019196 15821891-4#236#241#gene3600 15821891-4#38#41#diseaseC0019196 associated_with IL-15,HCV
236#241#gene360038#41#diseaseC0019196 15821891-4#236#241#gene3600 15821891-4#38#41#diseaseC0019196 associated_with IL-15,HCV

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1789 464-480 gene:64006 denotes envelope protein
T1790 460-463 disease:C0019196 denotes HCV
T1791 822-825 gene:309 denotes p70
T1792 632-635 disease:C0019196 denotes HCV
R1 T1789 T1790 associated_with envelope protein,HCV
R2 T1789 T1790 associated_with envelope protein,HCV
R3 T1791 T1792 associated_with p70,HCV
R4 T1791 T1792 associated_with p70,HCV

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-136 Sentence denotes Immunogenic properties of a chimeric plant virus expressing a hepatitis C virus (HCV)-derived epitope: new prospects for an HCV vaccine.
TextSentencer_T2 137-263 Sentence denotes A vaccine against Hepatitis C virus (HCV) is urgently needed due to the unsatisfactory clinical response to current therapies.
TextSentencer_T3 264-498 Sentence denotes We evaluated the immunological properties of a chimeric Cucumber mosaic virus (CMV), a plant virus engineered to express on its surface a synthetic peptide derived from many HVR1 sequences of the HCV envelope protein E2 (R9 mimotope).
TextSentencer_T4 499-593 Sentence denotes Evidence was obtained that the chimeric R9-CMV elicits a specific humoral response in rabbits.
TextSentencer_T5 594-863 Sentence denotes Furthermore, in patients with chronic HCV infection, purified preparations of R9-CMV down-modulated the lymphocyte surface density of CD3 and CD8, and induced a significant release of interferon (IFN)-gamma, interleukin (IL)-12 p70 and IL-15 by lymphomonocyte cultures.
TextSentencer_T6 864-1022 Sentence denotes Finally, an R9 mimotope-specific CD8 T-cell response, as assessed by intracellular IFN-gamma production, was achieved in the majority of the patients studied.
TextSentencer_T7 1023-1121 Sentence denotes Our results open up new prospects for the development of effective vaccines against HCV infection.
TextSentencer_T8 1122-1220 Sentence denotes Moreover, the wide edible host range of CMV makes the production of an edible vaccine conceivable.
T1 0-136 Sentence denotes Immunogenic properties of a chimeric plant virus expressing a hepatitis C virus (HCV)-derived epitope: new prospects for an HCV vaccine.
T2 137-263 Sentence denotes A vaccine against Hepatitis C virus (HCV) is urgently needed due to the unsatisfactory clinical response to current therapies.
T3 264-498 Sentence denotes We evaluated the immunological properties of a chimeric Cucumber mosaic virus (CMV), a plant virus engineered to express on its surface a synthetic peptide derived from many HVR1 sequences of the HCV envelope protein E2 (R9 mimotope).
T4 499-593 Sentence denotes Evidence was obtained that the chimeric R9-CMV elicits a specific humoral response in rabbits.
T5 594-863 Sentence denotes Furthermore, in patients with chronic HCV infection, purified preparations of R9-CMV down-modulated the lymphocyte surface density of CD3 and CD8, and induced a significant release of interferon (IFN)-gamma, interleukin (IL)-12 p70 and IL-15 by lymphomonocyte cultures.
T6 864-1022 Sentence denotes Finally, an R9 mimotope-specific CD8 T-cell response, as assessed by intracellular IFN-gamma production, was achieved in the majority of the patients studied.
T7 1023-1121 Sentence denotes Our results open up new prospects for the development of effective vaccines against HCV infection.
T8 1122-1220 Sentence denotes Moreover, the wide edible host range of CMV makes the production of an edible vaccine conceivable.