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PubMed:15820770 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes.
T2 101-112 Sentence denotes BACKGROUND:
T3 113-239 Sentence denotes Vitamin D-binding protein (DBP) is the main systemic transporter of 1.25(OH)2D3 and is essential for its cellular endocytosis.
T4 240-497 Sentence denotes There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: GAT-->GAG substitution replaces aspartic acid by glutamic acid in codon 416; and ACG-->AAG substitution in codon 420 leads to an exchange of threonine for lysine.
T5 498-569 Sentence denotes These DBP variants lead to differences in the affinity for 1.25(OH)2D3.
T6 570-668 Sentence denotes Correlations between DBP alleles and type 1 diabetes have been described in different populations.
T7 669-804 Sentence denotes Therefore, we investigated the polymorphism in codon 416 of the DBP gene for an association with autoimmune markers of type 1 diabetes.
T8 805-824 Sentence denotes DESIGN AND METHODS:
T9 825-871 Sentence denotes The present analysis was a case control study.
T10 872-983 Sentence denotes 110 patients, 68 controls, and 115 first-degree relatives were genotyped for the DBP polymorphism in codon 416.
T11 984-1088 Sentence denotes DNA typing of DBP locus was performed by the PCR-restriction fragment length polymorphism method (RFLP).
T12 1089-1097 Sentence denotes RESULTS:
T13 1098-1234 Sentence denotes The frequencies of the Asp/Glu and Glu/Glu were significantly increased in diabetic subjects with detectable IA-2 antibodies (P < 0.01).
T14 1235-1357 Sentence denotes On the contrary, the DBP Glu-containing genotype was not accompanied by differences in the prevalence of GAD65 antibodies.
T15 1358-1467 Sentence denotes These finding supports a role of the vitamin D endocrine system in the autoimmune process of type 1 diabetes.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 401-406 OrganismTaxon denotes codon NCBItxid:79338
T2 442-447 OrganismTaxon denotes codon NCBItxid:79338
T3 716-721 OrganismTaxon denotes codon NCBItxid:79338
T4 973-978 OrganismTaxon denotes codon NCBItxid:79338

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1747 0-25 GeneOrGeneProduct denotes Vitamin D-binding protein NCBIGene:2638
1748 61-65 GeneOrGeneProduct denotes IA-2 NCBIGene:5798
1749 84-99 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922
1750 113-138 GeneOrGeneProduct denotes Vitamin D-binding protein NCBIGene:2638
1751 140-143 GeneOrGeneProduct denotes DBP NCBIGene:2638
1752 181-192 ChemicalEntity denotes 1.25(OH)2D3 MESH:D002117
1753 292-295 GeneOrGeneProduct denotes DBP NCBIGene:2638
1754 335-410 SequenceVariant denotes GAT-->GAG substitution replaces aspartic acid by glutamic acid in codon 416 p|SUB|D|416|E
1755 416-451 SequenceVariant denotes ACG-->AAG substitution in codon 420 p|SUB|T|420|K
1756 476-496 SequenceVariant denotes threonine for lysine p|SUB|T||K
1757 504-507 GeneOrGeneProduct denotes DBP NCBIGene:2638
1758 557-568 ChemicalEntity denotes 1.25(OH)2D3 MESH:D002117
1759 591-594 GeneOrGeneProduct denotes DBP NCBIGene:2638
1760 607-622 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922
1761 733-736 GeneOrGeneProduct denotes DBP NCBIGene:2638
1762 788-803 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922
1763 876-884 OrganismTaxon denotes patients NCBITaxon:9606
1764 953-956 GeneOrGeneProduct denotes DBP NCBIGene:2638
1765 998-1001 GeneOrGeneProduct denotes DBP NCBIGene:2638
1766 1173-1181 DiseaseOrPhenotypicFeature denotes diabetic MESH:D003920
1767 1207-1211 GeneOrGeneProduct denotes IA-2 NCBIGene:5798
1768 1256-1259 GeneOrGeneProduct denotes DBP NCBIGene:2638
1769 1340-1345 GeneOrGeneProduct denotes GAD65 NCBIGene:2572
1770 1395-1404 ChemicalEntity denotes vitamin D MESH:D014807
1771 1451-1466 DiseaseOrPhenotypicFeature denotes type 1 diabetes MESH:D003922

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-25 GeneOrGeneProduct denotes Vitamin D-binding protein
T2 61-65 GeneOrGeneProduct denotes IA-2
T3 91-99 GeneOrGeneProduct denotes diabetes
T4 113-138 GeneOrGeneProduct denotes Vitamin D-binding protein
T5 152-156 GeneOrGeneProduct denotes main
T6 166-177 GeneOrGeneProduct denotes transporter
T7 314-324 GeneOrGeneProduct denotes amino acid
T8 335-338 GeneOrGeneProduct denotes GAT
T9 367-375 GeneOrGeneProduct denotes aspartic
T10 376-380 GeneOrGeneProduct denotes acid
T11 384-392 GeneOrGeneProduct denotes glutamic
T12 393-397 GeneOrGeneProduct denotes acid
T13 490-496 GeneOrGeneProduct denotes lysine
T14 614-622 GeneOrGeneProduct denotes diabetes
T15 795-803 GeneOrGeneProduct denotes diabetes
T16 812-823 GeneOrGeneProduct denotes AND METHODS
T17 852-856 GeneOrGeneProduct denotes case
T18 1074-1080 GeneOrGeneProduct denotes method
T19 1082-1086 GeneOrGeneProduct denotes RFLP
T20 1102-1113 GeneOrGeneProduct denotes frequencies
T21 1125-1128 GeneOrGeneProduct denotes Glu
T22 1133-1136 GeneOrGeneProduct denotes Glu
T23 1137-1140 GeneOrGeneProduct denotes Glu
T24 1173-1181 GeneOrGeneProduct denotes diabetic
T25 1207-1211 GeneOrGeneProduct denotes IA-2
T26 1260-1263 GeneOrGeneProduct denotes Glu
T27 1340-1345 GeneOrGeneProduct denotes GAD65
T28 1364-1371 GeneOrGeneProduct denotes finding
T29 1440-1447 GeneOrGeneProduct denotes process
T30 1458-1466 GeneOrGeneProduct denotes diabetes

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-25 GeneOrGeneProduct denotes Vitamin D-binding protein
T2 61-65 GeneOrGeneProduct denotes IA-2
T3 91-99 GeneOrGeneProduct denotes diabetes
T4 113-138 GeneOrGeneProduct denotes Vitamin D-binding protein
T5 166-177 GeneOrGeneProduct denotes transporter
T6 314-324 GeneOrGeneProduct denotes amino acid
T7 376-380 GeneOrGeneProduct denotes acid
T8 393-397 GeneOrGeneProduct denotes acid
T9 490-496 GeneOrGeneProduct denotes lysine
T10 614-622 GeneOrGeneProduct denotes diabetes
T11 795-803 GeneOrGeneProduct denotes diabetes
T12 1074-1080 GeneOrGeneProduct denotes method
T13 1207-1211 GeneOrGeneProduct denotes IA-2
T14 1340-1345 GeneOrGeneProduct denotes GAD65
T15 1458-1466 GeneOrGeneProduct denotes diabetes

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 84-99 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T2 607-622 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T3 788-803 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T4 1173-1181 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T5 1451-1466 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-25 GeneOrGeneProduct denotes Vitamin D-binding protein
T2 61-65 GeneOrGeneProduct denotes IA-2
T3 113-138 GeneOrGeneProduct denotes Vitamin D-binding protein
T4 1207-1211 GeneOrGeneProduct denotes IA-2
T5 1340-1345 GeneOrGeneProduct denotes GAD65

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 84-99 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147
T2 607-622 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147
T3 788-803 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147
T4 1451-1466 DiseaseOrPhenotypicFeature denotes type 1 diabetes 0005147

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 84-99 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T2 607-622 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T3 788-803 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T4 1173-1181 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T5 1451-1466 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 84-99 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T2 607-622 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T3 788-803 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T4 1173-1181 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T5 1451-1466 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-9 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T2 113-122 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T3 140-143 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T5 181-192 ChemicalEntity denotes 1.25(OH)2D3 ChemicalEntity
T6 292-295 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T8 335-338 ChemicalEntity denotes GAT C020749
T9 341-344 ChemicalEntity denotes GAG http://purl.obolibrary.org/obo/CHEBI_143889
T10 367-380 ChemicalEntity denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T11 384-397 ChemicalEntity denotes glutamic acid http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_16015
T13 416-419 ChemicalEntity denotes ACG http://purl.obolibrary.org/obo/CHEBI_73345
T14 422-425 ChemicalEntity denotes AAG http://purl.obolibrary.org/obo/CHEBI_73318
T15 476-485 ChemicalEntity denotes threonine http://purl.obolibrary.org/obo/CHEBI_26986
T16 490-496 ChemicalEntity denotes lysine http://purl.obolibrary.org/obo/CHEBI_25094|http://purl.obolibrary.org/obo/CHEBI_18019
T18 504-507 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T20 517-521 ChemicalEntity denotes lead D007854
T21 557-568 ChemicalEntity denotes 1.25(OH)2D3 ChemicalEntity
T22 591-594 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T24 733-736 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T26 953-956 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T28 998-1001 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T30 1121-1128 ChemicalEntity denotes Asp/Glu http://purl.obolibrary.org/obo/CHEBI_73828
T31 1133-1136 ChemicalEntity denotes Glu http://purl.obolibrary.org/obo/CHEBI_29972|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_16015
T34 1137-1140 ChemicalEntity denotes Glu http://purl.obolibrary.org/obo/CHEBI_29972|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_16015
T37 1256-1259 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687
T39 1260-1263 ChemicalEntity denotes Glu http://purl.obolibrary.org/obo/CHEBI_29972|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_16015
T42 1395-1404 ChemicalEntity denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 341-344 OrganismTaxon denotes GAG
T2 876-884 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T42 1395-1404 ChemicalEntity denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T39 1260-1263 ChemicalEntity denotes Glu http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_29972
T37 1256-1259 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T34 1137-1140 ChemicalEntity denotes Glu http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_29972
T31 1133-1136 ChemicalEntity denotes Glu http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_29972
T30 1121-1128 ChemicalEntity denotes Asp/Glu http://purl.obolibrary.org/obo/CHEBI_73828
T28 998-1001 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T26 953-956 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T24 733-736 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T22 591-594 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T21 557-568 ChemicalEntity denotes 1.25(OH)2D3 ChemicalEntity
T20 517-521 ChemicalEntity denotes lead D007854
T18 504-507 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T16 490-496 ChemicalEntity denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T15 476-485 ChemicalEntity denotes threonine http://purl.obolibrary.org/obo/CHEBI_26986
T14 422-425 ChemicalEntity denotes AAG http://purl.obolibrary.org/obo/CHEBI_73318
T13 416-419 ChemicalEntity denotes ACG http://purl.obolibrary.org/obo/CHEBI_73345
T11 384-397 ChemicalEntity denotes glutamic acid http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237
T10 367-380 ChemicalEntity denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T9 341-344 ChemicalEntity denotes GAG http://purl.obolibrary.org/obo/CHEBI_143889
T8 335-338 ChemicalEntity denotes GAT C020749
T6 292-295 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T5 181-192 ChemicalEntity denotes 1.25(OH)2D3 ChemicalEntity
T3 140-143 ChemicalEntity denotes DBP http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861
T2 113-122 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T1 0-9 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T14446 1340-1345 GeneOrGeneProduct denotes GAD65
T4 1207-1211 GeneOrGeneProduct denotes IA-2
T83311 113-138 GeneOrGeneProduct denotes Vitamin D-binding protein
T56714 61-65 GeneOrGeneProduct denotes IA-2
T30319 0-25 GeneOrGeneProduct denotes Vitamin D-binding protein
T33970 1451-1466 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T54075 1173-1181 DiseaseOrPhenotypicFeature denotes diabetic DISEASE
T15467 788-803 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T272 607-622 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T59695 84-99 DiseaseOrPhenotypicFeature denotes type 1 diabetes D003922
T86358 876-884 OrganismTaxon denotes patients
T1522 341-344 OrganismTaxon denotes GAG

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 335-344 DNAMutation:|SUB|GAT||GAG denotes GAT-->GAG
T2 416-451 DNAMutation:|SUB|ACG|CODON420|AAG denotes ACG-->AAG substitution in codon 420

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-25 gene:2638 denotes Vitamin D-binding protein
T1 84-99 disease:C0011854 denotes type 1 diabetes
T2 733-736 gene:1628 denotes DBP
T3 788-803 disease:C0011854 denotes type 1 diabetes
T4 733-736 gene:3295 denotes DBP
T5 788-803 disease:C0011854 denotes type 1 diabetes
T6 733-736 gene:2638 denotes DBP
T7 788-803 disease:C0011854 denotes type 1 diabetes
R1 T0 T1 associated_with Vitamin D-binding protein,type 1 diabetes
R2 T2 T3 associated_with DBP,type 1 diabetes
R3 T4 T5 associated_with DBP,type 1 diabetes
R4 T6 T7 associated_with DBP,type 1 diabetes