PubMed:15820225 JSONTXT

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"15820225-5#201#210#geners2619538","span":{"begin":934,"end":943},"obj":"geners2619538"},{"id":"15820225-5#56#74#diseaseC0338614","span":{"begin":789,"end":807},"obj":"diseaseC0338614"},{"id":"15820225-5#78#94#diseaseC2939186","span":{"begin":811,"end":827},"obj":"diseaseC2939186"},{"id":"15820225-5#273#286#diseaseC0036341","span":{"begin":1006,"end":1019},"obj":"diseaseC0036341"}],"relations":[{"id":"201#210#geners261953856#74#diseaseC0338614","pred":"associated_with","subj":"15820225-5#201#210#geners2619538","obj":"15820225-5#56#74#diseaseC0338614"},{"id":"201#210#geners261953878#94#diseaseC2939186","pred":"associated_with","subj":"15820225-5#201#210#geners2619538","obj":"15820225-5#78#94#diseaseC2939186"},{"id":"201#210#geners2619538273#286#diseaseC0036341","pred":"associated_with","subj":"15820225-5#201#210#geners2619538","obj":"15820225-5#273#286#diseaseC0036341"}],"text":"Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).\nBACKGROUND: Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia. We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample.\nMETHODS: Using similar methodology to our schizophrenia study, we have investigated this same 3-locus haplotype in a large, well-characterized bipolar sample (726 Caucasian UK DSM-IV bipolar I patients; 1407 ethnically matched controls).\nRESULTS: No significant differences were found in the distribution of the 3-locus haplotype in the full sample. Within the subset of bipolar I cases with predominantly psychotic episodes of mood disturbance (n = 133) we found nominally significant support for association at this haploptype (p \u003c .042) and at SNP rs2619538 (p = .003), with a pattern of findings similar to that in our schizophrenia sample. This finding was not significant after correction for multiple testing.\nCONCLUSIONS: Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis. However, our subset sample is small and the hypothesis requires testing in independent, adequately powered samples."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"15820225-0#58#64#gene84062","span":{"begin":58,"end":64},"obj":"gene84062"},{"id":"15820225-0#0#16#diseaseC0005586","span":{"begin":0,"end":16},"obj":"diseaseC0005586"},{"id":"15820225-1#39#69#gene84062","span":{"begin":118,"end":148},"obj":"gene84062"},{"id":"15820225-1#77#83#gene84062","span":{"begin":156,"end":162},"obj":"gene84062"},{"id":"15820225-1#114#127#diseaseC0036341","span":{"begin":193,"end":206},"obj":"diseaseC0036341"},{"id":"15820225-8#46#52#gene84062","span":{"begin":1306,"end":1312},"obj":"gene84062"},{"id":"15820225-8#122#131#diseaseC0033975","span":{"begin":1382,"end":1391},"obj":"diseaseC0033975"},{"id":"15820225-8#122#131#diseaseC0349204","span":{"begin":1382,"end":1391},"obj":"diseaseC0349204"}],"relations":[{"id":"58#64#gene840620#16#diseaseC0005586","pred":"associated_with","subj":"15820225-0#58#64#gene84062","obj":"15820225-0#0#16#diseaseC0005586"},{"id":"39#69#gene84062114#127#diseaseC0036341","pred":"associated_with","subj":"15820225-1#39#69#gene84062","obj":"15820225-1#114#127#diseaseC0036341"},{"id":"77#83#gene84062114#127#diseaseC0036341","pred":"associated_with","subj":"15820225-1#77#83#gene84062","obj":"15820225-1#114#127#diseaseC0036341"},{"id":"46#52#gene84062122#131#diseaseC0033975","pred":"associated_with","subj":"15820225-8#46#52#gene84062","obj":"15820225-8#122#131#diseaseC0033975"},{"id":"46#52#gene84062122#131#diseaseC0349204","pred":"associated_with","subj":"15820225-8#46#52#gene84062","obj":"15820225-8#122#131#diseaseC0349204"}],"text":"Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).\nBACKGROUND: Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia. We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample.\nMETHODS: Using similar methodology to our schizophrenia study, we have investigated this same 3-locus haplotype in a large, well-characterized bipolar sample (726 Caucasian UK DSM-IV bipolar I patients; 1407 ethnically matched controls).\nRESULTS: No significant differences were found in the distribution of the 3-locus haplotype in the full sample. Within the subset of bipolar I cases with predominantly psychotic episodes of mood disturbance (n = 133) we found nominally significant support for association at this haploptype (p \u003c .042) and at SNP rs2619538 (p = .003), with a pattern of findings similar to that in our schizophrenia sample. This finding was not significant after correction for multiple testing.\nCONCLUSIONS: Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis. However, our subset sample is small and the hypothesis requires testing in independent, adequately powered samples."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":58,"end":64},"obj":"gene:84062"},{"id":"T1","span":{"begin":0,"end":16},"obj":"disease:C0005586"},{"id":"T2","span":{"begin":118,"end":148},"obj":"gene:84062"},{"id":"T3","span":{"begin":193,"end":206},"obj":"disease:C0036341"},{"id":"T4","span":{"begin":156,"end":162},"obj":"gene:84062"},{"id":"T5","span":{"begin":193,"end":206},"obj":"disease:C0036341"},{"id":"T6","span":{"begin":1306,"end":1312},"obj":"gene:84062"},{"id":"T7","span":{"begin":1354,"end":1370},"obj":"disease:C0005586"},{"id":"T8","span":{"begin":1306,"end":1312},"obj":"gene:84062"},{"id":"T9","span":{"begin":1382,"end":1391},"obj":"disease:C0033975"},{"id":"T10","span":{"begin":1306,"end":1312},"obj":"gene:84062"},{"id":"T11","span":{"begin":1382,"end":1391},"obj":"disease:C0349204"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).\nBACKGROUND: Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia. We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample.\nMETHODS: Using similar methodology to our schizophrenia study, we have investigated this same 3-locus haplotype in a large, well-characterized bipolar sample (726 Caucasian UK DSM-IV bipolar I patients; 1407 ethnically matched controls).\nRESULTS: No significant differences were found in the distribution of the 3-locus haplotype in the full sample. Within the subset of bipolar I cases with predominantly psychotic episodes of mood disturbance (n = 133) we found nominally significant support for association at this haploptype (p \u003c .042) and at SNP rs2619538 (p = .003), with a pattern of findings similar to that in our schizophrenia sample. This finding was not significant after correction for multiple testing.\nCONCLUSIONS: Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis. However, our subset sample is small and the hypothesis requires testing in independent, adequately powered samples."}

{"project":"PubTator4TogoVar","denotations":[{"id":"36","span":{"begin":934,"end":943},"obj":"SNP"}],"attributes":[{"id":"A36","pred":"resolved_to","subj":"36","obj":"tmVar:rs2619538;VariantGroup:0;CorrespondingGene:84062;RS#:2619538;CorrespondingSpecies:9606"}],"text":"Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).\nBACKGROUND: Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia. We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample.\nMETHODS: Using similar methodology to our schizophrenia study, we have investigated this same 3-locus haplotype in a large, well-characterized bipolar sample (726 Caucasian UK DSM-IV bipolar I patients; 1407 ethnically matched controls).\nRESULTS: No significant differences were found in the distribution of the 3-locus haplotype in the full sample. Within the subset of bipolar I cases with predominantly psychotic episodes of mood disturbance (n = 133) we found nominally significant support for association at this haploptype (p \u003c .042) and at SNP rs2619538 (p = .003), with a pattern of findings similar to that in our schizophrenia sample. This finding was not significant after correction for multiple testing.\nCONCLUSIONS: Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis. However, our subset sample is small and the hypothesis requires testing in independent, adequately powered samples."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"36","span":{"begin":934,"end":943},"obj":"SNP"},{"id":"T1","span":{"begin":934,"end":943},"obj":"SNP"}],"attributes":[{"id":"A36","pred":"resolved_to","subj":"36","obj":"tmVar:rs2619538;VariantGroup:0;CorrespondingGene:84062;RS#:2619538;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs2619538;VariantGroup:0;CorrespondingGene:84062;RS#:2619538;CorrespondingSpecies:9606"}],"text":"Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).\nBACKGROUND: Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia. We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample.\nMETHODS: Using similar methodology to our schizophrenia study, we have investigated this same 3-locus haplotype in a large, well-characterized bipolar sample (726 Caucasian UK DSM-IV bipolar I patients; 1407 ethnically matched controls).\nRESULTS: No significant differences were found in the distribution of the 3-locus haplotype in the full sample. Within the subset of bipolar I cases with predominantly psychotic episodes of mood disturbance (n = 133) we found nominally significant support for association at this haploptype (p \u003c .042) and at SNP rs2619538 (p = .003), with a pattern of findings similar to that in our schizophrenia sample. This finding was not significant after correction for multiple testing.\nCONCLUSIONS: Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis. However, our subset sample is small and the hypothesis requires testing in independent, adequately powered samples."}