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PubMed:15788739 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 1158-1174 https://glytoucan.org/Structures/Glycans/G71142DF denotes Glucosylceramide

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1158-1174 Glycan_Motif denotes Glucosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71142DF

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1158-1174 https://glytoucan.org/Structures/Glycans/G71142DF denotes Glucosylceramide

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 334-349 http://purl.obolibrary.org/obo/MAT_0000250 denotes inner cell mass
T2 365-372 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos
T3 410-418 http://purl.obolibrary.org/obo/MAT_0000175 denotes endoderm

GlycoBiology-GDGDB

Id Subject Object Predicate Lexical cue
_T1 1004-1008 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00023 denotes GSLs

uniprot-human

Id Subject Object Predicate Lexical cue
T1 106-127 http://www.uniprot.org/uniprot/Q7Z5J4 denotes retinoic acid-induced
T2 106-127 http://www.uniprot.org/uniprot/Q6GMV2 denotes retinoic acid-induced
T3 106-127 http://www.uniprot.org/uniprot/Q8NFJ5 denotes retinoic acid-induced
T4 106-127 http://www.uniprot.org/uniprot/O75563 denotes retinoic acid-induced
T5 106-127 http://www.uniprot.org/uniprot/Q86V87 denotes retinoic acid-induced
T6 106-127 http://www.uniprot.org/uniprot/Q9P0K7 denotes retinoic acid-induced
T7 106-127 http://www.uniprot.org/uniprot/Q9ULJ6 denotes retinoic acid-induced
T8 106-127 http://www.uniprot.org/uniprot/Q9Y5P3 denotes retinoic acid-induced
T9 147-149 http://www.uniprot.org/uniprot/P00740 denotes F9
T10 183-185 http://www.uniprot.org/uniprot/P00740 denotes F9
T11 472-474 http://www.uniprot.org/uniprot/P00740 denotes F9
T12 938-940 http://www.uniprot.org/uniprot/P00740 denotes F9
T13 1409-1411 http://www.uniprot.org/uniprot/P00740 denotes F9
T14 2117-2119 http://www.uniprot.org/uniprot/P00740 denotes F9
T15 1158-1183 http://www.uniprot.org/uniprot/Q16739 denotes Glucosylceramide synthase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 66-69 http://www.uniprot.org/uniprot/P05480 denotes Src
T2 1611-1614 http://www.uniprot.org/uniprot/P05480 denotes Src
T3 147-149 http://www.uniprot.org/uniprot/P16294 denotes F9
T4 183-185 http://www.uniprot.org/uniprot/P16294 denotes F9
T5 472-474 http://www.uniprot.org/uniprot/P16294 denotes F9
T6 938-940 http://www.uniprot.org/uniprot/P16294 denotes F9
T7 1409-1411 http://www.uniprot.org/uniprot/P16294 denotes F9
T8 2117-2119 http://www.uniprot.org/uniprot/P16294 denotes F9
T9 1158-1183 http://www.uniprot.org/uniprot/O88693 denotes Glucosylceramide synthase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 160-169 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinoma
T2 170-175 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 196-205 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinoma
T4 206-211 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 262-271 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T6 1501-1505 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes beta
T7 1501-1505 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes beta
T8 1748-1753 http://purl.bioontology.org/ontology/NCBITAXON/62990 denotes laser
T9 2120-2125 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 12-21 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T2 1943-1953 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3 22-46 http://purl.obolibrary.org/obo/GO_0001574 denotes ganglioside biosynthesis
T4 1957-1981 http://purl.obolibrary.org/obo/GO_0001574 denotes ganglioside biosynthesis
T5 34-46 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T6 815-827 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T7 1969-1981 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T8 420-423 http://purl.obolibrary.org/obo/GO_0003904 denotes PrE
T9 962-965 http://purl.obolibrary.org/obo/GO_0003904 denotes PrE
T10 1153-1156 http://purl.obolibrary.org/obo/GO_0003904 denotes PrE
T11 1882-1885 http://purl.obolibrary.org/obo/GO_0003904 denotes PrE
T12 475-495 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T13 1412-1432 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T14 712-721 http://purl.obolibrary.org/obo/GO_0032502 denotes developed
T15 757-766 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitive
T16 832-842 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T17 1494-1500 http://purl.obolibrary.org/obo/GO_0032259 denotes methyl
T18 1778-1787 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T19 2008-2017 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

GO-CC

Id Subject Object Predicate Lexical cue
T1 170-175 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 206-211 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 340-344 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 475-479 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 1412-1416 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 1469-1477 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T7 1469-1490 http://purl.obolibrary.org/obo/GO_0098857 denotes membrane microdomains

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 334-349 http://purl.obolibrary.org/obo/UBERON_0000087 denotes inner cell mass
T2 365-372 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T3 410-418 http://purl.obolibrary.org/obo/UBERON_0000925 denotes endoderm

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 334-349 http://purl.obolibrary.org/obo/MAT_0000250 denotes inner cell mass
T2 365-372 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos
T3 410-418 http://purl.obolibrary.org/obo/MAT_0000175 denotes endoderm

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-176 Sentence denotes Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
TextSentencer_T2 177-464 Sentence denotes Mouse F9 embryonal carcinoma cells have been widely used as a model for studying the mechanism of embryonic differentiation, because they are similar to the inner cell mass of early mouse embryos and can differentiate into primitive endoderm (PrE) following retinoic acid (RA) treatment.
TextSentencer_T3 465-618 Sentence denotes During F9 cell differentiation, the carbohydrate chains of glycoproteins and their corresponding glycosyltransferases are known to undergo rapid changes.
TextSentencer_T4 619-703 Sentence denotes However, there have been no corresponding reports on the expression of gangliosides.
TextSentencer_T5 704-843 Sentence denotes We have developed a custom cDNA array that is highly sensitive for the genes responsible for sphingolipid (SL) biosynthesis and metabolism.
TextSentencer_T6 844-966 Sentence denotes Using this, we found that, of the 28 selected genes, 26 exhibited increased expression during F9 differentiation into PrE.
TextSentencer_T7 967-1157 Sentence denotes Although neutral glycosphingolipids (GSLs) were expressed at similar levels before and after differentiation, a greater than 20-fold increase in total ganglioside content was evident in PrE.
TextSentencer_T8 1158-1433 Sentence denotes Glucosylceramide synthase inhibitors (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [d-PDMP] and its analog) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2), suggesting the involvement of gangliosides in F9 cell differentiation.
TextSentencer_T9 1434-1558 Sentence denotes Disruption of cholesterol-enriched membrane microdomains by methyl-beta-cyclodextrin (MbetaCD) also delayed differentiation.
TextSentencer_T10 1559-1653 Sentence denotes Both MbetaCD and d-PDMP blocked the accumulation of Src family kinases (SFKs) to microdomains.
TextSentencer_T11 1654-1724 Sentence denotes However, d-PDMP did not block flotillin accumulation, yet MbetaCD did.
TextSentencer_T12 1725-1902 Sentence denotes Additionally, confocal laser microscopy revealed the formation of distinct functional microdomains integrating SFKs with gangliosides and cholesterol during PrE differentiation.
TextSentencer_T13 1903-2126 Sentence denotes Thus, we demonstrate the outstanding up-regulation of ganglioside biosynthesis and its importance in the formation of distinct microdomains incorporating SFKs with gangliosides during RA-induced differentiation of F9 cells.
T1 0-176 Sentence denotes Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
T2 177-464 Sentence denotes Mouse F9 embryonal carcinoma cells have been widely used as a model for studying the mechanism of embryonic differentiation, because they are similar to the inner cell mass of early mouse embryos and can differentiate into primitive endoderm (PrE) following retinoic acid (RA) treatment.
T3 465-618 Sentence denotes During F9 cell differentiation, the carbohydrate chains of glycoproteins and their corresponding glycosyltransferases are known to undergo rapid changes.
T4 619-703 Sentence denotes However, there have been no corresponding reports on the expression of gangliosides.
T5 704-843 Sentence denotes We have developed a custom cDNA array that is highly sensitive for the genes responsible for sphingolipid (SL) biosynthesis and metabolism.
T6 844-966 Sentence denotes Using this, we found that, of the 28 selected genes, 26 exhibited increased expression during F9 differentiation into PrE.
T7 967-1157 Sentence denotes Although neutral glycosphingolipids (GSLs) were expressed at similar levels before and after differentiation, a greater than 20-fold increase in total ganglioside content was evident in PrE.
T8 1158-1433 Sentence denotes Glucosylceramide synthase inhibitors (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [d-PDMP] and its analog) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2), suggesting the involvement of gangliosides in F9 cell differentiation.
T9 1434-1558 Sentence denotes Disruption of cholesterol-enriched membrane microdomains by methyl-beta-cyclodextrin (MbetaCD) also delayed differentiation.
T10 1559-1653 Sentence denotes Both MbetaCD and d-PDMP blocked the accumulation of Src family kinases (SFKs) to microdomains.
T11 1654-1724 Sentence denotes However, d-PDMP did not block flotillin accumulation, yet MbetaCD did.
T12 1725-1902 Sentence denotes Additionally, confocal laser microscopy revealed the formation of distinct functional microdomains integrating SFKs with gangliosides and cholesterol during PrE differentiation.
T13 1903-2126 Sentence denotes Thus, we demonstrate the outstanding up-regulation of ganglioside biosynthesis and its importance in the formation of distinct microdomains incorporating SFKs with gangliosides during RA-induced differentiation of F9 cells.
T1 0-176 Sentence denotes Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
T2 177-464 Sentence denotes Mouse F9 embryonal carcinoma cells have been widely used as a model for studying the mechanism of embryonic differentiation, because they are similar to the inner cell mass of early mouse embryos and can differentiate into primitive endoderm (PrE) following retinoic acid (RA) treatment.
T3 465-618 Sentence denotes During F9 cell differentiation, the carbohydrate chains of glycoproteins and their corresponding glycosyltransferases are known to undergo rapid changes.
T4 619-703 Sentence denotes However, there have been no corresponding reports on the expression of gangliosides.
T5 704-843 Sentence denotes We have developed a custom cDNA array that is highly sensitive for the genes responsible for sphingolipid (SL) biosynthesis and metabolism.
T6 844-966 Sentence denotes Using this, we found that, of the 28 selected genes, 26 exhibited increased expression during F9 differentiation into PrE.
T7 967-1157 Sentence denotes Although neutral glycosphingolipids (GSLs) were expressed at similar levels before and after differentiation, a greater than 20-fold increase in total ganglioside content was evident in PrE.
T8 1158-1433 Sentence denotes Glucosylceramide synthase inhibitors (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [d-PDMP] and its analog) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2), suggesting the involvement of gangliosides in F9 cell differentiation.
T9 1434-1558 Sentence denotes Disruption of cholesterol-enriched membrane microdomains by methyl-beta-cyclodextrin (MbetaCD) also delayed differentiation.
T10 1559-1653 Sentence denotes Both MbetaCD and d-PDMP blocked the accumulation of Src family kinases (SFKs) to microdomains.
T11 1654-1724 Sentence denotes However, d-PDMP did not block flotillin accumulation, yet MbetaCD did.
T12 1725-1902 Sentence denotes Additionally, confocal laser microscopy revealed the formation of distinct functional microdomains integrating SFKs with gangliosides and cholesterol during PrE differentiation.
T13 1903-2126 Sentence denotes Thus, we demonstrate the outstanding up-regulation of ganglioside biosynthesis and its importance in the formation of distinct microdomains incorporating SFKs with gangliosides during RA-induced differentiation of F9 cells.

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 66-69 https://acgg.asia/db/lfdb/LfDB0103 denotes Src
Lectin_T2 1611-1614 https://acgg.asia/db/lfdb/LfDB0103 denotes Src

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 878-880 http://www.glycoepitope.jp/epitopes/AN0746 denotes 28

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 334-349 http://purl.obolibrary.org/obo/UBERON_0000087 denotes inner cell mass
PD-UBERON-AE-B_T2 365-372 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
PD-UBERON-AE-B_T3 410-418 http://purl.obolibrary.org/obo/UBERON_0000925 denotes endoderm

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 150-169 Disease denotes embryonal carcinoma http://purl.obolibrary.org/obo/MONDO_0005440
T2 186-205 Disease denotes embryonal carcinoma http://purl.obolibrary.org/obo/MONDO_0005440

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 177-182 OrganismTaxon denotes Mouse 10088|10090
T3 359-364 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 334-349 Body_part denotes inner cell mass http://purl.obolibrary.org/obo/UBERON_0000087
T2 400-418 Body_part denotes primitive endoderm http://purl.obolibrary.org/obo/UBERON_0008776
T3 420-423 Body_part denotes PrE http://purl.obolibrary.org/obo/UBERON_0008776
T4 962-965 Body_part denotes PrE http://purl.obolibrary.org/obo/UBERON_0008776
T5 1153-1156 Body_part denotes PrE http://purl.obolibrary.org/obo/UBERON_0008776
T6 1469-1477 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T9 1882-1885 Body_part denotes PrE http://purl.obolibrary.org/obo/UBERON_0008776

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 334-349 Body_part denotes inner cell mass http://purl.obolibrary.org/obo/MAT_0000250
T2 365-372 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T3 410-418 Body_part denotes endoderm http://purl.obolibrary.org/obo/MAT_0000175

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 160-169 Phenotype denotes carcinoma HP:0030731
T2 196-205 Phenotype denotes carcinoma HP:0030731
T3 450-452 Phenotype denotes RA HP:0001370
T4 750-766 Phenotype denotes highly sensitive HP:0041092
T5 2087-2089 Phenotype denotes RA HP:0001370