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PubMed:15788404 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-180 Sentence denotes Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
T2 181-392 Sentence denotes Nucleotide pyrophosphatases/phosphodiesterases (NPPs) are ubiquitous membrane-associated or secreted ectoenzymes that release nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives.
T3 393-509 Sentence denotes The mammalian NPP family comprises seven members, but only three of these (NPP1-3) have been studied in some detail.
T4 510-659 Sentence denotes Previously we showed that lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) to produce lysophosphatidic acid, is identical to NPP2.
T5 660-770 Sentence denotes More recently an uncharacterized novel NPP member (NPP7) was shown to have alkaline sphingomyelinase activity.
T6 771-867 Sentence denotes These findings raised the possibility that other members of the NPP family act on phospholipids.
T7 868-990 Sentence denotes Here we show that the sixth member of the NPP family, NPP6, is a choline-specific glycerophosphodiester phosphodiesterase.
T8 991-1145 Sentence denotes The sequence of NPP6 encodes a transmembrane protein containing an NPP domain with significant homology to NPP4, NPP5, and NPP7/alkaline sphingomyelinase.
T9 1146-1296 Sentence denotes When expressed in HeLa cells, NPP6 was detected in both the cells and the cell culture medium as judged by Western blotting and by enzymatic activity.
T10 1297-1518 Sentence denotes Recombinant NPP6 efficiently hydrolyzed the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, but not the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate.
T11 1519-1676 Sentence denotes In addition, NPP6 hydrolyzed LPC to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity.
T12 1677-1784 Sentence denotes NPP6 showed a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids.
T13 1785-1873 Sentence denotes It also hydrolyzed glycerophosphorylcholine and sphingosylphosphorylcholine efficiently.
T14 1874-2024 Sentence denotes In mice, NPP6 mRNA was predominantly detected in kidney with a lesser expression in brain and heart, and in human it was detected in kidney and brain.
T15 2025-2203 Sentence denotes The present results suggest that NPP6 has a specific role through the hydrolysis of polyunsaturated LPC, glycerophosphorylcholine, or sphingosylphosphorylcholine in these organs.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1923-1929 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T2 1958-1963 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T3 1968-1973 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T4 2007-2013 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T5 2018-2023 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

LocText

Id Subject Object Predicate Lexical cue
T1 250-258 go:GO:0016020 denotes membrane
T2 273-281 go:GO:0005576 denotes secreted
T3 468-474 uniprot:P22413 denotes NPP1-3
T4 468-474 uniprot:P06802 denotes NPP1-3
T5 468-474 uniprot:Q13822 denotes NPP1-3
T6 468-474 uniprot:Q9R1E6 denotes NPP1-3
T7 468-474 uniprot:Q6DYE8 denotes NPP1-3
T8 468-474 uniprot:O14638 denotes NPP1-3
T9 536-555 uniprot:Q13822 denotes lysophospholipase D
T10 654-658 uniprot:Q13822 denotes NPP2
T11 711-715 uniprot:Q6UWV6 denotes NPP7
T12 735-760 uniprot:Q6UWV6 denotes alkaline sphingomyelinase
T13 922-926 uniprot:Q6UWR7 denotes NPP6
T14 1007-1011 uniprot:Q6UWR7 denotes NPP6
T15 1022-1035 go:GO:0016021 denotes transmembrane
T16 1098-1102 uniprot:Q9Y6X5 denotes NPP4
T17 1104-1108 uniprot:Q9UJA9 denotes NPP5
T18 1114-1118 uniprot:Q6UWV6 denotes NPP7
T19 1119-1144 uniprot:Q6UWV6 denotes alkaline sphingomyelinase
T20 1176-1180 uniprot:Q6UWR7 denotes NPP6
T21 1309-1313 uniprot:Q6UWR7 denotes NPP6
T22 1532-1536 uniprot:Q6UWR7 denotes NPP6
T23 1647-1666 uniprot:uniprot: denotes lysophospholipase C
T24 1677-1681 uniprot:Q6UWR7 denotes NPP6
T25 1877-1881 taxonomy:10090 denotes mice
T26 1883-1887 uniprot:Q6UWR7 denotes NPP6
T27 1982-1987 taxonomy:9606 denotes human
T28 2058-2062 uniprot:Q6UWR7 denotes NPP6
R1 T9 T1 localizeTo lysophospholipase D,membrane
R2 T10 T1 localizeTo NPP2,membrane
R3 T12 T1 localizeTo alkaline sphingomyelinase,membrane
R4 T11 T1 localizeTo NPP7,membrane
R5 T13 T1 localizeTo NPP6,membrane
R6 T17 T1 localizeTo NPP5,membrane
R7 T16 T1 localizeTo NPP4,membrane
R8 T23 T1 localizeTo lysophospholipase C,membrane
R9 T3 T2 localizeTo NPP1-3,secreted
R10 T3 T1 localizeTo NPP1-3,membrane
R11 T9 T2 localizeTo lysophospholipase D,secreted
R12 T10 T2 localizeTo NPP2,secreted
R13 T11 T2 localizeTo NPP7,secreted
R14 T12 T2 localizeTo alkaline sphingomyelinase,secreted
R15 T13 T2 localizeTo NPP6,secreted
R16 T14 T15 localizeTo NPP6,transmembrane
R17 T16 T2 localizeTo NPP4,secreted
R18 T17 T2 localizeTo NPP5,secreted
R19 T23 T2 localizeTo lysophospholipase C,secreted

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1923-1929 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T2 1958-1963 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 1968-1973 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 2007-2013 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T5 2018-2023 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1379-1383 Phenotype denotes C, p HP:0100021

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1877-1881 OrganismTaxon denotes mice 10088
T2 1982-1987 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 250-258 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1022-1035 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T5 1923-1929 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T6 1958-1963 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T8 1968-1973 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T12 2007-2013 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T13 2018-2023 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636