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PubMed:15777735 JSONTXT

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HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 511-529 Phenotype denotes lactose intolerant HP:0004789
T2 571-580 Phenotype denotes diarrhoea HP:0002014

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 353-360 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T2 511-518 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T3 685-692 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 175-194 Disease denotes lactase persistence http://purl.obolibrary.org/obo/MONDO_0009116
T2 511-529 Disease denotes lactose intolerant http://purl.obolibrary.org/obo/MONDO_0009116
T3 571-580 Disease denotes diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T4 596-614 Disease denotes lactase persistent http://purl.obolibrary.org/obo/MONDO_0009116
T5 704-723 Disease denotes Lactase persistence http://purl.obolibrary.org/obo/MONDO_0009116
T6 898-916 Disease denotes lactase persistent http://purl.obolibrary.org/obo/MONDO_0009116
T7 1200-1219 Disease denotes lactase persistence http://purl.obolibrary.org/obo/MONDO_0009116

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 511-529 Phenotype denotes lactose intolerant HP:0004789
T2 571-580 Phenotype denotes diarrhoea HP:0002014

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 175-194 Disease denotes lactase persistence http://purl.obolibrary.org/obo/MONDO_0009116
T2 511-529 Disease denotes lactose intolerant http://purl.obolibrary.org/obo/MONDO_0009116
T3 571-580 Disease denotes diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T4 596-614 Disease denotes lactase persistent http://purl.obolibrary.org/obo/MONDO_0009116
T5 704-723 Disease denotes Lactase persistence http://purl.obolibrary.org/obo/MONDO_0009116
T6 898-916 Disease denotes lactase persistent http://purl.obolibrary.org/obo/MONDO_0009116
T7 1200-1219 Disease denotes lactase persistence http://purl.obolibrary.org/obo/MONDO_0009116

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 114-119 OrganismTaxon denotes human 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 387-391 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-61 Sentence denotes Adult-type hypolactasia and regulation of lactase expression.
T2 62-249 Sentence denotes A common genetically determined polymorphism in the human population leads to two distinct phenotypes in adults, lactase persistence and adult-type hypolactasia (lactase non-persistence).
T3 250-392 Sentence denotes All healthy newborn children express high levels of lactase and are able to digest large quantities of lactose, the main carbohydrate in milk.
T4 393-582 Sentence denotes Individuals with adult-type hypolactasia lose their lactase expression before adulthood and consequently often become lactose intolerant with associated digestive problems (e.g. diarrhoea).
T5 583-703 Sentence denotes In contrast, lactase persistent individuals have a lifelong lactase expression and are able to digest lactose as adults.
T6 704-863 Sentence denotes Lactase persistence can be regarded as the mutant phenotype since other mammals down-regulate their lactase expression after weaning (the postweaning decline).
T7 864-929 Sentence denotes This phenomenon does not occur in lactase persistent individuals.
T8 930-1128 Sentence denotes The regulation of lactase expression is mainly transcriptional and it is well established that adult-type hypolactasia is inherited in an autosomal recessive manner, whereas persistence is dominant.
T9 1129-1311 Sentence denotes The recent findings of single nucleotide polymorphisms associated with lactase persistence have made it possible to study the potential mechanisms underlying adult-type hypolactasia.
T10 1312-1421 Sentence denotes This work has led to the identification of gene-regulatory sequences located far from the lactase gene (LCT).
T11 1422-1591 Sentence denotes The present review describes the recent advances in the understanding of the regulation of lactase expression and the possible mechanisms behind adult-type hypolactasia.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 353-360 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T2 511-518 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T3 685-692 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 114-119 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 387-391 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913