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Id Subject Object Predicate Lexical cue
T1 0-9 CL:0000738 denotes Leukocyte
T2 18-24 UBERON:0027368 denotes matrix
T4 18-44 P14780 denotes matrix metalloproteinase-9
T5 18-44 P41246 denotes matrix metalloproteinase-9
T6 18-44 P41245 denotes matrix metalloproteinase-9
T7 18-44 P50282 denotes matrix metalloproteinase-9
T8 18-44 PR:000010491 denotes matrix metalloproteinase-9
T9 18-44 P52176 denotes matrix metalloproteinase-9
T10 18-44 O18733 denotes matrix metalloproteinase-9
T3 18-44 D020780 denotes matrix metalloproteinase-9
T11 54-73 UBERON:0000120 denotes blood-brain barrier
T14 74-83 GO:0009056 denotes breakdown
T15 129-146 D002545 denotes cerebral ischemia
T16 129-146 D002545 denotes cerebral ischemia
T19 194-217 D018696 denotes neuroprotective effects
T20 194-217 D018696 denotes neuroprotective effects
T21 221-227 UBERON:0027368 denotes matrix
T23 221-247 P14780 denotes matrix metalloproteinase-9
T24 221-247 P41246 denotes matrix metalloproteinase-9
T25 221-247 P41245 denotes matrix metalloproteinase-9
T26 221-247 P50282 denotes matrix metalloproteinase-9
T27 221-247 PR:000010491 denotes matrix metalloproteinase-9
T28 221-247 P52176 denotes matrix metalloproteinase-9
T29 221-247 O18733 denotes matrix metalloproteinase-9
T22 221-247 D020780 denotes matrix metalloproteinase-9
T30 249-252 CHEBI:340824 denotes MMP
T33 249-252 CHEBI:59761 denotes MMP
T34 249-254 PR:P50282 denotes MMP-9
T35 249-254 PR:P14780 denotes MMP-9
T36 249-254 P14780 denotes MMP-9
T37 249-254 PR:P41245 denotes MMP-9
T38 249-254 P41246 denotes MMP-9
T39 249-254 P41245 denotes MMP-9
T40 249-254 PR:P52176 denotes MMP-9
T41 249-254 P50282 denotes MMP-9
T43 249-254 PR:000010491 denotes MMP-9
T44 249-254 P52176 denotes MMP-9
T45 249-254 O18733 denotes MMP-9
T42 249-254 GO:0004229 denotes MMP-9
T46 271-274 CHEBI:340824 denotes MMP
T49 271-274 CHEBI:59761 denotes MMP
T50 271-276 PR:P50282 denotes MMP-9
T51 271-276 PR:P14780 denotes MMP-9
T52 271-276 P14780 denotes MMP-9
T53 271-276 PR:P41245 denotes MMP-9
T54 271-276 P41246 denotes MMP-9
T55 271-276 P41245 denotes MMP-9
T56 271-276 PR:P52176 denotes MMP-9
T57 271-276 P50282 denotes MMP-9
T59 271-276 PR:000010491 denotes MMP-9
T60 271-276 P52176 denotes MMP-9
T61 271-276 O18733 denotes MMP-9
T58 271-276 GO:0004229 denotes MMP-9
T62 277-281 SO:0000704 denotes gene
T63 282-290 SO:0000159 denotes deletion
T64 347-350 CHEBI:340824 denotes MMP
T67 347-350 CHEBI:59761 denotes MMP
T68 347-352 PR:P50282 denotes MMP-9
T69 347-352 PR:P14780 denotes MMP-9
T70 347-352 P14780 denotes MMP-9
T71 347-352 PR:P41245 denotes MMP-9
T72 347-352 P41246 denotes MMP-9
T73 347-352 P41245 denotes MMP-9
T74 347-352 PR:P52176 denotes MMP-9
T75 347-352 P50282 denotes MMP-9
T77 347-352 PR:000010491 denotes MMP-9
T78 347-352 P52176 denotes MMP-9
T79 347-352 O18733 denotes MMP-9
T76 347-352 GO:0004229 denotes MMP-9
T80 378-383 UBERON:6110636 denotes brain
T81 378-383 UBERON:0000955 denotes brain
T82 413-416 CHEBI:340824 denotes MMP
T85 413-416 CHEBI:59761 denotes MMP
T86 413-418 PR:P50282 denotes MMP-9
T87 413-418 PR:P14780 denotes MMP-9
T88 413-418 P14780 denotes MMP-9
T89 413-418 PR:P41245 denotes MMP-9
T90 413-418 P41246 denotes MMP-9
T91 413-418 P41245 denotes MMP-9
T92 413-418 PR:P52176 denotes MMP-9
T93 413-418 P50282 denotes MMP-9
T95 413-418 PR:000010491 denotes MMP-9
T96 413-418 P52176 denotes MMP-9
T97 413-418 O18733 denotes MMP-9
T94 413-418 GO:0004229 denotes MMP-9
T98 428-433 UBERON:6110636 denotes brain
T99 428-433 UBERON:0000955 denotes brain
T100 428-440 D001930 denotes brain injury
T101 428-440 D001930 denotes brain injury
T102 492-495 CHEBI:340824 denotes MMP
T105 492-495 CHEBI:59761 denotes MMP
T106 492-497 PR:P50282 denotes MMP-9
T107 492-497 PR:P14780 denotes MMP-9
T108 492-497 P14780 denotes MMP-9
T109 492-497 PR:P41245 denotes MMP-9
T110 492-497 P41246 denotes MMP-9
T111 492-497 P41245 denotes MMP-9
T112 492-497 PR:P52176 denotes MMP-9
T113 492-497 P50282 denotes MMP-9
T115 492-497 PR:000010491 denotes MMP-9
T116 492-497 P52176 denotes MMP-9
T117 492-497 O18733 denotes MMP-9
T114 492-497 GO:0004229 denotes MMP-9
T118 501-505 PR:000005054 denotes mice
T120 501-505 O89094 denotes mice
T119 501-505 D051379 denotes mice
T121 501-505 10095 denotes mice
T122 544-547 CHEBI:340824 denotes MMP
T125 544-547 CHEBI:59761 denotes MMP
T126 544-549 PR:P50282 denotes MMP-9
T127 544-549 PR:P14780 denotes MMP-9
T128 544-549 P14780 denotes MMP-9
T129 544-549 PR:P41245 denotes MMP-9
T130 544-549 P41246 denotes MMP-9
T131 544-549 P41245 denotes MMP-9
T132 544-549 PR:P52176 denotes MMP-9
T133 544-549 P50282 denotes MMP-9
T135 544-549 PR:000010491 denotes MMP-9
T136 544-549 P52176 denotes MMP-9
T137 544-549 O18733 denotes MMP-9
T134 544-549 GO:0004229 denotes MMP-9
T138 579-584 UBERON:6110636 denotes brain
T139 579-584 UBERON:0000955 denotes brain
T140 619-622 CHEBI:340824 denotes MMP
T143 619-622 CHEBI:59761 denotes MMP
T144 619-624 PR:P50282 denotes MMP-9
T145 619-624 PR:P14780 denotes MMP-9
T146 619-624 P14780 denotes MMP-9
T147 619-624 PR:P41245 denotes MMP-9
T148 619-624 P41246 denotes MMP-9
T149 619-624 P41245 denotes MMP-9
T150 619-624 PR:P52176 denotes MMP-9
T151 619-624 P50282 denotes MMP-9
T153 619-624 PR:000010491 denotes MMP-9
T154 619-624 P52176 denotes MMP-9
T155 619-624 O18733 denotes MMP-9
T152 619-624 GO:0004229 denotes MMP-9
T156 663-672 UBERON:0000955 denotes the brain
T159 778-781 CHEBI:340824 denotes MMP
T162 778-781 CHEBI:59761 denotes MMP
T163 778-783 PR:P50282 denotes MMP-9
T164 778-783 PR:P14780 denotes MMP-9
T165 778-783 P14780 denotes MMP-9
T166 778-783 PR:P41245 denotes MMP-9
T167 778-783 P41246 denotes MMP-9
T168 778-783 P41245 denotes MMP-9
T169 778-783 PR:P52176 denotes MMP-9
T170 778-783 P50282 denotes MMP-9
T172 778-783 PR:000010491 denotes MMP-9
T173 778-783 P52176 denotes MMP-9
T174 778-783 O18733 denotes MMP-9
T171 778-783 GO:0004229 denotes MMP-9
T175 793-802 CL:0000738 denotes leukocyte
T176 831-836 UBERON:6110636 denotes brain
T177 831-836 UBERON:0000955 denotes brain
T178 880-899 UBERON:0000120 denotes blood-brain barrier
T181 901-904 UBERON:0000120 denotes BBB
T182 906-915 GO:0009056 denotes breakdown
T183 961-971 D007238 denotes infarction
T184 961-971 D007238 denotes infarction
T186 1048-1051 CHEBI:340824 denotes MMP
T189 1048-1051 CHEBI:59761 denotes MMP
T190 1048-1053 PR:P50282 denotes MMP-9
T191 1048-1053 PR:P14780 denotes MMP-9
T192 1048-1053 P14780 denotes MMP-9
T193 1048-1053 PR:P41245 denotes MMP-9
T194 1048-1053 P41246 denotes MMP-9
T195 1048-1053 P41245 denotes MMP-9
T196 1048-1053 PR:P52176 denotes MMP-9
T197 1048-1053 P50282 denotes MMP-9
T199 1048-1053 PR:000010491 denotes MMP-9
T200 1048-1053 P52176 denotes MMP-9
T201 1048-1053 O18733 denotes MMP-9
T198 1048-1053 GO:0004229 denotes MMP-9
T202 1057-1061 PR:000005054 denotes mice
T204 1057-1061 O89094 denotes mice
T203 1057-1061 D051379 denotes mice
T205 1057-1061 10095 denotes mice
T206 1069-1077 D002678 denotes chimeras
T207 1097-1100 CHEBI:340824 denotes MMP
T210 1097-1100 CHEBI:59761 denotes MMP
T211 1097-1102 PR:P50282 denotes MMP-9
T212 1097-1102 PR:P14780 denotes MMP-9
T213 1097-1102 P14780 denotes MMP-9
T214 1097-1102 PR:P41245 denotes MMP-9
T215 1097-1102 P41246 denotes MMP-9
T216 1097-1102 P41245 denotes MMP-9
T217 1097-1102 PR:P52176 denotes MMP-9
T218 1097-1102 P50282 denotes MMP-9
T220 1097-1102 PR:000010491 denotes MMP-9
T221 1097-1102 P52176 denotes MMP-9
T222 1097-1102 O18733 denotes MMP-9
T219 1097-1102 GO:0004229 denotes MMP-9
T223 1114-1122 D002678 denotes chimeras
T224 1128-1131 CHEBI:340824 denotes MMP
T227 1128-1131 CHEBI:59761 denotes MMP
T228 1128-1133 PR:P50282 denotes MMP-9
T229 1128-1133 PR:P14780 denotes MMP-9
T230 1128-1133 P14780 denotes MMP-9
T231 1128-1133 PR:P41245 denotes MMP-9
T232 1128-1133 P41246 denotes MMP-9
T233 1128-1133 P41245 denotes MMP-9
T234 1128-1133 PR:P52176 denotes MMP-9
T235 1128-1133 P50282 denotes MMP-9
T237 1128-1133 PR:000010491 denotes MMP-9
T238 1128-1133 P52176 denotes MMP-9
T239 1128-1133 O18733 denotes MMP-9
T236 1128-1133 GO:0004229 denotes MMP-9
T240 1205-1213 D002678 denotes chimeras
T241 1242-1245 CHEBI:340824 denotes MMP
T244 1242-1245 CHEBI:59761 denotes MMP
T245 1242-1247 PR:P50282 denotes MMP-9
T246 1242-1247 PR:P14780 denotes MMP-9
T247 1242-1247 P14780 denotes MMP-9
T248 1242-1247 PR:P41245 denotes MMP-9
T249 1242-1247 P41246 denotes MMP-9
T250 1242-1247 P41245 denotes MMP-9
T251 1242-1247 PR:P52176 denotes MMP-9
T252 1242-1247 P50282 denotes MMP-9
T254 1242-1247 PR:000010491 denotes MMP-9
T255 1242-1247 P52176 denotes MMP-9
T256 1242-1247 O18733 denotes MMP-9
T253 1242-1247 GO:0004229 denotes MMP-9
T257 1262-1271 UBERON:0000955 denotes the brain
T261 1275-1279 CVCL_8262 denotes 24 h
T262 1331-1334 CHEBI:340824 denotes MMP
T265 1331-1334 CHEBI:59761 denotes MMP
T266 1331-1336 PR:P50282 denotes MMP-9
T267 1331-1336 PR:P14780 denotes MMP-9
T268 1331-1336 P14780 denotes MMP-9
T269 1331-1336 PR:P41245 denotes MMP-9
T270 1331-1336 P41246 denotes MMP-9
T271 1331-1336 P41245 denotes MMP-9
T272 1331-1336 PR:P52176 denotes MMP-9
T273 1331-1336 P50282 denotes MMP-9
T275 1331-1336 PR:000010491 denotes MMP-9
T276 1331-1336 P52176 denotes MMP-9
T277 1331-1336 O18733 denotes MMP-9
T274 1331-1336 GO:0004229 denotes MMP-9
T278 1340-1344 PR:000005054 denotes mice
T280 1340-1344 O89094 denotes mice
T279 1340-1344 D051379 denotes mice
T281 1340-1344 10095 denotes mice
T282 1357-1366 MOP:0000569 denotes reduction
T283 1370-1379 CL:0000738 denotes leukocyte
T284 1408-1417 MOP:0000569 denotes reduction
T285 1498-1503 UBERON:6110636 denotes brain
T286 1498-1503 UBERON:0000955 denotes brain
T288 1557-1565 2714 denotes collagen
T289 1557-1565 D003094 denotes collagen
T290 1557-1565 CHEBI:3815 denotes collagen
T287 1557-1565 GO:0005202 denotes collagen
T291 1663-1666 CHEBI:340824 denotes MMP
T294 1663-1666 CHEBI:59761 denotes MMP
T295 1663-1668 PR:P50282 denotes MMP-9
T296 1663-1668 PR:P14780 denotes MMP-9
T297 1663-1668 P14780 denotes MMP-9
T298 1663-1668 PR:P41245 denotes MMP-9
T299 1663-1668 P41246 denotes MMP-9
T300 1663-1668 P41245 denotes MMP-9
T301 1663-1668 PR:P52176 denotes MMP-9
T302 1663-1668 P50282 denotes MMP-9
T304 1663-1668 PR:000010491 denotes MMP-9
T305 1663-1668 P52176 denotes MMP-9
T306 1663-1668 O18733 denotes MMP-9
T303 1663-1668 GO:0004229 denotes MMP-9
T307 1685-1690 UBERON:6110636 denotes brain
T308 1685-1690 UBERON:0000955 denotes brain
T309 1789-1792 CHEBI:340824 denotes MMP
T312 1789-1792 CHEBI:59761 denotes MMP
T313 1789-1794 PR:P50282 denotes MMP-9
T314 1789-1794 PR:P14780 denotes MMP-9
T315 1789-1794 P14780 denotes MMP-9
T316 1789-1794 PR:P41245 denotes MMP-9
T317 1789-1794 P41246 denotes MMP-9
T318 1789-1794 P41245 denotes MMP-9
T319 1789-1794 PR:P52176 denotes MMP-9
T320 1789-1794 P50282 denotes MMP-9
T322 1789-1794 PR:000010491 denotes MMP-9
T323 1789-1794 P52176 denotes MMP-9
T324 1789-1794 O18733 denotes MMP-9
T321 1789-1794 GO:0004229 denotes MMP-9
T325 1821-1830 CL:0000738 denotes leukocyte
T326 1851-1854 UBERON:0000120 denotes BBB
T327 1855-1864 GO:0009056 denotes breakdown
T328 1892-1904 GO:0005604 denotes basal lamina
T329 1892-1904 UBERON:0000482 denotes basal lamina
T333 1905-1916 GO:0006508 denotes proteolysis

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia.
T2 148-314 Sentence denotes Results of recent studies reveal vascular and neuroprotective effects of matrix metalloproteinase-9 (MMP-9) inhibition and MMP-9 gene deletion in experimental stroke.
T3 315-461 Sentence denotes However, the cellular source of MMP-9 produced in the ischemic brain and the mechanistic basis of MMP-9-mediated brain injury require elucidation.
T4 462-742 Sentence denotes In the present study, we used MMP-9-/- mice and chimeric knockouts lacking either MMP-9 in leukocytes or in resident brain cells to test the hypothesis that MMP-9 released from leukocytes recruited to the brain during postischemic reperfusion contributes to this injury phenotype.
T5 743-865 Sentence denotes We also tested the hypothesis that MMP-9 promotes leukocyte recruitment to the ischemic brain and thus is proinflammatory.
T6 866-1156 Sentence denotes The extent of blood-brain barrier (BBB) breakdown, the neurological deficit, and the volume of infarction resulting from transient focal stroke were abrogated to a similar extent in MMP-9-/- mice and in chimeras lacking leukocytic MMP-9 but not in chimeras with MMP-9-containing leukocytes.
T7 1157-1330 Sentence denotes Zymography and Western blot analysis from these chimeras confirmed that the elevated MMP-9 expression in the brain at 24 h of reperfusion is derived largely from leukocytes.
T8 1331-1605 Sentence denotes MMP-9-/- mice exhibited a reduction in leukocyte-endothelial adherence and a reduction in the number of neutrophils plugging capillaries and infiltrating the ischemic brain during reperfusion; microvessel immunopositivity for collagen IV was also preserved in these animals.
T9 1606-1691 Sentence denotes These latter results document proinflammatory actions of MMP-9 in the ischemic brain.
T10 1692-1993 Sentence denotes Overall, our findings implicate leukocytes, most likely neutrophils, as a key cellular source of MMP-9, which, in turn, promotes leukocyte recruitment, causes BBB breakdown secondary to microvascular basal lamina proteolysis, and ultimately contributes to neuronal injury after transient focal stroke.
T1 0-147 Sentence denotes Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia.
T2 148-314 Sentence denotes Results of recent studies reveal vascular and neuroprotective effects of matrix metalloproteinase-9 (MMP-9) inhibition and MMP-9 gene deletion in experimental stroke.
T3 315-461 Sentence denotes However, the cellular source of MMP-9 produced in the ischemic brain and the mechanistic basis of MMP-9-mediated brain injury require elucidation.
T4 462-742 Sentence denotes In the present study, we used MMP-9-/- mice and chimeric knockouts lacking either MMP-9 in leukocytes or in resident brain cells to test the hypothesis that MMP-9 released from leukocytes recruited to the brain during postischemic reperfusion contributes to this injury phenotype.
T5 743-865 Sentence denotes We also tested the hypothesis that MMP-9 promotes leukocyte recruitment to the ischemic brain and thus is proinflammatory.
T6 866-1156 Sentence denotes The extent of blood-brain barrier (BBB) breakdown, the neurological deficit, and the volume of infarction resulting from transient focal stroke were abrogated to a similar extent in MMP-9-/- mice and in chimeras lacking leukocytic MMP-9 but not in chimeras with MMP-9-containing leukocytes.
T7 1157-1330 Sentence denotes Zymography and Western blot analysis from these chimeras confirmed that the elevated MMP-9 expression in the brain at 24 h of reperfusion is derived largely from leukocytes.
T8 1331-1605 Sentence denotes MMP-9-/- mice exhibited a reduction in leukocyte-endothelial adherence and a reduction in the number of neutrophils plugging capillaries and infiltrating the ischemic brain during reperfusion; microvessel immunopositivity for collagen IV was also preserved in these animals.
T9 1606-1691 Sentence denotes These latter results document proinflammatory actions of MMP-9 in the ischemic brain.
T10 1692-1993 Sentence denotes Overall, our findings implicate leukocytes, most likely neutrophils, as a key cellular source of MMP-9, which, in turn, promotes leukocyte recruitment, causes BBB breakdown secondary to microvascular basal lamina proteolysis, and ultimately contributes to neuronal injury after transient focal stroke.

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-147 DRI_Challenge denotes Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia.
T2 148-314 DRI_Background denotes Results of recent studies reveal vascular and neuroprotective effects of matrix metalloproteinase-9 (MMP-9) inhibition and MMP-9 gene deletion in experimental stroke.
T3 315-461 DRI_Background denotes However, the cellular source of MMP-9 produced in the ischemic brain and the mechanistic basis of MMP-9-mediated brain injury require elucidation.
T4 462-742 DRI_Challenge denotes In the present study, we used MMP-9-/- mice and chimeric knockouts lacking either MMP-9 in leukocytes or in resident brain cells to test the hypothesis that MMP-9 released from leukocytes recruited to the brain during postischemic reperfusion contributes to this injury phenotype.
T5 743-865 DRI_Outcome denotes We also tested the hypothesis that MMP-9 promotes leukocyte recruitment to the ischemic brain and thus is proinflammatory.
T6 866-1085 DRI_Outcome denotes The extent of blood-brain barrier (BBB) breakdown, the neurological deficit, and the volume of infarction resulting from transient focal stroke were abrogated to a similar extent in MMP-9-/- mice and in chimeras lacking
T7 1086-1102 Token_Label.OUTSIDE denotes leukocytic MMP-9
T8 1103-1156 DRI_Outcome denotes but not in chimeras with MMP-9-containing leukocytes.
T9 1157-1330 DRI_Background denotes Zymography and Western blot analysis from these chimeras confirmed that the elevated MMP-9 expression in the brain at 24 h of reperfusion is derived largely from leukocytes.
T10 1331-1523 DRI_Background denotes MMP-9-/- mice exhibited a reduction in leukocyte-endothelial adherence and a reduction in the number of neutrophils plugging capillaries and infiltrating the ischemic brain during reperfusion;
T11 1524-1552 Token_Label.OUTSIDE denotes microvessel immunopositivity
T12 1553-1605 DRI_Background denotes for collagen IV was also preserved in these animals.
T13 1606-1691 DRI_Background denotes These latter results document proinflammatory actions of MMP-9 in the ischemic brain.
T14 1692-1993 DRI_Outcome denotes Overall, our findings implicate leukocytes, most likely neutrophils, as a key cellular source of MMP-9, which, in turn, promotes leukocyte recruitment, causes BBB breakdown secondary to microvascular basal lamina proteolysis, and ultimately contributes to neuronal injury after transient focal stroke.