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PubMed:15755837 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery.
T2 103-114 Sentence denotes BACKGROUND:
T3 115-193 Sentence denotes Folate is critical for cell division, a major feature of in utero development.
T4 194-431 Sentence denotes Dihydrofolate reductase (DHFR) is required to convert the folic acid used in supplements and for food fortification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced folate forms used by the cell.
T5 432-442 Sentence denotes OBJECTIVE:
T6 443-600 Sentence denotes We aimed to determine whether a common, recently discovered deletion polymorphism in the DHFR gene is a risk factor for preterm delivery or low birth weight.
T7 601-608 Sentence denotes DESIGN:
T8 609-655 Sentence denotes We studied 324 pregnant women from Camden, NJ.
T9 656-788 Sentence denotes Folate intake was computed from folate supplement intake plus the mean of two 24-h recalls completed during the course of pregnancy.
T10 789-857 Sentence denotes Genomic DNA was extracted from the women's leukocytes and genotyped.
T11 858-866 Sentence denotes RESULTS:
T12 867-976 Sentence denotes Women with a deletion allele had a significantly greater risk of preterm delivery [adjusted odds ratio (AOR):
T13 977-989 Sentence denotes 3.0; 95% CI:
T14 990-1051 Sentence denotes 1.0, 8.8; P < 0.05] than did those without a deletion allele.
T15 1052-1214 Sentence denotes Women with both a DHFR deletion allele and low folate intake (<400 microg/d from diet plus supplements) had a significantly greater risk of preterm delivery (AOR:
T16 1215-1227 Sentence denotes 5.5; 95% CI:
T17 1228-1331 Sentence denotes 1.5, 20.4; P = 0.01) and a significantly greater risk of having an infant with a low birth weight (AOR:
T18 1332-1344 Sentence denotes 8.3; 95% CI:
T19 1345-1448 Sentence denotes 1.8, 38.6; P = 0.01) than did women without a deletion allele and with a folate intake >/=400 microg/d.
T20 1449-1461 Sentence denotes CONCLUSIONS:
T21 1462-1542 Sentence denotes The DHFR 19-base pair deletion allele may be a risk factor for preterm delivery.
T22 1543-1640 Sentence denotes In the presence of low dietary folate, the allele may also be a risk factor for low birth weight.
T23 1641-1684 Sentence denotes This may be a gene-environment interaction.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1581 7-30 GeneOrGeneProduct denotes dihydrofolate reductase NCBIGene:1719
1582 31-52 SequenceVariant denotes 19-base pair deletion c|DEL||19
1583 85-101 DiseaseOrPhenotypicFeature denotes preterm delivery MESH:D047928
1584 115-121 ChemicalEntity denotes Folate MESH:D005492
1585 194-217 GeneOrGeneProduct denotes Dihydrofolate reductase NCBIGene:1719
1586 219-223 GeneOrGeneProduct denotes DHFR NCBIGene:1719
1587 252-262 ChemicalEntity denotes folic acid MESH:D005492
1588 318-331 ChemicalEntity denotes dihydrofolate MESH:C010920
1589 344-364 GeneOrGeneProduct denotes thymidylate synthase NCBIGene:7298
1590 401-407 ChemicalEntity denotes folate MESH:D005492
1591 532-536 GeneOrGeneProduct denotes DHFR NCBIGene:1719
1592 563-579 DiseaseOrPhenotypicFeature denotes preterm delivery MESH:D047928
1593 633-638 OrganismTaxon denotes women NCBITaxon:9606
1594 656-662 ChemicalEntity denotes Folate MESH:D005492
1595 688-694 ChemicalEntity denotes folate MESH:D005492
1596 824-829 OrganismTaxon denotes women NCBITaxon:9606
1597 867-872 OrganismTaxon denotes Women NCBITaxon:9606
1598 932-948 DiseaseOrPhenotypicFeature denotes preterm delivery MESH:D047928
1599 1052-1057 OrganismTaxon denotes Women NCBITaxon:9606
1600 1070-1074 GeneOrGeneProduct denotes DHFR NCBIGene:1719
1601 1099-1105 ChemicalEntity denotes folate MESH:D005492
1602 1192-1208 DiseaseOrPhenotypicFeature denotes preterm delivery MESH:D047928
1603 1375-1380 OrganismTaxon denotes women NCBITaxon:9606
1604 1418-1424 ChemicalEntity denotes folate MESH:D005492
1605 1466-1470 GeneOrGeneProduct denotes DHFR NCBIGene:1719
1606 1471-1492 SequenceVariant denotes 19-base pair deletion c|DEL||19
1607 1525-1541 DiseaseOrPhenotypicFeature denotes preterm delivery MESH:D047928
1608 1574-1580 ChemicalEntity denotes folate MESH:D005492

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 747-756 DiseaseOrPhenotypicFeature denotes completed 0700063

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 7-30 GeneOrGeneProduct denotes dihydrofolate reductase
T2 34-38 GeneOrGeneProduct denotes base
T3 39-43 GeneOrGeneProduct denotes pair
T4 63-68 GeneOrGeneProduct denotes novel
T5 74-80 GeneOrGeneProduct denotes factor
T6 138-142 GeneOrGeneProduct denotes cell
T7 155-160 GeneOrGeneProduct denotes major
T8 194-217 GeneOrGeneProduct denotes Dihydrofolate reductase
T9 219-223 GeneOrGeneProduct denotes DHFR
T10 258-262 GeneOrGeneProduct denotes acid
T11 318-331 GeneOrGeneProduct denotes dihydrofolate
T12 344-364 GeneOrGeneProduct denotes thymidylate synthase
T21 1070-1074 GeneOrGeneProduct denotes DHFR
T13 393-400 GeneOrGeneProduct denotes reduced
T14 426-430 GeneOrGeneProduct denotes cell
T15 455-464 GeneOrGeneProduct denotes determine
T16 532-536 GeneOrGeneProduct denotes DHFR
T17 537-546 GeneOrGeneProduct denotes gene is a
T18 552-558 GeneOrGeneProduct denotes factor
T19 587-599 GeneOrGeneProduct denotes birth weight
T20 896-901 GeneOrGeneProduct denotes had a
T22 1156-1161 GeneOrGeneProduct denotes had a
T23 1313-1325 GeneOrGeneProduct denotes birth weight
T24 1466-1470 GeneOrGeneProduct denotes DHFR
T25 1474-1478 GeneOrGeneProduct denotes base
T26 1479-1483 GeneOrGeneProduct denotes pair
T27 1500-1508 GeneOrGeneProduct denotes may be a
T28 1514-1520 GeneOrGeneProduct denotes factor
T29 1612-1618 GeneOrGeneProduct denotes factor
T30 1627-1639 GeneOrGeneProduct denotes birth weight
T31 1646-1654 GeneOrGeneProduct denotes may be a

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 7-30 GeneOrGeneProduct denotes dihydrofolate reductase
T2 63-68 GeneOrGeneProduct denotes novel
T3 74-80 GeneOrGeneProduct denotes factor
T4 138-142 GeneOrGeneProduct denotes cell
T5 155-160 GeneOrGeneProduct denotes major
T6 194-217 GeneOrGeneProduct denotes Dihydrofolate reductase
T7 219-223 GeneOrGeneProduct denotes DHFR
T8 258-262 GeneOrGeneProduct denotes acid
T9 318-331 GeneOrGeneProduct denotes dihydrofolate
T10 344-364 GeneOrGeneProduct denotes thymidylate synthase
T11 393-400 GeneOrGeneProduct denotes reduced
T12 426-430 GeneOrGeneProduct denotes cell
T13 532-536 GeneOrGeneProduct denotes DHFR
T14 552-558 GeneOrGeneProduct denotes factor
T15 587-599 GeneOrGeneProduct denotes birth weight
T16 1070-1074 GeneOrGeneProduct denotes DHFR
T17 1313-1325 GeneOrGeneProduct denotes birth weight
T18 1466-1470 GeneOrGeneProduct denotes DHFR
T19 1514-1520 GeneOrGeneProduct denotes factor
T20 1612-1618 GeneOrGeneProduct denotes factor
T21 1627-1639 GeneOrGeneProduct denotes birth weight

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 587-599 DiseaseOrPhenotypicFeature denotes birth weight D001724
T2 1313-1325 DiseaseOrPhenotypicFeature denotes birth weight D001724
T3 1627-1639 DiseaseOrPhenotypicFeature denotes birth weight D001724

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 7-30 GeneOrGeneProduct denotes dihydrofolate reductase
T2 194-217 GeneOrGeneProduct denotes Dihydrofolate reductase
T3 219-223 GeneOrGeneProduct denotes DHFR
T4 318-331 GeneOrGeneProduct denotes dihydrofolate
T5 344-364 GeneOrGeneProduct denotes thymidylate synthase
T6 532-536 GeneOrGeneProduct denotes DHFR
T7 1070-1074 GeneOrGeneProduct denotes DHFR
T8 1466-1470 GeneOrGeneProduct denotes DHFR

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 85-101 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T2 563-579 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T3 587-599 DiseaseOrPhenotypicFeature denotes birth weight D001724
T4 932-948 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T5 1192-1208 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T6 1313-1325 DiseaseOrPhenotypicFeature denotes birth weight D001724
T7 1525-1541 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T8 1627-1639 DiseaseOrPhenotypicFeature denotes birth weight D001724

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 633-638 OrganismTaxon denotes women
T2 867-872 OrganismTaxon denotes Women
T3 1052-1057 OrganismTaxon denotes Women
T4 1375-1380 OrganismTaxon denotes women

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 85-101 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T2 563-579 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T3 932-948 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T4 1192-1208 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T5 1525-1541 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 7-30 ChemicalEntity denotes dihydrofolate reductase D013762
T2 115-121 ChemicalEntity denotes Folate http://purl.obolibrary.org/obo/CHEBI_27470
T3 194-217 ChemicalEntity denotes Dihydrofolate reductase D013762
T4 219-223 ChemicalEntity denotes DHFR D013762
T5 252-262 ChemicalEntity denotes folic acid D005492|http://purl.obolibrary.org/obo/CHEBI_27470
T7 318-331 ChemicalEntity denotes dihydrofolate C010920|http://purl.obolibrary.org/obo/CHEBI_67014|http://purl.obolibrary.org/obo/CHEBI_23743
T10 344-364 ChemicalEntity denotes thymidylate synthase D013940
T11 401-407 ChemicalEntity denotes folate D005492|http://purl.obolibrary.org/obo/CHEBI_67011|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_37445
T15 532-536 ChemicalEntity denotes DHFR D013762
T16 656-662 ChemicalEntity denotes Folate http://purl.obolibrary.org/obo/CHEBI_27470
T17 688-694 ChemicalEntity denotes folate D005492|http://purl.obolibrary.org/obo/CHEBI_67011|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_37445
T21 1070-1074 ChemicalEntity denotes DHFR D013762
T22 1099-1105 ChemicalEntity denotes folate D005492|http://purl.obolibrary.org/obo/CHEBI_67011|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_37445
T26 1418-1424 ChemicalEntity denotes folate D005492|http://purl.obolibrary.org/obo/CHEBI_67011|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_37445
T30 1466-1470 ChemicalEntity denotes DHFR D013762
T31 1574-1580 ChemicalEntity denotes folate D005492|http://purl.obolibrary.org/obo/CHEBI_67011|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_37445

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T31 1574-1580 ChemicalEntity denotes folate http://purl.obolibrary.org/obo/CHEBI_37445|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_67011|D005492
T30 1466-1470 ChemicalEntity denotes DHFR D013762
T26 1418-1424 ChemicalEntity denotes folate http://purl.obolibrary.org/obo/CHEBI_37445|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_67011|D005492
T22 1099-1105 ChemicalEntity denotes folate http://purl.obolibrary.org/obo/CHEBI_37445|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_67011|D005492
T21 1070-1074 ChemicalEntity denotes DHFR D013762
T17 688-694 ChemicalEntity denotes folate http://purl.obolibrary.org/obo/CHEBI_37445|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_67011|D005492
T16 656-662 ChemicalEntity denotes Folate http://purl.obolibrary.org/obo/CHEBI_27470
T15 532-536 ChemicalEntity denotes DHFR D013762
T11 401-407 ChemicalEntity denotes folate http://purl.obolibrary.org/obo/CHEBI_37445|http://purl.obolibrary.org/obo/CHEBI_62501|http://purl.obolibrary.org/obo/CHEBI_67011|D005492
T10 344-364 ChemicalEntity denotes thymidylate synthase D013940
T7 318-331 ChemicalEntity denotes dihydrofolate http://purl.obolibrary.org/obo/CHEBI_23743|http://purl.obolibrary.org/obo/CHEBI_67014|C010920
T5 252-262 ChemicalEntity denotes folic acid http://purl.obolibrary.org/obo/CHEBI_27470|D005492
T4 219-223 ChemicalEntity denotes DHFR D013762
T3 194-217 ChemicalEntity denotes Dihydrofolate reductase D013762
T2 115-121 ChemicalEntity denotes Folate http://purl.obolibrary.org/obo/CHEBI_27470
T1 7-30 ChemicalEntity denotes dihydrofolate reductase D013762
T8 1466-1470 GeneOrGeneProduct denotes DHFR
T94638 1070-1074 GeneOrGeneProduct denotes DHFR
T6 532-536 GeneOrGeneProduct denotes DHFR
T89859 344-364 GeneOrGeneProduct denotes thymidylate synthase
T66735 318-331 GeneOrGeneProduct denotes dihydrofolate
T36019 219-223 GeneOrGeneProduct denotes DHFR
T49947 194-217 GeneOrGeneProduct denotes Dihydrofolate reductase
T75250 7-30 GeneOrGeneProduct denotes dihydrofolate reductase
T41594 1525-1541 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T16075 1192-1208 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T5607 932-948 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T37927 563-579 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T45779 85-101 DiseaseOrPhenotypicFeature denotes preterm delivery DISEASE
T65676 1375-1380 OrganismTaxon denotes women
T11143 1052-1057 OrganismTaxon denotes Women
T72572 867-872 OrganismTaxon denotes Women
T11893 633-638 OrganismTaxon denotes women