
PubMed:15755728
Annnotations
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-90 | Sentence | denotes | Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. |
T2 | 91-182 | Sentence | denotes | We report that DNA methyltransferase 1 (DNMT1) expression is dysregulated in breast cancer. |
T3 | 183-298 | Sentence | denotes | The elevated protein levels are not a result of increased mRNA levels, but rather an increase in protein half-life. |
T4 | 299-535 | Sentence | denotes | We found that DNMT1 protein levels were elevated in breast cancer tissues and in MCF-7 breast cancer cells relative to normal human mammary epithelial cells (HMECs) without a concomitant increase in DNMT1 mRNA or proliferative fraction. |
T5 | 536-683 | Sentence | denotes | Although DNMT1 mRNA levels were properly S-phase-regulated in both cell types, DNMT1 protein levels did not follow S-phase fraction in MCF-7 cells. |
T6 | 684-930 | Sentence | denotes | Rather, an increase in DNMT1 protein stability was found for MCF-7 cells relative to HMECs, and a destruction domain was mapped to the N-terminal 120 amino acids of DNMT1, which was required for its proper ubiquitination and degradation in HMECs. |
T7 | 931-1136 | Sentence | denotes | Furthermore, overexpression of DNMT1 with this deleted destruction domain in HMECs resulted in significantly increased genomic 5-methylcytosine levels relative to overexpression of the full-length protein. |
T8 | 1137-1288 | Sentence | denotes | The regulation of DNMT1 destruction via this domain may be dysfunctional in cancer cells leading to subsequent cytosine hypermethylation in the genome. |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
15755728-0#35#58#gene1786 | 35-58 | gene1786 | denotes | DNA methyltransferase 1 |
15755728-0#76#89#diseaseC0006142 | 76-89 | diseaseC0006142 | denotes | breast cancer |
15755728-0#76#89#diseaseC0678222 | 76-89 | diseaseC0678222 | denotes | breast cancer |
35#58#gene178676#89#diseaseC0006142 | 15755728-0#35#58#gene1786 | 15755728-0#76#89#diseaseC0006142 | associated_with | DNA methyltransferase 1,breast cancer |
35#58#gene178676#89#diseaseC0678222 | 15755728-0#35#58#gene1786 | 15755728-0#76#89#diseaseC0678222 | associated_with | DNA methyltransferase 1,breast cancer |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T19 | 1213-1219 | disease:C0006826 | denotes | cancer |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 76-89 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T2 | 168-181 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T3 | 351-364 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T4 | 386-399 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T5 | 1213-1219 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 425-430 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 76-82 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T2 | 168-174 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T3 | 351-357 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T4 | 386-392 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T5 | 431-455 | Body_part | denotes | mammary epithelial cells | http://purl.obolibrary.org/obo/CL_0002327 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 76-89 | Phenotype | denotes | breast cancer | HP:0003002 |
T2 | 168-181 | Phenotype | denotes | breast cancer | HP:0003002 |
T3 | 351-364 | Phenotype | denotes | breast cancer | HP:0003002 |
T4 | 386-399 | Phenotype | denotes | breast cancer | HP:0003002 |
T5 | 1213-1219 | Phenotype | denotes | cancer | HP:0002664 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 393-405 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
T2 | 431-455 | Cell | denotes | mammary epithelial cells | http://purl.obolibrary.org/obo/CL:0002327 |
T3 | 1213-1225 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |