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PubMed:15755728 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-90 Sentence denotes Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.
T2 91-182 Sentence denotes We report that DNA methyltransferase 1 (DNMT1) expression is dysregulated in breast cancer.
T3 183-298 Sentence denotes The elevated protein levels are not a result of increased mRNA levels, but rather an increase in protein half-life.
T4 299-535 Sentence denotes We found that DNMT1 protein levels were elevated in breast cancer tissues and in MCF-7 breast cancer cells relative to normal human mammary epithelial cells (HMECs) without a concomitant increase in DNMT1 mRNA or proliferative fraction.
T5 536-683 Sentence denotes Although DNMT1 mRNA levels were properly S-phase-regulated in both cell types, DNMT1 protein levels did not follow S-phase fraction in MCF-7 cells.
T6 684-930 Sentence denotes Rather, an increase in DNMT1 protein stability was found for MCF-7 cells relative to HMECs, and a destruction domain was mapped to the N-terminal 120 amino acids of DNMT1, which was required for its proper ubiquitination and degradation in HMECs.
T7 931-1136 Sentence denotes Furthermore, overexpression of DNMT1 with this deleted destruction domain in HMECs resulted in significantly increased genomic 5-methylcytosine levels relative to overexpression of the full-length protein.
T8 1137-1288 Sentence denotes The regulation of DNMT1 destruction via this domain may be dysfunctional in cancer cells leading to subsequent cytosine hypermethylation in the genome.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15755728-0#35#58#gene1786 35-58 gene1786 denotes DNA methyltransferase 1
15755728-0#76#89#diseaseC0006142 76-89 diseaseC0006142 denotes breast cancer
15755728-0#76#89#diseaseC0678222 76-89 diseaseC0678222 denotes breast cancer
35#58#gene178676#89#diseaseC0006142 15755728-0#35#58#gene1786 15755728-0#76#89#diseaseC0006142 associated_with DNA methyltransferase 1,breast cancer
35#58#gene178676#89#diseaseC0678222 15755728-0#35#58#gene1786 15755728-0#76#89#diseaseC0678222 associated_with DNA methyltransferase 1,breast cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T19 1213-1219 disease:C0006826 denotes cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 76-89 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 168-181 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 351-364 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T4 386-399 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T5 1213-1219 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 425-430 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 76-82 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 168-174 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 351-357 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T4 386-392 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 431-455 Body_part denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL_0002327

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 76-89 Phenotype denotes breast cancer HP:0003002
T2 168-181 Phenotype denotes breast cancer HP:0003002
T3 351-364 Phenotype denotes breast cancer HP:0003002
T4 386-399 Phenotype denotes breast cancer HP:0003002
T5 1213-1219 Phenotype denotes cancer HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 393-405 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 431-455 Cell denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL:0002327
T3 1213-1225 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064