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c_corpus

Id Subject Object Predicate Lexical cue
T3 0-24 D002285 denotes Ductal carcinoma in situ
T4 0-24 D002285 denotes Ductal carcinoma in situ
T9 32-38 UBERON:0000310 denotes breast
T12 43-53 C038253 denotes heparanase
T17 43-55 Q9Y251 denotes heparanase-1
T18 43-55 PR:000008741 denotes heparanase-1
T21 134-158 D002285 denotes Ductal carcinoma in situ
T22 134-158 D002285 denotes Ductal carcinoma in situ
T27 166-172 UBERON:0000310 denotes breast
T29 174-178 CVCL_5552 denotes DCIS
T28 174-178 D002285 denotes DCIS
T30 174-178 D002285 denotes DCIS
T33 278-288 C038253 denotes heparanase
T38 278-290 Q9Y251 denotes heparanase-1
T39 278-290 PR:000008741 denotes heparanase-1
T52 292-296 Q9C9W5 denotes HPR1
T53 292-296 PR:000008741 denotes HPR1
T54 292-296 PR:Q8R3N6 denotes HPR1
T55 292-296 PR:Q93VM9 denotes HPR1
T56 292-296 PR:Q9Y251 denotes HPR1
T57 292-296 PR:Q96FV9 denotes HPR1
T58 292-296 PR:P17629 denotes HPR1
T59 292-296 PR:000016310 denotes HPR1
T60 292-296 PR:G5EC44 denotes HPR1
T62 349-364 D006497 denotes heparan sulfate
T63 349-364 D006497 denotes heparan sulfate
T64 349-364 CHEBI:28815 denotes heparan sulfate
T66 370-383 CHEBI:37396 denotes proteoglycans
T67 370-383 D011509 denotes proteoglycans
T68 370-383 D011509 denotes proteoglycans
T69 391-397 UBERON:0000310 denotes breast
T71 398-418 GO:0031012 denotes extracellular matrix
T72 412-418 UBERON:0027368 denotes matrix
T74 460-464 CVCL_5552 denotes DCIS
T73 460-464 D002285 denotes DCIS
T75 460-464 D002285 denotes DCIS
T77 501-505 CVCL_5552 denotes DCIS
T76 501-505 D002285 denotes DCIS
T78 501-505 D002285 denotes DCIS
T79 530-536 UBERON:0000310 denotes breast
T92 565-569 Q9C9W5 denotes HPR1
T93 565-569 PR:000008741 denotes HPR1
T94 565-569 PR:Q8R3N6 denotes HPR1
T95 565-569 PR:Q93VM9 denotes HPR1
T96 565-569 PR:Q9Y251 denotes HPR1
T97 565-569 PR:Q96FV9 denotes HPR1
T98 565-569 PR:P17629 denotes HPR1
T99 565-569 PR:000016310 denotes HPR1
T100 565-569 PR:G5EC44 denotes HPR1
T113 741-745 Q9C9W5 denotes HPR1
T114 741-745 PR:000008741 denotes HPR1
T115 741-745 PR:Q8R3N6 denotes HPR1
T116 741-745 PR:Q93VM9 denotes HPR1
T117 741-745 PR:Q9Y251 denotes HPR1
T118 741-745 PR:Q96FV9 denotes HPR1
T119 741-745 PR:P17629 denotes HPR1
T120 741-745 PR:000016310 denotes HPR1
T121 741-745 PR:G5EC44 denotes HPR1
T134 898-902 Q9C9W5 denotes HPR1
T135 898-902 PR:000008741 denotes HPR1
T136 898-902 PR:Q8R3N6 denotes HPR1
T137 898-902 PR:Q93VM9 denotes HPR1
T138 898-902 PR:Q9Y251 denotes HPR1
T139 898-902 PR:Q96FV9 denotes HPR1
T140 898-902 PR:P17629 denotes HPR1
T141 898-902 PR:000016310 denotes HPR1
T142 898-902 PR:G5EC44 denotes HPR1
T144 972-976 CVCL_5552 denotes DCIS
T143 972-976 D002285 denotes DCIS
T145 972-976 D002285 denotes DCIS
T158 995-999 Q9C9W5 denotes HPR1
T159 995-999 PR:000008741 denotes HPR1
T160 995-999 PR:Q8R3N6 denotes HPR1
T161 995-999 PR:Q93VM9 denotes HPR1
T162 995-999 PR:Q9Y251 denotes HPR1
T163 995-999 PR:Q96FV9 denotes HPR1
T164 995-999 PR:P17629 denotes HPR1
T165 995-999 PR:000016310 denotes HPR1
T166 995-999 PR:G5EC44 denotes HPR1
T179 1091-1095 Q9C9W5 denotes HPR1
T180 1091-1095 PR:000008741 denotes HPR1
T181 1091-1095 PR:Q8R3N6 denotes HPR1
T182 1091-1095 PR:Q93VM9 denotes HPR1
T183 1091-1095 PR:Q9Y251 denotes HPR1
T184 1091-1095 PR:Q96FV9 denotes HPR1
T185 1091-1095 PR:P17629 denotes HPR1
T186 1091-1095 PR:000016310 denotes HPR1
T187 1091-1095 PR:G5EC44 denotes HPR1
T189 1151-1155 CVCL_5552 denotes DCIS
T188 1151-1155 D002285 denotes DCIS
T190 1151-1155 D002285 denotes DCIS
T203 1200-1204 Q9C9W5 denotes HPR1
T204 1200-1204 PR:000008741 denotes HPR1
T205 1200-1204 PR:Q8R3N6 denotes HPR1
T206 1200-1204 PR:Q93VM9 denotes HPR1
T207 1200-1204 PR:Q9Y251 denotes HPR1
T208 1200-1204 PR:Q96FV9 denotes HPR1
T209 1200-1204 PR:P17629 denotes HPR1
T210 1200-1204 PR:000016310 denotes HPR1
T211 1200-1204 PR:G5EC44 denotes HPR1
T213 1214-1218 CVCL_5552 denotes DCIS
T212 1214-1218 D002285 denotes DCIS
T214 1214-1218 D002285 denotes DCIS
T215 1251-1264 GO:0005576 denotes extracellular
T217 1265-1282 UBERON:0005769 denotes basement membrane
T216 1265-1282 GO:0005604 denotes basement membrane
T221 1284-1288 32644 denotes none
T234 1299-1303 Q9C9W5 denotes HPR1
T235 1299-1303 PR:000008741 denotes HPR1
T236 1299-1303 PR:Q8R3N6 denotes HPR1
T237 1299-1303 PR:Q93VM9 denotes HPR1
T238 1299-1303 PR:Q9Y251 denotes HPR1
T239 1299-1303 PR:Q96FV9 denotes HPR1
T240 1299-1303 PR:P17629 denotes HPR1
T241 1299-1303 PR:000016310 denotes HPR1
T242 1299-1303 PR:G5EC44 denotes HPR1
T244 1313-1317 CVCL_5552 denotes DCIS
T243 1313-1317 D002285 denotes DCIS
T245 1313-1317 D002285 denotes DCIS
T247 1358-1362 CVCL_5552 denotes DCIS
T246 1358-1362 D002285 denotes DCIS
T248 1358-1362 D002285 denotes DCIS
T251 1406-1410 CVCL_5552 denotes DCIS
T250 1406-1410 D002285 denotes DCIS
T252 1406-1410 D002285 denotes DCIS
T266 1440-1444 Q9C9W5 denotes HPR1
T267 1440-1444 PR:000008741 denotes HPR1
T268 1440-1444 PR:Q8R3N6 denotes HPR1
T269 1440-1444 PR:Q93VM9 denotes HPR1
T270 1440-1444 PR:Q9Y251 denotes HPR1
T271 1440-1444 PR:Q96FV9 denotes HPR1
T272 1440-1444 PR:P17629 denotes HPR1
T273 1440-1444 PR:000016310 denotes HPR1
T274 1440-1444 PR:G5EC44 denotes HPR1
T276 1474-1478 CVCL_5552 denotes DCIS
T275 1474-1478 D002285 denotes DCIS
T277 1474-1478 D002285 denotes DCIS
T290 1508-1512 Q9C9W5 denotes HPR1
T291 1508-1512 PR:000008741 denotes HPR1
T292 1508-1512 PR:Q8R3N6 denotes HPR1
T293 1508-1512 PR:Q93VM9 denotes HPR1
T294 1508-1512 PR:Q9Y251 denotes HPR1
T295 1508-1512 PR:Q96FV9 denotes HPR1
T296 1508-1512 PR:P17629 denotes HPR1
T297 1508-1512 PR:000016310 denotes HPR1
T298 1508-1512 PR:G5EC44 denotes HPR1
T299 1535-1540 SO:0001685 denotes score
T312 1558-1562 Q9C9W5 denotes HPR1
T313 1558-1562 PR:000008741 denotes HPR1
T314 1558-1562 PR:Q8R3N6 denotes HPR1
T315 1558-1562 PR:Q93VM9 denotes HPR1
T316 1558-1562 PR:Q9Y251 denotes HPR1
T317 1558-1562 PR:Q96FV9 denotes HPR1
T318 1558-1562 PR:P17629 denotes HPR1
T319 1558-1562 PR:000016310 denotes HPR1
T320 1558-1562 PR:G5EC44 denotes HPR1
T322 1572-1576 CVCL_5552 denotes DCIS
T321 1572-1576 D002285 denotes DCIS
T323 1572-1576 D002285 denotes DCIS
T338 1649-1653 Q9C9W5 denotes HPR1
T339 1649-1653 PR:000008741 denotes HPR1
T340 1649-1653 PR:Q8R3N6 denotes HPR1
T341 1649-1653 PR:Q93VM9 denotes HPR1
T342 1649-1653 PR:Q9Y251 denotes HPR1
T343 1649-1653 PR:Q96FV9 denotes HPR1
T344 1649-1653 PR:P17629 denotes HPR1
T345 1649-1653 PR:000016310 denotes HPR1
T346 1649-1653 PR:G5EC44 denotes HPR1
T348 1663-1667 CVCL_5552 denotes DCIS
T347 1663-1667 D002285 denotes DCIS
T349 1663-1667 D002285 denotes DCIS
T362 1694-1698 Q9C9W5 denotes HPR1
T363 1694-1698 PR:000008741 denotes HPR1
T364 1694-1698 PR:Q8R3N6 denotes HPR1
T365 1694-1698 PR:Q93VM9 denotes HPR1
T366 1694-1698 PR:Q9Y251 denotes HPR1
T367 1694-1698 PR:Q96FV9 denotes HPR1
T368 1694-1698 PR:P17629 denotes HPR1
T369 1694-1698 PR:000016310 denotes HPR1
T370 1694-1698 PR:G5EC44 denotes HPR1
T372 1776-1780 CVCL_5552 denotes DCIS
T371 1776-1780 D002285 denotes DCIS
T373 1776-1780 D002285 denotes DCIS
T386 1843-1847 Q9C9W5 denotes HPR1
T387 1843-1847 PR:000008741 denotes HPR1
T388 1843-1847 PR:Q8R3N6 denotes HPR1
T389 1843-1847 PR:Q93VM9 denotes HPR1
T390 1843-1847 PR:Q9Y251 denotes HPR1
T391 1843-1847 PR:Q96FV9 denotes HPR1
T392 1843-1847 PR:P17629 denotes HPR1
T393 1843-1847 PR:000016310 denotes HPR1
T394 1843-1847 PR:G5EC44 denotes HPR1
T395 1910-1923 GO:0005576 denotes extracellular
T397 1924-1941 UBERON:0005769 denotes basement membrane
T396 1924-1941 GO:0005604 denotes basement membrane
T402 1949-1953 CVCL_5552 denotes DCIS
T401 1949-1953 D002285 denotes DCIS
T403 1949-1953 D002285 denotes DCIS
T416 1955-1959 Q9C9W5 denotes HPR1
T417 1955-1959 PR:000008741 denotes HPR1
T418 1955-1959 PR:Q8R3N6 denotes HPR1
T419 1955-1959 PR:Q93VM9 denotes HPR1
T420 1955-1959 PR:Q9Y251 denotes HPR1
T421 1955-1959 PR:Q96FV9 denotes HPR1
T422 1955-1959 PR:P17629 denotes HPR1
T423 1955-1959 PR:000016310 denotes HPR1
T424 1955-1959 PR:G5EC44 denotes HPR1
T425 2005-2010 SO:0001685 denotes score
T438 2044-2048 Q9C9W5 denotes HPR1
T439 2044-2048 PR:000008741 denotes HPR1
T440 2044-2048 PR:Q8R3N6 denotes HPR1
T441 2044-2048 PR:Q93VM9 denotes HPR1
T442 2044-2048 PR:Q9Y251 denotes HPR1
T443 2044-2048 PR:Q96FV9 denotes HPR1
T444 2044-2048 PR:P17629 denotes HPR1
T445 2044-2048 PR:000016310 denotes HPR1
T446 2044-2048 PR:G5EC44 denotes HPR1
T448 2063-2067 CVCL_5552 denotes DCIS
T447 2063-2067 D002285 denotes DCIS
T449 2063-2067 D002285 denotes DCIS
T451 2113-2117 CVCL_5552 denotes DCIS
T450 2113-2117 D002285 denotes DCIS
T452 2113-2117 D002285 denotes DCIS
T453 2135-2141 UBERON:0000310 denotes breast
T454 2135-2148 D001943 denotes breast cancer
T455 2135-2148 D001943 denotes breast cancer

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-121 DRI_Background denotes Ductal carcinoma in situ of the breast and heparanase-1 expression: a molecular explanation for more aggressive subtypes.
T2 131-251 DRI_Background denotes D: Ductal carcinoma in situ of the breast (DCIS) forms a heterogeneous group of lesions with varying invasive potential.
T3 252-474 DRI_Approach denotes This study tested whether heparanase-1 (HPR1), an endoglycosidase that specifically degrades the heparan sulfate (HS) proteoglycans in the breast extracellular matrix, was associated with the most aggressive DCIS subtypes.
T4 489-616 DRI_Background denotes Fifty-seven DCIS specimens and 10 normal breast specimens were examined for HPR1 expression using immunohistochemical staining.
T5 617-755 DRI_Background denotes Twenty-seven arbitrarily selected specimens were also examined for HS deposition by immunofluorescence staining, confirming HPR1 activity.
T6 756-914 DRI_Background denotes Patient medical records were obtained to explore a possible association between biologic potential using Van Nuys Prognostic Index (VNPI) and HPR1 expression.
T7 924-1141 DRI_Unspecified denotes Twenty-one (75%) of 28 comedo and microinvasive DCIS specimens stained HPR1 positive; 4 (14%) of 29 other subtypes (papillary, cribriform, and solid subtypes) stained HPR1 positive on immunohistochemistry (p = 0.003).
T8 1142-1338 DRI_Outcome denotes Among 27 DCIS stained for HS, we found that 8 (67%) of 12 HPR1-negative DCIS had intact HS deposition in the extracellular basement membrane; none of the 15 HPR1-positive DCIS stained HS positive.
T9 1339-1522 DRI_Unspecified denotes Six (86%) of seven DCIS with VNPI scores 8 to 9 and 14 (50%) of 28 DCIS with VNPI scores 5 to 7 were HPR1 positive; only 3 (17%) of 18 DCIS with VNPI scores 3 to 4 were HPR1 positive.
T10 1523-1680 DRI_Outcome denotes Median VNPI score in patients with HPR1-positive DCIS was 7 (range 3 to 9), compared with 4.5 (range 3 to 7) in patients with HPR1-negative DCIS (p < 0.001).
T11 1694-1842 DRI_Outcome denotes HPR1 was expressed at a significantly higher frequency in the invasive comedo and DCIS with microinvasion subtypes than in the noninvasive subtypes.
T12 1843-1954 DRI_Outcome denotes HPR1 expression was inversely associated with HS deposition in the extracellular basement membrane of the DCIS.
T13 1955-2011 DRI_Approach denotes HPR1 expression was associated with a higher VNPI score.
T14 2012-2149 DRI_Challenge denotes These observations suggest that HPR1 expression in DCIS can play an important role in development of DCIS into an invasive breast cancer.

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 134-474 BACKGROUND denotes Ductal carcinoma in situ of the breast (DCIS) forms a heterogeneous group of lesions with varying invasive potential. This study tested whether heparanase-1 (HPR1), an endoglycosidase that specifically degrades the heparan sulfate (HS) proteoglycans in the breast extracellular matrix, was associated with the most aggressive DCIS subtypes.
T2 489-914 METHODS denotes Fifty-seven DCIS specimens and 10 normal breast specimens were examined for HPR1 expression using immunohistochemical staining. Twenty-seven arbitrarily selected specimens were also examined for HS deposition by immunofluorescence staining, confirming HPR1 activity. Patient medical records were obtained to explore a possible association between biologic potential using Van Nuys Prognostic Index (VNPI) and HPR1 expression.
T3 924-1680 RESULTS denotes Twenty-one (75%) of 28 comedo and microinvasive DCIS specimens stained HPR1 positive; 4 (14%) of 29 other subtypes (papillary, cribriform, and solid subtypes) stained HPR1 positive on immunohistochemistry (p = 0.003). Among 27 DCIS stained for HS, we found that 8 (67%) of 12 HPR1-negative DCIS had intact HS deposition in the extracellular basement membrane; none of the 15 HPR1-positive DCIS stained HS positive. Six (86%) of seven DCIS with VNPI scores 8 to 9 and 14 (50%) of 28 DCIS with VNPI scores 5 to 7 were HPR1 positive; only 3 (17%) of 18 DCIS with VNPI scores 3 to 4 were HPR1 positive. Median VNPI score in patients with HPR1-positive DCIS was 7 (range 3 to 9), compared with 4.5 (range 3 to 7) in patients with HPR1-negative DCIS (p < 0.001).
T4 1694-2149 CONCLUSIONS denotes HPR1 was expressed at a significantly higher frequency in the invasive comedo and DCIS with microinvasion subtypes than in the noninvasive subtypes. HPR1 expression was inversely associated with HS deposition in the extracellular basement membrane of the DCIS. HPR1 expression was associated with a higher VNPI score. These observations suggest that HPR1 expression in DCIS can play an important role in development of DCIS into an invasive breast cancer.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15737842-0#43#55#gene10855 43-55 gene10855 denotes heparanase-1
15737842-0#0#38#diseaseC0007124 0-38 diseaseC0007124 denotes Ductal carcinoma in situ of the breast
15737842-10#0#4#gene10855 1694-1698 gene10855 denotes HPR1
15737842-10#0#4#gene9984 1694-1698 gene9984 denotes HPR1
15737842-10#71#77#diseaseC0221228 1765-1771 diseaseC0221228 denotes comedo
15737842-11#106#110#diseaseC0007124 1949-1953 diseaseC0007124 denotes DCIS
15737842-13#32#36#gene10855 2044-2048 gene10855 denotes HPR1
15737842-13#114#136#diseaseC0853879 2126-2148 diseaseC0853879 denotes invasive breast cancer
15737842-6#71#75#gene10855 995-999 gene10855 denotes HPR1
15737842-6#167#171#gene10855 1091-1095 gene10855 denotes HPR1
15737842-6#34#47#diseaseC0205622 958-971 diseaseC0205622 denotes microinvasive
43#55#gene108550#38#diseaseC0007124 15737842-0#43#55#gene10855 15737842-0#0#38#diseaseC0007124 associated_with heparanase-1,Ductal carcinoma in situ of the breast
0#4#gene1085571#77#diseaseC0221228 15737842-10#0#4#gene10855 15737842-10#71#77#diseaseC0221228 associated_with HPR1,comedo
0#4#gene998471#77#diseaseC0221228 15737842-10#0#4#gene9984 15737842-10#71#77#diseaseC0221228 associated_with HPR1,comedo
32#36#gene10855114#136#diseaseC0853879 15737842-13#32#36#gene10855 15737842-13#114#136#diseaseC0853879 associated_with HPR1,invasive breast cancer
71#75#gene1085534#47#diseaseC0205622 15737842-6#71#75#gene10855 15737842-6#34#47#diseaseC0205622 associated_with HPR1,microinvasive
167#171#gene1085534#47#diseaseC0205622 15737842-6#167#171#gene10855 15737842-6#34#47#diseaseC0205622 associated_with HPR1,microinvasive

DisGeNET

Id Subject Object Predicate Lexical cue
T0 43-55 gene:10855 denotes heparanase-1
T1 0-38 disease:C0007124 denotes Ductal carcinoma in situ of the breast
T2 1440-1444 gene:10855 denotes HPR1
T3 1358-1362 disease:C0007124 denotes DCIS
T4 1440-1444 gene:10855 denotes HPR1
T5 1406-1410 disease:C0007124 denotes DCIS
T6 1440-1444 gene:10855 denotes HPR1
T7 1474-1478 disease:C0007124 denotes DCIS
T8 1508-1512 gene:10855 denotes HPR1
T9 1358-1362 disease:C0007124 denotes DCIS
T10 1508-1512 gene:10855 denotes HPR1
T11 1474-1478 disease:C0007124 denotes DCIS
T12 1508-1512 gene:10855 denotes HPR1
T13 1406-1410 disease:C0007124 denotes DCIS
T14 1558-1562 gene:10855 denotes HPR1
T15 1572-1576 disease:C0007124 denotes DCIS
T16 1558-1562 gene:10855 denotes HPR1
T17 1663-1667 disease:C0007124 denotes DCIS
T18 1649-1653 gene:10855 denotes HPR1
T19 1572-1576 disease:C0007124 denotes DCIS
T20 1649-1653 gene:10855 denotes HPR1
T21 1663-1667 disease:C0007124 denotes DCIS
R1 T0 T1 associated_with heparanase-1,Ductal carcinoma in situ of the breast
R2 T2 T3 associated_with HPR1,DCIS
R3 T4 T5 associated_with HPR1,DCIS
R4 T6 T7 associated_with HPR1,DCIS
R5 T8 T9 associated_with HPR1,DCIS
R6 T10 T11 associated_with HPR1,DCIS
R7 T12 T13 associated_with HPR1,DCIS
R8 T14 T15 associated_with HPR1,DCIS
R9 T16 T17 associated_with HPR1,DCIS
R10 T18 T19 associated_with HPR1,DCIS
R11 T20 T21 associated_with HPR1,DCIS