
PubMed:15729288
Annnotations
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-5 | D009369 | denotes | Tumor |
T2 | 0-5 | D009369 | denotes | Tumor |
T34 | 0-21 | GO:0005164 | denotes | Tumor necrosis factor |
T44 | 0-27 | PR:000000134 | denotes | Tumor necrosis factor-alpha |
T43 | 0-27 | D014409 | denotes | Tumor necrosis factor-alpha |
T45 | 0-27 | D014409 | denotes | Tumor necrosis factor-alpha |
T46 | 6-14 | GO:0019835 | denotes | necrosis |
T47 | 6-14 | GO:0008219 | denotes | necrosis |
T50 | 6-14 | GO:0008220 | denotes | necrosis |
T51 | 6-14 | GO:0001906 | denotes | necrosis |
T52 | 6-14 | GO:0070265 | denotes | necrosis |
T48 | 6-14 | D009336 | denotes | necrosis |
T49 | 6-14 | D009336 | denotes | necrosis |
T54 | 51-65 | D001929 | denotes | cerebral edema |
T55 | 51-65 | D001929 | denotes | cerebral edema |
T58 | 88-94 | UBERON:0027368 | denotes | matrix |
T59 | 146-163 | D002545 | denotes | cerebral ischemia |
T60 | 146-163 | D002545 | denotes | cerebral ischemia |
T63 | 177-194 | D002545 | denotes | cerebral ischemia |
T64 | 177-194 | D002545 | denotes | cerebral ischemia |
T67 | 196-201 | D009369 | denotes | tumor |
T68 | 196-201 | D009369 | denotes | tumor |
T100 | 196-217 | GO:0005164 | denotes | tumor necrosis factor |
T110 | 196-223 | PR:000000134 | denotes | tumor necrosis factor-alpha |
T109 | 196-223 | D014409 | denotes | tumor necrosis factor-alpha |
T111 | 196-223 | D014409 | denotes | tumor necrosis factor-alpha |
T112 | 202-210 | GO:0019835 | denotes | necrosis |
T113 | 202-210 | GO:0008219 | denotes | necrosis |
T116 | 202-210 | GO:0008220 | denotes | necrosis |
T117 | 202-210 | GO:0001906 | denotes | necrosis |
T118 | 202-210 | GO:0070265 | denotes | necrosis |
T114 | 202-210 | D009336 | denotes | necrosis |
T115 | 202-210 | D009336 | denotes | necrosis |
T120 | 237-251 | D001929 | denotes | cerebral edema |
T121 | 237-251 | D001929 | denotes | cerebral edema |
T124 | 282-287 | D009369 | denotes | tumor |
T125 | 282-287 | D009369 | denotes | tumor |
T157 | 282-303 | GO:0005164 | denotes | tumor necrosis factor |
T167 | 282-309 | PR:000000134 | denotes | tumor necrosis factor-alpha |
T166 | 282-309 | D014409 | denotes | tumor necrosis factor-alpha |
T168 | 282-309 | D014409 | denotes | tumor necrosis factor-alpha |
T169 | 288-296 | GO:0019835 | denotes | necrosis |
T170 | 288-296 | GO:0008219 | denotes | necrosis |
T173 | 288-296 | GO:0008220 | denotes | necrosis |
T174 | 288-296 | GO:0001906 | denotes | necrosis |
T175 | 288-296 | GO:0070265 | denotes | necrosis |
T171 | 288-296 | D009336 | denotes | necrosis |
T172 | 288-296 | D009336 | denotes | necrosis |
T177 | 383-400 | D002545 | denotes | cerebral ischemia |
T178 | 383-400 | D002545 | denotes | cerebral ischemia |
T181 | 407-429 | UBERON:0001627 | denotes | middle cerebral artery |
T182 | 407-439 | D020244 | denotes | middle cerebral artery occlusion |
T183 | 407-439 | D020244 | denotes | middle cerebral artery occlusion |
T188 | 520-529 | D006221 | denotes | halothane |
T189 | 520-529 | CHEBI:5615 | denotes | halothane |
T190 | 520-529 | D006221 | denotes | halothane |
T191 | 544-563 | D017207 | denotes | Sprague-Dawley rats |
T195 | 573-578 | D009369 | denotes | tumor |
T196 | 573-578 | D009369 | denotes | tumor |
T228 | 573-594 | GO:0005164 | denotes | tumor necrosis factor |
T238 | 573-600 | PR:000000134 | denotes | tumor necrosis factor-alpha |
T237 | 573-600 | D014409 | denotes | tumor necrosis factor-alpha |
T239 | 573-600 | D014409 | denotes | tumor necrosis factor-alpha |
T240 | 579-587 | GO:0019835 | denotes | necrosis |
T241 | 579-587 | GO:0008219 | denotes | necrosis |
T244 | 579-587 | GO:0008220 | denotes | necrosis |
T245 | 579-587 | GO:0001906 | denotes | necrosis |
T246 | 579-587 | GO:0070265 | denotes | necrosis |
T242 | 579-587 | D009336 | denotes | necrosis |
T243 | 579-587 | D009336 | denotes | necrosis |
T248 | 625-633 | GO:0019815 | denotes | antibody |
T249 | 625-633 | GO:0042571 | denotes | antibody |
T250 | 625-633 | GO:0019814 | denotes | antibody |
T251 | 625-633 | GO:0003823 | denotes | antibody |
T252 | 641-644 | 10116 | denotes | rat |
T256 | 641-644 | D051381 | denotes | rat |
T253 | 641-644 | PR:P63003-1 | denotes | rat |
T254 | 641-644 | PR:Q2G0B1 | denotes | rat |
T255 | 641-644 | PR:Q8VHJ4 | denotes | rat |
T257 | 645-648 | D007074 | denotes | IgG |
T258 | 722-728 | D020521 | denotes | Stroke |
T259 | 722-728 | D020521 | denotes | Stroke |
T260 | 735-740 | SO:0001685 | denotes | score |
T261 | 742-749 | D007238 | denotes | infarct |
T262 | 742-749 | D007238 | denotes | infarct |
T263 | 818-823 | D009369 | denotes | tumor |
T264 | 818-823 | D009369 | denotes | tumor |
T296 | 818-839 | GO:0005164 | denotes | tumor necrosis factor |
T306 | 818-845 | PR:000000134 | denotes | tumor necrosis factor-alpha |
T305 | 818-845 | D014409 | denotes | tumor necrosis factor-alpha |
T307 | 818-845 | D014409 | denotes | tumor necrosis factor-alpha |
T308 | 824-832 | GO:0019835 | denotes | necrosis |
T309 | 824-832 | GO:0008219 | denotes | necrosis |
T312 | 824-832 | GO:0008220 | denotes | necrosis |
T313 | 824-832 | GO:0001906 | denotes | necrosis |
T314 | 824-832 | GO:0070265 | denotes | necrosis |
T310 | 824-832 | D009336 | denotes | necrosis |
T311 | 824-832 | D009336 | denotes | necrosis |
T316 | 847-853 | UBERON:0027368 | denotes | matrix |
T317 | 854-879 | D020778 | denotes | metalloproteinase (MMP)-2 |
T322 | 873-879 | PR:P08253 | denotes | MMP)-2 |
T323 | 873-879 | Q9GLE5 | denotes | MMP)-2 |
T324 | 873-879 | P08253 | denotes | MMP)-2 |
T325 | 873-879 | Q90611 | denotes | MMP)-2 |
T327 | 873-879 | PR:Q8MPP3 | denotes | MMP)-2 |
T328 | 873-879 | P33436 | denotes | MMP)-2 |
T329 | 873-879 | PR:Q90611 | denotes | MMP)-2 |
T330 | 873-879 | PR:P33436 | denotes | MMP)-2 |
T331 | 873-879 | PR:000010479 | denotes | MMP)-2 |
T332 | 873-879 | PR:P33434 | denotes | MMP)-2 |
T333 | 873-879 | P33434 | denotes | MMP)-2 |
T334 | 873-879 | P50757 | denotes | MMP)-2 |
T326 | 873-879 | GO:0004228 | denotes | MMP)-2 |
T335 | 878-884 | PR:O04529 | denotes | 2, MMP |
T336 | 881-884 | CHEBI:340824 | denotes | MMP |
T339 | 881-884 | CHEBI:59761 | denotes | MMP |
T340 | 881-886 | PR:P50282 | denotes | MMP-9 |
T341 | 881-886 | PR:P14780 | denotes | MMP-9 |
T342 | 881-886 | P14780 | denotes | MMP-9 |
T343 | 881-886 | PR:P41245 | denotes | MMP-9 |
T344 | 881-886 | P41246 | denotes | MMP-9 |
T345 | 881-886 | P41245 | denotes | MMP-9 |
T346 | 881-886 | PR:P52176 | denotes | MMP-9 |
T347 | 881-886 | P50282 | denotes | MMP-9 |
T349 | 881-886 | PR:000010491 | denotes | MMP-9 |
T350 | 881-886 | P52176 | denotes | MMP-9 |
T351 | 881-886 | O18733 | denotes | MMP-9 |
T348 | 881-886 | GO:0004229 | denotes | MMP-9 |
T353 | 892-900 | GO:0016020 | denotes | membrane |
T352 | 892-900 | UBERON:0000094 | denotes | membrane |
T354 | 892-900 | UBERON:0000158 | denotes | membrane |
T355 | 906-911 | PR:O23507 | denotes | 1-MMP |
T356 | 908-911 | CHEBI:340824 | denotes | MMP |
T359 | 908-911 | CHEBI:59761 | denotes | MMP |
T357 | 908-911 | GO:0004235 | denotes | MMP |
T360 | 915-924 | UBERON:0000955 | denotes | the brain |
T363 | 925-931 | UBERON:0000479 | denotes | tissue |
T364 | 1002-1012 | UBERON:0001869 | denotes | hemisphere |
T365 | 1031-1039 | GO:0019835 | denotes | necrosis |
T366 | 1031-1039 | GO:0008219 | denotes | necrosis |
T369 | 1031-1039 | GO:0008220 | denotes | necrosis |
T370 | 1031-1039 | GO:0001906 | denotes | necrosis |
T371 | 1031-1039 | GO:0070265 | denotes | necrosis |
T367 | 1031-1039 | D009336 | denotes | necrosis |
T368 | 1031-1039 | D009336 | denotes | necrosis |
T372 | 1047-1052 | CHEBI:30216 | denotes | alpha |
T373 | 1053-1074 | D057134 | denotes | neutralizing antibody |
T374 | 1066-1074 | GO:0019815 | denotes | antibody |
T375 | 1066-1074 | GO:0042571 | denotes | antibody |
T376 | 1066-1074 | GO:0019814 | denotes | antibody |
T377 | 1066-1074 | GO:0003823 | denotes | antibody |
T378 | 1083-1087 | 10118 | denotes | rats |
T379 | 1083-1087 | 10116 | denotes | rats |
T380 | 1083-1087 | D051381 | denotes | rats |
T381 | 1089-1096 | D007238 | denotes | infarct |
T382 | 1089-1096 | D007238 | denotes | infarct |
T383 | 1224-1230 | UBERON:0001851 | denotes | cortex |
T384 | 1235-1250 | UBERON:0002435 | denotes | caudate putamen |
T385 | 1235-1250 | UBERON:0005383 | denotes | caudate putamen |
T387 | 1302-1311 | MOP:0000569 | denotes | reduction |
T388 | 1315-1318 | CHEBI:340824 | denotes | MMP |
T391 | 1315-1318 | CHEBI:59761 | denotes | MMP |
T392 | 1315-1320 | PR:P50282 | denotes | MMP-9 |
T393 | 1315-1320 | PR:P14780 | denotes | MMP-9 |
T394 | 1315-1320 | P14780 | denotes | MMP-9 |
T395 | 1315-1320 | PR:P41245 | denotes | MMP-9 |
T396 | 1315-1320 | P41246 | denotes | MMP-9 |
T397 | 1315-1320 | P41245 | denotes | MMP-9 |
T398 | 1315-1320 | PR:P52176 | denotes | MMP-9 |
T399 | 1315-1320 | P50282 | denotes | MMP-9 |
T401 | 1315-1320 | PR:000010491 | denotes | MMP-9 |
T402 | 1315-1320 | P52176 | denotes | MMP-9 |
T403 | 1315-1320 | O18733 | denotes | MMP-9 |
T400 | 1315-1320 | GO:0004229 | denotes | MMP-9 |
T404 | 1325-1333 | UBERON:0000094 | denotes | membrane |
T406 | 1325-1333 | UBERON:0000158 | denotes | membrane |
T405 | 1325-1333 | GO:0016020 | denotes | membrane |
T407 | 1339-1344 | PR:O23507 | denotes | 1-MMP |
T408 | 1341-1344 | CHEBI:340824 | denotes | MMP |
T411 | 1341-1344 | CHEBI:59761 | denotes | MMP |
T409 | 1341-1344 | GO:0004235 | denotes | MMP |
T412 | 1359-1364 | D009369 | denotes | Tumor |
T413 | 1359-1364 | D009369 | denotes | Tumor |
T445 | 1359-1380 | GO:0005164 | denotes | Tumor necrosis factor |
T455 | 1359-1386 | PR:000000134 | denotes | Tumor necrosis factor-alpha |
T454 | 1359-1386 | D014409 | denotes | Tumor necrosis factor-alpha |
T456 | 1359-1386 | D014409 | denotes | Tumor necrosis factor-alpha |
T457 | 1365-1373 | GO:0019835 | denotes | necrosis |
T458 | 1365-1373 | GO:0008219 | denotes | necrosis |
T461 | 1365-1373 | GO:0008220 | denotes | necrosis |
T462 | 1365-1373 | GO:0001906 | denotes | necrosis |
T463 | 1365-1373 | GO:0070265 | denotes | necrosis |
T459 | 1365-1373 | D009336 | denotes | necrosis |
T460 | 1365-1373 | D009336 | denotes | necrosis |
T465 | 1390-1399 | UBERON:0000955 | denotes | the brain |
T468 | 1400-1406 | UBERON:0000479 | denotes | tissue |
T469 | 1450-1460 | UBERON:0001869 | denotes | hemisphere |
T470 | 1502-1505 | D007074 | denotes | IgG |
T471 | 1514-1518 | 10118 | denotes | rats |
T472 | 1514-1518 | 10116 | denotes | rats |
T473 | 1514-1518 | D051381 | denotes | rats |
T474 | 1569-1577 | GO:0019835 | denotes | necrosis |
T475 | 1569-1577 | GO:0008219 | denotes | necrosis |
T478 | 1569-1577 | GO:0008220 | denotes | necrosis |
T479 | 1569-1577 | GO:0001906 | denotes | necrosis |
T480 | 1569-1577 | GO:0070265 | denotes | necrosis |
T476 | 1569-1577 | D009336 | denotes | necrosis |
T477 | 1569-1577 | D009336 | denotes | necrosis |
T481 | 1585-1590 | CHEBI:30216 | denotes | alpha |
T482 | 1591-1612 | D057134 | denotes | neutralizing antibody |
T483 | 1604-1612 | GO:0019815 | denotes | antibody |
T484 | 1604-1612 | GO:0042571 | denotes | antibody |
T485 | 1604-1612 | GO:0019814 | denotes | antibody |
T486 | 1604-1612 | GO:0003823 | denotes | antibody |
T487 | 1621-1625 | 10118 | denotes | rats |
T488 | 1621-1625 | 10116 | denotes | rats |
T489 | 1621-1625 | D051381 | denotes | rats |
T490 | 1681-1686 | D009369 | denotes | tumor |
T491 | 1681-1686 | D009369 | denotes | tumor |
T523 | 1681-1702 | GO:0005164 | denotes | tumor necrosis factor |
T533 | 1681-1708 | PR:000000134 | denotes | tumor necrosis factor-alpha |
T532 | 1681-1708 | D014409 | denotes | tumor necrosis factor-alpha |
T534 | 1681-1708 | D014409 | denotes | tumor necrosis factor-alpha |
T535 | 1687-1695 | GO:0019835 | denotes | necrosis |
T536 | 1687-1695 | GO:0008219 | denotes | necrosis |
T539 | 1687-1695 | GO:0008220 | denotes | necrosis |
T540 | 1687-1695 | GO:0001906 | denotes | necrosis |
T541 | 1687-1695 | GO:0070265 | denotes | necrosis |
T537 | 1687-1695 | D009336 | denotes | necrosis |
T538 | 1687-1695 | D009336 | denotes | necrosis |
T543 | 1709-1730 | D057134 | denotes | neutralizing antibody |
T544 | 1722-1730 | GO:0019815 | denotes | antibody |
T545 | 1722-1730 | GO:0042571 | denotes | antibody |
T546 | 1722-1730 | GO:0019814 | denotes | antibody |
T547 | 1722-1730 | GO:0003823 | denotes | antibody |
T548 | 1739-1744 | UBERON:6110636 | denotes | brain |
T549 | 1739-1744 | UBERON:0000955 | denotes | brain |
T550 | 1739-1752 | D020520 | denotes | brain infarct |
T551 | 1739-1752 | D020520 | denotes | brain infarct |
T554 | 1764-1778 | D001929 | denotes | cerebral edema |
T555 | 1764-1778 | D001929 | denotes | cerebral edema |
T558 | 1810-1819 | MOP:0000569 | denotes | reduction |
T561 | 1823-1826 | PR:O04529 | denotes | MMP |
T559 | 1823-1826 | CHEBI:340824 | denotes | MMP |
T562 | 1823-1826 | CHEBI:59761 | denotes | MMP |
T560 | 1823-1826 | GO:0004235 | denotes | MMP |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-164 | DRI_Challenge | denotes | Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia. |
T2 | 165-270 | DRI_Challenge | denotes | After focal cerebral ischemia, tumor necrosis factor-alpha deteriorates cerebral edema and survival rate. |
T3 | 271-401 | DRI_Challenge | denotes | Therefore, tumor necrosis factor-alpha neutralization could reduce cerebral microvascular permeability in acute cerebral ischemia. |
T4 | 402-564 | DRI_Background | denotes | Left middle cerebral artery occlusion for 120 mins followed by reperfusion was performed with the thread method under halothane anesthesia in Sprague-Dawley rats. |
T5 | 565-721 | DRI_Background | denotes | Antirat tumor necrosis factor-alpha neutralizing monoclonal antibody with a rat IgG Fc portion (15 mg/kg) was infused intravenously right after reperfusion. |
T6 | 722-1013 | DRI_Approach | denotes | Stroke index score, infarct volume, cerebral specific gravity, and the endogenous expression of tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in the brain tissue were quantified in the ischemic and matched contralateral nonischemic hemisphere. |
T7 | 1014-1358 | DRI_Outcome | denotes | In the antitumor necrosis factor-alpha neutralizing antibody-treated rats, infarct volume was significantly reduced (P=0.014, n=7; respectively), and cerebral specific gravity was dramatically increased in the cortex and caudate putamen (P<0.001, n=7; respectively) in association with a reduction in MMP-9 and membrane type 1-MMP upregulation. |
T8 | 1359-1641 | DRI_Background | denotes | Tumor necrosis factor-alpha in the brain tissue was significantly elevated in the ischemic hemisphere 6 h after reperfusion in the nonspecific IgG-treated rats (P=0.021, n=7) and was decreased in the antitumor necrosis factor-alpha neutralizing antibody-treated rats (P=0.001, n=7). |
T9 | 1642-1840 | DRI_Background | denotes | Postreperfusion treatment with antirat tumor necrosis factor-alpha neutralizing antibody reduced brain infarct volume and cerebral edema, which is likely mediated by a reduction in MMP upregulation. |