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PubMed:15721222 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 135-307 DRI_Background denotes The spontaneously hypertensive stroke-prone rat (SHR-SP) is an experimental model of malignant hypertension which lead to secondary alterations of the extracellular matrix.
T2 308-448 DRI_Approach denotes Our aim was to determine ACE-inhibitor related changes of proteases involved in the reconstruction of the extracellular matrix in the brain.
T3 449-500 DRI_Approach denotes Twelve SHR-SP rats were randomized into two groups.
T4 501-597 DRI_Background denotes Each group was treated with either an antihypertensive dose of ramipril or placebo for 6 months.
T5 598-857 DRI_Background denotes Brain tissue plasminogen activator (t-PA) and urokinase (u-PA) were quantified by using casein-dependent plasminogen zymography, matrix metalloproteinase (MMP)-2 and MMP-9, by MMP-zymography, and tissue inhibitor of MMP (TIMP)-1 and -2, by reverse zymography.
T6 858-959 DRI_Outcome denotes The amounts of u-PA, t-PA, and MMPs were significantly reduced in animals treated with ACE inhibitor.
T7 1144-1361 DRI_Approach denotes MMP-2 expression was reduced by 15% in the cortex (p < 0.05) and by 10% in the basal ganglia (p < 0.05); MMP-9 expression significantly decreased by 37% in the cortex and by 25% in the basal ganglia (p < 0.0001 each).
T8 1362-1425 DRI_Background denotes No differences were observed in the amount of TIMP-1 or TIMP-2.
T9 1426-1577 DRI_Background denotes These findings provide new insights into the biochemical mechanisms underlying extracellular matrix proliferation and its modulation by ACE inhibitors.
T10 1578-1766 DRI_Background denotes Therapeutic alterations that influence the proteolytic systems might prove important in the prevention of extracellular matrix accumulation and secondary microvascular vessel wall changes.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-3 Q10751 denotes ACE
T2 0-3 P09470 denotes ACE
T3 0-3 PR:P12821 denotes ACE
T4 0-3 Q50JE5 denotes ACE
T5 0-3 Q9GLN7 denotes ACE
T6 0-3 PR:000001322 denotes ACE
T7 0-3 P47820 denotes ACE
T8 0-3 PR:Q9S746 denotes ACE
T9 0-3 P12822 denotes ACE
T10 0-3 P12820 denotes ACE
T11 0-3 P12821 denotes ACE
T12 39-50 P33574 denotes plasminogen
T13 39-50 P20918 denotes plasminogen
T14 39-50 P06867 denotes plasminogen
T16 39-50 P83169 denotes plasminogen
T17 39-50 Q01177 denotes plasminogen
T18 39-50 PR:000012867 denotes plasminogen
T19 39-50 Q5R8X6 denotes plasminogen
T20 39-50 P81286 denotes plasminogen
T21 39-50 P06868 denotes plasminogen
T22 39-50 Q7M323 denotes plasminogen
T23 39-50 P12545 denotes plasminogen
T25 39-50 P80010 denotes plasminogen
T26 39-50 O18783 denotes plasminogen
T27 39-50 P80009 denotes plasminogen
T28 39-50 Q29485 denotes plasminogen
T29 39-50 P00747 denotes plasminogen
T15 39-50 CHEBI:8259 denotes plasminogen
T24 39-50 D010958 denotes plasminogen
T30 51-58 CHEBI:8258 denotes plasmin
T31 51-58 D005341 denotes plasmin
T34 63-66 PR:O04529 denotes MMP
T32 63-66 CHEBI:340824 denotes MMP
T35 63-66 CHEBI:59761 denotes MMP
T33 63-66 GO:0004235 denotes MMP
T36 78-87 UBERON:0000955 denotes the brain
T39 129-133 10118 denotes rats
T40 129-133 10116 denotes rats
T41 129-133 D051381 denotes rats
T43 179-182 PR:P63003-1 denotes rat
T44 179-182 PR:Q2G0B1 denotes rat
T45 179-182 PR:Q8VHJ4 denotes rat
T47 179-187 D011918 denotes rat (SHR
T48 184-187 PR:Q9SZF7 denotes SHR
T49 220-242 D006974 denotes malignant hypertension
T50 220-242 D006974 denotes malignant hypertension
T54 286-306 GO:0031012 denotes extracellular matrix
T55 300-306 UBERON:0027368 denotes matrix
T56 333-336 Q10751 denotes ACE
T57 333-336 P09470 denotes ACE
T58 333-336 PR:P12821 denotes ACE
T59 333-336 Q50JE5 denotes ACE
T60 333-336 Q9GLN7 denotes ACE
T61 333-336 PR:000001322 denotes ACE
T62 333-336 P47820 denotes ACE
T63 333-336 PR:Q9S746 denotes ACE
T64 333-336 P12822 denotes ACE
T65 333-336 P12820 denotes ACE
T66 333-336 P12821 denotes ACE
T67 333-346 CHEBI:35457 denotes ACE-inhibitor
T68 333-346 GO:0042031 denotes ACE-inhibitor
T70 366-375 D010447 denotes proteases
T72 414-434 GO:0031012 denotes extracellular matrix
T73 428-434 UBERON:0027368 denotes matrix
T74 438-447 UBERON:0000955 denotes the brain
T77 456-459 PR:Q9SZF7 denotes SHR
T78 463-467 10118 denotes rats
T79 463-467 10116 denotes rats
T80 463-467 D051381 denotes rats
T81 539-555 CHEBI:35674 denotes antihypertensive
T84 564-572 35296 denotes ramipril
T82 564-572 D017257 denotes ramipril
T83 564-572 CHEBI:8774 denotes ramipril
T85 564-572 D017257 denotes ramipril
T86 604-610 UBERON:0000479 denotes tissue
T87 604-632 D010959 denotes tissue plasminogen activator
T88 604-632 D010959 denotes tissue plasminogen activator
T107 611-632 P17811 denotes plasminogen activator
T109 634-638 Q28198 denotes t-PA
T110 634-638 Q5R8J0 denotes t-PA
T111 634-638 P19637 denotes t-PA
T112 634-638 P00750 denotes t-PA
T114 634-638 Q8SQ23 denotes t-PA
T115 634-638 PR:000012825 denotes t-PA
T116 634-638 P11214 denotes t-PA
T113 634-638 GO:0008243 denotes t-PA
T117 644-653 D014568 denotes urokinase
T119 655-659 D014568 denotes u-PA
T118 655-659 GO:0008243 denotes u-PA
T121 686-692 862460 denotes casein
T120 686-692 CHEBI:3448 denotes casein
T122 686-692 D002364 denotes casein
T123 703-714 P33574 denotes plasminogen
T124 703-714 P20918 denotes plasminogen
T125 703-714 P06867 denotes plasminogen
T127 703-714 P83169 denotes plasminogen
T128 703-714 Q01177 denotes plasminogen
T129 703-714 PR:000012867 denotes plasminogen
T130 703-714 Q5R8X6 denotes plasminogen
T131 703-714 P81286 denotes plasminogen
T132 703-714 P06868 denotes plasminogen
T133 703-714 Q7M323 denotes plasminogen
T134 703-714 P12545 denotes plasminogen
T136 703-714 P80010 denotes plasminogen
T137 703-714 O18783 denotes plasminogen
T138 703-714 P80009 denotes plasminogen
T139 703-714 Q29485 denotes plasminogen
T140 703-714 P00747 denotes plasminogen
T126 703-714 CHEBI:8259 denotes plasminogen
T135 703-714 D010958 denotes plasminogen
T141 727-733 UBERON:0027368 denotes matrix
T142 734-759 D020778 denotes metalloproteinase (MMP)-2
T147 753-759 PR:P08253 denotes MMP)-2
T148 753-759 Q9GLE5 denotes MMP)-2
T149 753-759 P08253 denotes MMP)-2
T150 753-759 Q90611 denotes MMP)-2
T152 753-759 PR:Q8MPP3 denotes MMP)-2
T153 753-759 P33436 denotes MMP)-2
T154 753-759 PR:Q90611 denotes MMP)-2
T155 753-759 PR:P33436 denotes MMP)-2
T156 753-759 PR:000010479 denotes MMP)-2
T157 753-759 PR:P33434 denotes MMP)-2
T158 753-759 P33434 denotes MMP)-2
T159 753-759 P50757 denotes MMP)-2
T151 753-759 GO:0004228 denotes MMP)-2
T160 764-767 CHEBI:340824 denotes MMP
T163 764-767 CHEBI:59761 denotes MMP
T164 764-769 PR:P50282 denotes MMP-9
T165 764-769 PR:P14780 denotes MMP-9
T166 764-769 P14780 denotes MMP-9
T167 764-769 PR:P41245 denotes MMP-9
T168 764-769 P41246 denotes MMP-9
T169 764-769 P41245 denotes MMP-9
T170 764-769 PR:P52176 denotes MMP-9
T171 764-769 P50282 denotes MMP-9
T173 764-769 PR:000010491 denotes MMP-9
T174 764-769 P52176 denotes MMP-9
T175 764-769 O18733 denotes MMP-9
T172 764-769 GO:0004229 denotes MMP-9
T178 774-777 PR:O04529 denotes MMP
T176 774-777 CHEBI:340824 denotes MMP
T179 774-777 CHEBI:59761 denotes MMP
T177 774-777 GO:0004235 denotes MMP
T180 794-800 UBERON:0000479 denotes tissue
T181 801-810 CHEBI:35222 denotes inhibitor
T184 814-817 PR:O04529 denotes MMP
T182 814-817 CHEBI:340824 denotes MMP
T185 814-817 CHEBI:59761 denotes MMP
T183 814-817 GO:0004235 denotes MMP
T190 819-826 P81546 denotes TIMP)-1
T191 819-826 O02722 denotes TIMP)-1
T192 819-826 P49061 denotes TIMP)-1
T193 819-826 P50122 denotes TIMP)-1
T194 819-826 P20614 denotes TIMP)-1
T195 819-826 P12032 denotes TIMP)-1
T196 819-826 P35624 denotes TIMP)-1
T197 819-826 P20414 denotes TIMP)-1
T198 819-826 Q95KL9 denotes TIMP)-1
T199 819-826 Q5RC60 denotes TIMP)-1
T200 819-826 PR:P30120 denotes TIMP)-1
T201 819-826 P30120 denotes TIMP)-1
T202 819-826 PR:000016352 denotes TIMP)-1
T204 819-826 PR:P12032 denotes TIMP)-1
T205 819-826 PR:P01033 denotes TIMP)-1
T206 819-826 P01033 denotes TIMP)-1
T203 819-826 D019715 denotes TIMP)-1
T208 838-845 SO:0001031 denotes reverse
T210 873-877 D014568 denotes u-PA
T209 873-877 GO:0008243 denotes u-PA
T211 879-883 Q28198 denotes t-PA
T212 879-883 Q5R8J0 denotes t-PA
T213 879-883 P19637 denotes t-PA
T214 879-883 P00750 denotes t-PA
T216 879-883 Q8SQ23 denotes t-PA
T217 879-883 PR:000012825 denotes t-PA
T218 879-883 P11214 denotes t-PA
T215 879-883 GO:0008243 denotes t-PA
T219 889-893 D020782 denotes MMPs
T220 945-948 Q10751 denotes ACE
T221 945-948 P09470 denotes ACE
T222 945-948 PR:P12821 denotes ACE
T223 945-948 Q50JE5 denotes ACE
T224 945-948 Q9GLN7 denotes ACE
T225 945-948 PR:000001322 denotes ACE
T226 945-948 P47820 denotes ACE
T227 945-948 PR:Q9S746 denotes ACE
T228 945-948 P12822 denotes ACE
T229 945-948 P12820 denotes ACE
T230 945-948 P12821 denotes ACE
T231 945-958 CHEBI:35457 denotes ACE inhibitor
T232 945-958 GO:0042031 denotes ACE inhibitor
T234 960-971 P33574 denotes Plasminogen
T235 960-971 P20918 denotes Plasminogen
T236 960-971 P06867 denotes Plasminogen
T238 960-971 P83169 denotes Plasminogen
T239 960-971 Q01177 denotes Plasminogen
T240 960-971 PR:000012867 denotes Plasminogen
T241 960-971 Q5R8X6 denotes Plasminogen
T242 960-971 P81286 denotes Plasminogen
T243 960-971 P06868 denotes Plasminogen
T244 960-971 Q7M323 denotes Plasminogen
T245 960-971 P12545 denotes Plasminogen
T247 960-971 P80010 denotes Plasminogen
T248 960-971 O18783 denotes Plasminogen
T249 960-971 P80009 denotes Plasminogen
T250 960-971 Q29485 denotes Plasminogen
T251 960-971 P00747 denotes Plasminogen
T237 960-971 CHEBI:8259 denotes Plasminogen
T246 960-971 D010958 denotes Plasminogen
T252 996-1005 MOP:0000569 denotes reduction
T254 1009-1013 D014568 denotes u-PA
T253 1009-1013 GO:0008243 denotes u-PA
T255 1021-1034 UBERON:0002420 denotes basal ganglia
T258 1021-1034 UBERON:0006098 denotes basal ganglia
T259 1021-1034 UBERON:0010011 denotes basal ganglia
T256 1021-1034 D001480 denotes basal ganglia
T257 1021-1034 D001480 denotes basal ganglia
T261 1049-1053 Q28198 denotes t-PA
T262 1049-1053 Q5R8J0 denotes t-PA
T263 1049-1053 P19637 denotes t-PA
T264 1049-1053 P00750 denotes t-PA
T266 1049-1053 Q8SQ23 denotes t-PA
T267 1049-1053 PR:000012825 denotes t-PA
T268 1049-1053 P11214 denotes t-PA
T265 1049-1053 GO:0008243 denotes t-PA
T269 1091-1097 UBERON:0001851 denotes cortex
T270 1116-1129 UBERON:0002420 denotes basal ganglia
T273 1116-1129 UBERON:0006098 denotes basal ganglia
T274 1116-1129 UBERON:0010011 denotes basal ganglia
T271 1116-1129 D001480 denotes basal ganglia
T272 1116-1129 D001480 denotes basal ganglia
T276 1144-1147 CHEBI:340824 denotes MMP
T279 1144-1147 CHEBI:59761 denotes MMP
T280 1144-1149 PR:P08253 denotes MMP-2
T281 1144-1149 Q9GLE5 denotes MMP-2
T282 1144-1149 P08253 denotes MMP-2
T283 1144-1149 Q90611 denotes MMP-2
T285 1144-1149 PR:Q8MPP3 denotes MMP-2
T286 1144-1149 P33436 denotes MMP-2
T287 1144-1149 PR:Q90611 denotes MMP-2
T288 1144-1149 PR:P33436 denotes MMP-2
T289 1144-1149 PR:000010479 denotes MMP-2
T290 1144-1149 PR:P33434 denotes MMP-2
T291 1144-1149 P33434 denotes MMP-2
T292 1144-1149 P50757 denotes MMP-2
T284 1144-1149 GO:0004228 denotes MMP-2
T293 1187-1193 UBERON:0001851 denotes cortex
T294 1223-1236 UBERON:0002420 denotes basal ganglia
T297 1223-1236 UBERON:0006098 denotes basal ganglia
T298 1223-1236 UBERON:0010011 denotes basal ganglia
T295 1223-1236 D001480 denotes basal ganglia
T296 1223-1236 D001480 denotes basal ganglia
T300 1249-1252 CHEBI:340824 denotes MMP
T303 1249-1252 CHEBI:59761 denotes MMP
T304 1249-1254 PR:P50282 denotes MMP-9
T305 1249-1254 PR:P14780 denotes MMP-9
T306 1249-1254 P14780 denotes MMP-9
T307 1249-1254 PR:P41245 denotes MMP-9
T308 1249-1254 P41246 denotes MMP-9
T309 1249-1254 P41245 denotes MMP-9
T310 1249-1254 PR:P52176 denotes MMP-9
T311 1249-1254 P50282 denotes MMP-9
T313 1249-1254 PR:000010491 denotes MMP-9
T314 1249-1254 P52176 denotes MMP-9
T315 1249-1254 O18733 denotes MMP-9
T312 1249-1254 GO:0004229 denotes MMP-9
T316 1304-1310 UBERON:0001851 denotes cortex
T317 1329-1342 UBERON:0002420 denotes basal ganglia
T320 1329-1342 UBERON:0006098 denotes basal ganglia
T321 1329-1342 UBERON:0010011 denotes basal ganglia
T318 1329-1342 D001480 denotes basal ganglia
T319 1329-1342 D001480 denotes basal ganglia
T327 1408-1414 P81546 denotes TIMP-1
T328 1408-1414 O02722 denotes TIMP-1
T329 1408-1414 P49061 denotes TIMP-1
T330 1408-1414 P50122 denotes TIMP-1
T331 1408-1414 P20614 denotes TIMP-1
T332 1408-1414 P12032 denotes TIMP-1
T333 1408-1414 P35624 denotes TIMP-1
T334 1408-1414 P20414 denotes TIMP-1
T335 1408-1414 Q95KL9 denotes TIMP-1
T336 1408-1414 Q5RC60 denotes TIMP-1
T337 1408-1414 PR:P30120 denotes TIMP-1
T338 1408-1414 P30120 denotes TIMP-1
T339 1408-1414 PR:000016352 denotes TIMP-1
T341 1408-1414 PR:P12032 denotes TIMP-1
T342 1408-1414 PR:P01033 denotes TIMP-1
T343 1408-1414 P01033 denotes TIMP-1
T340 1408-1414 D019715 denotes TIMP-1
T348 1418-1424 PR:P16035 denotes TIMP-2
T349 1418-1424 PR:000016353 denotes TIMP-2
T350 1418-1424 O42146 denotes TIMP-2
T351 1418-1424 Q9TRZ7 denotes TIMP-2
T352 1418-1424 Q9TTY1 denotes TIMP-2
T353 1418-1424 Q60453 denotes TIMP-2
T354 1418-1424 P16035 denotes TIMP-2
T356 1418-1424 P25785 denotes TIMP-2
T357 1418-1424 P16368 denotes TIMP-2
T358 1418-1424 O77717 denotes TIMP-2
T359 1418-1424 PR:P25785 denotes TIMP-2
T360 1418-1424 P30121 denotes TIMP-2
T361 1418-1424 Q9WUC6 denotes TIMP-2
T362 1418-1424 PR:P30121 denotes TIMP-2
T363 1418-1424 PR:O42146 denotes TIMP-2
T355 1418-1424 D019716 denotes TIMP-2
T365 1505-1525 GO:0031012 denotes extracellular matrix
T366 1519-1525 UBERON:0027368 denotes matrix
T367 1526-1539 UBERON:2000098 denotes proliferation
T368 1562-1565 Q10751 denotes ACE
T369 1562-1565 P09470 denotes ACE
T370 1562-1565 PR:P12821 denotes ACE
T371 1562-1565 Q50JE5 denotes ACE
T372 1562-1565 Q9GLN7 denotes ACE
T373 1562-1565 PR:000001322 denotes ACE
T374 1562-1565 P47820 denotes ACE
T375 1562-1565 PR:Q9S746 denotes ACE
T376 1562-1565 P12822 denotes ACE
T377 1562-1565 P12820 denotes ACE
T378 1562-1565 P12821 denotes ACE
T379 1562-1576 CHEBI:35457 denotes ACE inhibitors
T380 1562-1576 D000806 denotes ACE inhibitors
T381 1562-1576 D000806 denotes ACE inhibitors
T384 1684-1704 GO:0031012 denotes extracellular matrix
T385 1698-1704 UBERON:0027368 denotes matrix
T386 1746-1752 UBERON:0000055 denotes vessel
T387 1753-1757 UBERON:0000060 denotes wall

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-134 DRI_Outcome denotes ACE inhibition reduces activity of the plasminogen/plasmin and MMP systems in the brain of spontaneous hypertensive stroke-prone rats.
T2 135-307 DRI_Background denotes The spontaneously hypertensive stroke-prone rat (SHR-SP) is an experimental model of malignant hypertension which lead to secondary alterations of the extracellular matrix.
T3 308-448 DRI_Approach denotes Our aim was to determine ACE-inhibitor related changes of proteases involved in the reconstruction of the extracellular matrix in the brain.
T4 449-500 DRI_Approach denotes Twelve SHR-SP rats were randomized into two groups.
T5 501-597 DRI_Background denotes Each group was treated with either an antihypertensive dose of ramipril or placebo for 6 months.
T6 598-857 DRI_Background denotes Brain tissue plasminogen activator (t-PA) and urokinase (u-PA) were quantified by using casein-dependent plasminogen zymography, matrix metalloproteinase (MMP)-2 and MMP-9, by MMP-zymography, and tissue inhibitor of MMP (TIMP)-1 and -2, by reverse zymography.
T7 858-959 DRI_Outcome denotes The amounts of u-PA, t-PA, and MMPs were significantly reduced in animals treated with ACE inhibitor.
T8 960-1143 DRI_Outcome denotes Plasminogen zymography showed a 39% reduction of u-PA in the basal ganglia (p < 0.0001); t-PA expression was reduced by 26% in the cortex and by 33% in the basal ganglia (p < 0.0001).
T9 1144-1361 DRI_Outcome denotes MMP-2 expression was reduced by 15% in the cortex (p < 0.05) and by 10% in the basal ganglia (p < 0.05); MMP-9 expression significantly decreased by 37% in the cortex and by 25% in the basal ganglia (p < 0.0001 each).
T10 1362-1425 DRI_Background denotes No differences were observed in the amount of TIMP-1 or TIMP-2.
T11 1426-1577 DRI_Background denotes These findings provide new insights into the biochemical mechanisms underlying extracellular matrix proliferation and its modulation by ACE inhibitors.
T12 1578-1766 DRI_Background denotes Therapeutic alterations that influence the proteolytic systems might prove important in the prevention of extracellular matrix accumulation and secondary microvascular vessel wall changes.