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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 115-287 DRI_Background denotes One of the early features of diabetic retinopathy is the alteration of the blood-retinal barrier (BRB), which may involve the breakdown of endothelial cell tight junctions.
T2 288-475 DRI_Background denotes The aim of this study was to examine the expression of extracellular proteinases in an animal model of early diabetic retinopathy and to determine their role in the alteration of the BRB.
T3 476-579 DRI_Background denotes Matrix metalloproteinase (MMP) expression was studied in the retinas of rats with 12 weeks of diabetes.
T4 580-761 DRI_Background denotes The role of MMPs in regulating tight junction function was investigated in retinal endothelial and pigment epithelial cells by measuring transepithelial electrical resistance (TER).
T5 762-864 DRI_Background denotes The retinas of diabetic animals demonstrated elevated levels of MMP-2, MMP-9 and MMP-14 messenger RNA.
T6 865-975 DRI_Background denotes A significant increase in the production of MMP-9 was seen when cells were exposed to high glucose conditions.
T7 976-1113 DRI_Background denotes Both cell types treated with purified MMP-2 or MMP-9 were found to have alterations of tight junction function as shown by decreased TER.
T8 1114-1252 DRI_Background denotes Western blot analysis of cell extracts treated with MMP-2 or MMP-9, revealed specific degradation of the tight junction protein, occludin.
T9 1253-1517 DRI_Challenge denotes Results suggest that elevated expression of MMPs in the retina may facilitate an increase in vascular permeability by a mechanism involving proteolytic degradation of the tight junction protein occludin followed by disruption of the overall tight junction complex.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-25 D020782 denotes Matrix metalloproteinases
T3 35-55 D003930 denotes diabetic retinopathy
T4 35-55 D003930 denotes diabetic retinopathy
T5 98-105 D012172 denotes retinal
T6 98-105 CHEBI:17898 denotes retinal
T7 98-105 D012172 denotes retinal
T8 98-105 CHEBI:15035 denotes retinal
T9 98-105 CHEBI:45487 denotes retinal
T10 144-164 D003930 denotes diabetic retinopathy
T11 144-164 D003930 denotes diabetic retinopathy
T12 196-203 D012172 denotes retinal
T13 196-203 CHEBI:17898 denotes retinal
T14 196-203 D012172 denotes retinal
T15 196-203 CHEBI:15035 denotes retinal
T16 196-203 CHEBI:45487 denotes retinal
T17 213-216 P79351 denotes BRB
T18 213-216 P39873 denotes BRB
T19 213-216 Q29543 denotes BRB
T20 213-216 P87350 denotes BRB
T21 213-216 Q29542 denotes BRB
T22 213-216 UBERON:0001788 denotes BRB
T23 241-250 GO:0009056 denotes breakdown
T24 254-270 CL:0000115 denotes endothelial cell
T25 343-356 GO:0005576 denotes extracellular
T26 357-368 D010447 denotes proteinases
T27 375-381 UBERON:3010325 denotes animal
T28 375-381 UBERON:0000468 denotes animal
T29 397-417 D003930 denotes diabetic retinopathy
T30 397-417 D003930 denotes diabetic retinopathy
T31 471-474 P79351 denotes BRB
T32 471-474 P39873 denotes BRB
T33 471-474 Q29543 denotes BRB
T34 471-474 P87350 denotes BRB
T35 471-474 Q29542 denotes BRB
T36 471-474 UBERON:0001788 denotes BRB
T39 502-505 PR:O04529 denotes MMP
T37 502-505 CHEBI:340824 denotes MMP
T40 502-505 CHEBI:59761 denotes MMP
T38 502-505 GO:0004235 denotes MMP
T41 537-544 UBERON:0000966 denotes retinas
T42 548-552 10118 denotes rats
T43 548-552 10116 denotes rats
T44 548-552 D051381 denotes rats
T45 592-596 D020782 denotes MMPs
T46 611-625 GO:0070160 denotes tight junction
T47 617-625 UBERON:0007651 denotes junction
T48 617-625 SO:0000699 denotes junction
T49 655-662 D012172 denotes retinal
T50 655-662 CHEBI:17898 denotes retinal
T51 655-662 D012172 denotes retinal
T52 655-662 CHEBI:15035 denotes retinal
T53 655-662 CHEBI:45487 denotes retinal
T54 756-759 Q9KRA3 denotes TER
T55 756-759 Q9CY27 denotes TER
T56 756-759 Q55C17 denotes TER
T57 756-759 Q0SRA3 denotes TER
T58 756-759 PR:000008207 denotes TER
T59 756-759 A6LV73 denotes TER
T60 756-759 PR:000006598 denotes TER
T61 756-759 Q64232 denotes TER
T62 756-759 B8I4V6 denotes TER
T63 756-759 Q97LU2 denotes TER
T64 756-759 Q3ZCD7 denotes TER
T65 756-759 Q9NZ01 denotes TER
T66 756-759 PR:P11455 denotes TER
T67 756-759 Q62L02 denotes TER
T68 756-759 PR:Q6VY05 denotes TER
T69 756-759 Q0TNN6 denotes TER
T71 756-759 Q8XIP1 denotes TER
T72 756-759 Q9HZP8 denotes TER
T73 756-759 Q2P9J6 denotes TER
T74 756-759 Q73Q47 denotes TER
T75 756-759 C0QVH0 denotes TER
T70 756-759 GO:0097047 denotes TER
T76 766-773 UBERON:0000966 denotes retinas
T77 826-829 CHEBI:340824 denotes MMP
T80 826-829 CHEBI:59761 denotes MMP
T81 826-831 PR:P08253 denotes MMP-2
T82 826-831 Q9GLE5 denotes MMP-2
T83 826-831 P08253 denotes MMP-2
T84 826-831 Q90611 denotes MMP-2
T86 826-831 PR:Q8MPP3 denotes MMP-2
T87 826-831 P33436 denotes MMP-2
T88 826-831 PR:Q90611 denotes MMP-2
T89 826-831 PR:P33436 denotes MMP-2
T90 826-831 PR:000010479 denotes MMP-2
T91 826-831 PR:P33434 denotes MMP-2
T92 826-831 P33434 denotes MMP-2
T93 826-831 P50757 denotes MMP-2
T85 826-831 GO:0004228 denotes MMP-2
T94 830-836 PR:O04529 denotes 2, MMP
T95 833-836 CHEBI:340824 denotes MMP
T98 833-836 CHEBI:59761 denotes MMP
T99 833-838 PR:P50282 denotes MMP-9
T100 833-838 PR:P14780 denotes MMP-9
T101 833-838 P14780 denotes MMP-9
T102 833-838 PR:P41245 denotes MMP-9
T103 833-838 P41246 denotes MMP-9
T104 833-838 P41245 denotes MMP-9
T105 833-838 PR:P52176 denotes MMP-9
T106 833-838 P50282 denotes MMP-9
T108 833-838 PR:000010491 denotes MMP-9
T109 833-838 P52176 denotes MMP-9
T110 833-838 O18733 denotes MMP-9
T107 833-838 GO:0004229 denotes MMP-9
T111 843-846 CHEBI:340824 denotes MMP
T114 843-846 CHEBI:59761 denotes MMP
T112 843-846 GO:0004235 denotes MMP
T115 843-849 Q9XT90 denotes MMP-14
T116 843-849 PR:P53690 denotes MMP-14
T117 843-849 P50281 denotes MMP-14
T118 843-849 Q9GLE4 denotes MMP-14
T119 843-849 PR:000010474 denotes MMP-14
T120 843-849 Q10739 denotes MMP-14
T121 843-849 PR:P50281 denotes MMP-14
T122 843-849 PR:Q10739 denotes MMP-14
T123 843-849 Q95220 denotes MMP-14
T124 843-849 Q5RES1 denotes MMP-14
T125 843-849 P53690 denotes MMP-14
T128 850-863 SO:0000234 denotes messenger RNA
T126 850-863 D012333 denotes messenger RNA
T127 850-863 CHEBI:33699 denotes messenger RNA
T131 860-863 GO:0005562 denotes RNA
T133 909-912 CHEBI:340824 denotes MMP
T136 909-912 CHEBI:59761 denotes MMP
T137 909-914 PR:P50282 denotes MMP-9
T138 909-914 PR:P14780 denotes MMP-9
T139 909-914 P14780 denotes MMP-9
T140 909-914 PR:P41245 denotes MMP-9
T141 909-914 P41246 denotes MMP-9
T142 909-914 P41245 denotes MMP-9
T143 909-914 PR:P52176 denotes MMP-9
T144 909-914 P50282 denotes MMP-9
T146 909-914 PR:000010491 denotes MMP-9
T147 909-914 P52176 denotes MMP-9
T148 909-914 O18733 denotes MMP-9
T145 909-914 GO:0004229 denotes MMP-9
T151 956-963 4850 denotes glucose
T149 956-963 D005947 denotes glucose
T150 956-963 D005947 denotes glucose
T152 956-963 CHEBI:42758 denotes glucose
T153 956-963 CHEBI:4167 denotes glucose
T154 956-963 CHEBI:17234 denotes glucose
T155 1014-1017 CHEBI:340824 denotes MMP
T158 1014-1017 CHEBI:59761 denotes MMP
T159 1014-1019 PR:P08253 denotes MMP-2
T160 1014-1019 Q9GLE5 denotes MMP-2
T161 1014-1019 P08253 denotes MMP-2
T162 1014-1019 Q90611 denotes MMP-2
T164 1014-1019 PR:Q8MPP3 denotes MMP-2
T165 1014-1019 P33436 denotes MMP-2
T166 1014-1019 PR:Q90611 denotes MMP-2
T167 1014-1019 PR:P33436 denotes MMP-2
T168 1014-1019 PR:000010479 denotes MMP-2
T169 1014-1019 PR:P33434 denotes MMP-2
T170 1014-1019 P33434 denotes MMP-2
T171 1014-1019 P50757 denotes MMP-2
T163 1014-1019 GO:0004228 denotes MMP-2
T172 1023-1026 CHEBI:340824 denotes MMP
T175 1023-1026 CHEBI:59761 denotes MMP
T176 1023-1028 PR:P50282 denotes MMP-9
T177 1023-1028 PR:P14780 denotes MMP-9
T178 1023-1028 P14780 denotes MMP-9
T179 1023-1028 PR:P41245 denotes MMP-9
T180 1023-1028 P41246 denotes MMP-9
T181 1023-1028 P41245 denotes MMP-9
T182 1023-1028 PR:P52176 denotes MMP-9
T183 1023-1028 P50282 denotes MMP-9
T185 1023-1028 PR:000010491 denotes MMP-9
T186 1023-1028 P52176 denotes MMP-9
T187 1023-1028 O18733 denotes MMP-9
T184 1023-1028 GO:0004229 denotes MMP-9
T188 1063-1077 GO:0070160 denotes tight junction
T190 1069-1077 SO:0000699 denotes junction
T189 1069-1077 UBERON:0007651 denotes junction
T191 1109-1112 Q9KRA3 denotes TER
T192 1109-1112 Q9CY27 denotes TER
T193 1109-1112 Q55C17 denotes TER
T194 1109-1112 Q0SRA3 denotes TER
T195 1109-1112 PR:000008207 denotes TER
T196 1109-1112 A6LV73 denotes TER
T197 1109-1112 PR:000006598 denotes TER
T198 1109-1112 Q64232 denotes TER
T199 1109-1112 B8I4V6 denotes TER
T200 1109-1112 Q97LU2 denotes TER
T201 1109-1112 Q3ZCD7 denotes TER
T202 1109-1112 Q9NZ01 denotes TER
T203 1109-1112 PR:P11455 denotes TER
T204 1109-1112 Q62L02 denotes TER
T205 1109-1112 PR:Q6VY05 denotes TER
T206 1109-1112 Q0TNN6 denotes TER
T208 1109-1112 Q8XIP1 denotes TER
T209 1109-1112 Q9HZP8 denotes TER
T210 1109-1112 Q2P9J6 denotes TER
T211 1109-1112 Q73Q47 denotes TER
T212 1109-1112 C0QVH0 denotes TER
T207 1109-1112 GO:0097047 denotes TER
T213 1139-1152 D002457 denotes cell extracts
T214 1166-1169 CHEBI:340824 denotes MMP
T217 1166-1169 CHEBI:59761 denotes MMP
T218 1166-1171 PR:P08253 denotes MMP-2
T219 1166-1171 Q9GLE5 denotes MMP-2
T220 1166-1171 P08253 denotes MMP-2
T221 1166-1171 Q90611 denotes MMP-2
T223 1166-1171 PR:Q8MPP3 denotes MMP-2
T224 1166-1171 P33436 denotes MMP-2
T225 1166-1171 PR:Q90611 denotes MMP-2
T226 1166-1171 PR:P33436 denotes MMP-2
T227 1166-1171 PR:000010479 denotes MMP-2
T228 1166-1171 PR:P33434 denotes MMP-2
T229 1166-1171 P33434 denotes MMP-2
T230 1166-1171 P50757 denotes MMP-2
T222 1166-1171 GO:0004228 denotes MMP-2
T231 1175-1178 CHEBI:340824 denotes MMP
T234 1175-1178 CHEBI:59761 denotes MMP
T235 1175-1180 PR:P50282 denotes MMP-9
T236 1175-1180 PR:P14780 denotes MMP-9
T237 1175-1180 P14780 denotes MMP-9
T238 1175-1180 PR:P41245 denotes MMP-9
T239 1175-1180 P41246 denotes MMP-9
T240 1175-1180 P41245 denotes MMP-9
T241 1175-1180 PR:P52176 denotes MMP-9
T242 1175-1180 P50282 denotes MMP-9
T244 1175-1180 PR:000010491 denotes MMP-9
T245 1175-1180 P52176 denotes MMP-9
T246 1175-1180 O18733 denotes MMP-9
T243 1175-1180 GO:0004229 denotes MMP-9
T247 1200-1211 GO:0009056 denotes degradation
T248 1219-1233 GO:0070160 denotes tight junction
T250 1225-1233 SO:0000699 denotes junction
T249 1225-1233 UBERON:0007651 denotes junction
T255 1234-1241 SO:0000104 denotes protein
T254 1234-1241 PR:000000001 denotes protein
T252 1234-1241 CHEBI:36080 denotes protein
T253 1234-1241 CHEBI:11122 denotes protein
T251 1234-1241 GO:0003675 denotes protein
T257 1243-1251 Q91049 denotes occludin
T258 1243-1251 Q6P6T5 denotes occludin
T259 1243-1251 Q9PUN1 denotes occludin
T260 1243-1251 Q16625 denotes occludin
T261 1243-1251 PR:000002207 denotes occludin
T262 1243-1251 Q61146 denotes occludin
T263 1243-1251 Q28269 denotes occludin
T264 1243-1251 Q28793 denotes occludin
T265 1243-1251 Q5RFS5 denotes occludin
T256 1243-1251 D062793 denotes occludin
T266 1297-1301 D020782 denotes MMPs
T267 1309-1315 UBERON:0000966 denotes retina
T268 1405-1416 GO:0009056 denotes degradation
T269 1424-1438 GO:0070160 denotes tight junction
T271 1430-1438 SO:0000699 denotes junction
T270 1430-1438 UBERON:0007651 denotes junction
T276 1439-1446 SO:0000104 denotes protein
T275 1439-1446 PR:000000001 denotes protein
T273 1439-1446 CHEBI:36080 denotes protein
T274 1439-1446 CHEBI:11122 denotes protein
T272 1439-1446 GO:0003675 denotes protein
T278 1447-1455 Q91049 denotes occludin
T279 1447-1455 Q6P6T5 denotes occludin
T280 1447-1455 Q9PUN1 denotes occludin
T281 1447-1455 Q16625 denotes occludin
T282 1447-1455 PR:000002207 denotes occludin
T283 1447-1455 Q61146 denotes occludin
T284 1447-1455 Q28269 denotes occludin
T285 1447-1455 Q28793 denotes occludin
T286 1447-1455 Q5RFS5 denotes occludin
T277 1447-1455 D062793 denotes occludin
T287 1494-1508 GO:0070160 denotes tight junction
T289 1500-1508 SO:0000699 denotes junction
T288 1500-1508 UBERON:0007651 denotes junction

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-114 DRI_Background denotes Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier.
T2 115-287 DRI_Background denotes One of the early features of diabetic retinopathy is the alteration of the blood-retinal barrier (BRB), which may involve the breakdown of endothelial cell tight junctions.
T3 288-475 DRI_Background denotes The aim of this study was to examine the expression of extracellular proteinases in an animal model of early diabetic retinopathy and to determine their role in the alteration of the BRB.
T4 476-579 DRI_Background denotes Matrix metalloproteinase (MMP) expression was studied in the retinas of rats with 12 weeks of diabetes.
T5 580-761 DRI_Background denotes The role of MMPs in regulating tight junction function was investigated in retinal endothelial and pigment epithelial cells by measuring transepithelial electrical resistance (TER).
T6 762-864 DRI_Background denotes The retinas of diabetic animals demonstrated elevated levels of MMP-2, MMP-9 and MMP-14 messenger RNA.
T7 865-975 DRI_Background denotes A significant increase in the production of MMP-9 was seen when cells were exposed to high glucose conditions.
T8 976-1113 DRI_Background denotes Both cell types treated with purified MMP-2 or MMP-9 were found to have alterations of tight junction function as shown by decreased TER.
T9 1114-1252 DRI_Background denotes Western blot analysis of cell extracts treated with MMP-2 or MMP-9, revealed specific degradation of the tight junction protein, occludin.
T10 1253-1517 DRI_Challenge denotes Results suggest that elevated expression of MMPs in the retina may facilitate an increase in vascular permeability by a mechanism involving proteolytic degradation of the tight junction protein occludin followed by disruption of the overall tight junction complex.