PubMed:15699574 JSONTXT

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"15699574-2#101#105#gene2705","span":{"begin":337,"end":341},"obj":"gene2705"},{"id":"15699574-2#133#153#diseaseC0007134","span":{"begin":369,"end":389},"obj":"diseaseC0007134"}],"relations":[{"id":"101#105#gene2705133#153#diseaseC0007134","pred":"associated_with","subj":"15699574-2#101#105#gene2705","obj":"15699574-2#133#153#diseaseC0007134"}],"text":"Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene.\nWe have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of Cx32 in Caki-2 cells was required for PKI-166-induced cytotoxic effect at lower doses. The cyctotoxicity was dependent on the occurrence of apoptosis and partly mediated by Cx32-driven gap junction intercellular communications. These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":216,"end":221},"obj":"gene:2064"},{"id":"T1","span":{"begin":183,"end":195},"obj":"disease:C1378703"},{"id":"T2","span":{"begin":216,"end":221},"obj":"gene:2064"},{"id":"T3","span":{"begin":183,"end":195},"obj":"disease:C0740457"},{"id":"T4","span":{"begin":141,"end":147},"obj":"gene:2705"},{"id":"T5","span":{"begin":183,"end":195},"obj":"disease:C0740457"},{"id":"T6","span":{"begin":141,"end":147},"obj":"gene:2705"},{"id":"T7","span":{"begin":183,"end":195},"obj":"disease:C1378703"},{"id":"T8","span":{"begin":337,"end":341},"obj":"gene:2705"},{"id":"T9","span":{"begin":369,"end":389},"obj":"disease:C0007134"},{"id":"T10","span":{"begin":267,"end":272},"obj":"gene:1956"},{"id":"T11","span":{"begin":369,"end":389},"obj":"disease:C0007134"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene.\nWe have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of Cx32 in Caki-2 cells was required for PKI-166-induced cytotoxic effect at lower doses. The cyctotoxicity was dependent on the occurrence of apoptosis and partly mediated by Cx32-driven gap junction intercellular communications. These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis."}