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PubMed:15698950 JSONTXT

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GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
3 81-86 Species denotes human 9606
32 602-607 Species denotes human 9606

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 111-117 Protein denotes restin
T2 122-132 Protein denotes endostatin
T3 134-140 Protein denotes Restin
T4 145-155 Protein denotes endostatin
T5 214-225 Protein denotes collagen XV
T6 230-244 Protein denotes collagen XVIII
T7 877-883 Protein denotes restin
T8 912-922 Protein denotes endostatin
T9 928-938 Protein denotes endostatin
T10 1079-1093 Protein denotes beta1 integrin
T11 1532-1538 Protein denotes restin
T12 1864-1871 Protein denotes restins

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1349-1355 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 1456-1462 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 1509-1515 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 483-489 Phenotype denotes cancer HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1349-1355 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 1456-1462 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 1509-1515 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 391-397 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T2 483-489 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 483-489 Phenotype denotes cancer HP:0002664

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1145-1161 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1145-1161 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 1768-1779 Body_part denotes fingerprint http://purl.obolibrary.org/obo/UBERON_0013487

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 483-489 Disease denotes cancer MONDO:0004992

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Identification and characterization of novel endogenous proteolytic forms of the human angiogenesis inhibitors restin and endostatin.
T2 134-279 Sentence denotes Restin and endostatin are C-terminal fragments of the noncollagenous domains of collagen XV and collagen XVIII exhibiting high sequence homology.
T3 280-413 Sentence denotes Both polypeptides are distinguished by strong anti-angiogenic activity in vivo restricting the growth of solid tumors and metastasis.
T4 414-496 Sentence denotes They are therefore currently being tested in clinical trials as anti-cancer drugs.
T5 497-637 Sentence denotes We present the identification of new endogenous variants of both angiogenesis inhibitors isolated from a human hemofiltrate peptide library.
T6 638-827 Sentence denotes Using an immunological screening approach with time-resolved rare earth metal fluorometry, immunoreactive compounds were purified chromatographically and characterized by mass spectrometry.
T7 828-923 Sentence denotes We discovered four novel proteolytic products of restin as well as four variants of endostatin.
T8 924-1189 Sentence denotes Two endostatin products were characterized as short internal fragments (R176-L215 and R176-S219) of the entire molecule containing the recently identified beta1 integrin receptor binding site, which plays a major role in endothelial cell migration and angiogenesis.
T9 1190-1247 Sentence denotes Two additional forms contain mucin-type O-glycosylations.
T10 1248-1522 Sentence denotes The O-glycosylated variants possess an oligosaccharide unit consisting of one N-acetylgalactosamine (GalNAc), one N-acetylneuraminic acid (NANA) and two galactose residues (Gal) occurring as sialo-(V117-S311-GalNAc-Gal2-NANA) and asialoglycopeptides (V117-S311-GalNAc-Gal2).
T11 1523-1729 Sentence denotes The four restin variants (R(I)-R(IV)) were identified with identical C- but different N-termini and no posttranslational modification (R(I): P66-A254, R(II): P75-A254, R(III): Y81-A254 and R(IV): A89-A254).
T12 1730-1915 Sentence denotes Following a differential peptide mass fingerprint approach by reflector mode MALDI-TOFMS, the disulfide patterns of these circulating restins were determined as Cys1-Cys4 and Cys2-Cys3.
T13 1916-2045 Sentence denotes These endogenous circulating collagen fragments will help to understand the physiological processing of the therapeutic proteins.

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 81-86 OrganismTaxon denotes human 9606
T2 602-607 OrganismTaxon denotes human 9606

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 1145-1161 Body_part denotes endothelial cell FMA:66772

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 81-86 OrganismTaxon denotes human 9606
T2 602-607 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1145-1161 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 1768-1779 Body_part denotes fingerprint http://purl.obolibrary.org/obo/UBERON_0013487

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1145-1161 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115