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sentences

Id Subject Object Predicate Lexical cue
T1 0-171 Sentence denotes Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.
T2 172-327 Sentence denotes We report here the role of one of the less studied members of the family of suppressors of cytokine signaling (SOCS), namely SOCS-7, in cytokine signaling.
T3 328-488 Sentence denotes We demonstrate that SOCS-7 inhibits prolactin (PRL), growth hormone (GH), or leptin (LEP) signaling mediated through STAT3 and STAT5 in a dose-dependent manner.
T4 489-604 Sentence denotes SOCS-7 also attenuated STAT3 and STAT5 signaling induced by overexpression of JH1, the catalytic subdomain of JAK2.
T5 605-723 Sentence denotes Since SOCS-7 interacted with phosphorylated STAT3 or STAT5, we assumed that SOCS-7 acts at the level of STAT proteins.
T6 724-878 Sentence denotes Indeed, we showed that SOCS-7 inhibits PRL- and leptin-induced STAT5 and STAT3 phosphorylation and prevented the nuclear translocation of activated STAT3.
T7 879-1139 Sentence denotes Taken together, our results indicate that SOCS-7 is a physiological dysregulator of PRL, leptin, and probably also GH signaling and that its mode of action is a novel variation of SOCS protein inhibition of cytokine-inducible STAT-mediated signal transduction.

relna

Id Subject Object Predicate Lexical cue
T1 0-34 Protein denotes Suppressor of cytokine signaling 7
T2 44-53 Protein denotes prolactin
T3 55-69 Protein denotes growth hormone
T4 75-81 Protein denotes leptin
T5 112-117 DNA denotes STAT5
T6 121-126 DNA denotes STAT3
T7 297-303 Protein denotes SOCS-7
T8 348-354 Protein denotes SOCS-7
T9 364-373 Protein denotes prolactin
T10 375-378 Protein denotes PRL
T11 381-395 Protein denotes growth hormone
T12 405-411 Protein denotes leptin
T13 413-416 Protein denotes LEP
T14 445-450 DNA denotes STAT3
T15 455-460 DNA denotes STAT5
T16 489-495 Protein denotes SOCS-7
T17 512-517 DNA denotes STAT3
T18 522-527 DNA denotes STAT5
T19 567-570 Protein denotes JH1
T20 599-603 Protein denotes JAK2
T21 611-617 Protein denotes SOCS-7
T22 649-654 DNA denotes STAT3
T23 658-663 DNA denotes STAT5
T24 681-687 Protein denotes SOCS-7
T25 747-753 Protein denotes SOCS-7
T26 763-766 Protein denotes PRL
T27 772-778 Protein denotes leptin
T28 787-792 DNA denotes STAT5
T29 797-802 DNA denotes STAT3
T30 872-877 DNA denotes STAT3
T31 921-927 Protein denotes SOCS-7
T32 963-966 Protein denotes PRL
T33 968-974 Protein denotes leptin
R0 T1 T5 linked Suppressor of cytokine signaling 7,STAT5
R1 T1 T6 linked Suppressor of cytokine signaling 7,STAT3
R2 T8 T14 linked SOCS-7,STAT3
R3 T8 T15 linked SOCS-7,STAT5
R4 T16 T17 linked SOCS-7,STAT3
R5 T16 T18 linked SOCS-7,STAT5
R6 T21 T22 linked SOCS-7,STAT3
R7 T21 T23 linked SOCS-7,STAT5