PubMed:15673851
Annnotations
LitCoin-entities-OrganismTaxon-PD
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 416-420 | OrganismTaxon | denotes | rats | NCBItxid:10118|NCBItxid:10116|NCBItxid:10114 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-195 | Sentence | denotes | The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia. |
T2 | 196-421 | Sentence | denotes | We investigated the relationship between the degeneration of spinal motor neurons and activation of N-methyl-d-aspartate (NMDA) receptors after neuraxial morphine following a noninjurious interval of aortic occlusion in rats. |
T3 | 422-509 | Sentence | denotes | Spinal cord ischemia was induced by aortic occlusion for 6 min with a balloon catheter. |
T4 | 510-783 | Sentence | denotes | In a microdialysis study, 10 muL of saline (group C; n = 8) or 30 mug of morphine (group M; n = 8) was injected intrathecally (IT) 0.5 h after reflow, and 30 mug of morphine (group SM; n = 8) or 10 muL of saline (group SC; n = 8) was injected IT 0.5 h after sham operation. |
T5 | 784-920 | Sentence | denotes | Microdialysis samples were collected preischemia, before IT injection, and at 2, 4, 8, 24, and 48 h of reperfusion (after IT injection). |
T6 | 921-1071 | Sentence | denotes | Second, we investigated the effect of IT MK-801 (30 mug) on the histopathologic changes in the spinal cord after morphine-induced spastic paraparesis. |
T7 | 1072-1219 | Sentence | denotes | After IT morphine, the cerebrospinal fluid (CSF) glutamate concentration was increased in group M relative to both baseline and group C (P < 0.05). |
T8 | 1220-1254 | Sentence | denotes | This increase persisted for 8 hrs. |
T9 | 1255-1406 | Sentence | denotes | IT MK-801 significantly reduced the number of dark-stained alpha-motoneurons after morphine-induced spastic paraparesis compared with the saline group. |
T10 | 1407-1564 | Sentence | denotes | These data indicate that IT morphine induces spastic paraparesis with a concomitant increase in CSF glutamate, which is involved in NMDA receptor activation. |
T11 | 1565-1675 | Sentence | denotes | We suggest that opioids may be neurotoxic in the setting of spinal cord ischemia via NMDA receptor activation. |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
1433 | 25-55 | GeneOrGeneProduct | denotes | N-methyl-D-aspartate receptors | NCBIGene:24408 |
1434 | 132-140 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1435 | 174-194 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | MESH:D020760 |
1436 | 296-333 | GeneOrGeneProduct | denotes | N-methyl-d-aspartate (NMDA) receptors | NCBIGene:24408 |
1437 | 350-358 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1438 | 396-412 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | MESH:D001157 |
1439 | 416-420 | OrganismTaxon | denotes | rats | NCBITaxon:10116 |
1440 | 422-442 | DiseaseOrPhenotypicFeature | denotes | Spinal cord ischemia | MESH:D020760 |
1441 | 458-474 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | MESH:D001157 |
1442 | 583-591 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1443 | 675-683 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1444 | 962-968 | ChemicalEntity | denotes | MK-801 | MESH:D016291 |
1445 | 1034-1042 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1446 | 1051-1070 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | MESH:D020336 |
1447 | 1081-1089 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1448 | 1121-1130 | ChemicalEntity | denotes | glutamate | MESH:D018698 |
1449 | 1258-1264 | ChemicalEntity | denotes | MK-801 | MESH:D016291 |
1450 | 1338-1346 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1451 | 1355-1374 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | MESH:D020336 |
1452 | 1435-1443 | ChemicalEntity | denotes | morphine | MESH:D009020 |
1453 | 1452-1471 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | MESH:D020336 |
1454 | 1507-1516 | ChemicalEntity | denotes | glutamate | MESH:D018698 |
1455 | 1539-1552 | GeneOrGeneProduct | denotes | NMDA receptor | NCBIGene:24408 |
1456 | 1581-1588 | ChemicalEntity | denotes | opioids | MESH:D000701 |
1457 | 1596-1606 | DiseaseOrPhenotypicFeature | denotes | neurotoxic | MESH:D020258 |
1458 | 1625-1645 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | MESH:D020760 |
1459 | 1650-1663 | GeneOrGeneProduct | denotes | NMDA receptor | NCBIGene:24408 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 103-110 | DiseaseOrPhenotypicFeature | denotes | neurons | 0004466 |
T2 | 174-194 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | 0020688 |
T3 | 270-277 | DiseaseOrPhenotypicFeature | denotes | neurons | 0004466 |
T4 | 422-442 | DiseaseOrPhenotypicFeature | denotes | Spinal cord ischemia | 0020688 |
T5 | 1625-1645 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | 0020688 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21 | 729-738 | GeneOrGeneProduct | denotes | SC; n = 8 |
T22 | 768-772 | GeneOrGeneProduct | denotes | sham |
T23 | 859-863 | GeneOrGeneProduct | denotes | at 2 |
T24 | 1023-1027 | GeneOrGeneProduct | denotes | cord |
T25 | 1043-1050 | GeneOrGeneProduct | denotes | induced |
T26 | 1051-1058 | GeneOrGeneProduct | denotes | spastic |
T27 | 1121-1130 | GeneOrGeneProduct | denotes | glutamate |
T28 | 1200-1207 | GeneOrGeneProduct | denotes | group C |
T29 | 1234-1243 | GeneOrGeneProduct | denotes | persisted |
T30 | 1279-1286 | GeneOrGeneProduct | denotes | reduced |
T31 | 1301-1305 | GeneOrGeneProduct | denotes | dark |
T32 | 1314-1319 | GeneOrGeneProduct | denotes | alpha |
T33 | 1347-1354 | GeneOrGeneProduct | denotes | induced |
T34 | 1355-1362 | GeneOrGeneProduct | denotes | spastic |
T35 | 1444-1451 | GeneOrGeneProduct | denotes | induces |
T36 | 1452-1459 | GeneOrGeneProduct | denotes | spastic |
T37 | 1507-1516 | GeneOrGeneProduct | denotes | glutamate |
T38 | 1539-1552 | GeneOrGeneProduct | denotes | NMDA receptor |
T39 | 1553-1563 | GeneOrGeneProduct | denotes | activation |
T40 | 1632-1636 | GeneOrGeneProduct | denotes | cord |
T41 | 1650-1663 | GeneOrGeneProduct | denotes | NMDA receptor |
T42 | 1664-1674 | GeneOrGeneProduct | denotes | activation |
T7 | 264-269 | GeneOrGeneProduct | denotes | motor |
T8 | 282-292 | GeneOrGeneProduct | denotes | activation |
T9 | 307-316 | GeneOrGeneProduct | denotes | aspartate |
T10 | 318-322 | GeneOrGeneProduct | denotes | NMDA |
T11 | 324-333 | GeneOrGeneProduct | denotes | receptors |
T12 | 429-433 | GeneOrGeneProduct | denotes | cord |
T13 | 447-454 | GeneOrGeneProduct | denotes | induced |
T14 | 481-491 | GeneOrGeneProduct | denotes | min with a |
T15 | 492-499 | GeneOrGeneProduct | denotes | balloon |
T16 | 554-561 | GeneOrGeneProduct | denotes | group C |
T17 | 570-575 | GeneOrGeneProduct | denotes | or 30 |
T18 | 599-603 | GeneOrGeneProduct | denotes | M; n |
T19 | 691-696 | GeneOrGeneProduct | denotes | SM; n |
T20 | 702-707 | GeneOrGeneProduct | denotes | or 10 |
T1 | 4-14 | GeneOrGeneProduct | denotes | activation |
T2 | 36-45 | GeneOrGeneProduct | denotes | aspartate |
T3 | 46-55 | GeneOrGeneProduct | denotes | receptors |
T4 | 97-102 | GeneOrGeneProduct | denotes | motor |
T5 | 111-118 | GeneOrGeneProduct | denotes | induced |
T6 | 181-185 | GeneOrGeneProduct | denotes | cord |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 36-45 | GeneOrGeneProduct | denotes | aspartate |
T2 | 97-102 | GeneOrGeneProduct | denotes | motor |
T3 | 264-269 | GeneOrGeneProduct | denotes | motor |
T4 | 307-316 | GeneOrGeneProduct | denotes | aspartate |
T5 | 318-322 | GeneOrGeneProduct | denotes | NMDA |
T6 | 492-499 | GeneOrGeneProduct | denotes | balloon |
T7 | 554-561 | GeneOrGeneProduct | denotes | group C |
T8 | 1051-1058 | GeneOrGeneProduct | denotes | spastic |
T9 | 1121-1130 | GeneOrGeneProduct | denotes | glutamate |
T10 | 1200-1207 | GeneOrGeneProduct | denotes | group C |
T11 | 1279-1286 | GeneOrGeneProduct | denotes | reduced |
T12 | 1301-1305 | GeneOrGeneProduct | denotes | dark |
T13 | 1314-1319 | GeneOrGeneProduct | denotes | alpha |
T14 | 1355-1362 | GeneOrGeneProduct | denotes | spastic |
T15 | 1452-1459 | GeneOrGeneProduct | denotes | spastic |
T16 | 1507-1516 | GeneOrGeneProduct | denotes | glutamate |
T17 | 1539-1552 | GeneOrGeneProduct | denotes | NMDA receptor |
T18 | 1650-1663 | GeneOrGeneProduct | denotes | NMDA receptor |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 174-194 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 |
T2 | 422-442 | DiseaseOrPhenotypicFeature | denotes | Spinal cord ischemia | D020760 |
T3 | 1051-1070 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T4 | 1355-1374 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T5 | 1452-1471 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T6 | 1596-1606 | DiseaseOrPhenotypicFeature | denotes | neurotoxic | DISEASE |
T7 | 1625-1645 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 25-55 | GeneOrGeneProduct | denotes | N-methyl-D-aspartate receptors |
T2 | 492-499 | GeneOrGeneProduct | denotes | balloon |
T3 | 1121-1130 | GeneOrGeneProduct | denotes | glutamate |
T4 | 1301-1305 | GeneOrGeneProduct | denotes | dark |
T5 | 1314-1319 | GeneOrGeneProduct | denotes | alpha |
T6 | 1507-1516 | GeneOrGeneProduct | denotes | glutamate |
T7 | 1539-1552 | GeneOrGeneProduct | denotes | NMDA receptor |
T8 | 1650-1663 | GeneOrGeneProduct | denotes | NMDA receptor |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 174-194 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | 0020688 |
T2 | 422-442 | DiseaseOrPhenotypicFeature | denotes | Spinal cord ischemia | 0020688 |
T3 | 691-693 | DiseaseOrPhenotypicFeature | denotes | SM | 0016586 |
T4 | 1625-1645 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | 0020688 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 174-194 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 |
T2 | 396-412 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | DISEASE |
T3 | 422-442 | DiseaseOrPhenotypicFeature | denotes | Spinal cord ischemia | D020760 |
T4 | 458-474 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | DISEASE |
T5 | 1051-1070 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T6 | 1355-1374 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T7 | 1452-1471 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T8 | 1596-1606 | DiseaseOrPhenotypicFeature | denotes | neurotoxic | DISEASE |
T9 | 1625-1645 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 174-194 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 |
T2 | 396-412 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | DISEASE |
T3 | 422-442 | DiseaseOrPhenotypicFeature | denotes | Spinal cord ischemia | D020760 |
T4 | 458-474 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | DISEASE |
T5 | 1051-1070 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T6 | 1355-1374 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T7 | 1452-1471 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 |
T8 | 1596-1606 | DiseaseOrPhenotypicFeature | denotes | neurotoxic | DISEASE |
T9 | 1625-1645 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 25-45 | ChemicalEntity | denotes | N-methyl-D-aspartate | http://purl.obolibrary.org/obo/CHEBI_31882 |
T2 | 132-140 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T5 | 296-316 | ChemicalEntity | denotes | N-methyl-d-aspartate | http://purl.obolibrary.org/obo/CHEBI_31882 |
T6 | 318-322 | ChemicalEntity | denotes | NMDA | http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882 |
T8 | 350-358 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T11 | 583-591 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T14 | 675-683 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T17 | 962-968 | ChemicalEntity | denotes | MK-801 | D016291 |
T18 | 1034-1042 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T21 | 1081-1089 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T24 | 1121-1130 | ChemicalEntity | denotes | glutamate | http://purl.obolibrary.org/obo/CHEBI_29987|http://purl.obolibrary.org/obo/CHEBI_14321 |
T26 | 1258-1264 | ChemicalEntity | denotes | MK-801 | D016291 |
T27 | 1338-1346 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T30 | 1435-1443 | ChemicalEntity | denotes | morphine | D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303 |
T33 | 1507-1516 | ChemicalEntity | denotes | glutamate | http://purl.obolibrary.org/obo/CHEBI_29987|http://purl.obolibrary.org/obo/CHEBI_14321 |
T35 | 1539-1543 | ChemicalEntity | denotes | NMDA | http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882 |
T37 | 1581-1588 | ChemicalEntity | denotes | opioids | ChemicalEntity |
T38 | 1650-1654 | ChemicalEntity | denotes | NMDA | http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 416-420 | OrganismTaxon | denotes | rats |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T38 | 1650-1654 | ChemicalEntity | denotes | NMDA | http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121 | |
T37 | 1581-1588 | ChemicalEntity | denotes | opioids | ChemicalEntity | |
T35 | 1539-1543 | ChemicalEntity | denotes | NMDA | http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121 | |
T33 | 1507-1516 | ChemicalEntity | denotes | glutamate | http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987 | |
T30 | 1435-1443 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_58097|D009020|http://purl.obolibrary.org/obo/CHEBI_17303 | |
T27 | 1338-1346 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020 | |
T26 | 1258-1264 | ChemicalEntity | denotes | MK-801 | D016291 | |
T24 | 1121-1130 | ChemicalEntity | denotes | glutamate | http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987 | |
T21 | 1081-1089 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020 | |
T18 | 1034-1042 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020 | |
T17 | 962-968 | ChemicalEntity | denotes | MK-801 | D016291 | |
T14 | 675-683 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020 | |
T11 | 583-591 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020 | |
T8 | 350-358 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020 | |
T6 | 318-322 | ChemicalEntity | denotes | NMDA | http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121 | |
T5 | 296-316 | ChemicalEntity | denotes | N-methyl-d-aspartate | http://purl.obolibrary.org/obo/CHEBI_31882 | |
T2 | 132-140 | ChemicalEntity | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020 | |
T1 | 25-45 | ChemicalEntity | denotes | N-methyl-D-aspartate | http://purl.obolibrary.org/obo/CHEBI_31882 | |
T27780 | 1650-1663 | GeneOrGeneProduct | denotes | NMDA receptor | ||
T7 | 1539-1552 | GeneOrGeneProduct | denotes | NMDA receptor | ||
T52906 | 1507-1516 | GeneOrGeneProduct | denotes | glutamate | ||
T92505 | 1314-1319 | GeneOrGeneProduct | denotes | alpha | ||
T4 | 1301-1305 | GeneOrGeneProduct | denotes | dark | ||
T3 | 1121-1130 | GeneOrGeneProduct | denotes | glutamate | ||
T48382 | 492-499 | GeneOrGeneProduct | denotes | balloon | ||
T39889 | 25-55 | GeneOrGeneProduct | denotes | N-methyl-D-aspartate receptors | ||
T9 | 1625-1645 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 | |
T51692 | 1596-1606 | DiseaseOrPhenotypicFeature | denotes | neurotoxic | DISEASE | |
T1983 | 1452-1471 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 | |
T64560 | 1355-1374 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 | |
T26812 | 1051-1070 | DiseaseOrPhenotypicFeature | denotes | spastic paraparesis | D020336 | |
T26689 | 458-474 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | DISEASE | |
T53613 | 422-442 | DiseaseOrPhenotypicFeature | denotes | Spinal cord ischemia | D020760 | |
T64677 | 396-412 | DiseaseOrPhenotypicFeature | denotes | aortic occlusion | DISEASE | |
T30934 | 174-194 | DiseaseOrPhenotypicFeature | denotes | spinal cord ischemia | D020760 | |
T4521 | 416-420 | OrganismTaxon | denotes | rats |