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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 416-420 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-195 Sentence denotes The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia.
T2 196-421 Sentence denotes We investigated the relationship between the degeneration of spinal motor neurons and activation of N-methyl-d-aspartate (NMDA) receptors after neuraxial morphine following a noninjurious interval of aortic occlusion in rats.
T3 422-509 Sentence denotes Spinal cord ischemia was induced by aortic occlusion for 6 min with a balloon catheter.
T4 510-783 Sentence denotes In a microdialysis study, 10 muL of saline (group C; n = 8) or 30 mug of morphine (group M; n = 8) was injected intrathecally (IT) 0.5 h after reflow, and 30 mug of morphine (group SM; n = 8) or 10 muL of saline (group SC; n = 8) was injected IT 0.5 h after sham operation.
T5 784-920 Sentence denotes Microdialysis samples were collected preischemia, before IT injection, and at 2, 4, 8, 24, and 48 h of reperfusion (after IT injection).
T6 921-1071 Sentence denotes Second, we investigated the effect of IT MK-801 (30 mug) on the histopathologic changes in the spinal cord after morphine-induced spastic paraparesis.
T7 1072-1219 Sentence denotes After IT morphine, the cerebrospinal fluid (CSF) glutamate concentration was increased in group M relative to both baseline and group C (P < 0.05).
T8 1220-1254 Sentence denotes This increase persisted for 8 hrs.
T9 1255-1406 Sentence denotes IT MK-801 significantly reduced the number of dark-stained alpha-motoneurons after morphine-induced spastic paraparesis compared with the saline group.
T10 1407-1564 Sentence denotes These data indicate that IT morphine induces spastic paraparesis with a concomitant increase in CSF glutamate, which is involved in NMDA receptor activation.
T11 1565-1675 Sentence denotes We suggest that opioids may be neurotoxic in the setting of spinal cord ischemia via NMDA receptor activation.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1433 25-55 GeneOrGeneProduct denotes N-methyl-D-aspartate receptors NCBIGene:24408
1434 132-140 ChemicalEntity denotes morphine MESH:D009020
1435 174-194 DiseaseOrPhenotypicFeature denotes spinal cord ischemia MESH:D020760
1436 296-333 GeneOrGeneProduct denotes N-methyl-d-aspartate (NMDA) receptors NCBIGene:24408
1437 350-358 ChemicalEntity denotes morphine MESH:D009020
1438 396-412 DiseaseOrPhenotypicFeature denotes aortic occlusion MESH:D001157
1439 416-420 OrganismTaxon denotes rats NCBITaxon:10116
1440 422-442 DiseaseOrPhenotypicFeature denotes Spinal cord ischemia MESH:D020760
1441 458-474 DiseaseOrPhenotypicFeature denotes aortic occlusion MESH:D001157
1442 583-591 ChemicalEntity denotes morphine MESH:D009020
1443 675-683 ChemicalEntity denotes morphine MESH:D009020
1444 962-968 ChemicalEntity denotes MK-801 MESH:D016291
1445 1034-1042 ChemicalEntity denotes morphine MESH:D009020
1446 1051-1070 DiseaseOrPhenotypicFeature denotes spastic paraparesis MESH:D020336
1447 1081-1089 ChemicalEntity denotes morphine MESH:D009020
1448 1121-1130 ChemicalEntity denotes glutamate MESH:D018698
1449 1258-1264 ChemicalEntity denotes MK-801 MESH:D016291
1450 1338-1346 ChemicalEntity denotes morphine MESH:D009020
1451 1355-1374 DiseaseOrPhenotypicFeature denotes spastic paraparesis MESH:D020336
1452 1435-1443 ChemicalEntity denotes morphine MESH:D009020
1453 1452-1471 DiseaseOrPhenotypicFeature denotes spastic paraparesis MESH:D020336
1454 1507-1516 ChemicalEntity denotes glutamate MESH:D018698
1455 1539-1552 GeneOrGeneProduct denotes NMDA receptor NCBIGene:24408
1456 1581-1588 ChemicalEntity denotes opioids MESH:D000701
1457 1596-1606 DiseaseOrPhenotypicFeature denotes neurotoxic MESH:D020258
1458 1625-1645 DiseaseOrPhenotypicFeature denotes spinal cord ischemia MESH:D020760
1459 1650-1663 GeneOrGeneProduct denotes NMDA receptor NCBIGene:24408

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 103-110 DiseaseOrPhenotypicFeature denotes neurons 0004466
T2 174-194 DiseaseOrPhenotypicFeature denotes spinal cord ischemia 0020688
T3 270-277 DiseaseOrPhenotypicFeature denotes neurons 0004466
T4 422-442 DiseaseOrPhenotypicFeature denotes Spinal cord ischemia 0020688
T5 1625-1645 DiseaseOrPhenotypicFeature denotes spinal cord ischemia 0020688

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T21 729-738 GeneOrGeneProduct denotes SC; n = 8
T22 768-772 GeneOrGeneProduct denotes sham
T23 859-863 GeneOrGeneProduct denotes at 2
T24 1023-1027 GeneOrGeneProduct denotes cord
T25 1043-1050 GeneOrGeneProduct denotes induced
T26 1051-1058 GeneOrGeneProduct denotes spastic
T27 1121-1130 GeneOrGeneProduct denotes glutamate
T28 1200-1207 GeneOrGeneProduct denotes group C
T29 1234-1243 GeneOrGeneProduct denotes persisted
T30 1279-1286 GeneOrGeneProduct denotes reduced
T31 1301-1305 GeneOrGeneProduct denotes dark
T32 1314-1319 GeneOrGeneProduct denotes alpha
T33 1347-1354 GeneOrGeneProduct denotes induced
T34 1355-1362 GeneOrGeneProduct denotes spastic
T35 1444-1451 GeneOrGeneProduct denotes induces
T36 1452-1459 GeneOrGeneProduct denotes spastic
T37 1507-1516 GeneOrGeneProduct denotes glutamate
T38 1539-1552 GeneOrGeneProduct denotes NMDA receptor
T39 1553-1563 GeneOrGeneProduct denotes activation
T40 1632-1636 GeneOrGeneProduct denotes cord
T41 1650-1663 GeneOrGeneProduct denotes NMDA receptor
T42 1664-1674 GeneOrGeneProduct denotes activation
T7 264-269 GeneOrGeneProduct denotes motor
T8 282-292 GeneOrGeneProduct denotes activation
T9 307-316 GeneOrGeneProduct denotes aspartate
T10 318-322 GeneOrGeneProduct denotes NMDA
T11 324-333 GeneOrGeneProduct denotes receptors
T12 429-433 GeneOrGeneProduct denotes cord
T13 447-454 GeneOrGeneProduct denotes induced
T14 481-491 GeneOrGeneProduct denotes min with a
T15 492-499 GeneOrGeneProduct denotes balloon
T16 554-561 GeneOrGeneProduct denotes group C
T17 570-575 GeneOrGeneProduct denotes or 30
T18 599-603 GeneOrGeneProduct denotes M; n
T19 691-696 GeneOrGeneProduct denotes SM; n
T20 702-707 GeneOrGeneProduct denotes or 10
T1 4-14 GeneOrGeneProduct denotes activation
T2 36-45 GeneOrGeneProduct denotes aspartate
T3 46-55 GeneOrGeneProduct denotes receptors
T4 97-102 GeneOrGeneProduct denotes motor
T5 111-118 GeneOrGeneProduct denotes induced
T6 181-185 GeneOrGeneProduct denotes cord

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 36-45 GeneOrGeneProduct denotes aspartate
T2 97-102 GeneOrGeneProduct denotes motor
T3 264-269 GeneOrGeneProduct denotes motor
T4 307-316 GeneOrGeneProduct denotes aspartate
T5 318-322 GeneOrGeneProduct denotes NMDA
T6 492-499 GeneOrGeneProduct denotes balloon
T7 554-561 GeneOrGeneProduct denotes group C
T8 1051-1058 GeneOrGeneProduct denotes spastic
T9 1121-1130 GeneOrGeneProduct denotes glutamate
T10 1200-1207 GeneOrGeneProduct denotes group C
T11 1279-1286 GeneOrGeneProduct denotes reduced
T12 1301-1305 GeneOrGeneProduct denotes dark
T13 1314-1319 GeneOrGeneProduct denotes alpha
T14 1355-1362 GeneOrGeneProduct denotes spastic
T15 1452-1459 GeneOrGeneProduct denotes spastic
T16 1507-1516 GeneOrGeneProduct denotes glutamate
T17 1539-1552 GeneOrGeneProduct denotes NMDA receptor
T18 1650-1663 GeneOrGeneProduct denotes NMDA receptor

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 174-194 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760
T2 422-442 DiseaseOrPhenotypicFeature denotes Spinal cord ischemia D020760
T3 1051-1070 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T4 1355-1374 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T5 1452-1471 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T6 1596-1606 DiseaseOrPhenotypicFeature denotes neurotoxic DISEASE
T7 1625-1645 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 25-55 GeneOrGeneProduct denotes N-methyl-D-aspartate receptors
T2 492-499 GeneOrGeneProduct denotes balloon
T3 1121-1130 GeneOrGeneProduct denotes glutamate
T4 1301-1305 GeneOrGeneProduct denotes dark
T5 1314-1319 GeneOrGeneProduct denotes alpha
T6 1507-1516 GeneOrGeneProduct denotes glutamate
T7 1539-1552 GeneOrGeneProduct denotes NMDA receptor
T8 1650-1663 GeneOrGeneProduct denotes NMDA receptor

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 174-194 DiseaseOrPhenotypicFeature denotes spinal cord ischemia 0020688
T2 422-442 DiseaseOrPhenotypicFeature denotes Spinal cord ischemia 0020688
T3 691-693 DiseaseOrPhenotypicFeature denotes SM 0016586
T4 1625-1645 DiseaseOrPhenotypicFeature denotes spinal cord ischemia 0020688

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 174-194 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760
T2 396-412 DiseaseOrPhenotypicFeature denotes aortic occlusion DISEASE
T3 422-442 DiseaseOrPhenotypicFeature denotes Spinal cord ischemia D020760
T4 458-474 DiseaseOrPhenotypicFeature denotes aortic occlusion DISEASE
T5 1051-1070 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T6 1355-1374 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T7 1452-1471 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T8 1596-1606 DiseaseOrPhenotypicFeature denotes neurotoxic DISEASE
T9 1625-1645 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 174-194 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760
T2 396-412 DiseaseOrPhenotypicFeature denotes aortic occlusion DISEASE
T3 422-442 DiseaseOrPhenotypicFeature denotes Spinal cord ischemia D020760
T4 458-474 DiseaseOrPhenotypicFeature denotes aortic occlusion DISEASE
T5 1051-1070 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T6 1355-1374 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T7 1452-1471 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T8 1596-1606 DiseaseOrPhenotypicFeature denotes neurotoxic DISEASE
T9 1625-1645 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 25-45 ChemicalEntity denotes N-methyl-D-aspartate http://purl.obolibrary.org/obo/CHEBI_31882
T2 132-140 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T5 296-316 ChemicalEntity denotes N-methyl-d-aspartate http://purl.obolibrary.org/obo/CHEBI_31882
T6 318-322 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882
T8 350-358 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T11 583-591 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T14 675-683 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T17 962-968 ChemicalEntity denotes MK-801 D016291
T18 1034-1042 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T21 1081-1089 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T24 1121-1130 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_29987|http://purl.obolibrary.org/obo/CHEBI_14321
T26 1258-1264 ChemicalEntity denotes MK-801 D016291
T27 1338-1346 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T30 1435-1443 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T33 1507-1516 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_29987|http://purl.obolibrary.org/obo/CHEBI_14321
T35 1539-1543 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882
T37 1581-1588 ChemicalEntity denotes opioids ChemicalEntity
T38 1650-1654 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_6121|http://purl.obolibrary.org/obo/CHEBI_31882

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 416-420 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T38 1650-1654 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T37 1581-1588 ChemicalEntity denotes opioids ChemicalEntity
T35 1539-1543 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T33 1507-1516 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T30 1435-1443 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_58097|D009020|http://purl.obolibrary.org/obo/CHEBI_17303
T27 1338-1346 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T26 1258-1264 ChemicalEntity denotes MK-801 D016291
T24 1121-1130 ChemicalEntity denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T21 1081-1089 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T18 1034-1042 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T17 962-968 ChemicalEntity denotes MK-801 D016291
T14 675-683 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T11 583-591 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T8 350-358 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T6 318-322 ChemicalEntity denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T5 296-316 ChemicalEntity denotes N-methyl-d-aspartate http://purl.obolibrary.org/obo/CHEBI_31882
T2 132-140 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T1 25-45 ChemicalEntity denotes N-methyl-D-aspartate http://purl.obolibrary.org/obo/CHEBI_31882
T27780 1650-1663 GeneOrGeneProduct denotes NMDA receptor
T7 1539-1552 GeneOrGeneProduct denotes NMDA receptor
T52906 1507-1516 GeneOrGeneProduct denotes glutamate
T92505 1314-1319 GeneOrGeneProduct denotes alpha
T4 1301-1305 GeneOrGeneProduct denotes dark
T3 1121-1130 GeneOrGeneProduct denotes glutamate
T48382 492-499 GeneOrGeneProduct denotes balloon
T39889 25-55 GeneOrGeneProduct denotes N-methyl-D-aspartate receptors
T9 1625-1645 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760
T51692 1596-1606 DiseaseOrPhenotypicFeature denotes neurotoxic DISEASE
T1983 1452-1471 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T64560 1355-1374 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T26812 1051-1070 DiseaseOrPhenotypicFeature denotes spastic paraparesis D020336
T26689 458-474 DiseaseOrPhenotypicFeature denotes aortic occlusion DISEASE
T53613 422-442 DiseaseOrPhenotypicFeature denotes Spinal cord ischemia D020760
T64677 396-412 DiseaseOrPhenotypicFeature denotes aortic occlusion DISEASE
T30934 174-194 DiseaseOrPhenotypicFeature denotes spinal cord ischemia D020760
T4521 416-420 OrganismTaxon denotes rats