PubMed:15671273 / 332-967
Annnotations
PubMed_Structured_Abstracts
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2 | 0-635 | METHODS | denotes | Rabbit corneal myofibroblasts were identified by immunodetection of alpha-smooth muscle (alpha-SM)-actin. MT1-MMP, MMP-2, MMP-9, and tissue inhibitor of matrix metalloproteinase (TIMP)-2 were detected by immunofluorescence. Cells were treated with 100 nM cPAF, with or without the PAF antagonist BN 50730 or the furin inhibitor nona-D-arg-NH(2). Gene-expression levels for furin, urokinase plasminogen activator, MMP-2, MMP-9, MT1-MMP, and TIMP-2 were determined by real-time PCR. Protein expression was assessed by Western blot. MMP-2 and -9 activity was determined by gelatin zymography. Active MT1-MMP levels were measured by ELISA. |
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T113 | 0-6 | 813859 | denotes | Rabbit |
T112 | 0-6 | D011817 | denotes | Rabbit |
T114 | 0-6 | 9986 | denotes | Rabbit |
T115 | 68-73 | CHEBI:30216 | denotes | alpha |
T116 | 74-87 | UBERON:0001135 | denotes | smooth muscle |
T117 | 74-87 | UBERON:0000953 | denotes | smooth muscle |
T120 | 89-94 | CHEBI:30216 | denotes | alpha |
T121 | 99-104 | P53491 | denotes | actin |
T122 | 99-104 | P45520 | denotes | actin |
T123 | 99-104 | O00937 | denotes | actin |
T124 | 99-104 | Q05214 | denotes | actin |
T125 | 99-104 | P13363 | denotes | actin |
T126 | 99-104 | Q39596 | denotes | actin |
T127 | 99-104 | P30161 | denotes | actin |
T128 | 99-104 | P53476 | denotes | actin |
T129 | 99-104 | P51775 | denotes | actin |
T130 | 99-104 | P60011 | denotes | actin |
T131 | 99-104 | Q9P4D1 | denotes | actin |
T132 | 99-104 | P50138 | denotes | actin |
T133 | 99-104 | O65314 | denotes | actin |
T134 | 99-104 | P26183 | denotes | actin |
T135 | 99-104 | Q75D00 | denotes | actin |
T136 | 99-104 | P53502 | denotes | actin |
T137 | 99-104 | P11426 | denotes | actin |
T138 | 99-104 | P80709 | denotes | actin |
T139 | 99-104 | Q8X119 | denotes | actin |
T140 | 99-104 | Q6TCF2 | denotes | actin |
T141 | 99-104 | Q99023 | denotes | actin |
T142 | 99-104 | A5DQP9 | denotes | actin |
T143 | 99-104 | P60009 | denotes | actin |
T144 | 99-104 | O65315 | denotes | actin |
T145 | 99-104 | P26182 | denotes | actin |
T146 | 99-104 | Q9UVF3 | denotes | actin |
T147 | 99-104 | Q2U7A3 | denotes | actin |
T148 | 99-104 | Q92192 | denotes | actin |
T149 | 99-104 | Q9UVZ8 | denotes | actin |
T150 | 99-104 | P53689 | denotes | actin |
T151 | 99-104 | P68555 | denotes | actin |
T152 | 99-104 | P53455 | denotes | actin |
T153 | 99-104 | O13419 | denotes | actin |
T154 | 99-104 | P60010 | denotes | actin |
T155 | 99-104 | Q39758 | denotes | actin |
T156 | 99-104 | P81085 | denotes | actin |
T157 | 99-104 | P48465 | denotes | actin |
T158 | 99-104 | P78711 | denotes | actin |
T159 | 99-104 | P17128 | denotes | actin |
T160 | 99-104 | P91754 | denotes | actin |
T161 | 99-104 | Q24733 | denotes | actin |
T162 | 99-104 | P14235 | denotes | actin |
T163 | 99-104 | Q92193 | denotes | actin |
T164 | 99-104 | Q11212 | denotes | actin |
T165 | 99-104 | P45521 | denotes | actin |
T166 | 99-104 | P53477 | denotes | actin |
T167 | 99-104 | P53499 | denotes | actin |
T168 | 99-104 | P24902 | denotes | actin |
T169 | 99-104 | Q8SWN8 | denotes | actin |
T170 | 99-104 | O17320 | denotes | actin |
T171 | 99-104 | P10365 | denotes | actin |
T173 | 99-104 | O16808 | denotes | actin |
T174 | 99-104 | P53498 | denotes | actin |
T175 | 99-104 | Q9UVX4 | denotes | actin |
T176 | 99-104 | O81221 | denotes | actin |
T177 | 99-104 | P20904 | denotes | actin |
T178 | 99-104 | O65316 | denotes | actin |
T179 | 99-104 | O74258 | denotes | actin |
T180 | 99-104 | P53500 | denotes | actin |
T181 | 99-104 | P10989 | denotes | actin |
T182 | 99-104 | P90689 | denotes | actin |
T172 | 99-104 | D000199 | denotes | actin |
T205 | 106-109 | CVCL_2501 | denotes | MT1 |
T190 | 106-109 | GO:0047152 | denotes | MT1 |
T199 | 106-109 | GO:0043791 | denotes | MT1 |
T208 | 106-109 | GO:0043834 | denotes | MT1 |
T224 | 106-113 | Q9XT90 | denotes | MT1-MMP |
T225 | 106-113 | P50281 | denotes | MT1-MMP |
T226 | 106-113 | Q9GLE4 | denotes | MT1-MMP |
T227 | 106-113 | PR:000010474 | denotes | MT1-MMP |
T228 | 106-113 | Q10739 | denotes | MT1-MMP |
T229 | 106-113 | Q95220 | denotes | MT1-MMP |
T231 | 106-113 | P53690 | denotes | MT1-MMP |
T230 | 106-113 | D053511 | denotes | MT1-MMP |
T234 | 110-113 | GO:0004235 | denotes | MMP |
T237 | 115-118 | CHEBI:340824 | denotes | MMP |
T240 | 115-118 | CHEBI:59761 | denotes | MMP |
T241 | 115-120 | PR:P08253 | denotes | MMP-2 |
T242 | 115-120 | Q9GLE5 | denotes | MMP-2 |
T243 | 115-120 | P08253 | denotes | MMP-2 |
T244 | 115-120 | Q90611 | denotes | MMP-2 |
T246 | 115-120 | PR:Q8MPP3 | denotes | MMP-2 |
T247 | 115-120 | P33436 | denotes | MMP-2 |
T248 | 115-120 | PR:Q90611 | denotes | MMP-2 |
T249 | 115-120 | PR:P33436 | denotes | MMP-2 |
T250 | 115-120 | PR:000010479 | denotes | MMP-2 |
T251 | 115-120 | PR:P33434 | denotes | MMP-2 |
T252 | 115-120 | P33434 | denotes | MMP-2 |
T253 | 115-120 | P50757 | denotes | MMP-2 |
T245 | 115-120 | GO:0004228 | denotes | MMP-2 |
T254 | 119-125 | PR:O04529 | denotes | 2, MMP |
T255 | 122-125 | CHEBI:340824 | denotes | MMP |
T258 | 122-125 | CHEBI:59761 | denotes | MMP |
T259 | 122-127 | PR:P50282 | denotes | MMP-9 |
T260 | 122-127 | PR:P14780 | denotes | MMP-9 |
T261 | 122-127 | P14780 | denotes | MMP-9 |
T262 | 122-127 | PR:P41245 | denotes | MMP-9 |
T263 | 122-127 | P41246 | denotes | MMP-9 |
T264 | 122-127 | P41245 | denotes | MMP-9 |
T265 | 122-127 | PR:P52176 | denotes | MMP-9 |
T266 | 122-127 | P50282 | denotes | MMP-9 |
T268 | 122-127 | PR:000010491 | denotes | MMP-9 |
T269 | 122-127 | P52176 | denotes | MMP-9 |
T270 | 122-127 | O18733 | denotes | MMP-9 |
T267 | 122-127 | GO:0004229 | denotes | MMP-9 |
T271 | 133-139 | UBERON:0000479 | denotes | tissue |
T272 | 140-149 | CHEBI:35222 | denotes | inhibitor |
T273 | 153-159 | UBERON:0027368 | denotes | matrix |
T278 | 179-186 | PR:P16035 | denotes | TIMP)-2 |
T279 | 179-186 | PR:000016353 | denotes | TIMP)-2 |
T280 | 179-186 | O42146 | denotes | TIMP)-2 |
T281 | 179-186 | Q9TRZ7 | denotes | TIMP)-2 |
T282 | 179-186 | Q9TTY1 | denotes | TIMP)-2 |
T283 | 179-186 | Q60453 | denotes | TIMP)-2 |
T284 | 179-186 | P16035 | denotes | TIMP)-2 |
T286 | 179-186 | P25785 | denotes | TIMP)-2 |
T287 | 179-186 | P16368 | denotes | TIMP)-2 |
T288 | 179-186 | O77717 | denotes | TIMP)-2 |
T289 | 179-186 | PR:P25785 | denotes | TIMP)-2 |
T290 | 179-186 | P30121 | denotes | TIMP)-2 |
T291 | 179-186 | Q9WUC6 | denotes | TIMP)-2 |
T292 | 179-186 | PR:P30121 | denotes | TIMP)-2 |
T293 | 179-186 | PR:O42146 | denotes | TIMP)-2 |
T285 | 179-186 | D019716 | denotes | TIMP)-2 |
T294 | 255-259 | C083283 | denotes | cPAF |
T295 | 255-259 | C083283 | denotes | cPAF |
T296 | 281-284 | PR:Q6RIA2 | denotes | PAF |
T297 | 281-284 | PR:Q15004 | denotes | PAF |
T300 | 281-284 | PR:000012225 | denotes | PAF |
T302 | 281-284 | PR:Q9CQX4 | denotes | PAF |
T301 | 281-284 | CVCL_XY57 | denotes | PAF |
T303 | 281-295 | CHEBI:134182 | denotes | PAF antagonist |
T305 | 296-304 | C066686 | denotes | BN 50730 |
T306 | 296-304 | C066686 | denotes | BN 50730 |
T307 | 312-317 | P09958 | denotes | furin |
T308 | 312-317 | P23188 | denotes | furin |
T309 | 312-317 | PR:000003137 | denotes | furin |
T311 | 312-317 | PR:P09958 | denotes | furin |
T312 | 312-317 | Q28193 | denotes | furin |
T313 | 312-317 | PR:P23188 | denotes | furin |
T314 | 312-317 | P23377 | denotes | furin |
T315 | 312-317 | PR:P23377 | denotes | furin |
T310 | 312-317 | D045683 | denotes | furin |
T316 | 318-327 | CHEBI:35222 | denotes | inhibitor |
T317 | 328-332 | PR:Q04047 | denotes | nona |
T318 | 333-338 | CHEBI:32693 | denotes | D-arg |
T319 | 333-338 | CHEBI:32691 | denotes | D-arg |
T320 | 333-338 | CHEBI:29953 | denotes | D-arg |
T322 | 335-338 | PR:000013890 | denotes | arg |
T324 | 335-338 | PR:P42684 | denotes | arg |
T325 | 335-338 | PR:Q9P2R6 | denotes | arg |
T327 | 335-338 | PR:Q4JIM5 | denotes | arg |
T331 | 335-338 | PR:000003583 | denotes | arg |
T321 | 335-338 | SO:0001451 | denotes | arg |
T332 | 335-343 | C069339 | denotes | arg-NH(2 |
T333 | 335-343 | C069339 | denotes | arg-NH(2 |
T341 | 346-361 | GO:0010467 | denotes | Gene-expression |
T342 | 373-378 | P09958 | denotes | furin |
T343 | 373-378 | P23188 | denotes | furin |
T344 | 373-378 | PR:000003137 | denotes | furin |
T346 | 373-378 | PR:P09958 | denotes | furin |
T347 | 373-378 | Q28193 | denotes | furin |
T348 | 373-378 | PR:P23188 | denotes | furin |
T349 | 373-378 | P23377 | denotes | furin |
T350 | 373-378 | PR:P23377 | denotes | furin |
T345 | 373-378 | D045683 | denotes | furin |
T351 | 380-389 | D014568 | denotes | urokinase |
T352 | 380-411 | GO:0008243 | denotes | urokinase plasminogen activator |
T371 | 390-411 | P17811 | denotes | plasminogen activator |
T372 | 390-411 | D010960 | denotes | plasminogen activator |
T373 | 413-416 | CHEBI:340824 | denotes | MMP |
T376 | 413-416 | CHEBI:59761 | denotes | MMP |
T377 | 413-418 | PR:P08253 | denotes | MMP-2 |
T378 | 413-418 | Q9GLE5 | denotes | MMP-2 |
T379 | 413-418 | P08253 | denotes | MMP-2 |
T380 | 413-418 | Q90611 | denotes | MMP-2 |
T382 | 413-418 | PR:Q8MPP3 | denotes | MMP-2 |
T383 | 413-418 | P33436 | denotes | MMP-2 |
T384 | 413-418 | PR:Q90611 | denotes | MMP-2 |
T385 | 413-418 | PR:P33436 | denotes | MMP-2 |
T386 | 413-418 | PR:000010479 | denotes | MMP-2 |
T387 | 413-418 | PR:P33434 | denotes | MMP-2 |
T388 | 413-418 | P33434 | denotes | MMP-2 |
T389 | 413-418 | P50757 | denotes | MMP-2 |
T381 | 413-418 | GO:0004228 | denotes | MMP-2 |
T390 | 417-423 | PR:O04529 | denotes | 2, MMP |
T391 | 420-423 | CHEBI:340824 | denotes | MMP |
T394 | 420-423 | CHEBI:59761 | denotes | MMP |
T395 | 420-425 | PR:P50282 | denotes | MMP-9 |
T396 | 420-425 | PR:P14780 | denotes | MMP-9 |
T397 | 420-425 | P14780 | denotes | MMP-9 |
T398 | 420-425 | PR:P41245 | denotes | MMP-9 |
T399 | 420-425 | P41246 | denotes | MMP-9 |
T400 | 420-425 | P41245 | denotes | MMP-9 |
T401 | 420-425 | PR:P52176 | denotes | MMP-9 |
T402 | 420-425 | P50282 | denotes | MMP-9 |
T404 | 420-425 | PR:000010491 | denotes | MMP-9 |
T405 | 420-425 | P52176 | denotes | MMP-9 |
T406 | 420-425 | O18733 | denotes | MMP-9 |
T403 | 420-425 | GO:0004229 | denotes | MMP-9 |
T429 | 427-430 | CVCL_2501 | denotes | MT1 |
T414 | 427-430 | GO:0047152 | denotes | MT1 |
T423 | 427-430 | GO:0043791 | denotes | MT1 |
T432 | 427-430 | GO:0043834 | denotes | MT1 |
T448 | 427-434 | Q9XT90 | denotes | MT1-MMP |
T449 | 427-434 | P50281 | denotes | MT1-MMP |
T450 | 427-434 | Q9GLE4 | denotes | MT1-MMP |
T451 | 427-434 | PR:000010474 | denotes | MT1-MMP |
T452 | 427-434 | Q10739 | denotes | MT1-MMP |
T453 | 427-434 | Q95220 | denotes | MT1-MMP |
T455 | 427-434 | P53690 | denotes | MT1-MMP |
T454 | 427-434 | D053511 | denotes | MT1-MMP |
T458 | 431-434 | GO:0004235 | denotes | MMP |
T465 | 440-446 | PR:P16035 | denotes | TIMP-2 |
T466 | 440-446 | PR:000016353 | denotes | TIMP-2 |
T467 | 440-446 | O42146 | denotes | TIMP-2 |
T468 | 440-446 | Q9TRZ7 | denotes | TIMP-2 |
T469 | 440-446 | Q9TTY1 | denotes | TIMP-2 |
T470 | 440-446 | Q60453 | denotes | TIMP-2 |
T471 | 440-446 | P16035 | denotes | TIMP-2 |
T473 | 440-446 | P25785 | denotes | TIMP-2 |
T474 | 440-446 | P16368 | denotes | TIMP-2 |
T475 | 440-446 | O77717 | denotes | TIMP-2 |
T476 | 440-446 | PR:P25785 | denotes | TIMP-2 |
T477 | 440-446 | P30121 | denotes | TIMP-2 |
T478 | 440-446 | Q9WUC6 | denotes | TIMP-2 |
T479 | 440-446 | PR:P30121 | denotes | TIMP-2 |
T480 | 440-446 | PR:O42146 | denotes | TIMP-2 |
T472 | 440-446 | D019716 | denotes | TIMP-2 |
T481 | 476-479 | Q41249 | denotes | PCR |
T482 | 476-479 | O66148 | denotes | PCR |
T483 | 476-479 | Q59987 | denotes | PCR |
T484 | 476-479 | Q01289 | denotes | PCR |
T485 | 476-479 | O80333 | denotes | PCR |
T486 | 476-479 | P15904 | denotes | PCR |
T487 | 476-479 | Q9SDT1 | denotes | PCR |
T488 | 476-479 | Q39617 | denotes | PCR |
T489 | 481-488 | CHEBI:16541 | denotes | Protein |
T490 | 530-533 | CHEBI:340824 | denotes | MMP |
T493 | 530-533 | CHEBI:59761 | denotes | MMP |
T494 | 530-535 | PR:P08253 | denotes | MMP-2 |
T495 | 530-535 | Q9GLE5 | denotes | MMP-2 |
T496 | 530-535 | P08253 | denotes | MMP-2 |
T497 | 530-535 | Q90611 | denotes | MMP-2 |
T499 | 530-535 | PR:Q8MPP3 | denotes | MMP-2 |
T500 | 530-535 | P33436 | denotes | MMP-2 |
T501 | 530-535 | PR:Q90611 | denotes | MMP-2 |
T502 | 530-535 | PR:P33436 | denotes | MMP-2 |
T503 | 530-535 | PR:000010479 | denotes | MMP-2 |
T504 | 530-535 | PR:P33434 | denotes | MMP-2 |
T505 | 530-535 | P33434 | denotes | MMP-2 |
T506 | 530-535 | P50757 | denotes | MMP-2 |
T498 | 530-535 | GO:0004228 | denotes | MMP-2 |
T507 | 570-577 | 4716 | denotes | gelatin |
T508 | 570-577 | D005780 | denotes | gelatin |
T509 | 570-577 | CHEBI:5291 | denotes | gelatin |
T532 | 597-600 | CVCL_2501 | denotes | MT1 |
T517 | 597-600 | GO:0047152 | denotes | MT1 |
T526 | 597-600 | GO:0043791 | denotes | MT1 |
T535 | 597-600 | GO:0043834 | denotes | MT1 |
T551 | 597-604 | Q9XT90 | denotes | MT1-MMP |
T552 | 597-604 | P50281 | denotes | MT1-MMP |
T553 | 597-604 | Q9GLE4 | denotes | MT1-MMP |
T554 | 597-604 | PR:000010474 | denotes | MT1-MMP |
T555 | 597-604 | Q10739 | denotes | MT1-MMP |
T556 | 597-604 | Q95220 | denotes | MT1-MMP |
T558 | 597-604 | P53690 | denotes | MT1-MMP |
T557 | 597-604 | D053511 | denotes | MT1-MMP |
T561 | 601-604 | GO:0004235 | denotes | MMP |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4 | 0-105 | DRI_Background | denotes | Rabbit corneal myofibroblasts were identified by immunodetection of alpha-smooth muscle (alpha-SM)-actin. |
T5 | 106-223 | DRI_Background | denotes | MT1-MMP, MMP-2, MMP-9, and tissue inhibitor of matrix metalloproteinase (TIMP)-2 were detected by immunofluorescence. |
T6 | 224-345 | DRI_Approach | denotes | Cells were treated with 100 nM cPAF, with or without the PAF antagonist BN 50730 or the furin inhibitor nona-D-arg-NH(2). |
T7 | 346-480 | DRI_Background | denotes | Gene-expression levels for furin, urokinase plasminogen activator, MMP-2, MMP-9, MT1-MMP, and TIMP-2 were determined by real-time PCR. |
T8 | 481-529 | DRI_Background | denotes | Protein expression was assessed by Western blot. |
T9 | 530-589 | DRI_Unspecified | denotes | MMP-2 and -9 activity was determined by gelatin zymography. |
T10 | 590-635 | DRI_Background | denotes | Active MT1-MMP levels were measured by ELISA. |