PubMed:15671273 / 1530-2101 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T4 0-571 CONCLUSIONS denotes PAF, through a receptor-mediated mechanism, induces a specific pattern of furin, MMP, and TIMP-2 expression in corneal myofibroblasts. MMP-2 activity was unchanged by PAF treatment. These results suggest that in response to the inflammatory mediator PAF, induction of MT1-MMP is independent of MMP-2 activity in corneal myofibroblasts. Thus, PAF-mediated changes in extracellular matrix composition surrounding the myofibroblasts could be important in regulating the corneal scarring process. Moreover, PAF antagonists could be useful in maintaining corneal transparency.

c_corpus

Id Subject Object Predicate Lexical cue
T922 0-3 PR:Q6RIA2 denotes PAF
T923 0-3 PR:Q15004 denotes PAF
T926 0-3 PR:000012225 denotes PAF
T928 0-3 PR:Q9CQX4 denotes PAF
T927 0-3 CVCL_XY57 denotes PAF
T924 0-3 CHEBI:52450 denotes PAF
T925 0-3 CHEBI:44811 denotes PAF
T929 74-79 P09958 denotes furin
T930 74-79 P23188 denotes furin
T931 74-79 PR:000003137 denotes furin
T933 74-79 PR:P09958 denotes furin
T934 74-79 Q28193 denotes furin
T935 74-79 PR:P23188 denotes furin
T936 74-79 P23377 denotes furin
T937 74-79 PR:P23377 denotes furin
T932 74-79 D045683 denotes furin
T940 81-84 PR:O04529 denotes MMP
T938 81-84 CHEBI:340824 denotes MMP
T941 81-84 CHEBI:59761 denotes MMP
T939 81-84 GO:0004235 denotes MMP
T946 90-96 PR:P16035 denotes TIMP-2
T947 90-96 PR:000016353 denotes TIMP-2
T948 90-96 O42146 denotes TIMP-2
T949 90-96 Q9TRZ7 denotes TIMP-2
T950 90-96 Q9TTY1 denotes TIMP-2
T951 90-96 Q60453 denotes TIMP-2
T952 90-96 P16035 denotes TIMP-2
T954 90-96 P25785 denotes TIMP-2
T955 90-96 P16368 denotes TIMP-2
T956 90-96 O77717 denotes TIMP-2
T957 90-96 PR:P25785 denotes TIMP-2
T958 90-96 P30121 denotes TIMP-2
T959 90-96 Q9WUC6 denotes TIMP-2
T960 90-96 PR:P30121 denotes TIMP-2
T961 90-96 PR:O42146 denotes TIMP-2
T953 90-96 D019716 denotes TIMP-2
T962 135-138 CHEBI:340824 denotes MMP
T965 135-138 CHEBI:59761 denotes MMP
T966 135-140 PR:P08253 denotes MMP-2
T967 135-140 Q9GLE5 denotes MMP-2
T968 135-140 P08253 denotes MMP-2
T969 135-140 Q90611 denotes MMP-2
T971 135-140 PR:Q8MPP3 denotes MMP-2
T972 135-140 P33436 denotes MMP-2
T973 135-140 PR:Q90611 denotes MMP-2
T974 135-140 PR:P33436 denotes MMP-2
T975 135-140 PR:000010479 denotes MMP-2
T976 135-140 PR:P33434 denotes MMP-2
T977 135-140 P33434 denotes MMP-2
T978 135-140 P50757 denotes MMP-2
T970 135-140 GO:0004228 denotes MMP-2
T979 167-170 PR:Q6RIA2 denotes PAF
T980 167-170 PR:Q15004 denotes PAF
T983 167-170 PR:000012225 denotes PAF
T985 167-170 PR:Q9CQX4 denotes PAF
T984 167-170 CVCL_XY57 denotes PAF
T981 167-170 CHEBI:52450 denotes PAF
T982 167-170 CHEBI:44811 denotes PAF
T986 250-253 PR:Q6RIA2 denotes PAF
T987 250-253 PR:Q15004 denotes PAF
T990 250-253 PR:000012225 denotes PAF
T992 250-253 PR:Q9CQX4 denotes PAF
T991 250-253 CVCL_XY57 denotes PAF
T988 250-253 CHEBI:52450 denotes PAF
T989 250-253 CHEBI:44811 denotes PAF
T1015 268-271 CVCL_2501 denotes MT1
T1000 268-271 GO:0047152 denotes MT1
T1009 268-271 GO:0043791 denotes MT1
T1018 268-271 GO:0043834 denotes MT1
T1034 268-275 Q9XT90 denotes MT1-MMP
T1035 268-275 P50281 denotes MT1-MMP
T1036 268-275 Q9GLE4 denotes MT1-MMP
T1037 268-275 PR:000010474 denotes MT1-MMP
T1038 268-275 Q10739 denotes MT1-MMP
T1039 268-275 Q95220 denotes MT1-MMP
T1041 268-275 P53690 denotes MT1-MMP
T1040 268-275 D053511 denotes MT1-MMP
T1044 272-275 GO:0004235 denotes MMP
T1047 294-297 CHEBI:340824 denotes MMP
T1050 294-297 CHEBI:59761 denotes MMP
T1051 294-299 PR:P08253 denotes MMP-2
T1052 294-299 Q9GLE5 denotes MMP-2
T1053 294-299 P08253 denotes MMP-2
T1054 294-299 Q90611 denotes MMP-2
T1056 294-299 PR:Q8MPP3 denotes MMP-2
T1057 294-299 P33436 denotes MMP-2
T1058 294-299 PR:Q90611 denotes MMP-2
T1059 294-299 PR:P33436 denotes MMP-2
T1060 294-299 PR:000010479 denotes MMP-2
T1061 294-299 PR:P33434 denotes MMP-2
T1062 294-299 P33434 denotes MMP-2
T1063 294-299 P50757 denotes MMP-2
T1055 294-299 GO:0004228 denotes MMP-2
T1066 342-345 CHEBI:52450 denotes PAF
T1067 342-345 CHEBI:44811 denotes PAF
T1064 342-345 PR:Q6RIA2 denotes PAF
T1065 342-345 PR:Q15004 denotes PAF
T1068 342-345 PR:000012225 denotes PAF
T1070 342-345 PR:Q9CQX4 denotes PAF
T1069 342-345 CVCL_XY57 denotes PAF
T1072 366-386 GO:0031012 denotes extracellular matrix
T1073 380-386 UBERON:0027368 denotes matrix
T1074 475-483 D002921 denotes scarring
T1075 475-483 D002921 denotes scarring
T1076 503-506 PR:Q6RIA2 denotes PAF
T1077 503-506 PR:Q15004 denotes PAF
T1080 503-506 PR:000012225 denotes PAF
T1082 503-506 PR:Q9CQX4 denotes PAF
T1081 503-506 CVCL_XY57 denotes PAF
T1083 503-518 CHEBI:134182 denotes PAF antagonists

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T18 0-134 DRI_Approach denotes PAF, through a receptor-mediated mechanism, induces a specific pattern of furin, MMP, and TIMP-2 expression in corneal myofibroblasts.
T19 135-181 DRI_Unspecified denotes MMP-2 activity was unchanged by PAF treatment.
T20 182-335 DRI_Challenge denotes These results suggest that in response to the inflammatory mediator PAF, induction of MT1-MMP is independent of MMP-2 activity in corneal myofibroblasts.
T21 336-492 DRI_Approach denotes Thus, PAF-mediated changes in extracellular matrix composition surrounding the myofibroblasts could be important in regulating the corneal scarring process.
T22 493-571 DRI_Outcome denotes Moreover, PAF antagonists could be useful in maintaining corneal transparency.