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PubMed:15657660 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1950-1997 gene:1890 denotes platelet-derived endothelial cell growth factor
T1 2010-2027 disease:C0009402 denotes colorectal cancer
T2 1950-1997 gene:1890 denotes platelet-derived endothelial cell growth factor
T3 2010-2027 disease:C1527249 denotes colorectal cancer
R1 T0 T1 associated_with platelet-derived endothelial cell growth factor,colorectal cancer
R2 T2 T3 associated_with platelet-derived endothelial cell growth factor,colorectal cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15657660-0#32#79#gene1890 877-952 gene1890 denotes pecific RNA probe. RESULTS: Platelet-derived endothelial cell growth factor
15657660-0#102#119#diseaseC0009402 2010-2027 diseaseC0009402 denotes colorectal cancer
15657660-0#102#119#diseaseC1527249 2010-2027 diseaseC1527249 denotes colorectal cancer
15657660-1#0#47#gene1890 130-177 gene1890 denotes Platelet-derived endothelial cell growth factor
15657660-1#111#121#diseaseC0027627 241-251 diseaseC0027627 denotes metastases
32#79#gene1890102#119#diseaseC0009402 15657660-0#32#79#gene1890 15657660-0#102#119#diseaseC0009402 associated_with "pecific RNA probe. RESULTS: Platelet-derived endothelial cell growth factor",colorectal cancer
32#79#gene1890102#119#diseaseC1527249 15657660-0#32#79#gene1890 15657660-0#102#119#diseaseC1527249 associated_with "pecific RNA probe. RESULTS: Platelet-derived endothelial cell growth factor",colorectal cancer
0#47#gene1890111#121#diseaseC0027627 15657660-1#0#47#gene1890 15657660-1#111#121#diseaseC0027627 associated_with Platelet-derived endothelial cell growth factor,metastases

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 130-428 OBJECTIVE denotes Platelet-derived endothelial cell growth factor, identified to be an angiogenic factor, has been implicated in metastases of colorectal cancer. This study aimed to clarify the role and localization of platelet-derived endothelial cell growth factor associated with human colorectal cancer invasion.
T2 438-895 METHODS denotes Thirty-two patients with colorectal cancer who had undergone surgery were analyzed. Platelet-derived endothelial cell growth factor enzyme activities in the colorectal cancer specimens were measured. Cells that expressed platelet-derived endothelial cell growth factor were identified and localized by immunohistochemical analysis with anti-human platelet-derived endothelial cell growth factor antibody and by in situ hybridization with specific RNA probe.
T3 905-1871 RESULTS denotes Platelet-derived endothelial cell growth factor enzyme activity increased significantly in cancer tissues compared with normal colonic mucosa at various distances from the cancer. Immunohistochemical analysis and in situ hybridization demonstrated platelet-derived endothelial cell growth factor expression in stromal macrophages and fibroblasts located in cancer tissues and surrounding noncancerous tissues, although the tumor cells and normal colonic mucosa were negative. The value of platelet-derived endothelial cell growth factor expression was highest at the border of the colorectal cancer (35.3 +/- 8.9 percent), followed by the cancer nest (15.2 +/- 9.2 percent) and normal mucosa (7.7 +/- 3.4 percent). In the border area, the highest value of platelet-derived endothelial cell growth factor expression was observed in the submucosa (35.3 +/- 8.9 percent), followed by the muscular propria (21.9 +/- 7.7 percent) and the subserosa (14.9 +/- 5.5 percent).
T4 1885-2326 CONCLUSIONS denotes Stromal macrophages and fibroblasts are responsible for elevated platelet-derived endothelial cell growth factor activity in colorectal cancer. The significance of enhanced expression of platelet-derived endothelial cell growth factor in the submucosa at the cancer border remains unclear. Cancer stroma may be an important factor for cancer angiogenesis and may serve as a treatment target through specific modulation of angiogenic factors.