PubMed:15653325 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/15653325","sourcedb":"PubMed","sourceid":"15653325","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/15653325","text":"Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.\nNuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools.","tracks":[{"project":"2015-BEL-Sample-2","denotations":[{"id":"BEL:20003604","span":{"begin":236,"end":370},"obj":"p(HGNC:NFKBIA,pmod(P,S)) directlyIncreases deg(p(HGNC:NFKBIA))"}],"attributes":[{"subj":"BEL:20003604","pred":"source","obj":"2015-BEL-Sample-2"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":91},"obj":"Sentence"},{"id":"T2","span":{"begin":92,"end":235},"obj":"Sentence"},{"id":"T3","span":{"begin":236,"end":372},"obj":"Sentence"},{"id":"T4","span":{"begin":373,"end":575},"obj":"Sentence"},{"id":"T5","span":{"begin":576,"end":717},"obj":"Sentence"},{"id":"T6","span":{"begin":718,"end":850},"obj":"Sentence"},{"id":"T7","span":{"begin":851,"end":1093},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":91},"obj":"Sentence"},{"id":"T2","span":{"begin":92,"end":235},"obj":"Sentence"},{"id":"T3","span":{"begin":236,"end":372},"obj":"Sentence"},{"id":"T4","span":{"begin":373,"end":575},"obj":"Sentence"},{"id":"T5","span":{"begin":576,"end":717},"obj":"Sentence"},{"id":"T6","span":{"begin":718,"end":850},"obj":"Sentence"},{"id":"T7","span":{"begin":851,"end":1093},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2015-BEL-Sample-2","color":"#ae93ec","default":true},{"id":"Inflammaging","color":"#93ec94"}]}]}}