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PubMed:15649253 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Primary malignant lymphoma of the brain: frequent abnormalities and inactivation of p14 tumor suppressor gene.
T2 111-379 Sentence denotes Ten primary central nervous system lymphomas (PCNSL, brain lymphomas) were examined for p14 gene exon 1beta deletion, mutation and methylation by Southern blot analysis, nucleotide analysis of polymerase chain reaction clones and Southern blot-based methylation assay.
T3 380-670 Sentence denotes In Southern blot analysis, from the signal densities of the hybridized bands and their similarities to those of exons 2 and 3 in our previous quantitative study, we found that exon 1beta was homozygously deleted in four cases, hemizygously deleted in five cases and not deleted in one case.
T4 671-862 Sentence denotes Thus, the same deletion patterns covered the entire p14 gene for all cases except for one case, which suggested the hemizygous deletion of exons 1beta and 2 and homozygous deletion of exon 3.
T5 863-1010 Sentence denotes In addition, although exon 1beta mutation is rare in various tumors, we detected a missense mutation (L50R) in one case with a hemizygous deletion.
T6 1011-1118 Sentence denotes Methylation of the 5'CpG island of the p14 gene was not suggested for any case without homozygous deletion.
T7 1119-1425 Sentence denotes Our observation of frequent p14 gene abnormalities (90%) and inactivation (40-60%) was in striking contrast to the same pathological subtype of systemic lymphoma in which p14 gene abnormalities and inactivation were infrequent, suggesting a difference in carcinogenesis between PCNSL and systemic lymphoma.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1397 199-202 GeneOrGeneProduct denotes p14 NCBIGene:11102
1391 0-39 DiseaseOrPhenotypicFeature denotes Primary malignant lymphoma of the brain MESH:D016543
1392 84-87 GeneOrGeneProduct denotes p14 NCBIGene:11102
1393 88-93 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
1394 115-155 DiseaseOrPhenotypicFeature denotes primary central nervous system lymphomas MESH:D016543
1395 157-162 DiseaseOrPhenotypicFeature denotes PCNSL MESH:D016543
1396 164-179 DiseaseOrPhenotypicFeature denotes brain lymphomas MESH:D016543
1398 723-726 GeneOrGeneProduct denotes p14 NCBIGene:11102
1399 924-930 DiseaseOrPhenotypicFeature denotes tumors MESH:D009369
1400 965-969 SequenceVariant denotes L50R p|SUB|L|50|R
1401 1050-1053 GeneOrGeneProduct denotes p14 NCBIGene:11102
1402 1147-1150 GeneOrGeneProduct denotes p14 NCBIGene:11102
1403 1263-1280 DiseaseOrPhenotypicFeature denotes systemic lymphoma MESH:D008223
1404 1290-1293 GeneOrGeneProduct denotes p14 NCBIGene:11102
1405 1374-1388 DiseaseOrPhenotypicFeature denotes carcinogenesis MESH:D063646
1406 1397-1402 DiseaseOrPhenotypicFeature denotes PCNSL MESH:D016543
1407 1407-1424 DiseaseOrPhenotypicFeature denotes systemic lymphoma MESH:D008223

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 18-26 DiseaseOrPhenotypicFeature denotes lymphoma 0005062
T2 115-155 DiseaseOrPhenotypicFeature denotes primary central nervous system lymphomas 0002571
T3 170-179 DiseaseOrPhenotypicFeature denotes lymphomas 0005062
T4 908-912 DiseaseOrPhenotypicFeature denotes rare 0021136
T5 1272-1280 DiseaseOrPhenotypicFeature denotes lymphoma 0005062
T6 1416-1424 DiseaseOrPhenotypicFeature denotes lymphoma 0005062

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 798-815 SequenceVariant denotes deletion of exons
T2 843-859 SequenceVariant denotes deletion of exon
T3 965-969 SequenceVariant denotes L50R

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 34-39 GeneOrGeneProduct denotes brain
T2 88-104 GeneOrGeneProduct denotes tumor suppressor
T3 131-138 GeneOrGeneProduct denotes nervous
T4 164-169 GeneOrGeneProduct denotes brain
T5 229-237 GeneOrGeneProduct denotes mutation
T6 266-270 GeneOrGeneProduct denotes blot
T7 304-314 GeneOrGeneProduct denotes polymerase
T8 315-320 GeneOrGeneProduct denotes chain
T9 330-336 GeneOrGeneProduct denotes clones
T10 350-354 GeneOrGeneProduct denotes blot
T11 355-360 GeneOrGeneProduct denotes based
T12 392-396 GeneOrGeneProduct denotes blot
T13 451-460 GeneOrGeneProduct denotes bands and
T14 467-479 GeneOrGeneProduct denotes similarities
T15 500-505 GeneOrGeneProduct denotes and 3
T16 600-605 GeneOrGeneProduct denotes cases
T17 636-641 GeneOrGeneProduct denotes cases
T18 665-669 GeneOrGeneProduct denotes case
T19 716-722 GeneOrGeneProduct denotes entire
T20 736-739 GeneOrGeneProduct denotes all
T21 740-745 GeneOrGeneProduct denotes cases
T22 761-765 GeneOrGeneProduct denotes case
T23 822-827 GeneOrGeneProduct denotes and 2
T24 896-904 GeneOrGeneProduct denotes mutation
T25 908-912 GeneOrGeneProduct denotes rare
T26 924-930 GeneOrGeneProduct denotes tumors
T27 946-954 GeneOrGeneProduct denotes missense
T28 955-963 GeneOrGeneProduct denotes mutation
T29 978-982 GeneOrGeneProduct denotes case
T30 1085-1089 GeneOrGeneProduct denotes case
T31 1218-1226 GeneOrGeneProduct denotes contrast

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 34-39 GeneOrGeneProduct denotes brain
T2 88-104 GeneOrGeneProduct denotes tumor suppressor
T3 131-138 GeneOrGeneProduct denotes nervous
T4 164-169 GeneOrGeneProduct denotes brain
T5 266-270 GeneOrGeneProduct denotes blot
T6 304-314 GeneOrGeneProduct denotes polymerase
T7 315-320 GeneOrGeneProduct denotes chain
T8 350-354 GeneOrGeneProduct denotes blot
T9 392-396 GeneOrGeneProduct denotes blot
T10 908-912 GeneOrGeneProduct denotes rare

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 8-26 DiseaseOrPhenotypicFeature denotes malignant lymphoma D008223
T2 88-93 DiseaseOrPhenotypicFeature denotes tumor D009369
T3 146-155 DiseaseOrPhenotypicFeature denotes lymphomas D008223
T4 170-179 DiseaseOrPhenotypicFeature denotes lymphomas D008223
T5 924-930 DiseaseOrPhenotypicFeature denotes tumors D009369
T6 1272-1280 DiseaseOrPhenotypicFeature denotes lymphoma D008223
T7 1374-1388 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T8 1416-1424 DiseaseOrPhenotypicFeature denotes lymphoma D008223

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 94-104 GeneOrGeneProduct denotes suppressor

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 8-26 DiseaseOrPhenotypicFeature denotes malignant lymphoma 0005062
T2 88-93 DiseaseOrPhenotypicFeature denotes tumor 0005070
T3 115-155 DiseaseOrPhenotypicFeature denotes primary central nervous system lymphomas 0002571
T4 157-162 DiseaseOrPhenotypicFeature denotes PCNSL 0002571
T5 1272-1280 DiseaseOrPhenotypicFeature denotes lymphoma 0005062|0003660|0003659
T8 1397-1402 DiseaseOrPhenotypicFeature denotes PCNSL 0002571
T9 1416-1424 DiseaseOrPhenotypicFeature denotes lymphoma 0005062|0003660|0003659

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 0-39 DiseaseOrPhenotypicFeature denotes Primary malignant lymphoma of the brain DISEASE
T2 88-93 DiseaseOrPhenotypicFeature denotes tumor D009369
T3 115-155 DiseaseOrPhenotypicFeature denotes primary central nervous system lymphomas DISEASE
T4 157-162 DiseaseOrPhenotypicFeature denotes PCNSL DISEASE
T5 170-179 DiseaseOrPhenotypicFeature denotes lymphomas D008223
T6 924-930 DiseaseOrPhenotypicFeature denotes tumors DISEASE|D009369
T8 1272-1280 DiseaseOrPhenotypicFeature denotes lymphoma D008223
T9 1374-1388 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T10 1397-1402 DiseaseOrPhenotypicFeature denotes PCNSL DISEASE
T11 1416-1424 DiseaseOrPhenotypicFeature denotes lymphoma D008223

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 0-39 DiseaseOrPhenotypicFeature denotes Primary malignant lymphoma of the brain DISEASE
T2 88-93 DiseaseOrPhenotypicFeature denotes tumor D009369
T3 115-155 DiseaseOrPhenotypicFeature denotes primary central nervous system lymphomas DISEASE
T4 157-162 DiseaseOrPhenotypicFeature denotes PCNSL DISEASE
T5 170-179 DiseaseOrPhenotypicFeature denotes lymphomas D008223
T6 924-930 DiseaseOrPhenotypicFeature denotes tumors D009369
T7 1272-1280 DiseaseOrPhenotypicFeature denotes lymphoma D008223
T8 1374-1388 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T9 1397-1402 DiseaseOrPhenotypicFeature denotes PCNSL DISEASE
T10 1416-1424 DiseaseOrPhenotypicFeature denotes lymphoma D008223

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 1032-1035 ChemicalEntity denotes CpG http://purl.obolibrary.org/obo/CHEBI_165823

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T1 1032-1035 ChemicalEntity denotes CpG http://purl.obolibrary.org/obo/CHEBI_165823
T38040 94-104 GeneOrGeneProduct denotes suppressor
T10 1416-1424 DiseaseOrPhenotypicFeature denotes lymphoma D008223
T9 1397-1402 DiseaseOrPhenotypicFeature denotes PCNSL DISEASE
T8 1374-1388 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T7 1272-1280 DiseaseOrPhenotypicFeature denotes lymphoma D008223
T6 924-930 DiseaseOrPhenotypicFeature denotes tumors D009369
T5 170-179 DiseaseOrPhenotypicFeature denotes lymphomas D008223
T4 157-162 DiseaseOrPhenotypicFeature denotes PCNSL DISEASE
T3 115-155 DiseaseOrPhenotypicFeature denotes primary central nervous system lymphomas DISEASE
T2 88-93 DiseaseOrPhenotypicFeature denotes tumor D009369
T59806 0-39 DiseaseOrPhenotypicFeature denotes Primary malignant lymphoma of the brain DISEASE
T84748 965-969 SequenceVariant denotes L50R
T45796 843-859 SequenceVariant denotes deletion of exon
T98411 798-815 SequenceVariant denotes deletion of exons

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 965-969 ProteinMutation:p|SUB|L|50|R denotes L50R

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1147-1150 gene:10263 denotes p14
T1 1272-1280 disease:C0024299 denotes lymphoma
T2 1147-1150 gene:11102 denotes p14
T3 1272-1280 disease:C0024299 denotes lymphoma
T4 1147-1150 gene:1029 denotes p14
T5 1272-1280 disease:C0024299 denotes lymphoma
T6 1147-1150 gene:6280 denotes p14
T7 1272-1280 disease:C0024299 denotes lymphoma
T8 1147-1150 gene:51639 denotes p14
T9 1272-1280 disease:C0024299 denotes lymphoma
T10 1147-1150 gene:10923 denotes p14
T11 1272-1280 disease:C0024299 denotes lymphoma
T12 1147-1150 gene:56259 denotes p14
T13 1272-1280 disease:C0024299 denotes lymphoma
T14 1147-1150 gene:28956 denotes p14
T15 1272-1280 disease:C0024299 denotes lymphoma
T16 1147-1150 gene:10263 denotes p14
T17 1374-1388 disease:C0596263 denotes carcinogenesis
T18 1147-1150 gene:11102 denotes p14
T19 1374-1388 disease:C0596263 denotes carcinogenesis
T20 1147-1150 gene:1029 denotes p14
T21 1374-1388 disease:C0596263 denotes carcinogenesis
T22 1147-1150 gene:6280 denotes p14
T23 1374-1388 disease:C0596263 denotes carcinogenesis
T24 1147-1150 gene:51639 denotes p14
T25 1374-1388 disease:C0596263 denotes carcinogenesis
T26 1147-1150 gene:10923 denotes p14
T27 1374-1388 disease:C0596263 denotes carcinogenesis
T28 1147-1150 gene:56259 denotes p14
T29 1374-1388 disease:C0596263 denotes carcinogenesis
T30 1147-1150 gene:28956 denotes p14
T31 1374-1388 disease:C0596263 denotes carcinogenesis
T32 1147-1150 gene:10263 denotes p14
T33 1416-1424 disease:C0024299 denotes lymphoma
T34 1147-1150 gene:11102 denotes p14
T35 1416-1424 disease:C0024299 denotes lymphoma
T36 1147-1150 gene:1029 denotes p14
T37 1416-1424 disease:C0024299 denotes lymphoma
T38 1147-1150 gene:6280 denotes p14
T39 1416-1424 disease:C0024299 denotes lymphoma
T40 1147-1150 gene:51639 denotes p14
T41 1416-1424 disease:C0024299 denotes lymphoma
T42 1147-1150 gene:10923 denotes p14
T43 1416-1424 disease:C0024299 denotes lymphoma
T44 1147-1150 gene:56259 denotes p14
T45 1416-1424 disease:C0024299 denotes lymphoma
T46 1147-1150 gene:28956 denotes p14
T47 1416-1424 disease:C0024299 denotes lymphoma
T48 1290-1293 gene:10263 denotes p14
T49 1272-1280 disease:C0024299 denotes lymphoma
T50 1290-1293 gene:11102 denotes p14
T51 1272-1280 disease:C0024299 denotes lymphoma
T52 1290-1293 gene:1029 denotes p14
T53 1272-1280 disease:C0024299 denotes lymphoma
T54 1290-1293 gene:6280 denotes p14
T55 1272-1280 disease:C0024299 denotes lymphoma
T56 1290-1293 gene:51639 denotes p14
T57 1272-1280 disease:C0024299 denotes lymphoma
T58 1290-1293 gene:10923 denotes p14
T59 1272-1280 disease:C0024299 denotes lymphoma
T60 1290-1293 gene:56259 denotes p14
T61 1272-1280 disease:C0024299 denotes lymphoma
T62 1290-1293 gene:28956 denotes p14
T63 1272-1280 disease:C0024299 denotes lymphoma
R1 T0 T1 associated_with p14,lymphoma
R2 T2 T3 associated_with p14,lymphoma
R3 T4 T5 associated_with p14,lymphoma
R4 T6 T7 associated_with p14,lymphoma
R5 T8 T9 associated_with p14,lymphoma
R6 T10 T11 associated_with p14,lymphoma
R7 T12 T13 associated_with p14,lymphoma
R8 T14 T15 associated_with p14,lymphoma
R9 T16 T17 associated_with p14,carcinogenesis
R10 T18 T19 associated_with p14,carcinogenesis
R11 T20 T21 associated_with p14,carcinogenesis
R12 T22 T23 associated_with p14,carcinogenesis
R13 T24 T25 associated_with p14,carcinogenesis
R14 T26 T27 associated_with p14,carcinogenesis
R15 T28 T29 associated_with p14,carcinogenesis
R16 T30 T31 associated_with p14,carcinogenesis
R17 T32 T33 associated_with p14,lymphoma
R18 T34 T35 associated_with p14,lymphoma
R19 T36 T37 associated_with p14,lymphoma
R20 T38 T39 associated_with p14,lymphoma
R21 T40 T41 associated_with p14,lymphoma
R22 T42 T43 associated_with p14,lymphoma
R23 T44 T45 associated_with p14,lymphoma
R24 T46 T47 associated_with p14,lymphoma
R25 T48 T49 associated_with p14,lymphoma
R26 T50 T51 associated_with p14,lymphoma
R27 T52 T53 associated_with p14,lymphoma
R28 T54 T55 associated_with p14,lymphoma
R29 T56 T57 associated_with p14,lymphoma
R30 T58 T59 associated_with p14,lymphoma
R31 T60 T61 associated_with p14,lymphoma
R32 T62 T63 associated_with p14,lymphoma