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DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
15648059-3#278#287#geners1051931 657-666 geners1051931 denotes Val379Ala
15648059-3#278#287#geners755206701 657-666 geners755206701 denotes Val379Ala
15648059-3#337#346#geners5498 716-725 geners5498 denotes Lys469Glu
15648059-3#160#168#geners9808753 539-547 geners9808753 denotes Gln64Arg
15648059-3#407#409#diseaseC0030567 786-788 diseaseC0030567 denotes PD
278#287#geners1051931407#409#diseaseC0030567 15648059-3#278#287#geners1051931 15648059-3#407#409#diseaseC0030567 associated_with Val379Ala,PD
278#287#geners755206701407#409#diseaseC0030567 15648059-3#278#287#geners755206701 15648059-3#407#409#diseaseC0030567 associated_with Val379Ala,PD
337#346#geners5498407#409#diseaseC0030567 15648059-3#337#346#geners5498 15648059-3#407#409#diseaseC0030567 associated_with Lys469Glu,PD
160#168#geners9808753407#409#diseaseC0030567 15648059-3#160#168#geners9808753 15648059-3#407#409#diseaseC0030567 associated_with Gln64Arg,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15648059-3#68#84#gene3458 447-463 gene3458 denotes interferon-gamma
15648059-3#407#409#diseaseC0030567 786-788 diseaseC0030567 denotes PD
15648059-6#30#35#gene3586 1288-1293 gene3586 denotes IL-10
15648059-6#96#98#diseaseC0030567 1354-1356 diseaseC0030567 denotes PD
68#84#gene3458407#409#diseaseC0030567 15648059-3#68#84#gene3458 15648059-3#407#409#diseaseC0030567 associated_with interferon-gamma,PD
30#35#gene358696#98#diseaseC0030567 15648059-6#30#35#gene3586 15648059-6#96#98#diseaseC0030567 associated_with IL-10,PD

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Investigation of genes coding for inflammatory components in Parkinson's disease.
T2 82-207 Sentence denotes Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD).
T3 208-378 Sentence denotes Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset.
T4 379-806 Sentence denotes Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon-gamma (IFN-gamma; T874A in intron 1), interferon-gamma receptor 2 (IFN-gamma R2; Gln64Arg), interleukin-10 (IL-10; G1082A in the promoter region), platelet-activating factor acetylhydrolase (PAF-AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM-1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls.
T5 807-985 Sentence denotes None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL-10 gene promoter was found to be related to the age of disease onset.
T6 986-1257 Sentence denotes Linear regression showed a significantly earlier onset with more A-alleles (P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5-year delayed age of onset of the disease for individuals having two G-alleles compared with individuals having two A-alleles.
T7 1258-1357 Sentence denotes The results indicate that the IL-10 G1082A SNP could possibly be related to the age of onset of PD.
T1 0-81 Sentence denotes Investigation of genes coding for inflammatory components in Parkinson's disease.
T2 82-207 Sentence denotes Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD).
T3 208-378 Sentence denotes Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset.
T4 379-806 Sentence denotes Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon-gamma (IFN-gamma; T874A in intron 1), interferon-gamma receptor 2 (IFN-gamma R2; Gln64Arg), interleukin-10 (IL-10; G1082A in the promoter region), platelet-activating factor acetylhydrolase (PAF-AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM-1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls.
T5 807-985 Sentence denotes None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL-10 gene promoter was found to be related to the age of disease onset.
T6 986-1257 Sentence denotes Linear regression showed a significantly earlier onset with more A-alleles (P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5-year delayed age of onset of the disease for individuals having two G-alleles compared with individuals having two A-alleles.
T7 1258-1357 Sentence denotes The results indicate that the IL-10 G1082A SNP could possibly be related to the age of onset of PD.