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PubMed:15632154 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 899-910 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T2 960-981 Glycan_Motif denotes N-acetylgalactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB
T3 1041-1052 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T4 1136-1147 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T5 1362-1383 Glycan_Motif denotes N-acetylgalactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB

sentences

Id Subject Object Predicate Lexical cue
T1 0-56 Sentence denotes Glycosylation-related gene expression in prion diseases:
T2 57-160 Sentence denotes PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation.
T3 161-334 Sentence denotes Several lines of evidence indicate that some glycoconjugates are efficient effectors of the cellular prion protein (PrP(C)) conversion into its pathogenic (PrP(Sc)) isoform.
T4 335-672 Sentence denotes To assess how glycoconjugate glycan moieties participate in the biogenesis of PrP(Sc), an exhaustive comparative analysis of the expression of about 200 glycosylation-related genes was performed on prion-infected or not, hypothalamus-derived GT1 cells by hybridization of DNA microarrays, semiquantitative RT-PCR, and biochemical assays.
T5 673-831 Sentence denotes A significant up- (30-fold) and down- (17-fold) regulation of the expression of the ChGn1 and Chst8 genes, respectively, was observed in prion-infected cells.
T6 832-1005 Sentence denotes ChGn1 and Chst8 are involved in the initiation of the synthesis of chondroitin sulfate and in the 4-O-sulfation of non-reducing N-acetylgalactosamine residues, respectively.
T7 1006-1176 Sentence denotes A possible role for a hyposulfated chondroitin in PrP(Sc) accumulation was evidenced at the protein level and by determination of chondroitin and heparan sulfate amounts.
T8 1177-1407 Sentence denotes Treatment of Sc-GT1 cells with a heparan mimetic (HM2602) induced an important reduction of the amount of PrP(Sc), associated with a total reversion of the transcription pattern of the N-acetylgalactosamine-4-O-sulfotransferase 8.
T9 1408-1497 Sentence denotes It suggests a link between the genetic control of 4-O-sulfation and PrP(Sc) accumulation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 899-910 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T2 960-981 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine
T3 1041-1052 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T4 1136-1147 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T5 1362-1383 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 556-568 http://purl.obolibrary.org/obo/MAT_0000112 denotes hypothalamus

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 899-910 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
T2 1041-1052 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
T3 1136-1147 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
T4 1152-1167 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 41-46 Protein denotes prion
T2 57-62 Protein denotes PrPSc
T3 262-275 Protein denotes prion protein
T4 277-283 Protein denotes PrP(C)
T5 317-324 Protein denotes PrP(Sc)
T6 413-420 Protein denotes PrP(Sc)
T7 533-538 Protein denotes prion
T8 757-762 Protein denotes ChGn1
T9 767-772 Protein denotes Chst8
T10 810-815 Protein denotes prion
T11 832-837 Protein denotes ChGn1
T12 842-847 Protein denotes Chst8
T13 1056-1063 Protein denotes PrP(Sc)
T14 1283-1290 Protein denotes PrP(Sc)
T15 1362-1406 Protein denotes N-acetylgalactosamine-4-O-sulfotransferase 8
T16 1476-1483 Protein denotes PrP(Sc)

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 41-55 Disease denotes prion diseases http://purl.obolibrary.org/obo/MONDO_0005429
T2 79-86 Disease denotes scrapie http://purl.obolibrary.org/obo/MONDO_0006961

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 556-568 Body_part denotes hypothalamus http://purl.obolibrary.org/obo/MAT_0000112

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 133-139 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 899-910 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T3 1041-1052 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T4 1136-1147 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T5 1152-1167 Glycan denotes heparan sulfate https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 899-910 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 1041-1052 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T3 1136-1147 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T4 1152-1167 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 41-55 Disease denotes prion diseases http://purl.obolibrary.org/obo/MONDO_0005429
T2 79-86 Disease denotes scrapie http://purl.obolibrary.org/obo/MONDO_0006961

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 556-568 Body_part denotes hypothalamus http://purl.obolibrary.org/obo/UBERON_0001898

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 556-568 Body_part denotes hypothalamus http://purl.obolibrary.org/obo/MAT_0000112

sentences

Id Subject Object Predicate Lexical cue
T1 0-56 Sentence denotes Glycosylation-related gene expression in prion diseases:
T2 57-160 Sentence denotes PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation.
T3 161-334 Sentence denotes Several lines of evidence indicate that some glycoconjugates are efficient effectors of the cellular prion protein (PrP(C)) conversion into its pathogenic (PrP(Sc)) isoform.
T4 335-672 Sentence denotes To assess how glycoconjugate glycan moieties participate in the biogenesis of PrP(Sc), an exhaustive comparative analysis of the expression of about 200 glycosylation-related genes was performed on prion-infected or not, hypothalamus-derived GT1 cells by hybridization of DNA microarrays, semiquantitative RT-PCR, and biochemical assays.
T5 673-831 Sentence denotes A significant up- (30-fold) and down- (17-fold) regulation of the expression of the ChGn1 and Chst8 genes, respectively, was observed in prion-infected cells.
T6 832-1005 Sentence denotes ChGn1 and Chst8 are involved in the initiation of the synthesis of chondroitin sulfate and in the 4-O-sulfation of non-reducing N-acetylgalactosamine residues, respectively.
T7 1006-1176 Sentence denotes A possible role for a hyposulfated chondroitin in PrP(Sc) accumulation was evidenced at the protein level and by determination of chondroitin and heparan sulfate amounts.
T8 1177-1407 Sentence denotes Treatment of Sc-GT1 cells with a heparan mimetic (HM2602) induced an important reduction of the amount of PrP(Sc), associated with a total reversion of the transcription pattern of the N-acetylgalactosamine-4-O-sulfotransferase 8.
T9 1408-1497 Sentence denotes It suggests a link between the genetic control of 4-O-sulfation and PrP(Sc) accumulation.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-56 Sentence denotes Glycosylation-related gene expression in prion diseases:
T2 57-160 Sentence denotes PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation.
T3 161-334 Sentence denotes Several lines of evidence indicate that some glycoconjugates are efficient effectors of the cellular prion protein (PrP(C)) conversion into its pathogenic (PrP(Sc)) isoform.
T4 335-672 Sentence denotes To assess how glycoconjugate glycan moieties participate in the biogenesis of PrP(Sc), an exhaustive comparative analysis of the expression of about 200 glycosylation-related genes was performed on prion-infected or not, hypothalamus-derived GT1 cells by hybridization of DNA microarrays, semiquantitative RT-PCR, and biochemical assays.
T5 673-831 Sentence denotes A significant up- (30-fold) and down- (17-fold) regulation of the expression of the ChGn1 and Chst8 genes, respectively, was observed in prion-infected cells.
T6 832-1005 Sentence denotes ChGn1 and Chst8 are involved in the initiation of the synthesis of chondroitin sulfate and in the 4-O-sulfation of non-reducing N-acetylgalactosamine residues, respectively.
T7 1006-1176 Sentence denotes A possible role for a hyposulfated chondroitin in PrP(Sc) accumulation was evidenced at the protein level and by determination of chondroitin and heparan sulfate amounts.
T8 1177-1407 Sentence denotes Treatment of Sc-GT1 cells with a heparan mimetic (HM2602) induced an important reduction of the amount of PrP(Sc), associated with a total reversion of the transcription pattern of the N-acetylgalactosamine-4-O-sulfotransferase 8.
T9 1408-1497 Sentence denotes It suggests a link between the genetic control of 4-O-sulfation and PrP(Sc) accumulation.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 133-139 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 899-910 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T3 1041-1052 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T4 1136-1147 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T5 1152-1167 Glycan denotes heparan sulfate https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 899-910 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 1041-1052 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T3 1136-1147 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T4 1152-1167 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 556-568 Body_part denotes hypothalamus http://purl.obolibrary.org/obo/UBERON_0001898