PubMed:15607426 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/15607426","sourcedb":"PubMed","sourceid":"15607426","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/15607426","text":"Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.\nWe report the molecular cloning of SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. The gene SLC35D2 maps to chromosome 9q22.33. SLC35D2 cDNA codes for a hydrophobic protein consisting of 337 amino acid residues with 10 putative transmembrane helices. Northern blot analysis revealed the SLC35D2 mRNA as a single major band corresponding to 2.0 kb in length. SLC35D2 was localized in the Golgi membrane and exhibited around 50% similarity with three nucleotide sugar transporters: human SLC35D1 (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter), fruitfly fringe connection (frc) transporter, and nematode SQV-7 transporter, the latter two being involved in developmental and organogenetic processes. Heterologous expression of SLC35D2 protein in yeast indicated that UDP-N-acetylglucosamine is a candidate for the substrate(s) of the transporter. The sequence similarity, subcellular localization, and transporting substrate suggest that SLC35D2 is a good candidate for the ortholog of frc transporter, which is involved in the Notch signaling system by providing the fringe N-acetylglucosaminyltransferase with the substrate. We also describe the identification and categorization of the human SLC35 gene family.","tracks":[{"project":"ggdb-test","denotations":[{"id":"T1","span":{"begin":80,"end":87},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T2","span":{"begin":189,"end":196},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T3","span":{"begin":272,"end":279},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T4","span":{"begin":308,"end":315},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T5","span":{"begin":467,"end":474},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T6","span":{"begin":538,"end":545},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T7","span":{"begin":666,"end":673},"obj":"https://acgg.asia/db/ggdb/info/gg177"},{"id":"T8","span":{"begin":916,"end":923},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T9","span":{"begin":1127,"end":1134},"obj":"https://acgg.asia/db/ggdb/info/gg180"}],"attributes":[{"subj":"T1","pred":"source","obj":"ggdb-test"},{"subj":"T2","pred":"source","obj":"ggdb-test"},{"subj":"T3","pred":"source","obj":"ggdb-test"},{"subj":"T4","pred":"source","obj":"ggdb-test"},{"subj":"T5","pred":"source","obj":"ggdb-test"},{"subj":"T6","pred":"source","obj":"ggdb-test"},{"subj":"T7","pred":"source","obj":"ggdb-test"},{"subj":"T8","pred":"source","obj":"ggdb-test"},{"subj":"T9","pred":"source","obj":"ggdb-test"}]},{"project":"GGDB-2020","denotations":[{"id":"T1","span":{"begin":80,"end":87},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T2","span":{"begin":189,"end":196},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T3","span":{"begin":272,"end":279},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T4","span":{"begin":308,"end":315},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T5","span":{"begin":467,"end":474},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T6","span":{"begin":538,"end":545},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T7","span":{"begin":666,"end":673},"obj":"https://acgg.asia/db/ggdb/info/gg177"},{"id":"T8","span":{"begin":916,"end":923},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"T9","span":{"begin":1127,"end":1134},"obj":"https://acgg.asia/db/ggdb/info/gg180"}],"attributes":[{"subj":"T1","pred":"source","obj":"GGDB-2020"},{"subj":"T2","pred":"source","obj":"GGDB-2020"},{"subj":"T3","pred":"source","obj":"GGDB-2020"},{"subj":"T4","pred":"source","obj":"GGDB-2020"},{"subj":"T5","pred":"source","obj":"GGDB-2020"},{"subj":"T6","pred":"source","obj":"GGDB-2020"},{"subj":"T7","pred":"source","obj":"GGDB-2020"},{"subj":"T8","pred":"source","obj":"GGDB-2020"},{"subj":"T9","pred":"source","obj":"GGDB-2020"}]},{"project":"glycogenes","denotations":[{"id":"PD-GlycoGenes20190927-B_T1","span":{"begin":80,"end":87},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"PD-GlycoGenes20190927-B_T2","span":{"begin":189,"end":196},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"PD-GlycoGenes20190927-B_T3","span":{"begin":272,"end":279},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"PD-GlycoGenes20190927-B_T4","span":{"begin":308,"end":315},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"PD-GlycoGenes20190927-B_T5","span":{"begin":467,"end":474},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"PD-GlycoGenes20190927-B_T6","span":{"begin":538,"end":545},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"PD-GlycoGenes20190927-B_T7","span":{"begin":666,"end":673},"obj":"https://acgg.asia/db/ggdb/info/gg177"},{"id":"PD-GlycoGenes20190927-B_T8","span":{"begin":916,"end":923},"obj":"https://acgg.asia/db/ggdb/info/gg180"},{"id":"PD-GlycoGenes20190927-B_T9","span":{"begin":1127,"end":1134},"obj":"https://acgg.asia/db/ggdb/info/gg180"}],"attributes":[{"subj":"PD-GlycoGenes20190927-B_T1","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T2","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T3","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T4","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T5","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T6","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T7","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T8","pred":"source","obj":"glycogenes"},{"subj":"PD-GlycoGenes20190927-B_T9","pred":"source","obj":"glycogenes"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"ggdb-test","color":"#93d6ec","default":true},{"id":"GGDB-2020","color":"#ece893"},{"id":"glycogenes","color":"#ce93ec"}]}]}}