PubMed:15603661 JSONTXT

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"15603661-7#75#80#geners1800562","span":{"begin":1016,"end":1021},"obj":"geners1800562"},{"id":"15603661-7#51#66#diseaseC0018995","span":{"begin":992,"end":1007},"obj":"diseaseC0018995"},{"id":"15603661-7#51#66#diseaseC3469186","span":{"begin":992,"end":1007},"obj":"diseaseC3469186"},{"id":"15603661-7#148#163#diseaseC0240066","span":{"begin":1089,"end":1104},"obj":"diseaseC0240066"}],"relations":[{"id":"75#80#geners180056251#66#diseaseC0018995","pred":"associated_with","subj":"15603661-7#75#80#geners1800562","obj":"15603661-7#51#66#diseaseC0018995"},{"id":"75#80#geners180056251#66#diseaseC3469186","pred":"associated_with","subj":"15603661-7#75#80#geners1800562","obj":"15603661-7#51#66#diseaseC3469186"},{"id":"75#80#geners1800562148#163#diseaseC0240066","pred":"associated_with","subj":"15603661-7#75#80#geners1800562","obj":"15603661-7#148#163#diseaseC0240066"}],"text":"Hemochromatosis, HFE C282Y homozygosity, and bariatric surgery: report of three cases.\nBACKGROUND: Iron absorption is decreased in some individuals who have undergone bariatric surgery.\nMETHODS: We evaluated measures of iron metabolism and therapeutic phlebotomy in 3 adults with hemochromatosis and HFE C282Y homozygosity who underwent bariatric surgery.\nRESULTS: 1 male and 1 female had surgery before diagnosis of hemochromatosis (jejuno-ileal bypass and Roux-en-Y gastric bypass, respectively); neither had iron overload. Another man was treated with serial phlebotomy to induce iron depletion; later, he underwent Roux-en-Y gastric bypass. His maintenance phlebotomy requirement for hemochromatosis decreased substantially (on average approximately 1 unit each 71 days before surgery, and approximately 1 unit each 173 days after surgery). None of these patients developed iron deficiency, and none took supplemental iron.\nCONCLUSIONS: Iron absorption is decreased in some patients with hemochromatosis and HFE C282Y homozygosity after bariatric surgery, but their risk of developing iron deficiency may be diminished."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"15603661-7#71#74#gene3077","span":{"begin":1012,"end":1015},"obj":"gene3077"},{"id":"15603661-7#51#66#diseaseC0018995","span":{"begin":992,"end":1007},"obj":"diseaseC0018995"},{"id":"15603661-7#51#66#diseaseC3469186","span":{"begin":992,"end":1007},"obj":"diseaseC3469186"},{"id":"15603661-7#148#163#diseaseC0240066","span":{"begin":1089,"end":1104},"obj":"diseaseC0240066"}],"relations":[{"id":"71#74#gene307751#66#diseaseC0018995","pred":"associated_with","subj":"15603661-7#71#74#gene3077","obj":"15603661-7#51#66#diseaseC0018995"},{"id":"71#74#gene307751#66#diseaseC3469186","pred":"associated_with","subj":"15603661-7#71#74#gene3077","obj":"15603661-7#51#66#diseaseC3469186"},{"id":"71#74#gene3077148#163#diseaseC0240066","pred":"associated_with","subj":"15603661-7#71#74#gene3077","obj":"15603661-7#148#163#diseaseC0240066"}],"text":"Hemochromatosis, HFE C282Y homozygosity, and bariatric surgery: report of three cases.\nBACKGROUND: Iron absorption is decreased in some individuals who have undergone bariatric surgery.\nMETHODS: We evaluated measures of iron metabolism and therapeutic phlebotomy in 3 adults with hemochromatosis and HFE C282Y homozygosity who underwent bariatric surgery.\nRESULTS: 1 male and 1 female had surgery before diagnosis of hemochromatosis (jejuno-ileal bypass and Roux-en-Y gastric bypass, respectively); neither had iron overload. Another man was treated with serial phlebotomy to induce iron depletion; later, he underwent Roux-en-Y gastric bypass. His maintenance phlebotomy requirement for hemochromatosis decreased substantially (on average approximately 1 unit each 71 days before surgery, and approximately 1 unit each 173 days after surgery). None of these patients developed iron deficiency, and none took supplemental iron.\nCONCLUSIONS: Iron absorption is decreased in some patients with hemochromatosis and HFE C282Y homozygosity after bariatric surgery, but their risk of developing iron deficiency may be diminished."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":300,"end":303},"obj":"gene:3077"},{"id":"T1","span":{"begin":280,"end":295},"obj":"disease:C0018995"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Hemochromatosis, HFE C282Y homozygosity, and bariatric surgery: report of three cases.\nBACKGROUND: Iron absorption is decreased in some individuals who have undergone bariatric surgery.\nMETHODS: We evaluated measures of iron metabolism and therapeutic phlebotomy in 3 adults with hemochromatosis and HFE C282Y homozygosity who underwent bariatric surgery.\nRESULTS: 1 male and 1 female had surgery before diagnosis of hemochromatosis (jejuno-ileal bypass and Roux-en-Y gastric bypass, respectively); neither had iron overload. Another man was treated with serial phlebotomy to induce iron depletion; later, he underwent Roux-en-Y gastric bypass. His maintenance phlebotomy requirement for hemochromatosis decreased substantially (on average approximately 1 unit each 71 days before surgery, and approximately 1 unit each 173 days after surgery). None of these patients developed iron deficiency, and none took supplemental iron.\nCONCLUSIONS: Iron absorption is decreased in some patients with hemochromatosis and HFE C282Y homozygosity after bariatric surgery, but their risk of developing iron deficiency may be diminished."}