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PubMed:15599941 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1249 21-46 GeneOrGeneProduct denotes prostate specific antigen NCBIGene:354
1250 74-91 GeneOrGeneProduct denotes androgen receptor NCBIGene:367
1251 117-132 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
1252 198-223 GeneOrGeneProduct denotes prostate specific antigen NCBIGene:354
1253 225-228 GeneOrGeneProduct denotes PSA NCBIGene:354
1254 243-258 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
1255 260-262 DiseaseOrPhenotypicFeature denotes PC MESH:D011471
1256 274-277 GeneOrGeneProduct denotes PSA NCBIGene:354
1257 294-297 SequenceVariant denotes G/A c|SUB|G||A
1258 318-326 ChemicalEntity denotes androgen MESH:D000728
1259 364-381 GeneOrGeneProduct denotes androgen receptor NCBIGene:367
1260 383-385 GeneOrGeneProduct denotes AR NCBIGene:367
1261 518-520 DiseaseOrPhenotypicFeature denotes PC MESH:D011471
1262 541-543 DiseaseOrPhenotypicFeature denotes PC MESH:D011471
1263 555-558 GeneOrGeneProduct denotes PSA NCBIGene:354
1264 608-610 GeneOrGeneProduct denotes AR NCBIGene:367
1265 666-668 DiseaseOrPhenotypicFeature denotes PC MESH:D011471
1266 669-677 OrganismTaxon denotes patients NCBITaxon:9606
1267 710-737 DiseaseOrPhenotypicFeature denotes benign prostate hyperplasia MESH:D011470
1268 826-829 GeneOrGeneProduct denotes PSA NCBIGene:354
1269 895-900 GeneOrGeneProduct denotes Nhe 1 NCBIGene:6548
1270 935-938 SequenceVariant denotes G/A c|SUB|G||A
1271 948-950 GeneOrGeneProduct denotes AR NCBIGene:367
1272 951-969 SequenceVariant denotes CAG and GGC repeat c|DUP||CAG_GGC|
1273 1076-1079 GeneOrGeneProduct denotes PSA NCBIGene:354
1274 1099-1101 DiseaseOrPhenotypicFeature denotes PC MESH:D011471
1275 1120-1148 DiseaseOrPhenotypicFeature denotes benign prostatic hyperplasia MESH:D011470
1276 1150-1153 DiseaseOrPhenotypicFeature denotes BPH MESH:D011470
1277 1276-1279 OrganismTaxon denotes men NCBITaxon:9606
1278 1329-1332 GeneOrGeneProduct denotes PSA NCBIGene:354
1279 1368-1378 SequenceVariant denotes CAG repeat c|DUP||CAG|
1280 1415-1418 DiseaseOrPhenotypicFeature denotes BPH MESH:D011470
1281 1552-1555 GeneOrGeneProduct denotes PSA NCBIGene:354
1282 1601-1603 DiseaseOrPhenotypicFeature denotes PC MESH:D011471
1283 1629-1632 OrganismTaxon denotes men NCBITaxon:9606
1284 1685-1701 SequenceVariant denotes glutamine repeat c|DUP||G|
1285 1770-1787 DiseaseOrPhenotypicFeature denotes malignant disease MESH:D009369

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer.
T2 134-145 Sentence denotes BACKGROUND:
T3 146-269 Sentence denotes Recent data has suggested that polymorphisms in the prostate specific antigen (PSA) may increase prostate cancer (PC) risk.
T4 270-359 Sentence denotes The PSA gene contains a G/A substitution in the androgen response element (ARE) 1 region.
T5 360-526 Sentence denotes The androgen receptor (AR) gene has polymorphic regions containing variable length glutamine and glycine repeats and these are believed to be associated with PC risk.
T6 527-644 Sentence denotes The effect on PC risks from PSA polymorphisms alone and synergistically with the AR gene was examined in this report.
T7 645-653 Sentence denotes METHODS:
T8 654-792 Sentence denotes One hundred PC patients and an age matched cohort of 79 benign prostate hyperplasia and 67 population controls were entered in this study.
T9 793-867 Sentence denotes DNA was extracted from blood and PSA/ARE promoter region amplified by PCR.
T10 868-947 Sentence denotes PCR products were cut with Nhe 1 restriction enzyme to distinguish G/A alleles.
T11 948-1034 Sentence denotes AR/CAG and GGC repeat length was detected by automated fluorescence from PCR products.
T12 1035-1043 Sentence denotes RESULTS:
T13 1044-1202 Sentence denotes We found a significantly higher PSA/GG distribution in PC (30%) than either benign prostatic hyperplasia (BPH) (18%) or population controls (16%) (P = 0.025).
T14 1203-1309 Sentence denotes Furthermore the GG distribution within cases was even greater in younger men (< 65 years; 42%; P = 0.012).
T15 1310-1508 Sentence denotes Additionally, when PSA genotype was cross classified with CAG repeat, significantly more cases than both BPH and population controls were observed to have a short (< 22) CAG/GG genotype (P = 0.006).
T16 1509-1521 Sentence denotes CONCLUSIONS:
T17 1522-1633 Sentence denotes Our results indicate that the PSA/ARE GG genotype confers an increased risk of PC especially among younger men.
T18 1634-1788 Sentence denotes Moreover, we confirm previous results that a short glutamine repeat in conjunction with GG genotype significantly increases the risk of malignant disease.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 21-29 DiseaseOrPhenotypicFeature denotes prostate 0005280
T2 117-132 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T3 126-132 DiseaseOrPhenotypicFeature denotes cancer 0004992
T4 198-206 DiseaseOrPhenotypicFeature denotes prostate 0005280
T5 243-258 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T6 252-258 DiseaseOrPhenotypicFeature denotes cancer 0004992
T7 710-737 DiseaseOrPhenotypicFeature denotes benign prostate hyperplasia 0010811
T8 726-737 DiseaseOrPhenotypicFeature denotes hyperplasia 0005043
T9 770-777 DiseaseOrPhenotypicFeature denotes entered 0043579
T10 1120-1148 DiseaseOrPhenotypicFeature denotes benign prostatic hyperplasia 0010811
T11 1137-1148 DiseaseOrPhenotypicFeature denotes hyperplasia 0005043
T12 1705-1716 DiseaseOrPhenotypicFeature denotes conjunction 0003799

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 39-46 GeneOrGeneProduct denotes antigen
T2 74-91 GeneOrGeneProduct denotes androgen receptor
T3 216-223 GeneOrGeneProduct denotes antigen
T4 225-228 GeneOrGeneProduct denotes PSA
T5 274-277 GeneOrGeneProduct denotes PSA
T6 364-381 GeneOrGeneProduct denotes androgen receptor
T7 383-385 GeneOrGeneProduct denotes AR
T8 443-452 GeneOrGeneProduct denotes glutamine
T9 555-558 GeneOrGeneProduct denotes PSA
T10 608-610 GeneOrGeneProduct denotes AR
T11 645-652 GeneOrGeneProduct denotes METHODS
T12 826-829 GeneOrGeneProduct denotes PSA
T13 872-880 GeneOrGeneProduct denotes products
T14 886-889 GeneOrGeneProduct denotes cut
T15 895-900 GeneOrGeneProduct denotes Nhe 1
T16 913-919 GeneOrGeneProduct denotes enzyme
T17 948-950 GeneOrGeneProduct denotes AR
T18 951-954 GeneOrGeneProduct denotes CAG
T19 1025-1033 GeneOrGeneProduct denotes products
T20 1076-1079 GeneOrGeneProduct denotes PSA
T21 1096-1101 GeneOrGeneProduct denotes in PC
T22 1155-1163 GeneOrGeneProduct denotes (18%) or
T23 1242-1247 GeneOrGeneProduct denotes cases
T24 1252-1256 GeneOrGeneProduct denotes even
T25 1286-1291 GeneOrGeneProduct denotes years
T26 1329-1332 GeneOrGeneProduct denotes PSA
T27 1368-1371 GeneOrGeneProduct denotes CAG
T28 1399-1404 GeneOrGeneProduct denotes cases
T29 1480-1483 GeneOrGeneProduct denotes CAG
T30 1552-1555 GeneOrGeneProduct denotes PSA
T31 1685-1694 GeneOrGeneProduct denotes glutamine

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 39-46 GeneOrGeneProduct denotes antigen
T2 74-91 GeneOrGeneProduct denotes androgen receptor
T3 216-223 GeneOrGeneProduct denotes antigen
T4 225-228 GeneOrGeneProduct denotes PSA
T5 274-277 GeneOrGeneProduct denotes PSA
T6 364-381 GeneOrGeneProduct denotes androgen receptor
T7 383-385 GeneOrGeneProduct denotes AR
T8 443-452 GeneOrGeneProduct denotes glutamine
T9 555-558 GeneOrGeneProduct denotes PSA
T10 608-610 GeneOrGeneProduct denotes AR
T11 826-829 GeneOrGeneProduct denotes PSA
T12 895-900 GeneOrGeneProduct denotes Nhe 1
T13 913-919 GeneOrGeneProduct denotes enzyme
T14 948-950 GeneOrGeneProduct denotes AR
T15 1076-1079 GeneOrGeneProduct denotes PSA
T16 1252-1256 GeneOrGeneProduct denotes even
T17 1329-1332 GeneOrGeneProduct denotes PSA
T18 1552-1555 GeneOrGeneProduct denotes PSA
T19 1685-1694 GeneOrGeneProduct denotes glutamine

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 74-82 DiseaseOrPhenotypicFeature denotes androgen D014770
T2 117-132 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T3 243-258 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T4 260-262 DiseaseOrPhenotypicFeature denotes PC D011471
T5 318-326 DiseaseOrPhenotypicFeature denotes androgen D014770
T6 364-372 DiseaseOrPhenotypicFeature denotes androgen D014770
T7 518-520 DiseaseOrPhenotypicFeature denotes PC D011471
T8 541-543 DiseaseOrPhenotypicFeature denotes PC D011471
T9 666-668 DiseaseOrPhenotypicFeature denotes PC D011471
T10 710-737 DiseaseOrPhenotypicFeature denotes benign prostate hyperplasia D011470
T11 1099-1101 DiseaseOrPhenotypicFeature denotes PC D011471
T12 1120-1148 DiseaseOrPhenotypicFeature denotes benign prostatic hyperplasia D011470
T13 1601-1603 DiseaseOrPhenotypicFeature denotes PC D011471
T14 1770-1779 DiseaseOrPhenotypicFeature denotes malignant D009369
T15 1780-1787 DiseaseOrPhenotypicFeature denotes disease D004194

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 21-46 GeneOrGeneProduct denotes prostate specific antigen
T2 74-91 GeneOrGeneProduct denotes androgen receptor
T3 198-223 GeneOrGeneProduct denotes prostate specific antigen
T4 225-228 GeneOrGeneProduct denotes PSA
T5 274-277 GeneOrGeneProduct denotes PSA
T6 364-381 GeneOrGeneProduct denotes androgen receptor
T7 383-385 GeneOrGeneProduct denotes AR
T8 555-558 GeneOrGeneProduct denotes PSA
T9 608-610 GeneOrGeneProduct denotes AR
T10 826-829 GeneOrGeneProduct denotes PSA
T11 895-900 GeneOrGeneProduct denotes Nhe 1
T12 948-950 GeneOrGeneProduct denotes AR
T13 1076-1079 GeneOrGeneProduct denotes PSA
T14 1329-1332 GeneOrGeneProduct denotes PSA
T15 1552-1555 GeneOrGeneProduct denotes PSA

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 117-132 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T2 243-258 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T3 260-262 DiseaseOrPhenotypicFeature denotes PC 0016471|0008315
T5 518-520 DiseaseOrPhenotypicFeature denotes PC 0016471|0008315
T7 541-543 DiseaseOrPhenotypicFeature denotes PC 0016471|0008315
T9 666-668 DiseaseOrPhenotypicFeature denotes PC 0016471|0008315
T11 710-737 DiseaseOrPhenotypicFeature denotes benign prostate hyperplasia 0010811
T12 1099-1101 DiseaseOrPhenotypicFeature denotes PC 0016471|0008315
T14 1120-1148 DiseaseOrPhenotypicFeature denotes benign prostatic hyperplasia 0010811
T15 1150-1153 DiseaseOrPhenotypicFeature denotes BPH 0010811
T16 1276-1279 DiseaseOrPhenotypicFeature denotes men 0017169
T17 1415-1418 DiseaseOrPhenotypicFeature denotes BPH 0010811
T18 1601-1603 DiseaseOrPhenotypicFeature denotes PC 0016471|0008315
T20 1629-1632 DiseaseOrPhenotypicFeature denotes men 0017169

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 117-132 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T2 243-258 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T3 260-262 DiseaseOrPhenotypicFeature denotes PC D011471
T4 518-520 DiseaseOrPhenotypicFeature denotes PC D011471
T5 541-543 DiseaseOrPhenotypicFeature denotes PC D011471
T6 666-668 DiseaseOrPhenotypicFeature denotes PC D011471
T7 710-737 DiseaseOrPhenotypicFeature denotes benign prostate hyperplasia D011470
T8 1099-1101 DiseaseOrPhenotypicFeature denotes PC D011471
T9 1120-1148 DiseaseOrPhenotypicFeature denotes benign prostatic hyperplasia D011470
T10 1150-1153 DiseaseOrPhenotypicFeature denotes BPH DISEASE|D011470
T12 1415-1418 DiseaseOrPhenotypicFeature denotes BPH DISEASE|D011470
T14 1601-1603 DiseaseOrPhenotypicFeature denotes PC D011471
T15 1780-1787 DiseaseOrPhenotypicFeature denotes disease D004194

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 117-132 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T2 243-258 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T3 260-262 DiseaseOrPhenotypicFeature denotes PC D011471
T4 518-520 DiseaseOrPhenotypicFeature denotes PC D011471
T5 541-543 DiseaseOrPhenotypicFeature denotes PC D011471
T6 666-668 DiseaseOrPhenotypicFeature denotes PC D011471
T7 710-737 DiseaseOrPhenotypicFeature denotes benign prostate hyperplasia D011470
T8 1099-1101 DiseaseOrPhenotypicFeature denotes PC D011471
T9 1120-1148 DiseaseOrPhenotypicFeature denotes benign prostatic hyperplasia D011470
T10 1150-1153 DiseaseOrPhenotypicFeature denotes BPH DISEASE|D011470
T12 1415-1418 DiseaseOrPhenotypicFeature denotes BPH DISEASE|D011470
T14 1601-1603 DiseaseOrPhenotypicFeature denotes PC D011471

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 74-82 ChemicalEntity denotes androgen ChemicalEntity
T2 225-228 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T3 274-277 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T4 318-326 ChemicalEntity denotes androgen ChemicalEntity
T5 364-372 ChemicalEntity denotes androgen ChemicalEntity
T6 443-452 ChemicalEntity denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T7 457-464 ChemicalEntity denotes glycine http://purl.obolibrary.org/obo/CHEBI_57305|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_15428
T10 555-558 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T11 826-829 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T12 1076-1079 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T13 1329-1332 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T14 1552-1555 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T15 1685-1694 ChemicalEntity denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 669-677 OrganismTaxon denotes patients
T2 1276-1279 OrganismTaxon denotes men
T3 1629-1632 OrganismTaxon denotes men

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T15 1685-1694 ChemicalEntity denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T14 1552-1555 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T13 1329-1332 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T12 1076-1079 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T11 826-829 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T10 555-558 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T7 457-464 ChemicalEntity denotes glycine http://purl.obolibrary.org/obo/CHEBI_15428|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_57305
T6 443-452 ChemicalEntity denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T5 364-372 ChemicalEntity denotes androgen ChemicalEntity
T4 318-326 ChemicalEntity denotes androgen ChemicalEntity
T3 274-277 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T2 225-228 ChemicalEntity denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T1 74-82 ChemicalEntity denotes androgen ChemicalEntity
T23595 1552-1555 GeneOrGeneProduct denotes PSA
T6734 1329-1332 GeneOrGeneProduct denotes PSA
T26821 1076-1079 GeneOrGeneProduct denotes PSA
T48100 948-950 GeneOrGeneProduct denotes AR
T9609 895-900 GeneOrGeneProduct denotes Nhe 1
T62726 826-829 GeneOrGeneProduct denotes PSA
T9 608-610 GeneOrGeneProduct denotes AR
T8 555-558 GeneOrGeneProduct denotes PSA
T76466 383-385 GeneOrGeneProduct denotes AR
T88648 364-381 GeneOrGeneProduct denotes androgen receptor
T18911 274-277 GeneOrGeneProduct denotes PSA
T38986 225-228 GeneOrGeneProduct denotes PSA
T11854 198-223 GeneOrGeneProduct denotes prostate specific antigen
T30784 74-91 GeneOrGeneProduct denotes androgen receptor
T72372 21-46 GeneOrGeneProduct denotes prostate specific antigen
T54963 1601-1603 DiseaseOrPhenotypicFeature denotes PC D011471
T40161 1415-1418 DiseaseOrPhenotypicFeature denotes BPH D011470|DISEASE
T7956 1150-1153 DiseaseOrPhenotypicFeature denotes BPH D011470|DISEASE
T12008 1120-1148 DiseaseOrPhenotypicFeature denotes benign prostatic hyperplasia D011470
T4307 1099-1101 DiseaseOrPhenotypicFeature denotes PC D011471
T55191 710-737 DiseaseOrPhenotypicFeature denotes benign prostate hyperplasia D011470
T27431 666-668 DiseaseOrPhenotypicFeature denotes PC D011471
T18017 541-543 DiseaseOrPhenotypicFeature denotes PC D011471
T74900 518-520 DiseaseOrPhenotypicFeature denotes PC D011471
T47311 260-262 DiseaseOrPhenotypicFeature denotes PC D011471
T37973 243-258 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T86746 117-132 DiseaseOrPhenotypicFeature denotes prostate cancer D011471
T91015 1629-1632 OrganismTaxon denotes men
T64648 1276-1279 OrganismTaxon denotes men
T43479 669-677 OrganismTaxon denotes patients

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15599941-0#21#46#gene354 21-46 gene354 denotes prostate specific antigen
15599941-0#74#91#gene367 74-91 gene367 denotes androgen receptor
15599941-0#117#132#diseaseC0376358 117-132 diseaseC0376358 denotes prostate cancer
15599941-0#117#132#diseaseC0600139 117-132 diseaseC0600139 denotes prostate cancer
15599941-0#117#132#diseaseC0376358 117-132 diseaseC0376358 denotes prostate cancer
15599941-0#117#132#diseaseC0600139 117-132 diseaseC0600139 denotes prostate cancer
15599941-11#19#22#gene354 1329-1332 gene354 denotes PSA
15599941-11#105#108#diseaseC1704272 1415-1418 diseaseC1704272 denotes BPH
21#46#gene354117#132#diseaseC0376358 15599941-0#21#46#gene354 15599941-0#117#132#diseaseC0376358 associated_with prostate specific antigen,prostate cancer
21#46#gene354117#132#diseaseC0600139 15599941-0#21#46#gene354 15599941-0#117#132#diseaseC0600139 associated_with prostate specific antigen,prostate cancer
21#46#gene354117#132#diseaseC0376358 15599941-0#21#46#gene354 15599941-0#117#132#diseaseC0376358 associated_with prostate specific antigen,prostate cancer
21#46#gene354117#132#diseaseC0600139 15599941-0#21#46#gene354 15599941-0#117#132#diseaseC0600139 associated_with prostate specific antigen,prostate cancer
74#91#gene367117#132#diseaseC0376358 15599941-0#74#91#gene367 15599941-0#117#132#diseaseC0376358 associated_with androgen receptor,prostate cancer
74#91#gene367117#132#diseaseC0600139 15599941-0#74#91#gene367 15599941-0#117#132#diseaseC0600139 associated_with androgen receptor,prostate cancer
74#91#gene367117#132#diseaseC0376358 15599941-0#74#91#gene367 15599941-0#117#132#diseaseC0376358 associated_with androgen receptor,prostate cancer
74#91#gene367117#132#diseaseC0600139 15599941-0#74#91#gene367 15599941-0#117#132#diseaseC0600139 associated_with androgen receptor,prostate cancer
19#22#gene354105#108#diseaseC1704272 15599941-11#19#22#gene354 15599941-11#105#108#diseaseC1704272 associated_with PSA,BPH

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 294-297 DNAMutation:|SUB|G||A denotes G/A
T2 935-938 DNAMutation:|SUB|G||A denotes G/A

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1552-1555 gene:354 denotes PSA
T1 1601-1603 disease:C0376358 denotes PC
T2 1552-1555 gene:354 denotes PSA
T3 1601-1603 disease:C0600139 denotes PC
R1 T0 T1 associated_with PSA,PC
R2 T2 T3 associated_with PSA,PC