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PubMed:15590773 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 197-204 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 197-204 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 511-518 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 511-518 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 909-915 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T6 1003-1009 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T7 1308-1315 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 1308-1315 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1636-1643 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 1636-1643 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 1735-1742 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1735-1742 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 2090-2097 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 2090-2097 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 197-204 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 511-518 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 909-915 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T6 1003-1009 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T7 1308-1315 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T9 1636-1643 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T11 1735-1742 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T13 2090-2097 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-250 Sentence denotes Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
TextSentencer_T2 251-531 Sentence denotes A linear sulfated fucan with a regular repeating sequence of [3)-alpha-L-Fucp-(2SO4)-(1-->3)-alpha-L-Fucp-(4SO4)-(1-->3)-alpha-L-Fucp-(2,4SO4)-(1-->3)-alpha-L-Fucp-(2SO4)-(1-->]n is an anticoagulant polysaccharide mainly due to thrombin inhibition mediated by heparin cofactor II.
TextSentencer_T3 532-656 Sentence denotes No specific enzymatic or chemical method is available for the preparation of tailored oligosaccharides from sulfated fucans.
TextSentencer_T4 657-767 Sentence denotes We employ an apparently nonspecific approach to cleave this polysaccharide based on mild hydrolysis with acid.
TextSentencer_T5 768-867 Sentence denotes Surprisingly, the linear sulfated fucan was cleaved by mild acid hydrolysis on an ordered sequence.
TextSentencer_T6 868-944 Sentence denotes Initially a 2-sulfate ester of the first fucose unit is selectively removed.
TextSentencer_T7 945-1150 Sentence denotes Thereafter the glycosidic linkage between the nonsulfated fucose residue and the subsequent 4-sulfated residue is preferentially cleaved by acid hydrolysis, forming oligosaccharides with well-defined size.
TextSentencer_T8 1151-1372 Sentence denotes The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.
TextSentencer_T9 1373-1504 Sentence denotes The linear sulfated fucan requires significantly longer chains than mammalian glycosaminoglycans to achieve anticoagulant activity.
TextSentencer_T10 1505-1656 Sentence denotes A slight decrease in the molecular size of the sulfated fucan dramatically reduces its effect on thrombin inactivation mediated by heparin cofactor II.
TextSentencer_T11 1657-1823 Sentence denotes Sulfated fucan with approximately 45 tetrasaccharide repeating units binds to heparin cofactor II but is unable to link efficiently the plasma inhibitor and thrombin.
TextSentencer_T12 1824-1920 Sentence denotes This last effect requires chains with approximately 100 or more tetrasaccharide repeating units.
TextSentencer_T13 1921-2110 Sentence denotes We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II.
T1 0-250 Sentence denotes Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
T2 251-531 Sentence denotes A linear sulfated fucan with a regular repeating sequence of [3)-alpha-L-Fucp-(2SO4)-(1-->3)-alpha-L-Fucp-(4SO4)-(1-->3)-alpha-L-Fucp-(2,4SO4)-(1-->3)-alpha-L-Fucp-(2SO4)-(1-->]n is an anticoagulant polysaccharide mainly due to thrombin inhibition mediated by heparin cofactor II.
T3 532-656 Sentence denotes No specific enzymatic or chemical method is available for the preparation of tailored oligosaccharides from sulfated fucans.
T4 657-767 Sentence denotes We employ an apparently nonspecific approach to cleave this polysaccharide based on mild hydrolysis with acid.
T5 768-867 Sentence denotes Surprisingly, the linear sulfated fucan was cleaved by mild acid hydrolysis on an ordered sequence.
T6 868-944 Sentence denotes Initially a 2-sulfate ester of the first fucose unit is selectively removed.
T7 945-1150 Sentence denotes Thereafter the glycosidic linkage between the nonsulfated fucose residue and the subsequent 4-sulfated residue is preferentially cleaved by acid hydrolysis, forming oligosaccharides with well-defined size.
T8 1151-1372 Sentence denotes The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.
T9 1373-1504 Sentence denotes The linear sulfated fucan requires significantly longer chains than mammalian glycosaminoglycans to achieve anticoagulant activity.
T10 1505-1656 Sentence denotes A slight decrease in the molecular size of the sulfated fucan dramatically reduces its effect on thrombin inactivation mediated by heparin cofactor II.
T11 1657-1823 Sentence denotes Sulfated fucan with approximately 45 tetrasaccharide repeating units binds to heparin cofactor II but is unable to link efficiently the plasma inhibitor and thrombin.
T12 1824-1920 Sentence denotes This last effect requires chains with approximately 100 or more tetrasaccharide repeating units.
T13 1921-2110 Sentence denotes We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II.
T1 0-250 Sentence denotes Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
T2 251-531 Sentence denotes A linear sulfated fucan with a regular repeating sequence of [3)-alpha-L-Fucp-(2SO4)-(1-->3)-alpha-L-Fucp-(4SO4)-(1-->3)-alpha-L-Fucp-(2,4SO4)-(1-->3)-alpha-L-Fucp-(2SO4)-(1-->]n is an anticoagulant polysaccharide mainly due to thrombin inhibition mediated by heparin cofactor II.
T3 532-656 Sentence denotes No specific enzymatic or chemical method is available for the preparation of tailored oligosaccharides from sulfated fucans.
T4 657-767 Sentence denotes We employ an apparently nonspecific approach to cleave this polysaccharide based on mild hydrolysis with acid.
T5 768-867 Sentence denotes Surprisingly, the linear sulfated fucan was cleaved by mild acid hydrolysis on an ordered sequence.
T6 868-944 Sentence denotes Initially a 2-sulfate ester of the first fucose unit is selectively removed.
T7 945-1150 Sentence denotes Thereafter the glycosidic linkage between the nonsulfated fucose residue and the subsequent 4-sulfated residue is preferentially cleaved by acid hydrolysis, forming oligosaccharides with well-defined size.
T8 1151-1372 Sentence denotes The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.
T9 1373-1504 Sentence denotes The linear sulfated fucan requires significantly longer chains than mammalian glycosaminoglycans to achieve anticoagulant activity.
T10 1505-1656 Sentence denotes A slight decrease in the molecular size of the sulfated fucan dramatically reduces its effect on thrombin inactivation mediated by heparin cofactor II.
T11 1657-1823 Sentence denotes Sulfated fucan with approximately 45 tetrasaccharide repeating units binds to heparin cofactor II but is unable to link efficiently the plasma inhibitor and thrombin.
T12 1824-1920 Sentence denotes This last effect requires chains with approximately 100 or more tetrasaccharide repeating units.
T13 1921-2110 Sentence denotes We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 197-204 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 197-204 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 511-518 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 511-518 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 909-915 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T6 1003-1009 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T7 1308-1315 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 1308-1315 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1636-1643 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 1636-1643 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 1735-1742 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1735-1742 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 2090-2097 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 2090-2097 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

uniprot-human

Id Subject Object Predicate Lexical cue
T1 197-216 http://www.uniprot.org/uniprot/P05546 denotes heparin cofactor II
T2 511-530 http://www.uniprot.org/uniprot/P05546 denotes heparin cofactor II
T3 1308-1327 http://www.uniprot.org/uniprot/P05546 denotes heparin cofactor II
T4 1636-1655 http://www.uniprot.org/uniprot/P05546 denotes heparin cofactor II
T5 1735-1754 http://www.uniprot.org/uniprot/P05546 denotes heparin cofactor II
T6 2090-2109 http://www.uniprot.org/uniprot/P05546 denotes heparin cofactor II

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 197-216 http://www.uniprot.org/uniprot/P49182 denotes heparin cofactor II
T2 511-530 http://www.uniprot.org/uniprot/P49182 denotes heparin cofactor II
T3 1308-1327 http://www.uniprot.org/uniprot/P49182 denotes heparin cofactor II
T4 1636-1655 http://www.uniprot.org/uniprot/P49182 denotes heparin cofactor II
T5 1735-1754 http://www.uniprot.org/uniprot/P49182 denotes heparin cofactor II
T6 2090-2109 http://www.uniprot.org/uniprot/P49182 denotes heparin cofactor II

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1952-1961 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

GO-BP

Id Subject Object Predicate Lexical cue
T1 23-45 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T2 227-249 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T3 1481-1503 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T4 51-59 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T5 260-268 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T6 640-648 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T7 793-801 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T8 1039-1047 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T9 1206-1214 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T10 1384-1392 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T11 1552-1560 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T12 97-104 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T13 882-889 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T14 1657-1665 http://purl.obolibrary.org/obo/GO_0051923 denotes Sulfated

GO-MF

Id Subject Object Predicate Lexical cue
T1 1726-1731 http://purl.obolibrary.org/obo/GO_0070026 denotes binds
T2 1726-1731 http://purl.obolibrary.org/obo/GO_0003680 denotes binds
T3 1726-1731 http://purl.obolibrary.org/obo/GO_0017091 denotes binds
T4 1726-1731 http://purl.obolibrary.org/obo/GO_0005488 denotes binds
T5 1726-1742 http://purl.obolibrary.org/obo/GO_0008201 denotes binds to heparin

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 197-204 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T2 511-518 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T3 1308-1315 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T4 1636-1643 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T5 1735-1742 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T6 2090-2097 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1793-1799 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969