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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 152-411 DRI_Background denotes Studies in Dictyostelium discoideum have established that the cycle of myosin II bipolar filament assembly and disassembly controls the temporal and spatial localization of myosin II during critical cellular processes, such as cytokinesis and cell locomotion.
T2 412-567 DRI_Background denotes Myosin heavy chain kinase A (MHCK A) is a key enzyme regulating myosin II filament disassembly through myosin heavy chain phosphorylation in Dictyostelium.
T3 568-830 DRI_Background denotes Under various cellular conditions, MHCK A is recruited to actin-rich cortical sites and is preferentially enriched at sites of pseudopod formation, and thus MHCK A is proposed to play a role in regulating localized disassembly of myosin II filaments in the cell.
T4 831-992 DRI_Background denotes MHCK A possesses an aminoterminal coiled-coil domain that participates in the oligomerization, cellular localization, and actin binding activities of the kinase.
T5 993-1199 DRI_Outcome denotes In the current study, we show that the interaction between the coiled-coil domain of MHCK A and filamentous actin leads to an approximately 40-fold increase in the initial rate of kinase catalytic activity.
T6 1200-1343 DRI_Background denotes Actin-mediated activation of MHCK A involves increased rates of kinase autophosphorylation and requires the presence of the coiled-coil domain.
T7 1344-1554 DRI_Approach denotes Structure-function analyses revealed that the coiled-coil domain alone binds to actin filaments (apparent K(D) = 0.9 microm) and thus mediates the direct interaction with F-actin required for MHCK A activation.
T8 1555-1923 DRI_Challenge denotes Collectively, these results indicate that MHCK A recruitment to actin-rich sites could lead to localized activation of the kinase via direct interaction with actin filaments, and thus this mode of kinase regulation may represent an important mechanism by which the cell achieves localized disassembly of myosin II filaments required for specific changes in cell shape.

sentences

Id Subject Object Predicate Lexical cue
T1 0-151 Sentence denotes Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly.
T2 152-411 Sentence denotes Studies in Dictyostelium discoideum have established that the cycle of myosin II bipolar filament assembly and disassembly controls the temporal and spatial localization of myosin II during critical cellular processes, such as cytokinesis and cell locomotion.
T3 412-567 Sentence denotes Myosin heavy chain kinase A (MHCK A) is a key enzyme regulating myosin II filament disassembly through myosin heavy chain phosphorylation in Dictyostelium.
T4 568-830 Sentence denotes Under various cellular conditions, MHCK A is recruited to actin-rich cortical sites and is preferentially enriched at sites of pseudopod formation, and thus MHCK A is proposed to play a role in regulating localized disassembly of myosin II filaments in the cell.
T5 831-992 Sentence denotes MHCK A possesses an aminoterminal coiled-coil domain that participates in the oligomerization, cellular localization, and actin binding activities of the kinase.
T6 993-1199 Sentence denotes In the current study, we show that the interaction between the coiled-coil domain of MHCK A and filamentous actin leads to an approximately 40-fold increase in the initial rate of kinase catalytic activity.
T7 1200-1343 Sentence denotes Actin-mediated activation of MHCK A involves increased rates of kinase autophosphorylation and requires the presence of the coiled-coil domain.
T8 1344-1554 Sentence denotes Structure-function analyses revealed that the coiled-coil domain alone binds to actin filaments (apparent K(D) = 0.9 microm) and thus mediates the direct interaction with F-actin required for MHCK A activation.
T9 1555-1923 Sentence denotes Collectively, these results indicate that MHCK A recruitment to actin-rich sites could lead to localized activation of the kinase via direct interaction with actin filaments, and thus this mode of kinase regulation may represent an important mechanism by which the cell achieves localized disassembly of myosin II filaments required for specific changes in cell shape.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 51-64 OrganismTaxon denotes Dictyostelium 5782
T2 163-187 OrganismTaxon denotes Dictyostelium discoideum 44689
T3 553-566 OrganismTaxon denotes Dictyostelium 5782

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 351-369 Body_part denotes cellular processes http://purl.obolibrary.org/obo/GO_0042995
T2 695-704 Body_part denotes pseudopod http://purl.obolibrary.org/obo/GO_0031143
T3 1424-1439 Body_part denotes actin filaments http://purl.obolibrary.org/obo/GO_0005884
T4 1713-1728 Body_part denotes actin filaments http://purl.obolibrary.org/obo/GO_0005884