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PubMed:15525819 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 386-393 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X
T2 402-406 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le X
T3 411-416 https://glytoucan.org/Structures/Glycans/G00065MO denotes VIM-2
T4 411-416 https://glytoucan.org/Structures/Glycans/G22418PV denotes VIM-2
T5 902-908 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T6 1085-1089 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le X

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 386-393 Glycan_Motif denotes Lewis X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO
T3 402-406 Glycan_Motif denotes Le X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC
T4 411-416 Glycan_Motif denotes VIM-2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G22418PV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00065MO
T6 902-908 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T7 1085-1089 Glycan_Motif denotes Le X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 386-393 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X
T2 402-406 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le X
T3 411-416 https://glytoucan.org/Structures/Glycans/G00065MO denotes VIM-2
T4 411-416 https://glytoucan.org/Structures/Glycans/G22418PV denotes VIM-2
T5 902-908 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T6 1085-1089 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le X

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
TextSentencer_T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
TextSentencer_T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
TextSentencer_T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
TextSentencer_T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
TextSentencer_T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
TextSentencer_T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
TextSentencer_T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
TextSentencer_T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
TextSentencer_T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
TextSentencer_T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.
T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.
T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 386-393 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis X
T2 411-416 http://www.glycoepitope.jp/epitopes/AN0111 denotes VIM-2
T3 411-416 http://www.glycoepitope.jp/epitopes/EP0019 denotes VIM-2

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.
T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.

uniprot-human

Id Subject Object Predicate Lexical cue
T1 136-164 http://www.uniprot.org/uniprot/Q6P4F1 denotes alpha(1,3)fucosyltransferase
T2 136-164 http://www.uniprot.org/uniprot/Q11128 denotes alpha(1,3)fucosyltransferase
T3 136-164 http://www.uniprot.org/uniprot/Q11130 denotes alpha(1,3)fucosyltransferase
T4 136-164 http://www.uniprot.org/uniprot/P51993 denotes alpha(1,3)fucosyltransferase
T5 136-164 http://www.uniprot.org/uniprot/Q495W5 denotes alpha(1,3)fucosyltransferase
T6 136-164 http://www.uniprot.org/uniprot/P22083 denotes alpha(1,3)fucosyltransferase
T7 136-164 http://www.uniprot.org/uniprot/Q9Y231 denotes alpha(1,3)fucosyltransferase
T8 411-414 http://www.uniprot.org/uniprot/Q8N850 denotes VIM
T9 501-511 http://www.uniprot.org/uniprot/P16581 denotes E-selectin
T10 878-885 http://www.uniprot.org/uniprot/Q9NQQ7 denotes SLC35C2
T11 1064-1071 http://www.uniprot.org/uniprot/Q9NQQ7 denotes SLC35C2
T12 934-940 http://www.uniprot.org/uniprot/Q9NQQ7 denotes CGI-15
T13 898-920 http://www.uniprot.org/uniprot/Q96A29 denotes GDP-fucose transporter

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 501-511 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin
T2 944-950 http://www.uniprot.org/uniprot/Q8VCX2 denotes Ovcov1
T3 953-957 http://www.uniprot.org/uniprot/P41731 denotes Cd63
T4 1180-1184 http://www.uniprot.org/uniprot/P41731 denotes Cd63
T5 1769-1773 http://www.uniprot.org/uniprot/P41731 denotes Cd63
T6 995-1000 http://www.uniprot.org/uniprot/Q9Z2V6 denotes Hdac5
T7 1302-1307 http://www.uniprot.org/uniprot/Q9Z2V6 denotes Hdac5
T8 1434-1439 http://www.uniprot.org/uniprot/Q9Z2V6 denotes Hdac5
T9 1517-1522 http://www.uniprot.org/uniprot/Q9Z2V6 denotes Hdac5
T10 1555-1560 http://www.uniprot.org/uniprot/Q9Z2V6 denotes Hdac5
T11 1583-1588 http://www.uniprot.org/uniprot/Q9Z2V6 denotes Hdac5
T12 1691-1696 http://www.uniprot.org/uniprot/Q9Z2V6 denotes Hdac5

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 256-262 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 716-721 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 927-933 http://purl.bioontology.org/ontology/NCBITAXON/62951 denotes termed
T4 1054-1059 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 1843-1853 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms

GO-BP

Id Subject Object Predicate Lexical cue
T1 25-37 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylation
T2 693-705 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylation
T3 1347-1358 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylated
T4 102-105 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO
T5 127-135 http://purl.obolibrary.org/obo/GO_0065007 denotes regulate
T6 225-234 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T7 136-173 http://purl.obolibrary.org/obo/GO_0046920 denotes alpha(1,3)fucosyltransferase activity
T8 146-173 http://purl.obolibrary.org/obo/GO_0008417 denotes fucosyltransferase activity
T9 242-254 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T10 395-401 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T11 446-459 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T12 780-793 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T13 716-735 http://purl.obolibrary.org/obo/GO_0048468 denotes cells was developed
T14 726-735 http://purl.obolibrary.org/obo/GO_0032502 denotes developed
T15 898-920 http://purl.obolibrary.org/obo/GO_0015783 denotes GDP-fucose transporter
T16 902-920 http://purl.obolibrary.org/obo/GO_0015756 denotes fucose transporter
T17 909-920 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T18 1147-1158 http://purl.obolibrary.org/obo/GO_0006351 denotes transcripts
T19 1266-1277 http://purl.obolibrary.org/obo/GO_0006351 denotes transcripts
T20 1417-1428 http://purl.obolibrary.org/obo/GO_0006351 denotes transcripts
T21 1617-1628 http://purl.obolibrary.org/obo/GO_0006351 denotes transcripts
T22 1212-1217 http://purl.obolibrary.org/obo/GO_0030598 denotes ricin
T23 1321-1326 http://purl.obolibrary.org/obo/GO_0030598 denotes ricin
T24 1612-1641 http://purl.obolibrary.org/obo/GO_0006355 denotes gene transcripts specifically
T25 1612-1641 http://purl.obolibrary.org/obo/GO_0045893 denotes gene transcripts specifically
T26 1612-1641 http://purl.obolibrary.org/obo/GO_0045892 denotes gene transcripts specifically
T27 1882-1897 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression

GO-MF

Id Subject Object Predicate Lexical cue
T1 482-500 http://purl.obolibrary.org/obo/GO_0003823 denotes antigens and binds
T2 495-500 http://purl.obolibrary.org/obo/GO_0070026 denotes binds
T3 495-500 http://purl.obolibrary.org/obo/GO_0003680 denotes binds
T4 495-500 http://purl.obolibrary.org/obo/GO_0017091 denotes binds
T5 495-500 http://purl.obolibrary.org/obo/GO_0005488 denotes binds
T6 503-511 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin

GO-CC

Id Subject Object Predicate Lexical cue
T1 346-350 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 716-721 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 1054-1059 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 346-358 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T5 973-981 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 386-391 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T2 386-393 http://rdf.glycoinfo.org/glycan/G00051MO denotes Lewis X
T3 411-414 http://rdf.glycoinfo.org/glycan/G00065MO denotes VIM

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 501-511 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T2 503-511 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T3 503-511 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 386-393 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis X
PD-GlycoEpitope-B_T2 411-416 http://www.glycoepitope.jp/epitopes/EP0019 denotes VIM-2
PD-GlycoEpitope-B_T3 411-416 http://www.glycoepitope.jp/epitopes/AN0111 denotes VIM-2

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 242-254 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 256-262 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 280-285 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 256-262 Phenotype denotes cancer HP:0002664
T2 280-285 Phenotype denotes tumor HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 386-393 Glycan denotes Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO
T2 411-416 Glycan denotes VIM-2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G22418PV

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 256-262 Phenotype denotes cancer HP:0002664
T2 280-285 Phenotype denotes tumor HP:0002664

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 242-254 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 256-262 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 280-285 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1732-1747 OrganismTaxon denotes Chinese hamster 10029

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 973-981 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1748-1753 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
TextSentencer_T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
TextSentencer_T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
TextSentencer_T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
TextSentencer_T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
TextSentencer_T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
TextSentencer_T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
TextSentencer_T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
TextSentencer_T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
TextSentencer_T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
TextSentencer_T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.
T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.
T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Suppressors of alpha(1,3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant.
T2 114-297 Sentence denotes Factors that regulate alpha(1,3)fucosyltransferase activity are important to identify because FUT genes are up-regulated during inflammation, cancer progression, and tumor metastasis.
T3 298-417 Sentence denotes FUT gene activation increases the expression of cell surface oncofetal antigens such as Lewis X, sialyl-Le X and VIM-2.
T4 418-615 Sentence denotes The LEC11B gain-of-function glycosylation mutant displays these antigens and binds E-selectin because it expresses the Fut6B gene that is shown here to lie immediately downstream of the Fut6A gene.
T5 616-1024 Sentence denotes A retroviral strategy for expression cloning factors that suppress alpha(1,3)fucosylation in LEC11B cells was developed, and several cDNAs that reverted the LEC11B glycosylation phenotype were isolated. cDNAs that arose most frequently and independently encoded SLC35C2, a putative GDP-fucose transporter (also termed CGI-15 or Ovcov1); Cd63, a tetraspanin membrane protein; and Hdac5, a histone deacetylase.
T6 1025-1159 Sentence denotes When transfected into LEC11B cells the SLC35C2 cDNA reduced Le X expression with no concomitant suppression of Fut6B gene transcripts.
T7 1160-1288 Sentence denotes Transfection of the Cd63 cDNA induced low levels of ricin resistance and also did not suppress Fut6B gene transcripts in LEC11B.
T8 1289-1429 Sentence denotes However, the Hdac5 cDNA induced ricin resistance, reduced fucosylated antigen expression, and essentially eliminated Fut6B gene transcripts.
T9 1430-1523 Sentence denotes The Hdac5 cDNA isolated by expression cloning encoded the C-terminal region of hamster Hdac5.
T10 1524-1642 Sentence denotes Overexpression of this partial Hdac5 cDNA or a full-length Hdac5 cDNA, suppressed Fut6B gene transcripts specifically.
T11 1643-1898 Sentence denotes Thus the expression cloning strategy identified Hdac5 as a trans-acting repressor of the Chinese hamster ovary Fut6B gene and Cd63 and SLC35C2 as novel factors that suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on Fut gene expression.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue glycosmos_id image
T1 386-393 Glycan denotes Lewis X https://glycosmos.org/glycans/show/G00051MO https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO
T2 411-416 Glycan denotes VIM-2 https://glycosmos.org/glycans/show/G22418PV https://api.glycosmos.org/wurcs2image/latest/png/binary/G22418PV

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 386-393 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis X http://www.glycoepitope.jp/epitopes/EP0011
T2 411-416 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes VIM-2 http://www.glycoepitope.jp/epitopes/AN0111|http://www.glycoepitope.jp/epitopes/EP0019

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1732-1747 OrganismTaxon denotes Chinese hamster 10029

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 386-393 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis X http://www.glycoepitope.jp/epitopes/EP0011
T2 411-416 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes VIM-2 http://www.glycoepitope.jp/epitopes/AN0111|http://www.glycoepitope.jp/epitopes/EP0019

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 973-981 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1748-1753 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992