> top > docs > PubMed:15523499 > annotations

PubMed:15523499 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1185 27-51 GeneOrGeneProduct denotes beta adrenergic receptor NCBIGene:153|NCBIGene:154|NCBIGene:155
1186 102-127 GeneOrGeneProduct denotes beta-adrenergic receptors NCBIGene:153|NCBIGene:154|NCBIGene:155
1187 129-136 GeneOrGeneProduct denotes beta-AR NCBIGene:153|NCBIGene:154|NCBIGene:155
1188 183-194 ChemicalEntity denotes epinephrine MESH:D004837
1189 199-213 ChemicalEntity denotes norepinephrine MESH:D009638
1190 296-303 GeneOrGeneProduct denotes beta-AR NCBIGene:153|NCBIGene:154|NCBIGene:155
1191 311-316 GeneOrGeneProduct denotes ADRB1 NCBIGene:153
1192 318-323 GeneOrGeneProduct denotes ADRB2 NCBIGene:154
1193 328-333 GeneOrGeneProduct denotes ADRB3 NCBIGene:155
1194 428-466 DiseaseOrPhenotypicFeature denotes cardiovascular and metabolic disorders MESH:D002318|MESH:D008659
1195 584-589 GeneOrGeneProduct denotes ADRB1 NCBIGene:153
1196 590-599 SequenceVariant denotes Arg389Gly p|SUB|R|389|G
1197 604-612 SequenceVariant denotes Gly49Ser p|SUB|G|49|S
1198 614-619 GeneOrGeneProduct denotes ADRB2 NCBIGene:154
1199 620-628 SequenceVariant denotes Arg16Gly p|SUB|R|16|G
1200 633-641 SequenceVariant denotes Gln27Glu p|SUB|Q|27|E
1201 647-652 GeneOrGeneProduct denotes ADRB3 NCBIGene:155
1202 653-661 SequenceVariant denotes Arg64Trp p|SUB|R|64|W
1203 788-795 GeneOrGeneProduct denotes beta-AR NCBIGene:153|NCBIGene:154|NCBIGene:155
1204 1479-1486 GeneOrGeneProduct denotes beta-AR NCBIGene:153|NCBIGene:154|NCBIGene:155
1205 1557-1564 GeneOrGeneProduct denotes beta-AR NCBIGene:153|NCBIGene:154|NCBIGene:155

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African Americans.
T2 98-277 Sentence denotes The beta-adrenergic receptors (beta-AR) are G protein-coupled receptors activated by epinephrine and norepinephrine and are involved in a variety of their physiological functions.
T3 278-467 Sentence denotes Previously, three beta-AR genes (ADRB1, ADRB2 and ADRB3) were resequenced, identifying polymorphisms that were used in genetic association studies of cardiovascular and metabolic disorders.
T4 468-742 Sentence denotes These studies have produced intriguing but inconsistent results, potentially because the known functional variants: ADRB1 Arg389Gly and Gly49Ser, ADRB2 Arg16Gly and Gln27Glu, and ADRB3 Arg64Trp provided an incomplete picture of the total functional diversity at these genes.
T5 743-983 Sentence denotes Therefore, we created marker panels for each beta-AR gene that included the known functional markers and also other markers evenly spaced and with sufficient density to identify haplotype block structure and to maximize haplotype diversity.
T6 984-1066 Sentence denotes A total of 27 markers were genotyped in 96 US Caucasians and 96 African Americans.
T7 1067-1183 Sentence denotes In both populations and for each gene, a single block with little evidence of historical recombination was observed.
T8 1184-1433 Sentence denotes For each gene, haplotype captured most of the information content of each functional locus, even if that locus was not genotyped, and presumably haplotype would capture the signal from unknown functional loci whose alleles are of moderate abundance.
T9 1434-1574 Sentence denotes This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 1100-1107 OrganismTaxon denotes gene, a NCBItxid:695940|NCBItxid:137249

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 590-599 SequenceVariant denotes Arg389Gly
T2 604-612 SequenceVariant denotes Gly49Ser
T3 620-628 SequenceVariant denotes Arg16Gly
T4 633-641 SequenceVariant denotes Gln27Glu
T5 653-661 SequenceVariant denotes Arg64Trp

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 27-51 GeneOrGeneProduct denotes beta adrenergic receptor
T2 102-106 GeneOrGeneProduct denotes beta
T3 107-127 GeneOrGeneProduct denotes adrenergic receptors
T4 129-136 GeneOrGeneProduct denotes beta-AR
T5 142-151 GeneOrGeneProduct denotes G protein
T6 160-169 GeneOrGeneProduct denotes receptors
T7 170-179 GeneOrGeneProduct denotes activated
T8 231-235 GeneOrGeneProduct denotes in a
T9 296-303 GeneOrGeneProduct denotes beta-AR
T10 311-316 GeneOrGeneProduct denotes ADRB1
T11 318-323 GeneOrGeneProduct denotes ADRB2
T12 328-333 GeneOrGeneProduct denotes ADRB3
T13 584-589 GeneOrGeneProduct denotes ADRB1
T14 614-619 GeneOrGeneProduct denotes ADRB2
T15 647-652 GeneOrGeneProduct denotes ADRB3
T16 700-705 GeneOrGeneProduct denotes total
T17 757-764 GeneOrGeneProduct denotes created
T18 788-795 GeneOrGeneProduct denotes beta-AR
T19 853-858 GeneOrGeneProduct denotes other
T20 867-873 GeneOrGeneProduct denotes evenly
T21 931-936 GeneOrGeneProduct denotes block
T22 986-991 GeneOrGeneProduct denotes total
T23 1100-1107 GeneOrGeneProduct denotes gene, a
T24 1115-1120 GeneOrGeneProduct denotes block
T25 1126-1132 GeneOrGeneProduct denotes little
T26 1156-1169 GeneOrGeneProduct denotes recombination
T27 1276-1280 GeneOrGeneProduct denotes even
T28 1369-1376 GeneOrGeneProduct denotes unknown
T29 1479-1486 GeneOrGeneProduct denotes beta-AR
T30 1502-1506 GeneOrGeneProduct denotes maps
T31 1557-1564 GeneOrGeneProduct denotes beta-AR

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 27-51 GeneOrGeneProduct denotes beta adrenergic receptor
T2 102-106 GeneOrGeneProduct denotes beta
T3 107-127 GeneOrGeneProduct denotes adrenergic receptors
T4 129-136 GeneOrGeneProduct denotes beta-AR
T5 142-151 GeneOrGeneProduct denotes G protein
T6 296-303 GeneOrGeneProduct denotes beta-AR
T7 311-316 GeneOrGeneProduct denotes ADRB1
T8 318-323 GeneOrGeneProduct denotes ADRB2
T9 328-333 GeneOrGeneProduct denotes ADRB3
T10 584-589 GeneOrGeneProduct denotes ADRB1
T11 614-619 GeneOrGeneProduct denotes ADRB2
T12 647-652 GeneOrGeneProduct denotes ADRB3
T13 788-795 GeneOrGeneProduct denotes beta-AR
T14 853-858 GeneOrGeneProduct denotes other
T15 1100-1107 GeneOrGeneProduct denotes gene, a
T16 1126-1132 GeneOrGeneProduct denotes little
T17 1156-1169 GeneOrGeneProduct denotes recombination
T18 1276-1280 GeneOrGeneProduct denotes even
T19 1369-1376 GeneOrGeneProduct denotes unknown
T20 1479-1486 GeneOrGeneProduct denotes beta-AR
T21 1557-1564 GeneOrGeneProduct denotes beta-AR

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 447-466 DiseaseOrPhenotypicFeature denotes metabolic disorders 0005066

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 27-51 GeneOrGeneProduct denotes beta adrenergic receptor
T2 107-127 GeneOrGeneProduct denotes adrenergic receptors
T3 129-136 GeneOrGeneProduct denotes beta-AR
T4 142-151 GeneOrGeneProduct denotes G protein
T5 296-303 GeneOrGeneProduct denotes beta-AR
T6 311-316 GeneOrGeneProduct denotes ADRB1
T7 318-323 GeneOrGeneProduct denotes ADRB2
T8 328-333 GeneOrGeneProduct denotes ADRB3
T9 584-589 GeneOrGeneProduct denotes ADRB1
T10 614-619 GeneOrGeneProduct denotes ADRB2
T11 647-652 GeneOrGeneProduct denotes ADRB3
T12 788-795 GeneOrGeneProduct denotes beta-AR
T13 1479-1486 GeneOrGeneProduct denotes beta-AR
T14 1557-1564 GeneOrGeneProduct denotes beta-AR

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 428-466 DiseaseOrPhenotypicFeature denotes cardiovascular and metabolic disorders DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 428-466 DiseaseOrPhenotypicFeature denotes cardiovascular and metabolic disorders DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 183-194 ChemicalEntity denotes epinephrine D004837|http://purl.obolibrary.org/obo/CHEBI_28918
T3 199-213 ChemicalEntity denotes norepinephrine D009638|http://purl.obolibrary.org/obo/CHEBI_33569|http://purl.obolibrary.org/obo/CHEBI_18357

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 1100-1107 OrganismTaxon denotes gene, a

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T3 199-213 ChemicalEntity denotes norepinephrine http://purl.obolibrary.org/obo/CHEBI_18357|http://purl.obolibrary.org/obo/CHEBI_33569|D009638
T1 183-194 ChemicalEntity denotes epinephrine http://purl.obolibrary.org/obo/CHEBI_28918|D004837
T14 1557-1564 GeneOrGeneProduct denotes beta-AR
T13 1479-1486 GeneOrGeneProduct denotes beta-AR
T12 788-795 GeneOrGeneProduct denotes beta-AR
T11 647-652 GeneOrGeneProduct denotes ADRB3
T10 614-619 GeneOrGeneProduct denotes ADRB2
T9 584-589 GeneOrGeneProduct denotes ADRB1
T8 328-333 GeneOrGeneProduct denotes ADRB3
T7 318-323 GeneOrGeneProduct denotes ADRB2
T6 311-316 GeneOrGeneProduct denotes ADRB1
T5 296-303 GeneOrGeneProduct denotes beta-AR
T4 142-151 GeneOrGeneProduct denotes G protein
T16977 129-136 GeneOrGeneProduct denotes beta-AR
T2 107-127 GeneOrGeneProduct denotes adrenergic receptors
T87039 27-51 GeneOrGeneProduct denotes beta adrenergic receptor
T32674 428-466 DiseaseOrPhenotypicFeature denotes cardiovascular and metabolic disorders DISEASE
T33128 1100-1107 OrganismTaxon denotes gene, a
T43187 653-661 SequenceVariant denotes Arg64Trp
T80854 633-641 SequenceVariant denotes Gln27Glu
T9448 620-628 SequenceVariant denotes Arg16Gly
T58979 604-612 SequenceVariant denotes Gly49Ser
T81879 590-599 SequenceVariant denotes Arg389Gly