PubMed:15467433
Annnotations
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-15 | GO:0006298 | denotes | Mismatch repair |
T2 | 16-20 | SO:0000704 | denotes | gene |
T3 | 16-31 | GO:0010467 | denotes | gene expression |
T4 | 59-85 | C563236 | denotes | testicular germ cell tumor |
T5 | 59-85 | C563236 | denotes | testicular germ cell tumor |
T6 | 70-79 | CL:0000586 | denotes | germ cell |
T11 | 93-108 | GO:0006298 | denotes | mismatch repair |
T12 | 110-113 | GO:0006298 | denotes | MMR |
T14 | 110-113 | P22897 | denotes | MMR |
T15 | 110-113 | PR:000002972 | denotes | MMR |
T16 | 110-113 | Q61830 | denotes | MMR |
T13 | 110-113 | CVCL_E779 | denotes | MMR |
T17 | 135-144 | SO:0000856 | denotes | conserved |
T18 | 157-165 | CHEBI:36080 | denotes | proteins |
T19 | 260-272 | D009369 | denotes | malignancies |
T20 | 260-272 | D009369 | denotes | malignancies |
T21 | 309-315 | D009369 | denotes | tumors |
T22 | 309-315 | D009369 | denotes | tumors |
T23 | 330-333 | GO:0006298 | denotes | MMR |
T25 | 330-333 | P22897 | denotes | MMR |
T26 | 330-333 | PR:000002972 | denotes | MMR |
T27 | 330-333 | Q61830 | denotes | MMR |
T24 | 330-333 | CVCL_E779 | denotes | MMR |
T28 | 330-344 | C536928 | denotes | MMR deficiency |
T29 | 330-344 | C536928 | denotes | MMR deficiency |
T30 | 334-344 | SO:1000029 | denotes | deficiency |
T31 | 397-411 | SO:0000289 | denotes | microsatellite |
T32 | 397-423 | D053842 | denotes | microsatellite instability |
T33 | 397-423 | D053842 | denotes | microsatellite instability |
T34 | 425-428 | PR:000006870 | denotes | MSI |
T35 | 425-428 | PR:P70245 | denotes | MSI |
T36 | 433-444 | CL:0001064 | denotes | cancer cell |
T38 | 445-448 | CHEBI:16991 | denotes | DNA |
T40 | 445-448 | D004247 | denotes | DNA |
T39 | 445-448 | SO:0000352 | denotes | DNA |
T37 | 445-448 | GO:0005574 | denotes | DNA |
T41 | 510-513 | GO:0006298 | denotes | MMR |
T43 | 510-513 | P22897 | denotes | MMR |
T44 | 510-513 | PR:000002972 | denotes | MMR |
T45 | 510-513 | Q61830 | denotes | MMR |
T42 | 510-513 | CVCL_E779 | denotes | MMR |
T47 | 521-524 | CHEBI:16768 | denotes | MSH |
T51 | 521-524 | D009074 | denotes | MSH |
T52 | 521-524 | D009074 | denotes | MSH |
T53 | 521-525 | PR:000010666 | denotes | MSH2 |
T54 | 521-525 | PR:P25847 | denotes | MSH2 |
T55 | 521-525 | PR:P43246 | denotes | MSH2 |
T56 | 521-525 | P22711 | denotes | MSH2 |
T57 | 521-525 | PR:P22711 | denotes | MSH2 |
T58 | 521-525 | PR:P54275 | denotes | MSH2 |
T59 | 521-525 | PR:O74773 | denotes | MSH2 |
T60 | 521-525 | PR:P43247 | denotes | MSH2 |
T61 | 521-525 | PR:Q553L4 | denotes | MSH2 |
T62 | 521-525 | PR:O24617 | denotes | MSH2 |
T63 | 530-534 | PR:Q9ZRV4 | denotes | MLH1 |
T64 | 530-534 | PR:P38920 | denotes | MLH1 |
T65 | 530-534 | PR:Q54KD8 | denotes | MLH1 |
T67 | 530-534 | PR:Q9JK91 | denotes | MLH1 |
T68 | 530-534 | PR:P97679 | denotes | MLH1 |
T69 | 530-534 | PR:Q9P7W6 | denotes | MLH1 |
T70 | 530-534 | PR:000010442 | denotes | MLH1 |
T71 | 530-534 | PR:P40692 | denotes | MLH1 |
T66 | 530-534 | CVCL_G669 | denotes | MLH1 |
T72 | 548-574 | C563236 | denotes | testicular germ cell tumor |
T73 | 548-574 | C563236 | denotes | testicular germ cell tumor |
T74 | 559-568 | CL:0000586 | denotes | germ cell |
T80 | 576-579 | Q8RKI6 | denotes | GCT |
T81 | 576-579 | PR:F4I096 | denotes | GCT |
T82 | 576-579 | Q2G2X2 | denotes | GCT |
T83 | 576-579 | P27623 | denotes | GCT |
T79 | 576-579 | CVCL_1229 | denotes | GCT |
T86 | 634-637 | CHEBI:16768 | denotes | MSH |
T90 | 634-637 | D009074 | denotes | MSH |
T91 | 634-637 | D009074 | denotes | MSH |
T92 | 634-638 | PR:000010666 | denotes | MSH2 |
T93 | 634-638 | PR:P25847 | denotes | MSH2 |
T94 | 634-638 | PR:P43246 | denotes | MSH2 |
T95 | 634-638 | P22711 | denotes | MSH2 |
T96 | 634-638 | PR:P22711 | denotes | MSH2 |
T97 | 634-638 | PR:P54275 | denotes | MSH2 |
T98 | 634-638 | PR:O74773 | denotes | MSH2 |
T99 | 634-638 | PR:P43247 | denotes | MSH2 |
T100 | 634-638 | PR:Q553L4 | denotes | MSH2 |
T101 | 634-638 | PR:O24617 | denotes | MSH2 |
T102 | 643-647 | PR:Q9ZRV4 | denotes | MLH1 |
T103 | 643-647 | PR:P38920 | denotes | MLH1 |
T104 | 643-647 | PR:Q54KD8 | denotes | MLH1 |
T106 | 643-647 | PR:Q9JK91 | denotes | MLH1 |
T107 | 643-647 | PR:P97679 | denotes | MLH1 |
T108 | 643-647 | PR:Q9P7W6 | denotes | MLH1 |
T109 | 643-647 | PR:000010442 | denotes | MLH1 |
T110 | 643-647 | PR:P40692 | denotes | MLH1 |
T105 | 643-647 | CVCL_G669 | denotes | MLH1 |
T111 | 648-656 | CHEBI:36080 | denotes | proteins |
T113 | 716-719 | Q8RKI6 | denotes | GCT |
T114 | 716-719 | PR:F4I096 | denotes | GCT |
T115 | 716-719 | Q2G2X2 | denotes | GCT |
T116 | 716-719 | P27623 | denotes | GCT |
T112 | 716-719 | CVCL_1229 | denotes | GCT |
T117 | 744-747 | GO:0006298 | denotes | MMR |
T119 | 744-747 | P22897 | denotes | MMR |
T120 | 744-747 | PR:000002972 | denotes | MMR |
T121 | 744-747 | Q61830 | denotes | MMR |
T118 | 744-747 | CVCL_E779 | denotes | MMR |
T122 | 748-752 | SO:0000704 | denotes | gene |
T123 | 748-763 | GO:0010467 | denotes | gene expression |
T125 | 792-795 | Q8RKI6 | denotes | GCT |
T126 | 792-795 | PR:F4I096 | denotes | GCT |
T127 | 792-795 | Q2G2X2 | denotes | GCT |
T128 | 792-795 | P27623 | denotes | GCT |
T124 | 792-795 | CVCL_1229 | denotes | GCT |
T131 | 891-894 | Q8RKI6 | denotes | GCT |
T132 | 891-894 | PR:F4I096 | denotes | GCT |
T133 | 891-894 | Q2G2X2 | denotes | GCT |
T134 | 891-894 | P27623 | denotes | GCT |
T130 | 891-894 | CVCL_1229 | denotes | GCT |
T136 | 922-925 | CHEBI:16768 | denotes | MSH |
T140 | 922-925 | D009074 | denotes | MSH |
T141 | 922-925 | D009074 | denotes | MSH |
T142 | 922-926 | PR:000010666 | denotes | MSH2 |
T143 | 922-926 | PR:P25847 | denotes | MSH2 |
T144 | 922-926 | PR:P43246 | denotes | MSH2 |
T145 | 922-926 | P22711 | denotes | MSH2 |
T146 | 922-926 | PR:P22711 | denotes | MSH2 |
T147 | 922-926 | PR:P54275 | denotes | MSH2 |
T148 | 922-926 | PR:O74773 | denotes | MSH2 |
T149 | 922-926 | PR:P43247 | denotes | MSH2 |
T150 | 922-926 | PR:Q553L4 | denotes | MSH2 |
T151 | 922-926 | PR:O24617 | denotes | MSH2 |
T152 | 931-935 | PR:Q9ZRV4 | denotes | MLH1 |
T153 | 931-935 | PR:P38920 | denotes | MLH1 |
T154 | 931-935 | PR:Q54KD8 | denotes | MLH1 |
T156 | 931-935 | PR:Q9JK91 | denotes | MLH1 |
T157 | 931-935 | PR:P97679 | denotes | MLH1 |
T158 | 931-935 | PR:Q9P7W6 | denotes | MLH1 |
T159 | 931-935 | PR:000010442 | denotes | MLH1 |
T160 | 931-935 | PR:P40692 | denotes | MLH1 |
T155 | 931-935 | CVCL_G669 | denotes | MLH1 |
T162 | 1025-1028 | CHEBI:16768 | denotes | MSH |
T166 | 1025-1028 | D009074 | denotes | MSH |
T167 | 1025-1028 | D009074 | denotes | MSH |
T168 | 1025-1029 | PR:000010666 | denotes | MSH2 |
T169 | 1025-1029 | PR:P25847 | denotes | MSH2 |
T170 | 1025-1029 | PR:P43246 | denotes | MSH2 |
T171 | 1025-1029 | P22711 | denotes | MSH2 |
T172 | 1025-1029 | PR:P22711 | denotes | MSH2 |
T173 | 1025-1029 | PR:P54275 | denotes | MSH2 |
T174 | 1025-1029 | PR:O74773 | denotes | MSH2 |
T175 | 1025-1029 | PR:P43247 | denotes | MSH2 |
T176 | 1025-1029 | PR:Q553L4 | denotes | MSH2 |
T177 | 1025-1029 | PR:O24617 | denotes | MSH2 |
T178 | 1061-1076 | GO:0007283 | denotes | spermatogenesis |
T181 | 1104-1109 | CL:0000019 | denotes | sperm |
T179 | 1104-1109 | UBERON:3010295 | denotes | sperm |
T180 | 1104-1109 | UBERON:0001968 | denotes | sperm |
T182 | 1118-1122 | PR:Q9ZRV4 | denotes | MLH1 |
T183 | 1118-1122 | PR:P38920 | denotes | MLH1 |
T184 | 1118-1122 | PR:Q54KD8 | denotes | MLH1 |
T186 | 1118-1122 | PR:Q9JK91 | denotes | MLH1 |
T187 | 1118-1122 | PR:P97679 | denotes | MLH1 |
T188 | 1118-1122 | PR:Q9P7W6 | denotes | MLH1 |
T189 | 1118-1122 | PR:000010442 | denotes | MLH1 |
T190 | 1118-1122 | PR:P40692 | denotes | MLH1 |
T185 | 1118-1122 | CVCL_G669 | denotes | MLH1 |
T191 | 1165-1175 | UBERON:3010292 | denotes | germ cells |
T193 | 1194-1197 | Q8RKI6 | denotes | GCT |
T194 | 1194-1197 | PR:F4I096 | denotes | GCT |
T195 | 1194-1197 | Q2G2X2 | denotes | GCT |
T196 | 1194-1197 | P27623 | denotes | GCT |
T192 | 1194-1197 | CVCL_1229 | denotes | GCT |
T198 | 1246-1249 | CHEBI:16768 | denotes | MSH |
T202 | 1246-1249 | D009074 | denotes | MSH |
T203 | 1246-1249 | D009074 | denotes | MSH |
T204 | 1246-1250 | PR:000010666 | denotes | MSH2 |
T205 | 1246-1250 | PR:P25847 | denotes | MSH2 |
T206 | 1246-1250 | PR:P43246 | denotes | MSH2 |
T207 | 1246-1250 | P22711 | denotes | MSH2 |
T208 | 1246-1250 | PR:P22711 | denotes | MSH2 |
T209 | 1246-1250 | PR:P54275 | denotes | MSH2 |
T210 | 1246-1250 | PR:O74773 | denotes | MSH2 |
T211 | 1246-1250 | PR:P43247 | denotes | MSH2 |
T212 | 1246-1250 | PR:Q553L4 | denotes | MSH2 |
T213 | 1246-1250 | PR:O24617 | denotes | MSH2 |
T214 | 1255-1259 | PR:Q9ZRV4 | denotes | MLH1 |
T215 | 1255-1259 | PR:P38920 | denotes | MLH1 |
T216 | 1255-1259 | PR:Q54KD8 | denotes | MLH1 |
T218 | 1255-1259 | PR:Q9JK91 | denotes | MLH1 |
T219 | 1255-1259 | PR:P97679 | denotes | MLH1 |
T220 | 1255-1259 | PR:Q9P7W6 | denotes | MLH1 |
T221 | 1255-1259 | PR:000010442 | denotes | MLH1 |
T222 | 1255-1259 | PR:P40692 | denotes | MLH1 |
T217 | 1255-1259 | CVCL_G669 | denotes | MLH1 |
T223 | 1268-1272 | PR:Q8FYW3 | denotes | pure |
T224 | 1268-1272 | PR:Q54QE4 | denotes | pure |
T225 | 1268-1272 | PR:P52558 | denotes | pure |
T226 | 1268-1272 | PR:P0AG18 | denotes | pure |
T228 | 1268-1272 | PR:000023640 | denotes | pure |
T227 | 1268-1272 | GO:0034023 | denotes | pure |
T229 | 1273-1281 | D018239 | denotes | seminoma |
T230 | 1273-1281 | D018239 | denotes | seminoma |
T232 | 1322-1325 | CHEBI:16768 | denotes | MSH |
T236 | 1322-1325 | D009074 | denotes | MSH |
T237 | 1322-1325 | D009074 | denotes | MSH |
T238 | 1322-1326 | PR:000010666 | denotes | MSH2 |
T239 | 1322-1326 | PR:P25847 | denotes | MSH2 |
T240 | 1322-1326 | PR:P43246 | denotes | MSH2 |
T241 | 1322-1326 | P22711 | denotes | MSH2 |
T242 | 1322-1326 | PR:P22711 | denotes | MSH2 |
T243 | 1322-1326 | PR:P54275 | denotes | MSH2 |
T244 | 1322-1326 | PR:O74773 | denotes | MSH2 |
T245 | 1322-1326 | PR:P43247 | denotes | MSH2 |
T246 | 1322-1326 | PR:Q553L4 | denotes | MSH2 |
T247 | 1322-1326 | PR:O24617 | denotes | MSH2 |
T248 | 1336-1342 | D009369 | denotes | tumors |
T249 | 1336-1342 | D009369 | denotes | tumors |
T251 | 1399-1402 | Q8RKI6 | denotes | GCT |
T252 | 1399-1402 | PR:F4I096 | denotes | GCT |
T253 | 1399-1402 | Q2G2X2 | denotes | GCT |
T254 | 1399-1402 | P27623 | denotes | GCT |
T250 | 1399-1402 | CVCL_1229 | denotes | GCT |
T255 | 1436-1439 | PR:000006870 | denotes | MSI |
T256 | 1436-1439 | PR:P70245 | denotes | MSI |
T257 | 1441-1444 | PR:000006870 | denotes | MSI |
T258 | 1441-1444 | PR:P70245 | denotes | MSI |
T259 | 1446-1452 | D009369 | denotes | tumors |
T260 | 1446-1452 | D009369 | denotes | tumors |
T261 | 1477-1480 | PR:000006870 | denotes | MSI |
T262 | 1477-1480 | PR:P70245 | denotes | MSI |
T263 | 1482-1488 | D009369 | denotes | tumors |
T264 | 1482-1488 | D009369 | denotes | tumors |
T266 | 1504-1507 | CHEBI:16768 | denotes | MSH |
T270 | 1504-1507 | D009074 | denotes | MSH |
T271 | 1504-1507 | D009074 | denotes | MSH |
T272 | 1504-1508 | PR:000010666 | denotes | MSH2 |
T273 | 1504-1508 | PR:P25847 | denotes | MSH2 |
T274 | 1504-1508 | PR:P43246 | denotes | MSH2 |
T275 | 1504-1508 | P22711 | denotes | MSH2 |
T276 | 1504-1508 | PR:P22711 | denotes | MSH2 |
T277 | 1504-1508 | PR:P54275 | denotes | MSH2 |
T278 | 1504-1508 | PR:O74773 | denotes | MSH2 |
T279 | 1504-1508 | PR:P43247 | denotes | MSH2 |
T280 | 1504-1508 | PR:Q553L4 | denotes | MSH2 |
T281 | 1504-1508 | PR:O24617 | denotes | MSH2 |
T282 | 1514-1518 | PR:Q9ZRV4 | denotes | MLH1 |
T283 | 1514-1518 | PR:P38920 | denotes | MLH1 |
T284 | 1514-1518 | PR:Q54KD8 | denotes | MLH1 |
T286 | 1514-1518 | PR:Q9JK91 | denotes | MLH1 |
T287 | 1514-1518 | PR:P97679 | denotes | MLH1 |
T288 | 1514-1518 | PR:Q9P7W6 | denotes | MLH1 |
T289 | 1514-1518 | PR:000010442 | denotes | MLH1 |
T290 | 1514-1518 | PR:P40692 | denotes | MLH1 |
T285 | 1514-1518 | CVCL_G669 | denotes | MLH1 |
T292 | 1526-1529 | CHEBI:16768 | denotes | MSH |
T296 | 1526-1529 | D009074 | denotes | MSH |
T297 | 1526-1529 | D009074 | denotes | MSH |
T298 | 1526-1530 | PR:000010666 | denotes | MSH2 |
T299 | 1526-1530 | PR:P25847 | denotes | MSH2 |
T300 | 1526-1530 | PR:P43246 | denotes | MSH2 |
T301 | 1526-1530 | P22711 | denotes | MSH2 |
T302 | 1526-1530 | PR:P22711 | denotes | MSH2 |
T303 | 1526-1530 | PR:P54275 | denotes | MSH2 |
T304 | 1526-1530 | PR:O74773 | denotes | MSH2 |
T305 | 1526-1530 | PR:P43247 | denotes | MSH2 |
T306 | 1526-1530 | PR:Q553L4 | denotes | MSH2 |
T307 | 1526-1530 | PR:O24617 | denotes | MSH2 |
T308 | 1539-1543 | PR:Q9ZRV4 | denotes | MLH1 |
T309 | 1539-1543 | PR:P38920 | denotes | MLH1 |
T310 | 1539-1543 | PR:Q54KD8 | denotes | MLH1 |
T312 | 1539-1543 | PR:Q9JK91 | denotes | MLH1 |
T313 | 1539-1543 | PR:P97679 | denotes | MLH1 |
T314 | 1539-1543 | PR:Q9P7W6 | denotes | MLH1 |
T315 | 1539-1543 | PR:000010442 | denotes | MLH1 |
T316 | 1539-1543 | PR:P40692 | denotes | MLH1 |
T311 | 1539-1543 | CVCL_G669 | denotes | MLH1 |
T318 | 1597-1600 | Q8RKI6 | denotes | GCT |
T319 | 1597-1600 | PR:F4I096 | denotes | GCT |
T320 | 1597-1600 | Q2G2X2 | denotes | GCT |
T321 | 1597-1600 | P27623 | denotes | GCT |
T317 | 1597-1600 | CVCL_1229 | denotes | GCT |
T322 | 1611-1633 | SO:0001786 | denotes | loss of heterozygosity |
T323 | 1635-1638 | SO:0001786 | denotes | LOH |
T324 | 1647-1650 | PR:000006870 | denotes | MSI |
T325 | 1647-1650 | PR:P70245 | denotes | MSI |
T326 | 1652-1655 | SO:0001786 | denotes | LOH |
T327 | 1661-1667 | D009369 | denotes | tumors |
T328 | 1661-1667 | D009369 | denotes | tumors |
T330 | 1691-1694 | SO:0001786 | denotes | LOH |
T331 | 1700-1706 | D009369 | denotes | tumors |
T332 | 1700-1706 | D009369 | denotes | tumors |
T334 | 1721-1724 | CHEBI:16768 | denotes | MSH |
T338 | 1721-1724 | D009074 | denotes | MSH |
T339 | 1721-1724 | D009074 | denotes | MSH |
T340 | 1721-1725 | PR:000010666 | denotes | MSH2 |
T341 | 1721-1725 | PR:P25847 | denotes | MSH2 |
T342 | 1721-1725 | PR:P43246 | denotes | MSH2 |
T343 | 1721-1725 | P22711 | denotes | MSH2 |
T344 | 1721-1725 | PR:P22711 | denotes | MSH2 |
T345 | 1721-1725 | PR:P54275 | denotes | MSH2 |
T346 | 1721-1725 | PR:O74773 | denotes | MSH2 |
T347 | 1721-1725 | PR:P43247 | denotes | MSH2 |
T348 | 1721-1725 | PR:Q553L4 | denotes | MSH2 |
T349 | 1721-1725 | PR:O24617 | denotes | MSH2 |
T350 | 1731-1735 | PR:Q9ZRV4 | denotes | MLH1 |
T351 | 1731-1735 | PR:P38920 | denotes | MLH1 |
T352 | 1731-1735 | PR:Q54KD8 | denotes | MLH1 |
T354 | 1731-1735 | PR:Q9JK91 | denotes | MLH1 |
T355 | 1731-1735 | PR:P97679 | denotes | MLH1 |
T356 | 1731-1735 | PR:Q9P7W6 | denotes | MLH1 |
T357 | 1731-1735 | PR:000010442 | denotes | MLH1 |
T358 | 1731-1735 | PR:P40692 | denotes | MLH1 |
T353 | 1731-1735 | CVCL_G669 | denotes | MLH1 |
T360 | 1743-1746 | CHEBI:16768 | denotes | MSH |
T364 | 1743-1746 | D009074 | denotes | MSH |
T365 | 1743-1746 | D009074 | denotes | MSH |
T366 | 1743-1747 | PR:000010666 | denotes | MSH2 |
T367 | 1743-1747 | PR:P25847 | denotes | MSH2 |
T368 | 1743-1747 | PR:P43246 | denotes | MSH2 |
T369 | 1743-1747 | P22711 | denotes | MSH2 |
T370 | 1743-1747 | PR:P22711 | denotes | MSH2 |
T371 | 1743-1747 | PR:P54275 | denotes | MSH2 |
T372 | 1743-1747 | PR:O74773 | denotes | MSH2 |
T373 | 1743-1747 | PR:P43247 | denotes | MSH2 |
T374 | 1743-1747 | PR:Q553L4 | denotes | MSH2 |
T375 | 1743-1747 | PR:O24617 | denotes | MSH2 |
T376 | 1756-1760 | PR:Q9ZRV4 | denotes | MLH1 |
T377 | 1756-1760 | PR:P38920 | denotes | MLH1 |
T378 | 1756-1760 | PR:Q54KD8 | denotes | MLH1 |
T380 | 1756-1760 | PR:Q9JK91 | denotes | MLH1 |
T381 | 1756-1760 | PR:P97679 | denotes | MLH1 |
T382 | 1756-1760 | PR:Q9P7W6 | denotes | MLH1 |
T383 | 1756-1760 | PR:000010442 | denotes | MLH1 |
T384 | 1756-1760 | PR:P40692 | denotes | MLH1 |
T379 | 1756-1760 | CVCL_G669 | denotes | MLH1 |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-86 | DRI_Background | denotes | Mismatch repair gene expression and genetic instability in testicular germ cell tumor. |
T2 | 87-273 | DRI_Challenge | denotes | Human mismatch repair (MMR) genes encode highly conserved interacting proteins that correct replication errors predisposing to hereditary gastrointestinal and genitourinary malignancies. |
T3 | 274-449 | DRI_Background | denotes | A subset of sporadic genitourinary tumors also exhibits MMR deficiency and can be identified by measuring the frequency of microsatellite instability (MSI) in cancer cell DNA. |
T4 | 450-921 | DRI_Background | denotes | We investigated expression of the two most commonly mutated MMR genes, MSH2 and MLH1, in sporadic testicular germ cell tumor (GCT) in order to: (1) determine the expression pattern of MSH2 and MLH1 proteins in normal seminiferous tubules and histologically distinct GCT subtypes, (2) correlate MMR gene expression with genetic instability in GCT and (3) develop a panel of molecular markers that can identify genetically distinct subsets of GCT for prognostic assessment. |
T5 | 922-1024 | DRI_Background | denotes | MSH2 and MLH1 had differential staining patterns in normal seminiferous tubules and malignant tissues. |
T6 | 1025-1176 | DRI_Outcome | denotes | MSH2 was expressed in all stages of spermatogenesis up to but excluding mature sperm whereas MLH1 was predominantly expressed in premeiotic germ cells. |
T7 | 1177-1375 | DRI_Outcome | denotes | All histological GCT subtypes showed differential immunostaining for MSH2 and MLH1 however pure seminoma had statistically significant fewer low MSH2 staining tumors than other subtypes (p = 0.046). |
T8 | 1376-1566 | DRI_Background | denotes | Twenty-five percent of GCT exhibited increased frequency of MSI (MSI+ tumors) with 73, 70 and 43% of MSI+ tumors exhibiting low MSH2, low MLH1 or low MSH2 and low MLH1 staining respectively. |
T9 | 1567-1669 | DRI_Background | denotes | Fifteen percent of testicular GCT exhibited loss of heterozygosity (LOH) but no MSI (LOH only tumors). |
T10 | 1670-1783 | DRI_Outcome | denotes | Only 28, 17 or 6% of LOH only tumors exhibited low MSH2, low MLH1 or low MSH2 and low MLH1 staining respectively. |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
15467433-3#60#63#gene4360 | 510-513 | gene4360 | denotes | MMR |
15467433-3#80#84#gene4292 | 530-534 | gene4292 | denotes | MLH1 |
15467433-3#184#188#gene4436 | 634-638 | gene4436 | denotes | MSH2 |
15467433-3#193#197#gene4292 | 643-647 | gene4292 | denotes | MLH1 |
15467433-3#294#297#gene4360 | 744-747 | gene4360 | denotes | MMR |
15467433-3#342#345#diseaseC0220620 | 792-795 | diseaseC0220620 | denotes | GCT |
15467433-3#441#444#diseaseC0220620 | 891-894 | diseaseC0220620 | denotes | GCT |
15467433-3#98#124#diseaseC1336708 | 548-574 | diseaseC1336708 | denotes | testicular germ cell tumor |
15467433-3#126#129#diseaseC0220620 | 576-579 | diseaseC0220620 | denotes | GCT |
15467433-3#266#269#diseaseC0220620 | 716-719 | diseaseC0220620 | denotes | GCT |
15467433-3#342#345#diseaseC0220620 | 792-795 | diseaseC0220620 | denotes | GCT |
15467433-3#441#444#diseaseC0220620 | 891-894 | diseaseC0220620 | denotes | GCT |
15467433-6#69#73#gene4436 | 1246-1250 | gene4436 | denotes | MSH2 |
15467433-6#78#82#gene4292 | 1255-1259 | gene4292 | denotes | MLH1 |
15467433-6#145#149#gene4436 | 1322-1326 | gene4436 | denotes | MSH2 |
15467433-6#91#104#diseaseC0036631 | 1268-1281 | diseaseC0036631 | denotes | pure seminoma |
15467433-7#128#132#gene4436 | 1504-1508 | gene4436 | denotes | MSH2 |
15467433-7#138#142#gene4292 | 1514-1518 | gene4292 | denotes | MLH1 |
15467433-7#150#154#gene4436 | 1526-1530 | gene4436 | denotes | MSH2 |
15467433-7#163#167#gene4292 | 1539-1543 | gene4292 | denotes | MLH1 |
15467433-7#23#26#diseaseC0220620 | 1399-1402 | diseaseC0220620 | denotes | GCT |
60#63#gene4360342#345#diseaseC0220620 | 15467433-3#60#63#gene4360 | 15467433-3#342#345#diseaseC0220620 | associated_with | MMR,GCT |
60#63#gene4360441#444#diseaseC0220620 | 15467433-3#60#63#gene4360 | 15467433-3#441#444#diseaseC0220620 | associated_with | MMR,GCT |
60#63#gene436098#124#diseaseC1336708 | 15467433-3#60#63#gene4360 | 15467433-3#98#124#diseaseC1336708 | associated_with | MMR,testicular germ cell tumor |
60#63#gene4360126#129#diseaseC0220620 | 15467433-3#60#63#gene4360 | 15467433-3#126#129#diseaseC0220620 | associated_with | MMR,GCT |
60#63#gene4360266#269#diseaseC0220620 | 15467433-3#60#63#gene4360 | 15467433-3#266#269#diseaseC0220620 | associated_with | MMR,GCT |
60#63#gene4360342#345#diseaseC0220620 | 15467433-3#60#63#gene4360 | 15467433-3#342#345#diseaseC0220620 | associated_with | MMR,GCT |
60#63#gene4360441#444#diseaseC0220620 | 15467433-3#60#63#gene4360 | 15467433-3#441#444#diseaseC0220620 | associated_with | MMR,GCT |
80#84#gene4292342#345#diseaseC0220620 | 15467433-3#80#84#gene4292 | 15467433-3#342#345#diseaseC0220620 | associated_with | MLH1,GCT |
80#84#gene4292441#444#diseaseC0220620 | 15467433-3#80#84#gene4292 | 15467433-3#441#444#diseaseC0220620 | associated_with | MLH1,GCT |
80#84#gene429298#124#diseaseC1336708 | 15467433-3#80#84#gene4292 | 15467433-3#98#124#diseaseC1336708 | associated_with | MLH1,testicular germ cell tumor |
80#84#gene4292126#129#diseaseC0220620 | 15467433-3#80#84#gene4292 | 15467433-3#126#129#diseaseC0220620 | associated_with | MLH1,GCT |
80#84#gene4292266#269#diseaseC0220620 | 15467433-3#80#84#gene4292 | 15467433-3#266#269#diseaseC0220620 | associated_with | MLH1,GCT |
80#84#gene4292342#345#diseaseC0220620 | 15467433-3#80#84#gene4292 | 15467433-3#342#345#diseaseC0220620 | associated_with | MLH1,GCT |
80#84#gene4292441#444#diseaseC0220620 | 15467433-3#80#84#gene4292 | 15467433-3#441#444#diseaseC0220620 | associated_with | MLH1,GCT |
184#188#gene4436342#345#diseaseC0220620 | 15467433-3#184#188#gene4436 | 15467433-3#342#345#diseaseC0220620 | associated_with | MSH2,GCT |
184#188#gene4436441#444#diseaseC0220620 | 15467433-3#184#188#gene4436 | 15467433-3#441#444#diseaseC0220620 | associated_with | MSH2,GCT |
184#188#gene443698#124#diseaseC1336708 | 15467433-3#184#188#gene4436 | 15467433-3#98#124#diseaseC1336708 | associated_with | MSH2,testicular germ cell tumor |
184#188#gene4436126#129#diseaseC0220620 | 15467433-3#184#188#gene4436 | 15467433-3#126#129#diseaseC0220620 | associated_with | MSH2,GCT |
184#188#gene4436266#269#diseaseC0220620 | 15467433-3#184#188#gene4436 | 15467433-3#266#269#diseaseC0220620 | associated_with | MSH2,GCT |
184#188#gene4436342#345#diseaseC0220620 | 15467433-3#184#188#gene4436 | 15467433-3#342#345#diseaseC0220620 | associated_with | MSH2,GCT |
184#188#gene4436441#444#diseaseC0220620 | 15467433-3#184#188#gene4436 | 15467433-3#441#444#diseaseC0220620 | associated_with | MSH2,GCT |
193#197#gene4292342#345#diseaseC0220620 | 15467433-3#193#197#gene4292 | 15467433-3#342#345#diseaseC0220620 | associated_with | MLH1,GCT |
193#197#gene4292441#444#diseaseC0220620 | 15467433-3#193#197#gene4292 | 15467433-3#441#444#diseaseC0220620 | associated_with | MLH1,GCT |
193#197#gene429298#124#diseaseC1336708 | 15467433-3#193#197#gene4292 | 15467433-3#98#124#diseaseC1336708 | associated_with | MLH1,testicular germ cell tumor |
193#197#gene4292126#129#diseaseC0220620 | 15467433-3#193#197#gene4292 | 15467433-3#126#129#diseaseC0220620 | associated_with | MLH1,GCT |
193#197#gene4292266#269#diseaseC0220620 | 15467433-3#193#197#gene4292 | 15467433-3#266#269#diseaseC0220620 | associated_with | MLH1,GCT |
193#197#gene4292342#345#diseaseC0220620 | 15467433-3#193#197#gene4292 | 15467433-3#342#345#diseaseC0220620 | associated_with | MLH1,GCT |
193#197#gene4292441#444#diseaseC0220620 | 15467433-3#193#197#gene4292 | 15467433-3#441#444#diseaseC0220620 | associated_with | MLH1,GCT |
294#297#gene4360342#345#diseaseC0220620 | 15467433-3#294#297#gene4360 | 15467433-3#342#345#diseaseC0220620 | associated_with | MMR,GCT |
294#297#gene4360441#444#diseaseC0220620 | 15467433-3#294#297#gene4360 | 15467433-3#441#444#diseaseC0220620 | associated_with | MMR,GCT |
294#297#gene436098#124#diseaseC1336708 | 15467433-3#294#297#gene4360 | 15467433-3#98#124#diseaseC1336708 | associated_with | MMR,testicular germ cell tumor |
294#297#gene4360126#129#diseaseC0220620 | 15467433-3#294#297#gene4360 | 15467433-3#126#129#diseaseC0220620 | associated_with | MMR,GCT |
294#297#gene4360266#269#diseaseC0220620 | 15467433-3#294#297#gene4360 | 15467433-3#266#269#diseaseC0220620 | associated_with | MMR,GCT |
294#297#gene4360342#345#diseaseC0220620 | 15467433-3#294#297#gene4360 | 15467433-3#342#345#diseaseC0220620 | associated_with | MMR,GCT |
294#297#gene4360441#444#diseaseC0220620 | 15467433-3#294#297#gene4360 | 15467433-3#441#444#diseaseC0220620 | associated_with | MMR,GCT |
69#73#gene443691#104#diseaseC0036631 | 15467433-6#69#73#gene4436 | 15467433-6#91#104#diseaseC0036631 | associated_with | MSH2,pure seminoma |
78#82#gene429291#104#diseaseC0036631 | 15467433-6#78#82#gene4292 | 15467433-6#91#104#diseaseC0036631 | associated_with | MLH1,pure seminoma |
145#149#gene443691#104#diseaseC0036631 | 15467433-6#145#149#gene4436 | 15467433-6#91#104#diseaseC0036631 | associated_with | MSH2,pure seminoma |
128#132#gene443623#26#diseaseC0220620 | 15467433-7#128#132#gene4436 | 15467433-7#23#26#diseaseC0220620 | associated_with | MSH2,GCT |
138#142#gene429223#26#diseaseC0220620 | 15467433-7#138#142#gene4292 | 15467433-7#23#26#diseaseC0220620 | associated_with | MLH1,GCT |
150#154#gene443623#26#diseaseC0220620 | 15467433-7#150#154#gene4436 | 15467433-7#23#26#diseaseC0220620 | associated_with | MSH2,GCT |
163#167#gene429223#26#diseaseC0220620 | 15467433-7#163#167#gene4292 | 15467433-7#23#26#diseaseC0220620 | associated_with | MLH1,GCT |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 1504-1508 | gene:4436 | denotes | MSH2 |
T1 | 1399-1402 | disease:C1336708 | denotes | GCT |
T2 | 1514-1518 | gene:4292 | denotes | MLH1 |
T3 | 1399-1402 | disease:C1336708 | denotes | GCT |
T4 | 1526-1530 | gene:4436 | denotes | MSH2 |
T5 | 1399-1402 | disease:C1336708 | denotes | GCT |
T6 | 1539-1543 | gene:4292 | denotes | MLH1 |
T7 | 1399-1402 | disease:C1336708 | denotes | GCT |
R1 | T0 | T1 | associated_with | MSH2,GCT |
R2 | T2 | T3 | associated_with | MLH1,GCT |
R3 | T4 | T5 | associated_with | MSH2,GCT |
R4 | T6 | T7 | associated_with | MLH1,GCT |