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PubMed:15464247 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1129 13-28 GeneOrGeneProduct denotes interleukin 12B NCBIGene:3593
1130 30-35 GeneOrGeneProduct denotes IL12B NCBIGene:3593
1131 102-129 DiseaseOrPhenotypicFeature denotes hepatitis C virus infection MESH:D006526
1132 148-162 GeneOrGeneProduct denotes Interleukin-12 NCBIGene:3593
1133 164-169 GeneOrGeneProduct denotes IL-12 NCBIGene:3593
1134 271-284 DiseaseOrPhenotypicFeature denotes HCV-infection MESH:D006526
1135 314-319 GeneOrGeneProduct denotes IL12B NCBIGene:3593
1136 362-385 SequenceVariant denotes 4 bp insertion/deletion c|INDEL||4
1137 403-411 SequenceVariant denotes 1188-A/C c|SUB|A|1188|C
1138 452-457 GeneOrGeneProduct denotes IL-12 NCBIGene:3593
1139 504-517 DiseaseOrPhenotypicFeature denotes HCV infection MESH:D006526
1140 573-576 OrganismTaxon denotes HCV NCBITaxon:11103
1141 604-616 DiseaseOrPhenotypicFeature denotes HCV infected MESH:D006526
1142 617-625 OrganismTaxon denotes patients NCBITaxon:9606
1143 653-658 GeneOrGeneProduct denotes IL12B NCBIGene:3593
1144 748-763 ChemicalEntity denotes oligonucleotide MESH:D009841
1145 861-866 GeneOrGeneProduct denotes IL12B NCBIGene:3593
1146 966-989 DiseaseOrPhenotypicFeature denotes HCV genotype 1-infected MESH:D006526
1147 990-998 OrganismTaxon denotes patients NCBITaxon:9606
1148 1018-1025 DiseaseOrPhenotypicFeature denotes viremia MESH:D014766
1149 1039-1044 GeneOrGeneProduct denotes IL12B NCBIGene:3593
1150 1052-1058 SequenceVariant denotes 1188-C c|Allele|C|1188
1151 1273-1278 GeneOrGeneProduct denotes IL12B NCBIGene:3593
1152 1286-1292 SequenceVariant denotes 1188-C c|Allele|C|1188
1153 1456-1461 GeneOrGeneProduct denotes IL12B NCBIGene:3593
1154 1493-1506 DiseaseOrPhenotypicFeature denotes HCV infection MESH:D006526

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection.
T2 131-147 Sentence denotes BACKGROUND/AIMS:
T3 148-285 Sentence denotes Interleukin-12 (IL-12) governs the Th1-type immune response, affecting the spontaneous and treatment-induced recovery from HCV-infection.
T4 286-518 Sentence denotes We investigated whether the IL12B polymorphisms within the promoter region (4 bp insertion/deletion) and the 3'-UTR (1188-A/C), which have been reported to influence IL-12 synthesis, are associated with the outcome of HCV infection.
T5 519-527 Sentence denotes METHODS:
T6 528-652 Sentence denotes We analyzed 186 individuals with spontaneous HCV clearance, 501 chronically HCV infected patients, and 217 healthy controls.
T7 653-833 Sentence denotes IL12B 3'-UTR and promoter genotyping was performed by Taqman-based assays with allele-specific oligonucleotide probes and PCR-based allele-specific DNA-amplification, respectively.
T8 834-842 Sentence denotes RESULTS:
T9 843-956 Sentence denotes The proportion of IL12B promoter and 3'-UTR genotypes did not differ significantly between the different cohorts.
T10 957-1259 Sentence denotes However, HCV genotype 1-infected patients with high baseline viremia carrying the IL12B 3'-UTR 1188-C-allele showed significantly higher sustained virologic response (SVR) rates (25.3% vs. 46% vs. 54.5% for A/A, A/C and C/C) due to reduced relapse rates (24.2% vs. 12% vs. zero % for A/A, A/C and C/C).
T11 1260-1437 Sentence denotes CONCLUSIONS: IL12B 3'-UTR 1188-C-allele carriers appear to be capable of responding more efficiently to antiviral combination therapy as a consequence of a reduced relapse rate.
T12 1438-1529 Sentence denotes No association of IL12B polymorphisms and self-limited HCV infection could be demonstrated.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 102-119 OrganismTaxon denotes hepatitis C virus NCBItxid:11103
T2 271-274 OrganismTaxon denotes HCV NCBItxid:11103
T3 504-507 OrganismTaxon denotes HCV NCBItxid:11103
T4 573-576 OrganismTaxon denotes HCV NCBItxid:11103
T5 604-607 OrganismTaxon denotes HCV NCBItxid:11103
T6 966-969 OrganismTaxon denotes HCV NCBItxid:11103
T7 1493-1496 OrganismTaxon denotes HCV NCBItxid:11103

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 102-129 DiseaseOrPhenotypicFeature denotes hepatitis C virus infection 0005231
T2 102-111 DiseaseOrPhenotypicFeature denotes hepatitis 0002251

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 25-28 SequenceVariant denotes 12B
T2 362-376 SequenceVariant denotes 4 bp insertion
T3 403-411 SequenceVariant denotes 1188-A/C
T4 1052-1058 SequenceVariant denotes 1188-C
T5 1286-1292 SequenceVariant denotes 1188-C

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 13-28 GeneOrGeneProduct denotes interleukin 12B
T2 30-35 GeneOrGeneProduct denotes IL12B
T3 80-87 GeneOrGeneProduct denotes induced
T4 148-162 GeneOrGeneProduct denotes Interleukin-12
T5 164-169 GeneOrGeneProduct denotes IL-12
T6 183-186 GeneOrGeneProduct denotes Th1
T7 192-198 GeneOrGeneProduct denotes immune
T8 249-256 GeneOrGeneProduct denotes induced
T9 314-319 GeneOrGeneProduct denotes IL12B
T10 395-401 GeneOrGeneProduct denotes 3'-UTR
T11 452-457 GeneOrGeneProduct denotes IL-12
T12 519-526 GeneOrGeneProduct denotes METHODS
T13 588-591 GeneOrGeneProduct denotes 501
T14 653-658 GeneOrGeneProduct denotes IL12B
T15 659-665 GeneOrGeneProduct denotes 3'-UTR
T16 714-719 GeneOrGeneProduct denotes based
T17 779-784 GeneOrGeneProduct denotes based
T18 861-866 GeneOrGeneProduct denotes IL12B
T19 880-886 GeneOrGeneProduct denotes 3'-UTR
T20 1004-1008 GeneOrGeneProduct denotes high
T21 1039-1044 GeneOrGeneProduct denotes IL12B
T22 1045-1051 GeneOrGeneProduct denotes 3'-UTR
T23 1164-1170 GeneOrGeneProduct denotes A/A, A
T24 1189-1196 GeneOrGeneProduct denotes reduced
T25 1241-1247 GeneOrGeneProduct denotes A/A, A
T26 1273-1278 GeneOrGeneProduct denotes IL12B
T27 1279-1285 GeneOrGeneProduct denotes 3'-UTR
T28 1300-1308 GeneOrGeneProduct denotes carriers
T29 1322-1329 GeneOrGeneProduct denotes capable
T30 1416-1423 GeneOrGeneProduct denotes reduced
T31 1456-1461 GeneOrGeneProduct denotes IL12B
T32 1485-1492 GeneOrGeneProduct denotes limited

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 13-28 GeneOrGeneProduct denotes interleukin 12B
T2 30-35 GeneOrGeneProduct denotes IL12B
T3 148-162 GeneOrGeneProduct denotes Interleukin-12
T4 164-169 GeneOrGeneProduct denotes IL-12
T5 314-319 GeneOrGeneProduct denotes IL12B
T6 395-401 GeneOrGeneProduct denotes 3'-UTR
T7 452-457 GeneOrGeneProduct denotes IL-12
T8 588-591 GeneOrGeneProduct denotes 501
T9 653-658 GeneOrGeneProduct denotes IL12B
T10 659-665 GeneOrGeneProduct denotes 3'-UTR
T11 861-866 GeneOrGeneProduct denotes IL12B
T12 880-886 GeneOrGeneProduct denotes 3'-UTR
T13 1004-1008 GeneOrGeneProduct denotes high
T14 1039-1044 GeneOrGeneProduct denotes IL12B
T15 1045-1051 GeneOrGeneProduct denotes 3'-UTR
T16 1189-1196 GeneOrGeneProduct denotes reduced
T17 1273-1278 GeneOrGeneProduct denotes IL12B
T18 1279-1285 GeneOrGeneProduct denotes 3'-UTR
T19 1416-1423 GeneOrGeneProduct denotes reduced
T20 1456-1461 GeneOrGeneProduct denotes IL12B
T21 1485-1492 GeneOrGeneProduct denotes limited

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 102-113 DiseaseOrPhenotypicFeature denotes hepatitis C D006526
T2 114-129 DiseaseOrPhenotypicFeature denotes virus infection D014777
T3 275-284 DiseaseOrPhenotypicFeature denotes infection D007239
T4 508-517 DiseaseOrPhenotypicFeature denotes infection D007239
T5 1018-1025 DiseaseOrPhenotypicFeature denotes viremia D014766
T6 1197-1204 DiseaseOrPhenotypicFeature denotes relapse D012008
T7 1424-1431 DiseaseOrPhenotypicFeature denotes relapse D012008
T8 1497-1506 DiseaseOrPhenotypicFeature denotes infection D007239

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 13-28 GeneOrGeneProduct denotes interleukin 12B
T2 30-35 GeneOrGeneProduct denotes IL12B
T3 148-162 GeneOrGeneProduct denotes Interleukin-12
T4 164-169 GeneOrGeneProduct denotes IL-12
T5 314-319 GeneOrGeneProduct denotes IL12B
T6 452-457 GeneOrGeneProduct denotes IL-12
T7 588-591 GeneOrGeneProduct denotes 501
T8 653-658 GeneOrGeneProduct denotes IL12B
T9 861-866 GeneOrGeneProduct denotes IL12B
T10 1039-1044 GeneOrGeneProduct denotes IL12B
T11 1273-1278 GeneOrGeneProduct denotes IL12B
T12 1456-1461 GeneOrGeneProduct denotes IL12B

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 102-129 DiseaseOrPhenotypicFeature denotes hepatitis C virus infection 0005231
T2 275-284 DiseaseOrPhenotypicFeature denotes infection 0005550
T3 508-517 DiseaseOrPhenotypicFeature denotes infection 0005550
T4 1497-1506 DiseaseOrPhenotypicFeature denotes infection 0005550

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 102-113 DiseaseOrPhenotypicFeature denotes hepatitis C D006526
T2 114-129 DiseaseOrPhenotypicFeature denotes virus infection D014777
T3 275-284 DiseaseOrPhenotypicFeature denotes infection D007239
T4 508-517 DiseaseOrPhenotypicFeature denotes infection D007239
T5 604-616 DiseaseOrPhenotypicFeature denotes HCV infected DISEASE
T6 966-989 DiseaseOrPhenotypicFeature denotes HCV genotype 1-infected DISEASE
T7 1018-1025 DiseaseOrPhenotypicFeature denotes viremia D014766
T8 1197-1204 DiseaseOrPhenotypicFeature denotes relapse D012008
T9 1424-1431 DiseaseOrPhenotypicFeature denotes relapse D012008
T10 1497-1506 DiseaseOrPhenotypicFeature denotes infection D007239

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 102-113 DiseaseOrPhenotypicFeature denotes hepatitis C D006526
T2 271-284 DiseaseOrPhenotypicFeature denotes HCV-infection Eisukeadded
T3 504-517 DiseaseOrPhenotypicFeature denotes HCV infection Eisukeadded
T4 604-616 DiseaseOrPhenotypicFeature denotes HCV infected DISEASE
T5 966-989 DiseaseOrPhenotypicFeature denotes HCV genotype 1-infected DISEASE
T6 1018-1025 DiseaseOrPhenotypicFeature denotes viremia D014766
T7 1493-1506 DiseaseOrPhenotypicFeature denotes HCV infection Eisukeadded

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 102-119 OrganismTaxon denotes hepatitis C virus
T2 271-274 OrganismTaxon denotes HCV
T3 504-507 OrganismTaxon denotes HCV
T4 573-576 OrganismTaxon denotes HCV
T5 604-607 OrganismTaxon denotes HCV
T6 617-625 OrganismTaxon denotes patients
T7 966-969 OrganismTaxon denotes HCV
T8 990-998 OrganismTaxon denotes patients
T9 1493-1496 OrganismTaxon denotes HCV

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label
T12 1456-1461 GeneOrGeneProduct denotes IL12B
T11 1273-1278 GeneOrGeneProduct denotes IL12B
T10 1039-1044 GeneOrGeneProduct denotes IL12B
T9 861-866 GeneOrGeneProduct denotes IL12B
T8 653-658 GeneOrGeneProduct denotes IL12B
T7 588-591 GeneOrGeneProduct denotes 501
T6 452-457 GeneOrGeneProduct denotes IL-12
T5 314-319 GeneOrGeneProduct denotes IL12B
T4 164-169 GeneOrGeneProduct denotes IL-12
T3 148-162 GeneOrGeneProduct denotes Interleukin-12
T2 30-35 GeneOrGeneProduct denotes IL12B
T1 13-28 GeneOrGeneProduct denotes interleukin 12B
T39418 1493-1506 DiseaseOrPhenotypicFeature denotes HCV infection Eisukeadded
T69592 1018-1025 DiseaseOrPhenotypicFeature denotes viremia D014766
T37045 966-989 DiseaseOrPhenotypicFeature denotes HCV genotype 1-infected DISEASE
T2531 604-616 DiseaseOrPhenotypicFeature denotes HCV infected DISEASE
T22052 504-517 DiseaseOrPhenotypicFeature denotes HCV infection Eisukeadded
T61718 271-284 DiseaseOrPhenotypicFeature denotes HCV-infection Eisukeadded
T93260 102-113 DiseaseOrPhenotypicFeature denotes hepatitis C D006526
T54801 1493-1496 OrganismTaxon denotes HCV
T72728 990-998 OrganismTaxon denotes patients
T96562 966-969 OrganismTaxon denotes HCV
T81224 617-625 OrganismTaxon denotes patients
T91168 604-607 OrganismTaxon denotes HCV
T34462 573-576 OrganismTaxon denotes HCV
T68858 504-507 OrganismTaxon denotes HCV
T20395 271-274 OrganismTaxon denotes HCV
T29972 102-119 OrganismTaxon denotes hepatitis C virus
T10897 1286-1292 SequenceVariant denotes 1188-C
T75229 1052-1058 SequenceVariant denotes 1188-C
T1192 403-411 SequenceVariant denotes 1188-A/C
T17743 362-376 SequenceVariant denotes 4 bp insertion
T81210 25-28 SequenceVariant denotes 12B

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15464247-0#13#28#gene3593 13-28 gene3593 denotes interleukin 12B
15464247-0#30#35#gene3593 30-35 gene3593 denotes IL12B
15464247-0#102#113#diseaseC0019196 102-113 diseaseC0019196 denotes hepatitis C
15464247-0#114#129#diseaseC0042769 114-129 diseaseC0042769 denotes virus infection
15464247-0#102#113#diseaseC0019196 102-113 diseaseC0019196 denotes hepatitis C
15464247-0#114#129#diseaseC0042769 114-129 diseaseC0042769 denotes virus infection
13#28#gene3593102#113#diseaseC0019196 15464247-0#13#28#gene3593 15464247-0#102#113#diseaseC0019196 associated_with interleukin 12B,hepatitis C
13#28#gene3593114#129#diseaseC0042769 15464247-0#13#28#gene3593 15464247-0#114#129#diseaseC0042769 associated_with interleukin 12B,virus infection
13#28#gene3593102#113#diseaseC0019196 15464247-0#13#28#gene3593 15464247-0#102#113#diseaseC0019196 associated_with interleukin 12B,hepatitis C
13#28#gene3593114#129#diseaseC0042769 15464247-0#13#28#gene3593 15464247-0#114#129#diseaseC0042769 associated_with interleukin 12B,virus infection
30#35#gene3593102#113#diseaseC0019196 15464247-0#30#35#gene3593 15464247-0#102#113#diseaseC0019196 associated_with IL12B,hepatitis C
30#35#gene3593114#129#diseaseC0042769 15464247-0#30#35#gene3593 15464247-0#114#129#diseaseC0042769 associated_with IL12B,virus infection
30#35#gene3593102#113#diseaseC0019196 15464247-0#30#35#gene3593 15464247-0#102#113#diseaseC0019196 associated_with IL12B,hepatitis C
30#35#gene3593114#129#diseaseC0042769 15464247-0#30#35#gene3593 15464247-0#114#129#diseaseC0042769 associated_with IL12B,virus infection

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 403-411 DNAMutation:g|SUB|A|1188|C denotes 1188-A/C

DisGeNET

Id Subject Object Predicate Lexical cue
T0 13-28 gene:3593 denotes interleukin 12B
T1 102-113 disease:C0019196 denotes hepatitis C
T2 13-28 gene:3593 denotes interleukin 12B
T3 114-129 disease:C0042769 denotes virus infection
T4 30-35 gene:3593 denotes IL12B
T5 102-113 disease:C0019196 denotes hepatitis C
T6 30-35 gene:3593 denotes IL12B
T7 114-129 disease:C0042769 denotes virus infection
R1 T0 T1 associated_with interleukin 12B,hepatitis C
R2 T2 T3 associated_with interleukin 12B,virus infection
R3 T4 T5 associated_with IL12B,hepatitis C
R4 T6 T7 associated_with IL12B,virus infection