PubMed:15452264 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/15452264","sourcedb":"PubMed","sourceid":"15452264","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/15452264","text":"Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection.\nND10 structures are disrupted during herpes simplex virus type 1 (HSV-1) infection by viral regulatory protein ICP0. The significance of this effect remains controversial, partly because of a report that high-level expression of the major ND10 promyelocytic leukemia (PML) protein precludes ND10 disruption yet does not inhibit HSV-1 infection. Here we demonstrate dramatic reorganization of ND10 during HSV-1 infection by live-cell microscopy, even in the presence of overexpressed PML.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":350,"end":372},"obj":"gene:5371"},{"id":"T1","span":{"begin":434,"end":437},"obj":"disease:C0019348"},{"id":"T2","span":{"begin":374,"end":377},"obj":"gene:5371"},{"id":"T3","span":{"begin":434,"end":437},"obj":"disease:C0019348"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#ac93ec","default":true}]}]}}