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PubMed:1545132 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 36-68 protein denotes activation-inducer molecule/CD69
T2 94-119 protein denotes transcription factor AP-1
T3 142-167 protein denotes AP-1 transcription factor
T4 290-294 protein denotes AP-1
T5 307-343 cell_type denotes human peripheral blood T lymphocytes
T6 401-405 protein denotes CD69
T7 464-472 protein denotes AIM/CD69
T8 544-551 cell_type denotes T cells
T9 572-584 protein denotes anti-AIM mAb
T10 632-644 protein denotes anti-AIM mAb
T11 648-673 cell_type denotes PMA-treated T lymphocytes
T12 716-720 protein denotes AP-1
T13 750-780 DNA denotes phorbol ester response element
T14 795-807 protein denotes anti-AIM mAb
T15 861-871 protein denotes NF-kappa B
T16 875-895 protein denotes transcription factor
T17 932-948 protein denotes protein kinase C
T18 966-970 protein denotes AP-1
T19 1054-1059 protein denotes c-fos
T20 1076-1081 protein denotes c-jun
T21 1099-1120 protein denotes DNA-binding complexes
T22 1129-1141 protein denotes anti-Fos mAb
T23 1181-1186 protein denotes c-Fos
T24 1194-1208 protein denotes AP-1 complexes
T25 1220-1232 protein denotes anti-AIM mAb
T26 1246-1250 protein denotes AP-1
T27 1289-1301 protein denotes anti-AIM mAb
T28 1442-1446 protein denotes AP-1
T29 1516-1546 cell_type denotes human peripheral blood T cells
T30 1607-1611 protein denotes AP-1

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 0-12 NP denotes Human T cell
C1 0-23 NP denotes Human T cell activation
C3 32-68 NP denotes the activation-inducer molecule/CD69
C5 94-119 NP denotes transcription factor AP-1
C4 78-119 NP denotes the activity of transcription factor AP-1
C6 138-167 NP denotes the AP-1 transcription factor
C8 290-294 NP denotes AP-1
C7 290-303 NP denotes AP-1 activity
C9 307-343 NP denotes human peripheral blood T lymphocytes
C10 363-424 NP denotes the activation inducer molecule (AIM)/CD69 activation pathway
C11 544-551 NP denotes T cells
C12 572-584 NP denotes anti-AIM mAb
C13 632-644 NP denotes anti-AIM mAb
C15 716-720 NP denotes AP-1
C14 692-720 NP denotes the binding activity of AP-1
C16 724-727 NP denotes its
C17 795-807 NP denotes anti-AIM mAb
C18 861-871 NP denotes NF-kappa B
C19 873-895 NP denotes a transcription factor
C20 896-901 NP denotes whose
C22 966-970 NP denotes AP-1
C21 966-987 NP denotes AP-1-binding activity
C23 1054-1059 NP denotes c-fos
C24 1068-1072 NP denotes that
C25 1181-1186 NP denotes c-Fos
C26 1190-1208 NP denotes the AP-1 complexes
C27 1220-1232 NP denotes anti-AIM mAb
C29 1246-1250 NP denotes AP-1
C28 1242-1259 NP denotes the AP-1 activity
C30 1285-1301 NP denotes the anti-AIM mAb
C32 1442-1446 NP denotes AP-1
C31 1442-1463 NP denotes AP-1-binding activity
C34 1516-1546 NP denotes human peripheral blood T cells
C33 1502-1546 NP denotes activation of human peripheral blood T cells
C35 1555-1581 NP denotes the AIM activation pathway
C37 1607-1611 NP denotes AP-1
C36 1591-1611 NP denotes the activity of AP-1
C38 1624-1636 NP denotes this pathway
C40 1690-1696 NP denotes T cell
C39 1684-1707 NP denotes early T cell activation
R1 C6 C5 coref-ident the AP-1 transcription factor,transcription factor AP-1
R2 C8 C6 coref-ident AP-1,the AP-1 transcription factor
R3 C7 C4 coref-ident AP-1 activity,the activity of transcription factor AP-1
R4 C9 C2 coref-ident human peripheral blood T lymphocytes,Human T cell
R5 C10 C3 coref-other the activation inducer molecule (AIM)/CD69 activation pathway,the activation-inducer molecule/CD69
R6 C11 C9 coref-ident T cells,human peripheral blood T lymphocytes
R7 C13 C12 coref-ident anti-AIM mAb,anti-AIM mAb
R8 C15 C8 coref-ident AP-1,AP-1
R9 C14 C7 coref-ident the binding activity of AP-1,AP-1 activity
R10 C16 C15 coref-pron its,AP-1
R11 C17 C13 coref-ident anti-AIM mAb,anti-AIM mAb
R12 C19 C18 coref-appos a transcription factor,NF-kappa B
R13 C20 C19 coref-relat whose,a transcription factor
R14 C22 C15 coref-ident AP-1,AP-1
R15 C21 C14 coref-ident AP-1-binding activity,the binding activity of AP-1
R16 C24 C21 coref-pron that,AP-1-binding activity
R17 C25 C23 coref-ident c-Fos,c-fos
R18 C26 C22 coref-ident the AP-1 complexes,AP-1
R19 C27 C17 coref-ident anti-AIM mAb,anti-AIM mAb
R20 C29 C26 coref-ident AP-1,the AP-1 complexes
R21 C28 C21 coref-ident the AP-1 activity,AP-1-binding activity
R22 C30 C27 coref-ident the anti-AIM mAb,anti-AIM mAb
R23 C32 C29 coref-ident AP-1,AP-1
R24 C31 C28 coref-ident AP-1-binding activity,the AP-1 activity
R25 C34 C11 coref-ident human peripheral blood T cells,T cells
R26 C33 C1 coref-ident activation of human peripheral blood T cells,Human T cell activation
R27 C35 C10 coref-ident the AIM activation pathway,the activation inducer molecule (AIM)/CD69 activation pathway
R28 C37 C32 coref-ident AP-1,AP-1
R29 C36 C31 coref-ident the activity of AP-1,AP-1-binding activity
R30 C38 C35 coref-ident this pathway,the AIM activation pathway
R31 C40 C34 coref-ident T cell,human peripheral blood T cells
R32 C39 C33 coref-other early T cell activation,activation of human peripheral blood T cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-120 Sentence denotes Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.
S2 121-255 Sentence denotes The induction of the AP-1 transcription factor has been ascribed to the early events leading to T cell differentiation and activation.
S3 256-425 Sentence denotes We have studied the regulation of AP-1 activity in human peripheral blood T lymphocytes stimulated through the activation inducer molecule (AIM)/CD69 activation pathway.
S4 426-585 Sentence denotes Phorbol esters are required to induce AIM/CD69 cell-surface expression as well as for triggering the proliferation of T cells in conjunction with anti-AIM mAb.
S5 586-781 Sentence denotes Mobility shift assays showed that addition of anti-AIM mAb to PMA-treated T lymphocytes markedly enhanced the binding activity of AP-1 to its cognate sequence, the phorbol ester response element.
S6 782-949 Sentence denotes In contrast, anti-AIM mAb did not induce any change in the binding activity of NF-kappa B, a transcription factor whose activity is also regulated by protein kinase C.
S7 950-1082 Sentence denotes The increase in AP-1-binding activity was accompanied by the marked stimulation of the transcription of c-fos but not that of c-jun.
S8 1083-1233 Sentence denotes Blockade of the DNA-binding complexes with an anti-Fos mAb demonstrated a direct participation of c-Fos in the AP-1 complexes induced by anti-AIM mAb.
S9 1234-1464 Sentence denotes Most of the AP-1 activity could be eliminated when the anti-AIM mAb was added to the culture medium in the presence of cycloheximide, suggesting that de novo protein synthesis is crucial for the induction of AP-1-binding activity.
S10 1465-1612 Sentence denotes These data provide the evidence that activation of human peripheral blood T cells through the AIM activation pathway regulate the activity of AP-1.
S11 1613-1715 Sentence denotes Therefore, this pathway appears as a crucial step in the initiation of early T cell activation events.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-23 other_name denotes Human T cell activation
T2 36-68 protein_molecule denotes activation-inducer molecule/CD69
T3 94-119 protein_molecule denotes transcription factor AP-1
T4 142-167 protein_molecule denotes AP-1 transcription factor
T5 217-239 other_name denotes T cell differentiation
T6 244-254 other_name denotes activation
T7 290-294 protein_molecule denotes AP-1
T8 307-312 multi_cell denotes human
T9 367-401 other_name denotes activation inducer molecule (AIM)/
T10 401-405 protein_molecule denotes CD69
T11 426-440 other_organic_compound denotes Phorbol esters
T12 464-472 protein_molecule denotes AIM/CD69
T13 544-551 cell_type denotes T cells
T14 572-584 protein_molecule denotes anti-AIM mAb
T15 632-644 protein_molecule denotes anti-AIM mAb
T16 648-651 protein_molecule denotes PMA
T17 660-673 cell_type denotes T lymphocytes
T18 716-720 protein_molecule denotes AP-1
T19 750-763 other_organic_compound denotes phorbol ester
T20 795-807 protein_molecule denotes anti-AIM mAb
T21 861-871 protein_molecule denotes NF-kappa B
T22 875-895 protein_family_or_group denotes transcription factor
T23 932-948 protein_molecule denotes protein kinase C
T24 966-970 protein_molecule denotes AP-1
T25 1054-1059 protein_molecule denotes c-fos
T26 1076-1081 protein_molecule denotes c-jun
T27 1099-1120 protein_complex denotes DNA-binding complexes
T28 1129-1141 protein_molecule denotes anti-Fos mAb
T29 1181-1186 protein_molecule denotes c-Fos
T30 1194-1198 protein_molecule denotes AP-1
T31 1220-1232 protein_molecule denotes anti-AIM mAb
T32 1246-1250 protein_molecule denotes AP-1
T33 1289-1301 protein_molecule denotes anti-AIM mAb
T34 1319-1333 other_name denotes culture medium
T35 1353-1366 other_organic_compound denotes cycloheximide
T36 1392-1409 other_name denotes protein synthesis
T37 1442-1446 protein_molecule denotes AP-1
T38 1516-1521 multi_cell denotes human
T39 1539-1546 cell_type denotes T cells
T40 1559-1581 other_name denotes AIM activation pathway
T41 1607-1611 protein_molecule denotes AP-1
T42 1684-1714 other_name denotes early T cell activation events