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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-57 Sentence denotes Etiology of Paget's disease and osteoclast abnormalities.
TextSentencer_T2 58-186 Sentence denotes Paget's disease of bone is a chronic focal skeletal disorder that affects up to 2-3% of the population over the age of 60 years.
TextSentencer_T3 187-244 Sentence denotes Paget's disease is primarily a disease of the osteoclast.
TextSentencer_T4 245-424 Sentence denotes The pathologic abnormality in patients with Paget's disease involves increased bone resorption by the osteoclasts, followed by abundant new bone formation that is of poor quality.
TextSentencer_T5 425-581 Sentence denotes Genetic linkage analysis indicated that 40% of patients with Paget's disease have an affected first degree relative and 1% of patients develop osteosarcoma.
TextSentencer_T6 582-656 Sentence denotes Paget's disease is an autosomal dominant trait with genetic heterogeneity.
TextSentencer_T7 657-797 Sentence denotes Recurrent mutations in the ubiquitin-associated (UBA) domain of sequestosome 1 (SQSTM1/p62) are identified in patients with Paget's disease.
TextSentencer_T8 798-972 Sentence denotes Osteoclasts and osteoclast precursors from patients with Paget's disease contain paramyxoviral transcripts and appear hyperresponsive to 1,25-(OH)2D3 and RANK ligand (RANKL).
TextSentencer_T9 973-1164 Sentence denotes It has been suggested that the enhanced sensitivity of osteoclast precursors for 1,25-(OH)2D3 in Paget's disease results from increased expression of coactivators of vitamin D receptor (VDR).
TextSentencer_T10 1165-1338 Sentence denotes However, a cause and effect relationship for the paramyxoviral infection and SQSTM1/p62 gene mutations associated with this disease and osteoclast abnormalities are unclear.
TextSentencer_T11 1339-1400 Sentence denotes Therefore, the etiology of Paget's disease remains uncertain.
T1 0-57 Sentence denotes Etiology of Paget's disease and osteoclast abnormalities.
T2 58-186 Sentence denotes Paget's disease of bone is a chronic focal skeletal disorder that affects up to 2-3% of the population over the age of 60 years.
T3 187-244 Sentence denotes Paget's disease is primarily a disease of the osteoclast.
T4 245-424 Sentence denotes The pathologic abnormality in patients with Paget's disease involves increased bone resorption by the osteoclasts, followed by abundant new bone formation that is of poor quality.
T5 425-581 Sentence denotes Genetic linkage analysis indicated that 40% of patients with Paget's disease have an affected first degree relative and 1% of patients develop osteosarcoma.
T6 582-656 Sentence denotes Paget's disease is an autosomal dominant trait with genetic heterogeneity.
T7 657-797 Sentence denotes Recurrent mutations in the ubiquitin-associated (UBA) domain of sequestosome 1 (SQSTM1/p62) are identified in patients with Paget's disease.
T8 798-972 Sentence denotes Osteoclasts and osteoclast precursors from patients with Paget's disease contain paramyxoviral transcripts and appear hyperresponsive to 1,25-(OH)2D3 and RANK ligand (RANKL).
T9 973-1164 Sentence denotes It has been suggested that the enhanced sensitivity of osteoclast precursors for 1,25-(OH)2D3 in Paget's disease results from increased expression of coactivators of vitamin D receptor (VDR).
T10 1165-1338 Sentence denotes However, a cause and effect relationship for the paramyxoviral infection and SQSTM1/p62 gene mutations associated with this disease and osteoclast abnormalities are unclear.
T11 1339-1400 Sentence denotes Therefore, the etiology of Paget's disease remains uncertain.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15389972-6#64#78#gene8878 721-735 gene8878 denotes sequestosome 1
15389972-6#80#86#gene8878 737-743 gene8878 denotes SQSTM1
15389972-6#124#139#diseaseC0029401 781-796 diseaseC0029401 denotes Paget's disease
15389972-6#124#139#diseaseC1368019 781-796 diseaseC1368019 denotes Paget's disease
15389972-6#124#139#diseaseC0029401 781-796 diseaseC0029401 denotes Paget's disease
15389972-6#124#139#diseaseC1368019 781-796 diseaseC1368019 denotes Paget's disease
15389972-7#154#158#gene8792 952-956 gene8792 denotes RANK
15389972-7#57#72#diseaseC0029401 855-870 diseaseC0029401 denotes Paget's disease
15389972-7#57#72#diseaseC1368019 855-870 diseaseC1368019 denotes Paget's disease
15389972-8#166#184#gene7421 1139-1157 gene7421 denotes vitamin D receptor
15389972-8#186#189#gene7421 1159-1162 gene7421 denotes VDR
15389972-8#97#112#diseaseC0029401 1070-1085 diseaseC0029401 denotes Paget's disease
15389972-8#97#112#diseaseC1368019 1070-1085 diseaseC1368019 denotes Paget's disease
15389972-8#97#112#diseaseC0029401 1070-1085 diseaseC0029401 denotes Paget's disease
15389972-8#97#112#diseaseC1368019 1070-1085 diseaseC1368019 denotes Paget's disease
64#78#gene8878124#139#diseaseC0029401 15389972-6#64#78#gene8878 15389972-6#124#139#diseaseC0029401 associated_with sequestosome 1,Paget's disease
64#78#gene8878124#139#diseaseC1368019 15389972-6#64#78#gene8878 15389972-6#124#139#diseaseC1368019 associated_with sequestosome 1,Paget's disease
64#78#gene8878124#139#diseaseC0029401 15389972-6#64#78#gene8878 15389972-6#124#139#diseaseC0029401 associated_with sequestosome 1,Paget's disease
64#78#gene8878124#139#diseaseC1368019 15389972-6#64#78#gene8878 15389972-6#124#139#diseaseC1368019 associated_with sequestosome 1,Paget's disease
80#86#gene8878124#139#diseaseC0029401 15389972-6#80#86#gene8878 15389972-6#124#139#diseaseC0029401 associated_with SQSTM1,Paget's disease
80#86#gene8878124#139#diseaseC1368019 15389972-6#80#86#gene8878 15389972-6#124#139#diseaseC1368019 associated_with SQSTM1,Paget's disease
80#86#gene8878124#139#diseaseC0029401 15389972-6#80#86#gene8878 15389972-6#124#139#diseaseC0029401 associated_with SQSTM1,Paget's disease
80#86#gene8878124#139#diseaseC1368019 15389972-6#80#86#gene8878 15389972-6#124#139#diseaseC1368019 associated_with SQSTM1,Paget's disease
154#158#gene879257#72#diseaseC0029401 15389972-7#154#158#gene8792 15389972-7#57#72#diseaseC0029401 associated_with RANK,Paget's disease
154#158#gene879257#72#diseaseC1368019 15389972-7#154#158#gene8792 15389972-7#57#72#diseaseC1368019 associated_with RANK,Paget's disease
166#184#gene742197#112#diseaseC0029401 15389972-8#166#184#gene7421 15389972-8#97#112#diseaseC0029401 associated_with vitamin D receptor,Paget's disease
166#184#gene742197#112#diseaseC1368019 15389972-8#166#184#gene7421 15389972-8#97#112#diseaseC1368019 associated_with vitamin D receptor,Paget's disease
166#184#gene742197#112#diseaseC0029401 15389972-8#166#184#gene7421 15389972-8#97#112#diseaseC0029401 associated_with vitamin D receptor,Paget's disease
166#184#gene742197#112#diseaseC1368019 15389972-8#166#184#gene7421 15389972-8#97#112#diseaseC1368019 associated_with vitamin D receptor,Paget's disease
186#189#gene742197#112#diseaseC0029401 15389972-8#186#189#gene7421 15389972-8#97#112#diseaseC0029401 associated_with VDR,Paget's disease
186#189#gene742197#112#diseaseC1368019 15389972-8#186#189#gene7421 15389972-8#97#112#diseaseC1368019 associated_with VDR,Paget's disease
186#189#gene742197#112#diseaseC0029401 15389972-8#186#189#gene7421 15389972-8#97#112#diseaseC0029401 associated_with VDR,Paget's disease
186#189#gene742197#112#diseaseC1368019 15389972-8#186#189#gene7421 15389972-8#97#112#diseaseC1368019 associated_with VDR,Paget's disease

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2148 721-735 gene:8878 denotes sequestosome 1
T2149 781-796 disease:C0029401 denotes Paget's disease
T2150 737-743 gene:8878 denotes SQSTM1
T2151 952-956 gene:8792 denotes RANK
T2152 855-870 disease:C0029401 denotes Paget's disease
T2153 1139-1157 gene:7421 denotes vitamin D receptor
T2154 1070-1085 disease:C0029401 denotes Paget's disease
T2155 1159-1162 gene:7421 denotes VDR
R1 T2148 T2149 associated_with sequestosome 1,Paget's disease
R2 T2148 T2149 associated_with sequestosome 1,Paget's disease
R3 T2150 T2149 associated_with SQSTM1,Paget's disease
R4 T2150 T2149 associated_with SQSTM1,Paget's disease
R5 T2151 T2152 associated_with RANK,Paget's disease
R6 T2151 T2152 associated_with RANK,Paget's disease
R7 T2153 T2154 associated_with vitamin D receptor,Paget's disease
R8 T2153 T2154 associated_with vitamin D receptor,Paget's disease
R9 T2155 T2154 associated_with VDR,Paget's disease
R10 T2155 T2154 associated_with VDR,Paget's disease