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PubMed:15385432 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 66-69 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 66-69 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 187-190 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 187-190 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 204-207 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 204-207 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 469-472 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 469-472 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 1027-1030 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 1027-1030 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1077-1080 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1077-1080 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1130-1133 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1130-1133 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1260-1263 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1260-1263 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 1398-1401 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 1398-1401 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 1629-1645 https://glytoucan.org/Structures/Glycans/G71142DF denotes glucosylceramide
T20 1783-1786 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T21 1783-1786 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T22 1853-1856 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T23 1853-1856 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T24 1934-1937 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T25 1934-1937 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 66-69 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 187-190 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 204-207 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 469-472 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T9 1027-1030 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T11 1077-1080 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T13 1130-1133 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T15 1260-1263 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T17 1398-1401 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T19 1629-1645 Glycan_Motif denotes glucosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71142DF
T20 1783-1786 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T22 1853-1856 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T24 1934-1937 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-130 Sentence denotes Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells.
TextSentencer_T2 131-392 Sentence denotes Previous studies have demonstrated that the activity of GM3 synthase and GM3 content are increased during the differentiation of human promyelocytic leukemia HL-60 cells into the monocyte/macrophage lineage after phorbol 12-myristate 13-acetate (PMA) treatment.
TextSentencer_T3 393-556 Sentence denotes However, the molecular mechanisms involved in transcriptional activation of GM3 synthase during differentiation of PMA-induced HL-60 cells are not well understood.
TextSentencer_T4 557-765 Sentence denotes As evidenced by western blot analysis, PMA induced the marked activation of protein kinase C (PKC)/extracellular regulated kinases (ERKs) signal transduction pathway during the differentiation of HL-60 cells.
TextSentencer_T5 766-932 Sentence denotes In addition, PKC/ERKs activation induced by PMA in HL-60 cells led to the phosphorylation of cAMP-responsive element binding protein (CREB) as a transcription factor.
TextSentencer_T6 933-1089 Sentence denotes In PMA-stimulated HL-60 cells, the PKC/ERKs-dependent CREB activation regulated expression of GM3 synthase, inducing a synthesis of ganglioside GM3 product.
TextSentencer_T7 1090-1356 Sentence denotes On the other hand, although ganglioside GM3 was shown to be able to induce the differentiation of HL-60 cells into the monocyte/macrophage lineage, effect of ganglioside GM3 on expression of CD11b as a differentiation marker in HL-60 cells has been not reported yet.
TextSentencer_T8 1357-1548 Sentence denotes Interestingly, the increased ganglioside GM3 through PKC/ERKs/CREB-dependent pathway by PMA resulted in an increase of CD11b surface antigen expression and induction of HL-60 cells adherence.
TextSentencer_T9 1549-1787 Sentence denotes Treatment with L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), glucosylceramide synthase inhibitor, decreased induction of not only CD11b expression but also cellular adherence by reduction of PMA-induced ganglioside GM3.
TextSentencer_T10 1788-1882 Sentence denotes Furthermore, treatment of HL-60 cells with exogenous ganglioside GM3 induced CD11b expression.
TextSentencer_T11 1883-2136 Sentence denotes These results show that the enhanced expression of GM3 synthase through PKC/ERKs-dependent CREB activation by PMA is associated with the differentiation of HL-60 cells by inducing expression of CD11b known as a monocyte/macrophage differentiation maker.
T1 0-130 Sentence denotes Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells.
T2 131-392 Sentence denotes Previous studies have demonstrated that the activity of GM3 synthase and GM3 content are increased during the differentiation of human promyelocytic leukemia HL-60 cells into the monocyte/macrophage lineage after phorbol 12-myristate 13-acetate (PMA) treatment.
T3 393-556 Sentence denotes However, the molecular mechanisms involved in transcriptional activation of GM3 synthase during differentiation of PMA-induced HL-60 cells are not well understood.
T4 557-765 Sentence denotes As evidenced by western blot analysis, PMA induced the marked activation of protein kinase C (PKC)/extracellular regulated kinases (ERKs) signal transduction pathway during the differentiation of HL-60 cells.
T5 766-932 Sentence denotes In addition, PKC/ERKs activation induced by PMA in HL-60 cells led to the phosphorylation of cAMP-responsive element binding protein (CREB) as a transcription factor.
T6 933-1089 Sentence denotes In PMA-stimulated HL-60 cells, the PKC/ERKs-dependent CREB activation regulated expression of GM3 synthase, inducing a synthesis of ganglioside GM3 product.
T7 1090-1356 Sentence denotes On the other hand, although ganglioside GM3 was shown to be able to induce the differentiation of HL-60 cells into the monocyte/macrophage lineage, effect of ganglioside GM3 on expression of CD11b as a differentiation marker in HL-60 cells has been not reported yet.
T8 1357-1548 Sentence denotes Interestingly, the increased ganglioside GM3 through PKC/ERKs/CREB-dependent pathway by PMA resulted in an increase of CD11b surface antigen expression and induction of HL-60 cells adherence.
T9 1549-1787 Sentence denotes Treatment with L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), glucosylceramide synthase inhibitor, decreased induction of not only CD11b expression but also cellular adherence by reduction of PMA-induced ganglioside GM3.
T10 1788-1882 Sentence denotes Furthermore, treatment of HL-60 cells with exogenous ganglioside GM3 induced CD11b expression.
T11 1883-2136 Sentence denotes These results show that the enhanced expression of GM3 synthase through PKC/ERKs-dependent CREB activation by PMA is associated with the differentiation of HL-60 cells by inducing expression of CD11b known as a monocyte/macrophage differentiation maker.
T1 0-130 Sentence denotes Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells.
T2 131-392 Sentence denotes Previous studies have demonstrated that the activity of GM3 synthase and GM3 content are increased during the differentiation of human promyelocytic leukemia HL-60 cells into the monocyte/macrophage lineage after phorbol 12-myristate 13-acetate (PMA) treatment.
T3 393-556 Sentence denotes However, the molecular mechanisms involved in transcriptional activation of GM3 synthase during differentiation of PMA-induced HL-60 cells are not well understood.
T4 557-765 Sentence denotes As evidenced by western blot analysis, PMA induced the marked activation of protein kinase C (PKC)/extracellular regulated kinases (ERKs) signal transduction pathway during the differentiation of HL-60 cells.
T5 766-932 Sentence denotes In addition, PKC/ERKs activation induced by PMA in HL-60 cells led to the phosphorylation of cAMP-responsive element binding protein (CREB) as a transcription factor.
T6 933-1089 Sentence denotes In PMA-stimulated HL-60 cells, the PKC/ERKs-dependent CREB activation regulated expression of GM3 synthase, inducing a synthesis of ganglioside GM3 product.
T7 1090-1356 Sentence denotes On the other hand, although ganglioside GM3 was shown to be able to induce the differentiation of HL-60 cells into the monocyte/macrophage lineage, effect of ganglioside GM3 on expression of CD11b as a differentiation marker in HL-60 cells has been not reported yet.
T8 1357-1548 Sentence denotes Interestingly, the increased ganglioside GM3 through PKC/ERKs/CREB-dependent pathway by PMA resulted in an increase of CD11b surface antigen expression and induction of HL-60 cells adherence.
T9 1549-1787 Sentence denotes Treatment with L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), glucosylceramide synthase inhibitor, decreased induction of not only CD11b expression but also cellular adherence by reduction of PMA-induced ganglioside GM3.
T10 1788-1882 Sentence denotes Furthermore, treatment of HL-60 cells with exogenous ganglioside GM3 induced CD11b expression.
T11 1883-2136 Sentence denotes These results show that the enhanced expression of GM3 synthase through PKC/ERKs-dependent CREB activation by PMA is associated with the differentiation of HL-60 cells by inducing expression of CD11b known as a monocyte/macrophage differentiation maker.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 66-69 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 66-69 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 187-190 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 187-190 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 204-207 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 204-207 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 469-472 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 469-472 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 1027-1030 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 1027-1030 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1077-1080 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1077-1080 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1130-1133 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1130-1133 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1260-1263 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1260-1263 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 1398-1401 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 1398-1401 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 1629-1645 https://glytoucan.org/Structures/Glycans/G71142DF denotes glucosylceramide
T20 1783-1786 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T21 1783-1786 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T22 1853-1856 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T23 1853-1856 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T24 1934-1937 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T25 1934-1937 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1103-1107 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

uniprot-human

Id Subject Object Predicate Lexical cue
T1 54-78 http://www.uniprot.org/uniprot/Q9UNP4 denotes ganglioside GM3 synthase
T2 118-120 http://www.uniprot.org/uniprot/P11150 denotes HL
T3 289-291 http://www.uniprot.org/uniprot/P11150 denotes HL
T4 520-522 http://www.uniprot.org/uniprot/P11150 denotes HL
T5 753-755 http://www.uniprot.org/uniprot/P11150 denotes HL
T6 817-819 http://www.uniprot.org/uniprot/P11150 denotes HL
T7 951-953 http://www.uniprot.org/uniprot/P11150 denotes HL
T8 1188-1190 http://www.uniprot.org/uniprot/P11150 denotes HL
T9 1318-1320 http://www.uniprot.org/uniprot/P11150 denotes HL
T10 1526-1528 http://www.uniprot.org/uniprot/P11150 denotes HL
T11 1814-1816 http://www.uniprot.org/uniprot/P11150 denotes HL
T12 2039-2041 http://www.uniprot.org/uniprot/P11150 denotes HL
T13 118-120 http://www.uniprot.org/uniprot/P35914 denotes HL
T14 289-291 http://www.uniprot.org/uniprot/P35914 denotes HL
T15 520-522 http://www.uniprot.org/uniprot/P35914 denotes HL
T16 753-755 http://www.uniprot.org/uniprot/P35914 denotes HL
T17 817-819 http://www.uniprot.org/uniprot/P35914 denotes HL
T18 951-953 http://www.uniprot.org/uniprot/P35914 denotes HL
T19 1188-1190 http://www.uniprot.org/uniprot/P35914 denotes HL
T20 1318-1320 http://www.uniprot.org/uniprot/P35914 denotes HL
T21 1526-1528 http://www.uniprot.org/uniprot/P35914 denotes HL
T22 1814-1816 http://www.uniprot.org/uniprot/P35914 denotes HL
T23 2039-2041 http://www.uniprot.org/uniprot/P35914 denotes HL
T24 118-120 http://www.uniprot.org/uniprot/Q14469 denotes HL
T25 289-291 http://www.uniprot.org/uniprot/Q14469 denotes HL
T26 520-522 http://www.uniprot.org/uniprot/Q14469 denotes HL
T27 753-755 http://www.uniprot.org/uniprot/Q14469 denotes HL
T28 817-819 http://www.uniprot.org/uniprot/Q14469 denotes HL
T29 951-953 http://www.uniprot.org/uniprot/Q14469 denotes HL
T30 1188-1190 http://www.uniprot.org/uniprot/Q14469 denotes HL
T31 1318-1320 http://www.uniprot.org/uniprot/Q14469 denotes HL
T32 1526-1528 http://www.uniprot.org/uniprot/Q14469 denotes HL
T33 1814-1816 http://www.uniprot.org/uniprot/Q14469 denotes HL
T34 2039-2041 http://www.uniprot.org/uniprot/Q14469 denotes HL
T35 883-904 http://www.uniprot.org/uniprot/Q92793 denotes binding protein (CREB
T36 1281-1286 http://www.uniprot.org/uniprot/P11215 denotes CD11b
T37 1476-1481 http://www.uniprot.org/uniprot/P11215 denotes CD11b
T38 1698-1703 http://www.uniprot.org/uniprot/P11215 denotes CD11b
T39 1865-1870 http://www.uniprot.org/uniprot/P11215 denotes CD11b
T40 2077-2082 http://www.uniprot.org/uniprot/P11215 denotes CD11b
T41 1629-1654 http://www.uniprot.org/uniprot/Q16739 denotes glucosylceramide synthase
T42 2094-2129 http://www.uniprot.org/uniprot/Q15546 denotes monocyte/macrophage differentiation

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 54-78 http://www.uniprot.org/uniprot/Q9QWF9 denotes ganglioside GM3 synthase
T2 118-120 http://www.uniprot.org/uniprot/P27656 denotes HL
T3 289-291 http://www.uniprot.org/uniprot/P27656 denotes HL
T4 520-522 http://www.uniprot.org/uniprot/P27656 denotes HL
T5 753-755 http://www.uniprot.org/uniprot/P27656 denotes HL
T6 817-819 http://www.uniprot.org/uniprot/P27656 denotes HL
T7 951-953 http://www.uniprot.org/uniprot/P27656 denotes HL
T8 1188-1190 http://www.uniprot.org/uniprot/P27656 denotes HL
T9 1318-1320 http://www.uniprot.org/uniprot/P27656 denotes HL
T10 1526-1528 http://www.uniprot.org/uniprot/P27656 denotes HL
T11 1814-1816 http://www.uniprot.org/uniprot/P27656 denotes HL
T12 2039-2041 http://www.uniprot.org/uniprot/P27656 denotes HL
T13 118-120 http://www.uniprot.org/uniprot/P38060 denotes HL
T14 289-291 http://www.uniprot.org/uniprot/P38060 denotes HL
T15 520-522 http://www.uniprot.org/uniprot/P38060 denotes HL
T16 753-755 http://www.uniprot.org/uniprot/P38060 denotes HL
T17 817-819 http://www.uniprot.org/uniprot/P38060 denotes HL
T18 951-953 http://www.uniprot.org/uniprot/P38060 denotes HL
T19 1188-1190 http://www.uniprot.org/uniprot/P38060 denotes HL
T20 1318-1320 http://www.uniprot.org/uniprot/P38060 denotes HL
T21 1526-1528 http://www.uniprot.org/uniprot/P38060 denotes HL
T22 1814-1816 http://www.uniprot.org/uniprot/P38060 denotes HL
T23 2039-2041 http://www.uniprot.org/uniprot/P38060 denotes HL
T24 883-904 http://www.uniprot.org/uniprot/P45481 denotes binding protein (CREB
T25 1281-1286 http://www.uniprot.org/uniprot/P05555 denotes CD11b
T26 1476-1481 http://www.uniprot.org/uniprot/P05555 denotes CD11b
T27 1698-1703 http://www.uniprot.org/uniprot/P05555 denotes CD11b
T28 1865-1870 http://www.uniprot.org/uniprot/P05555 denotes CD11b
T29 2077-2082 http://www.uniprot.org/uniprot/P05555 denotes CD11b
T30 1629-1654 http://www.uniprot.org/uniprot/O88693 denotes glucosylceramide synthase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 10-19 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T2 124-129 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 295-300 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 416-426 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms
T5 526-531 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T6 759-764 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 823-828 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 957-962 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 1194-1199 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 1324-1329 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T11 1532-1537 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T12 1820-1825 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T13 2045-2050 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 24-39 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T2 439-454 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3 911-924 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4 40-69 http://purl.obolibrary.org/obo/GO_0047291 denotes activation of ganglioside GM3
T5 40-78 http://purl.obolibrary.org/obo/GO_0047291 denotes activation of ganglioside GM3 synthase
T6 175-199 http://purl.obolibrary.org/obo/GO_0047291 denotes activity of GM3 synthase
T7 455-481 http://purl.obolibrary.org/obo/GO_0047291 denotes activation of GM3 synthase
T8 40-69 http://purl.obolibrary.org/obo/GO_0003947 denotes activation of ganglioside GM3
T9 87-114 http://purl.obolibrary.org/obo/GO_0048469 denotes function in differentiation
T10 619-647 http://purl.obolibrary.org/obo/GO_0004691 denotes activation of protein kinase
T11 619-647 http://purl.obolibrary.org/obo/GO_0004674 denotes activation of protein kinase
T12 619-647 http://purl.obolibrary.org/obo/GO_0004713 denotes activation of protein kinase
T13 619-647 http://purl.obolibrary.org/obo/GO_0034199 denotes activation of protein kinase
T14 619-647 http://purl.obolibrary.org/obo/GO_0050321 denotes activation of protein kinase
T15 619-647 http://purl.obolibrary.org/obo/GO_2000479 denotes activation of protein kinase
T16 619-647 http://purl.obolibrary.org/obo/GO_0004860 denotes activation of protein kinase
T17 619-649 http://purl.obolibrary.org/obo/GO_0004697 denotes activation of protein kinase C
T18 619-649 http://purl.obolibrary.org/obo/GO_1990051 denotes activation of protein kinase C
T19 619-649 http://purl.obolibrary.org/obo/GO_0004698 denotes activation of protein kinase C
T20 619-649 http://purl.obolibrary.org/obo/GO_0004699 denotes activation of protein kinase C
T21 619-649 http://purl.obolibrary.org/obo/GO_1900019 denotes activation of protein kinase C
T22 619-649 http://purl.obolibrary.org/obo/GO_0008426 denotes activation of protein kinase C
T23 633-649 http://purl.obolibrary.org/obo/GO_0042313 denotes protein kinase C
T24 633-649 http://purl.obolibrary.org/obo/GO_0070528 denotes protein kinase C
T25 651-654 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T26 779-782 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T27 968-971 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T28 1410-1413 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T29 1955-1958 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T30 670-679 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T31 1003-1012 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T32 689-693 http://purl.obolibrary.org/obo/GO_0004707 denotes ERKs
T33 783-787 http://purl.obolibrary.org/obo/GO_0004707 denotes ERKs
T34 972-976 http://purl.obolibrary.org/obo/GO_0004707 denotes ERKs
T35 1414-1418 http://purl.obolibrary.org/obo/GO_0004707 denotes ERKs
T36 1959-1963 http://purl.obolibrary.org/obo/GO_0004707 denotes ERKs
T37 695-701 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T38 695-714 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T39 695-722 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathway
T40 695-722 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathway
T41 695-722 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathway
T42 695-722 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathway
T43 702-714 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T44 840-855 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T45 859-874 http://purl.obolibrary.org/obo/GO_0051591 denotes cAMP-responsive
T46 987-1002 http://purl.obolibrary.org/obo/GO_0032793 denotes CREB activation
T47 1974-1989 http://purl.obolibrary.org/obo/GO_0032793 denotes CREB activation
T48 1052-1061 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T49 1052-1076 http://purl.obolibrary.org/obo/GO_0001574 denotes synthesis of ganglioside
T50 1724-1732 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T51 1831-1840 http://purl.obolibrary.org/obo/GO_0042638 denotes exogenous
T52 2103-2129 http://purl.obolibrary.org/obo/GO_0030225 denotes macrophage differentiation

GO-MF

Id Subject Object Predicate Lexical cue
T1 619-647 http://purl.obolibrary.org/obo/GO_0034237 denotes activation of protein kinase
T2 619-647 http://purl.obolibrary.org/obo/GO_0051018 denotes activation of protein kinase
T3 633-649 http://purl.obolibrary.org/obo/GO_0005080 denotes protein kinase C
T4 883-890 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 883-890 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 883-890 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T7 883-890 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T8 883-898 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein

GO-CC

Id Subject Object Predicate Lexical cue
T1 124-129 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 295-300 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 526-531 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 759-764 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 823-828 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 957-962 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1194-1199 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 1324-1329 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9 1532-1537 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 1820-1825 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11 2045-2050 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12 656-669 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1103-1107 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 377-380 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA
Lectin_T2 508-511 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA
Lectin_T3 596-599 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA
Lectin_T4 810-813 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA
Lectin_T5 936-939 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA
Lectin_T6 1445-1448 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA
Lectin_T7 1759-1762 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA
Lectin_T8 1993-1996 https://acgg.asia/db/lfdb/LfDB0219 denotes PMA

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 66-69 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 187-190 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 204-207 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 469-472 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 1027-1030 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1077-1080 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1130-1133 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1260-1263 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 1398-1401 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 1783-1786 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T11 1853-1856 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 1934-1937 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1103-1107 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 280-288 Phenotype denotes leukemia HP:0001909

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 266-288 Disease denotes promyelocytic leukemia http://purl.obolibrary.org/obo/MONDO_0012883
T2 377-380 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T4 508-511 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T6 596-599 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T8 810-813 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T10 936-939 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T12 1445-1448 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T14 1759-1762 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T16 1993-1996 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 66-69 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 187-190 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 204-207 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 469-472 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 1027-1030 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1077-1080 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1130-1133 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1260-1263 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 1398-1401 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 1783-1786 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T11 1853-1856 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 1934-1937 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 280-288 Phenotype denotes leukemia HP:0001909

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 266-279 Cell denotes promyelocytic http://purl.obolibrary.org/obo/CL:0000836
T2 310-318 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T4 319-329 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T6 1209-1217 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T8 1218-1228 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T10 2094-2102 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T12 2103-2113 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 310-318 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T3 319-329 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T4 656-669 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T5 1103-1107 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T6 1209-1217 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T8 1218-1228 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T9 2094-2102 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T11 2103-2113 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 266-288 Disease denotes promyelocytic leukemia MONDO:0012883

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 260-265 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells.
T2 131-392 Sentence denotes Previous studies have demonstrated that the activity of GM3 synthase and GM3 content are increased during the differentiation of human promyelocytic leukemia HL-60 cells into the monocyte/macrophage lineage after phorbol 12-myristate 13-acetate (PMA) treatment.
T3 393-556 Sentence denotes However, the molecular mechanisms involved in transcriptional activation of GM3 synthase during differentiation of PMA-induced HL-60 cells are not well understood.
T4 557-765 Sentence denotes As evidenced by western blot analysis, PMA induced the marked activation of protein kinase C (PKC)/extracellular regulated kinases (ERKs) signal transduction pathway during the differentiation of HL-60 cells.
T5 766-932 Sentence denotes In addition, PKC/ERKs activation induced by PMA in HL-60 cells led to the phosphorylation of cAMP-responsive element binding protein (CREB) as a transcription factor.
T6 933-1089 Sentence denotes In PMA-stimulated HL-60 cells, the PKC/ERKs-dependent CREB activation regulated expression of GM3 synthase, inducing a synthesis of ganglioside GM3 product.
T7 1090-1356 Sentence denotes On the other hand, although ganglioside GM3 was shown to be able to induce the differentiation of HL-60 cells into the monocyte/macrophage lineage, effect of ganglioside GM3 on expression of CD11b as a differentiation marker in HL-60 cells has been not reported yet.
T8 1357-1548 Sentence denotes Interestingly, the increased ganglioside GM3 through PKC/ERKs/CREB-dependent pathway by PMA resulted in an increase of CD11b surface antigen expression and induction of HL-60 cells adherence.
T9 1549-1787 Sentence denotes Treatment with L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), glucosylceramide synthase inhibitor, decreased induction of not only CD11b expression but also cellular adherence by reduction of PMA-induced ganglioside GM3.
T10 1788-1882 Sentence denotes Furthermore, treatment of HL-60 cells with exogenous ganglioside GM3 induced CD11b expression.
T11 1883-2136 Sentence denotes These results show that the enhanced expression of GM3 synthase through PKC/ERKs-dependent CREB activation by PMA is associated with the differentiation of HL-60 cells by inducing expression of CD11b known as a monocyte/macrophage differentiation maker.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 266-279 Body_part denotes promyelocytic FMA:83530
T2 310-318 Body_part denotes monocyte FMA:62864
T3 319-329 Body_part denotes macrophage FMA:63261
T4 1103-1107 Body_part denotes hand FMA:9712
T5 1209-1217 Body_part denotes monocyte FMA:62864
T6 1218-1228 Body_part denotes macrophage FMA:63261
T7 2094-2102 Body_part denotes monocyte FMA:62864
T8 2103-2113 Body_part denotes macrophage FMA:63261

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1103-1107 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 260-265 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 310-318 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T3 319-329 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T4 656-669 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T5 1103-1107 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T6 1209-1217 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T8 1218-1228 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T9 2094-2102 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T11 2103-2113 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 266-279 Cell denotes promyelocytic http://purl.obolibrary.org/obo/CL:0000836
T2 310-318 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T4 319-329 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T6 1209-1217 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T8 1218-1228 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T10 2094-2102 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T12 2103-2113 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394