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PubMed:15355992 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration.
T2 113-263 Sentence denotes Activation of the receptor tyrosine kinase ErbB4 leads to various cellular responses such as proliferation, survival, differentiation, and chemotaxis.
T3 264-401 Sentence denotes Two pairs of naturally occurring ErbB4 isoforms differing in their juxtamembrane (JMa/JMb) and C termini (cyt1/cyt2) have been described.
T4 402-676 Sentence denotes To examine the role of ErbB4 in neuron migration, we cloned and stably transfected each of the four ErbB4 isoforms in ST14A cells (a neural progenitor cell line derived from the striatum of embryonic day 14 rats) endogenously expressing the other members of the ErbB family:
T5 677-701 Sentence denotes ErbB1, ErbB2, and ErbB3.
T6 702-1014 Sentence denotes Using immunoprecipitation assays, we showed that the neuregulin-1beta1 (NRG1beta1) stimulus induced ErbB4 tyrosine phosphorylation and phosphatidylinositol 3-kinase (PI3K) recruitment and activation (as demonstrated by Akt phosphorylation) either directly (ErbB4 cyt1 isoform) or indirectly (ErbB4 cyt2 isoform).
T7 1015-1147 Sentence denotes We examined the ability of the four ErbB4 isoforms to induce chemotaxis and cell proliferation in response to NRG1beta1 stimulation.
T8 1148-1330 Sentence denotes Using migration assays, we observed that only ErbB4-expressing cells stimulated with NRG1beta1 showed a significant increase in migration, whereas the growth rate remained unchanged.
T9 1331-1454 Sentence denotes Additional assays showed that inhibition of PI3K (but not of phospholipase Cgamma) dramatically reduced migratory activity.
T10 1455-1578 Sentence denotes Our data show that ErbB4 signaling via PI3K activation plays a fundamental role in controlling NRG1beta1-induced migration.

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes ErbB4
T2 76-93 protein denotes neuregulin-1beta1
T3 131-155 protein denotes receptor tyrosine kinase
T4 156-161 protein denotes ErbB4
T5 297-302 protein denotes ErbB4
T6 425-430 protein denotes ErbB4
T7 502-507 protein denotes ErbB4
T8 664-675 protein denotes ErbB family
T9 677-682 protein denotes ErbB1
T10 684-689 protein denotes ErbB2
T11 695-700 protein denotes ErbB3
T12 755-772 protein denotes neuregulin-1beta1
T13 774-783 protein denotes NRG1beta1
T14 802-807 protein denotes ErbB4
T15 837-866 protein denotes phosphatidylinositol 3-kinase
T16 868-872 protein denotes PI3K
T17 921-924 protein denotes Akt
T18 959-964 protein denotes ErbB4
T19 994-999 protein denotes ErbB4
T20 1051-1056 protein denotes ErbB4
T21 1125-1134 protein denotes NRG1beta1
T22 1194-1199 protein denotes ErbB4
T23 1233-1242 protein denotes NRG1beta1
T24 1375-1379 protein denotes PI3K
T25 1392-1412 protein denotes phospholipase Cgamma
T26 1474-1479 protein denotes ErbB4
T27 1494-1498 protein denotes PI3K
T28 1550-1559 protein denotes NRG1beta1

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 609-613 OrganismTaxon denotes rats 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 27-43 Body_part denotes progenitor cells http://purl.obolibrary.org/obo/CL_0011026
T2 331-344 Body_part denotes juxtamembrane http://purl.obolibrary.org/obo/GO_0005886
T3 434-440 Body_part denotes neuron http://purl.obolibrary.org/obo/CL_0000540
T4 542-557 Body_part denotes progenitor cell http://purl.obolibrary.org/obo/CL_0011026
T5 580-588 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435|http://purl.obolibrary.org/obo/UBERON_0005383

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 20-43 Cell denotes neural progenitor cells http://purl.obolibrary.org/obo/CL:0011020
T2 434-440 Cell denotes neuron http://purl.obolibrary.org/obo/CL:0000540
T3 535-557 Cell denotes neural progenitor cell http://purl.obolibrary.org/obo/CL:0011020
T4 542-557 Cell denotes progenitor cell http://purl.obolibrary.org/obo/CL:0011026