PubMed:1532661
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 60-84 | DNA | denotes | human interleukin 4 gene |
| T2 | 159-170 | DNA | denotes | DNA segment |
| T3 | 237-266 | DNA | denotes | human interleukin (IL) 4 gene |
| T4 | 270-282 | cell_line | denotes | Jurkat cells |
| T5 | 288-303 | DNA | denotes | human IL-4 gene |
| T6 | 342-347 | DNA | denotes | exons |
| T7 | 358-365 | DNA | denotes | introns |
| T8 | 369-387 | DNA | denotes | cis-acting element |
| T9 | 389-399 | DNA | denotes | P sequence |
| T10 | 416-434 | DNA | denotes | 5' upstream region |
| T11 | 450-462 | DNA | denotes | DNA segments |
| T12 | 509-524 | DNA | denotes | human IL-4 gene |
| T13 | 558-573 | DNA | denotes | fusion promoter |
| T14 | 599-662 | DNA | denotes | granulocyte/macrophage colony-stimulating factor basic promoter |
| T15 | 674-699 | DNA | denotes | 60 base pairs of sequence |
| T16 | 718-726 | DNA | denotes | cap site |
| T17 | 734-793 | DNA | denotes | mouse granulocyte/macrophage colony-stimulating factor gene |
| T18 | 821-841 | DNA | denotes | 5' upstream sequence |
| T19 | 849-858 | DNA | denotes | IL-4 gene |
| T20 | 864-874 | DNA | denotes | P sequence |
| T21 | 933-957 | DNA | denotes | transcription start site |
| T22 | 965-980 | DNA | denotes | human IL-4 gene |
| T23 | 1091-1101 | DNA | denotes | P sequence |
| T24 | 1155-1170 | protein | denotes | binding protein |
| T25 | 1193-1203 | DNA | denotes | P sequence |
| T26 | 1211-1220 | DNA | denotes | IL-4 gene |
| T27 | 1282-1287 | protein | denotes | NF(P) |
| T28 | 1291-1310 | protein | denotes | DNA binding protein |
| T29 | 1344-1354 | DNA | denotes | P sequence |
| T30 | 1363-1373 | DNA | denotes | P sequence |
| T31 | 1469-1474 | protein | denotes | NF(P) |
| T32 | 1593-1597 | protein | denotes | IL-4 |
| T33 | 1622-1632 | DNA | denotes | P sequence |
| T34 | 1666-1686 | DNA | denotes | 5' upstream sequence |
| T35 | 1694-1703 | DNA | denotes | IL-2 gene |
| T36 | 1746-1755 | DNA | denotes | IL-4 gene |
| T37 | 1785-1794 | DNA | denotes | IL-2 gene |
| T38 | 1832-1840 | protein | denotes | proteins |
| T39 | 1851-1870 | DNA | denotes | IL-2 and IL-4 genes |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 56-84 | NP | denotes | the human interleukin 4 gene |
| C2 | 157-170 | NP | denotes | a DNA segment |
| C3 | 171-175 | NP | denotes | that |
| C4 | 233-266 | NP | denotes | the human interleukin (IL) 4 gene |
| C5 | 284-303 | NP | denotes | The human IL-4 gene |
| C6 | 305-320 | NP | denotes | of 10 kilobases |
| C7 | 389-399 | NP | denotes | P sequence |
| C8 | 505-524 | NP | denotes | the human IL-4 gene |
| C9 | 845-858 | NP | denotes | the IL-4 gene |
| C10 | 860-874 | NP | denotes | The P sequence |
| C12 | 961-980 | NP | denotes | the human IL-4 gene |
| C11 | 895-980 | NP | denotes | positions -79 and -69 relative to the transcription start site of the human IL-4 gene |
| C13 | 986-999 | NP | denotes | this location |
| C14 | 1087-1101 | NP | denotes | the P sequence |
| C15 | 1151-1173 | NP | denotes | The binding protein(s) |
| C16 | 1174-1178 | NP | denotes | that |
| C17 | 1189-1203 | NP | denotes | the P sequence |
| C18 | 1207-1220 | NP | denotes | the IL-4 gene |
| C19 | 1289-1310 | NP | denotes | a DNA binding protein |
| C20 | 1311-1315 | NP | denotes | that |
| C21 | 1340-1354 | NP | denotes | the P sequence |
| C22 | 1359-1373 | NP | denotes | the P sequence |
| C23 | 1540-1551 | NP | denotes | the protein |
| C24 | 1618-1632 | NP | denotes | The P sequence |
| C25 | 1690-1703 | NP | denotes | the IL-2 gene |
| C26 | 1742-1755 | NP | denotes | the IL-4 gene |
| C27 | 1781-1794 | NP | denotes | the IL-2 gene |
| C28 | 1851-1855 | NP | denotes | IL-2 |
| C29 | 1860-1870 | NP | denotes | IL-4 genes |
| R1 | C3 | C2 | coref-relat | that,a DNA segment |
| R2 | C4 | C1 | coref-ident | the human interleukin (IL) 4 gene,the human interleukin 4 gene |
| R3 | C5 | C4 | coref-ident | The human IL-4 gene,the human interleukin (IL) 4 gene |
| R4 | C6 | C5 | coref-appos | of 10 kilobases,The human IL-4 gene |
| R5 | C8 | C5 | coref-ident | the human IL-4 gene,The human IL-4 gene |
| R6 | C9 | C8 | coref-ident | the IL-4 gene,the human IL-4 gene |
| R7 | C10 | C7 | coref-ident | The P sequence,P sequence |
| R8 | C12 | C9 | coref-ident | the human IL-4 gene,the IL-4 gene |
| R9 | C13 | C11 | coref-ident | this location,positions -79 and -69 relative to the transcription start site of the human IL-4 gene |
| R10 | C14 | C10 | coref-ident | the P sequence,The P sequence |
| R11 | C16 | C15 | coref-relat | that,The binding protein(s) |
| R12 | C17 | C14 | coref-ident | the P sequence,the P sequence |
| R13 | C18 | C12 | coref-ident | the IL-4 gene,the human IL-4 gene |
| R14 | C20 | C19 | coref-relat | that,a DNA binding protein |
| R15 | C21 | C17 | coref-ident | the P sequence,the P sequence |
| R16 | C22 | C21 | coref-ident | the P sequence,the P sequence |
| R17 | C23 | C19 | coref-ident | the protein,a DNA binding protein |
| R18 | C24 | C22 | coref-ident | The P sequence,the P sequence |
| R19 | C26 | C18 | coref-ident | the IL-4 gene,the IL-4 gene |
| R20 | C27 | C25 | coref-ident | the IL-2 gene,the IL-2 gene |
| R21 | C28 | C27 | coref-ident | IL-2,the IL-2 gene |
| R22 | C29 | C26 | coref-ident | IL-4 genes,the IL-4 gene |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-137 | Sentence | denotes | An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals. |
| S2 | 138-283 | Sentence | denotes | We have identified a DNA segment that confers responsiveness to antigen stimulation signals on the human interleukin (IL) 4 gene in Jurkat cells. |
| S3 | 284-366 | Sentence | denotes | The human IL-4 gene, of 10 kilobases, is composed of four exons and three introns. |
| S4 | 367-525 | Sentence | denotes | A cis-acting element (P sequence) resides in the 5' upstream region; no additional DNA segments with enhancer activity were identified in the human IL-4 gene. |
| S5 | 526-859 | Sentence | denotes | For further mapping purposes, a fusion promoter was constructed with the granulocyte/macrophage colony-stimulating factor basic promoter containing 60 base pairs of sequence upstream from the cap site of the mouse granulocyte/macrophage colony-stimulating factor gene and various lengths of the 5' upstream sequence of the IL-4 gene. |
| S6 | 860-1045 | Sentence | denotes | The P sequence was located between positions -79 and -69 relative to the transcription start site of the human IL-4 gene, and this location was confirmed by base-substitution mutations. |
| S7 | 1046-1150 | Sentence | denotes | The plasmids carrying multiple copies of the P sequence showed higher responsiveness to the stimulation. |
| S8 | 1151-1266 | Sentence | denotes | The binding protein(s) that recognize the P sequence of the IL-4 gene were identified by DNA-mobility-shift assays. |
| S9 | 1267-1617 | Sentence | denotes | The binding of NF(P) (a DNA binding protein that specifically recognizes the P sequence) to the P sequence was abolished when oligonucleotides carrying base substitutions were used, indicating that the NF(P) interaction is sequence-specific and that binding specificity of the protein paralleled the sequence requirements for IL-4 expression in vivo. |
| S10 | 1618-1795 | Sentence | denotes | The P sequence does not share homology with the 5' upstream sequence of the IL-2 gene, even though surrounding sequences of the IL-4 gene share high homology with the IL-2 gene. |
| S11 | 1796-1871 | Sentence | denotes | We conclude that a different set of proteins recognize IL-2 and IL-4 genes. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 3-34 | DNA_substructure | denotes | 11-base-pair DNA sequence motif |
| T2 | 60-84 | DNA_domain_or_region | denotes | human interleukin 4 gene |
| T3 | 111-136 | other_name | denotes | T-cell activation signals |
| T4 | 159-170 | DNA_domain_or_region | denotes | DNA segment |
| T5 | 237-266 | DNA_domain_or_region | denotes | human interleukin (IL) 4 gene |
| T6 | 270-282 | cell_line | denotes | Jurkat cells |
| T7 | 288-303 | DNA_domain_or_region | denotes | human IL-4 gene |
| T8 | 308-320 | polynucleotide | denotes | 10 kilobases |
| T9 | 342-347 | DNA_domain_or_region | denotes | exons |
| T10 | 358-365 | DNA_domain_or_region | denotes | introns |
| T11 | 369-387 | DNA_domain_or_region | denotes | cis-acting element |
| T12 | 389-399 | DNA_domain_or_region | denotes | P sequence |
| T13 | 416-434 | DNA_domain_or_region | denotes | 5' upstream region |
| T14 | 450-462 | DNA_domain_or_region | denotes | DNA segments |
| T15 | 468-485 | other_name | denotes | enhancer activity |
| T16 | 509-524 | DNA_domain_or_region | denotes | human IL-4 gene |
| T17 | 558-573 | DNA_domain_or_region | denotes | fusion promoter |
| T18 | 599-662 | DNA_domain_or_region | denotes | granulocyte/macrophage colony-stimulating factor basic promoter |
| T19 | 674-699 | DNA_domain_or_region | denotes | 60 base pairs of sequence |
| T20 | 718-726 | DNA_domain_or_region | denotes | cap site |
| T21 | 734-788 | protein_molecule | denotes | mouse granulocyte/macrophage colony-stimulating factor |
| T22 | 821-841 | DNA_domain_or_region | denotes | 5' upstream sequence |
| T23 | 849-858 | DNA_domain_or_region | denotes | IL-4 gene |
| T24 | 864-874 | DNA_domain_or_region | denotes | P sequence |
| T25 | 933-957 | DNA_domain_or_region | denotes | transcription start site |
| T26 | 965-970 | DNA_domain_or_region | denotes | human |
| T27 | 971-980 | DNA_domain_or_region | denotes | IL-4 gene |
| T28 | 1017-1044 | other_name | denotes | base-substitution mutations |
| T29 | 1091-1101 | DNA_domain_or_region | denotes | P sequence |
| T30 | 1155-1170 | protein_family_or_group | denotes | binding protein |
| T31 | 1193-1203 | DNA_domain_or_region | denotes | P sequence |
| T32 | 1211-1220 | DNA_domain_or_region | denotes | IL-4 gene |
| T33 | 1240-1265 | other_name | denotes | DNA-mobility-shift assays |
| T34 | 1282-1287 | protein_molecule | denotes | NF(P) |
| T35 | 1291-1310 | protein_family_or_group | denotes | DNA binding protein |
| T36 | 1344-1354 | DNA_domain_or_region | denotes | P sequence |
| T37 | 1363-1373 | DNA_domain_or_region | denotes | P sequence |
| T38 | 1393-1409 | polynucleotide | denotes | oligonucleotides |
| T39 | 1469-1474 | protein_molecule | denotes | NF(P) |
| T40 | 1567-1588 | other_name | denotes | sequence requirements |
| T41 | 1593-1597 | protein_molecule | denotes | IL-4 |
| T42 | 1622-1632 | DNA_domain_or_region | denotes | P sequence |
| T43 | 1666-1686 | DNA_domain_or_region | denotes | 5' upstream sequence |
| T44 | 1694-1703 | DNA_domain_or_region | denotes | IL-2 gene |
| T45 | 1746-1755 | DNA_domain_or_region | denotes | IL-4 gene |
| T46 | 1785-1794 | DNA_domain_or_region | denotes | IL-2 gene |
| T47 | 1832-1840 | protein_family_or_group | denotes | proteins |