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PubMed:15319452 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-98 Sentence denotes Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells.
TextSentencer_T2 99-458 Sentence denotes The importance of prolactin (PRL) in physiological proliferation and differentiation of the mammary gland, together with high levels of PRL receptors in breast tumors, the association of circulating PRL with incidence of breast cancer, and the recognition of locally produced PRL, point to the need for greater understanding of PRL actions in mammary disease.
TextSentencer_T3 459-742 Sentence denotes Although PRL has been shown to activate multiple kinase cascades in various target cells, relatively little is known of its signaling pathways in the mammary gland apart from the Janus kinase 2/ signal transducer and activator of transcription 5 pathway, particularly in tumor cells.
TextSentencer_T4 743-936 Sentence denotes Another potential effector is activating protein-1 (AP-1), a transcription complex that regulates processes essential for neoplastic progression, including proliferation, survival and invasion.
TextSentencer_T5 937-1042 Sentence denotes We demonstrate that PRL activates AP-1 in MCF-7 cells, detectable at 4 h and sustained for at least 24 h.
TextSentencer_T6 1043-1232 Sentence denotes Although Janus kinase 2 and ERK1/2 are the primary mediators of PRL-induced signals, c-Src, phosphatidylinositol 3'-kinase, protein kinase C, and other MAPKs contribute to maximal activity.
TextSentencer_T7 1233-1420 Sentence denotes PRL activation of these pathways leads to increased c-Jun protein and phosphorylation, JunB protein, and phosphorylation of c-Fos, elevating the levels of AP-1 complexes able to bind DNA.
TextSentencer_T8 1421-1545 Sentence denotes These active AP-1 dimers may direct expression of multiple target genes, mediating some of PRL's actions in mammary disease.
T1 0-98 Sentence denotes Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells.
T2 99-458 Sentence denotes The importance of prolactin (PRL) in physiological proliferation and differentiation of the mammary gland, together with high levels of PRL receptors in breast tumors, the association of circulating PRL with incidence of breast cancer, and the recognition of locally produced PRL, point to the need for greater understanding of PRL actions in mammary disease.
T3 459-742 Sentence denotes Although PRL has been shown to activate multiple kinase cascades in various target cells, relatively little is known of its signaling pathways in the mammary gland apart from the Janus kinase 2/ signal transducer and activator of transcription 5 pathway, particularly in tumor cells.
T4 743-936 Sentence denotes Another potential effector is activating protein-1 (AP-1), a transcription complex that regulates processes essential for neoplastic progression, including proliferation, survival and invasion.
T5 937-1042 Sentence denotes We demonstrate that PRL activates AP-1 in MCF-7 cells, detectable at 4 h and sustained for at least 24 h.
T6 1043-1232 Sentence denotes Although Janus kinase 2 and ERK1/2 are the primary mediators of PRL-induced signals, c-Src, phosphatidylinositol 3'-kinase, protein kinase C, and other MAPKs contribute to maximal activity.
T7 1233-1420 Sentence denotes PRL activation of these pathways leads to increased c-Jun protein and phosphorylation, JunB protein, and phosphorylation of c-Fos, elevating the levels of AP-1 complexes able to bind DNA.
T8 1421-1545 Sentence denotes These active AP-1 dimers may direct expression of multiple target genes, mediating some of PRL's actions in mammary disease.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15319452-1#199#202#gene5617 298-301 gene5617 denotes PRL
15319452-1#18#27#gene5617 117-126 gene5617 denotes prolactin
15319452-1#29#32#gene5617 128-131 gene5617 denotes PRL
15319452-1#136#139#gene5617 235-238 gene5617 denotes PRL
15319452-1#221#234#diseaseC0006142 320-333 diseaseC0006142 denotes breast cancer
15319452-1#221#234#diseaseC0678222 320-333 diseaseC0678222 denotes breast cancer
15319452-1#153#166#diseaseC1458155 252-265 diseaseC1458155 denotes breast tumors
199#202#gene5617221#234#diseaseC0006142 15319452-1#199#202#gene5617 15319452-1#221#234#diseaseC0006142 associated_with PRL,breast cancer
199#202#gene5617221#234#diseaseC0678222 15319452-1#199#202#gene5617 15319452-1#221#234#diseaseC0678222 associated_with PRL,breast cancer
199#202#gene5617153#166#diseaseC1458155 15319452-1#199#202#gene5617 15319452-1#153#166#diseaseC1458155 associated_with PRL,breast tumors
18#27#gene5617221#234#diseaseC0006142 15319452-1#18#27#gene5617 15319452-1#221#234#diseaseC0006142 associated_with prolactin,breast cancer
18#27#gene5617221#234#diseaseC0678222 15319452-1#18#27#gene5617 15319452-1#221#234#diseaseC0678222 associated_with prolactin,breast cancer
18#27#gene5617153#166#diseaseC1458155 15319452-1#18#27#gene5617 15319452-1#153#166#diseaseC1458155 associated_with prolactin,breast tumors
29#32#gene5617221#234#diseaseC0006142 15319452-1#29#32#gene5617 15319452-1#221#234#diseaseC0006142 associated_with PRL,breast cancer
29#32#gene5617221#234#diseaseC0678222 15319452-1#29#32#gene5617 15319452-1#221#234#diseaseC0678222 associated_with PRL,breast cancer
29#32#gene5617153#166#diseaseC1458155 15319452-1#29#32#gene5617 15319452-1#153#166#diseaseC1458155 associated_with PRL,breast tumors
136#139#gene5617221#234#diseaseC0006142 15319452-1#136#139#gene5617 15319452-1#221#234#diseaseC0006142 associated_with PRL,breast cancer
136#139#gene5617221#234#diseaseC0678222 15319452-1#136#139#gene5617 15319452-1#221#234#diseaseC0678222 associated_with PRL,breast cancer
136#139#gene5617153#166#diseaseC1458155 15319452-1#136#139#gene5617 15319452-1#153#166#diseaseC1458155 associated_with PRL,breast tumors

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T207 298-301 gene:5617 denotes PRL
T208 320-333 disease:C0006142 denotes breast cancer
R1 T207 T208 associated_with PRL,breast cancer
R2 T207 T208 associated_with PRL,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 78-84 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 252-258 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 320-326 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 191-204 http://purl.obolibrary.org/obo/UBERON_0001911 denotes mammary gland
PD-UBERON-AE-B_T5 609-622 http://purl.obolibrary.org/obo/UBERON_0001911 denotes mammary gland
PD-UBERON-AE-B_T6 199-204 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland
PD-UBERON-AE-B_T7 617-622 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 78-84 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 252-258 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 320-326 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 191-204 http://purl.obolibrary.org/obo/UBERON_0001911 denotes mammary gland
PD-UBERON-AE-B_T5 609-622 http://purl.obolibrary.org/obo/UBERON_0001911 denotes mammary gland
PD-UBERON-AE-B_T6 199-204 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland
PD-UBERON-AE-B_T7 617-622 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland

DisGeNET

Id Subject Object Predicate Lexical cue
T0 117-126 gene:5617 denotes prolactin
T1 252-265 disease:C1458155 denotes breast tumors
T2 117-126 gene:5617 denotes prolactin
T3 320-333 disease:C0006142 denotes breast cancer
T4 117-126 gene:5617 denotes prolactin
T5 320-333 disease:C0678222 denotes breast cancer
T6 128-131 gene:5617 denotes PRL
T7 252-265 disease:C1458155 denotes breast tumors
T8 128-131 gene:5617 denotes PRL
T9 320-333 disease:C0006142 denotes breast cancer
T10 128-131 gene:5617 denotes PRL
T11 320-333 disease:C0678222 denotes breast cancer
T12 235-238 gene:5617 denotes PRL
T13 252-265 disease:C1458155 denotes breast tumors
T14 298-301 gene:5617 denotes PRL
T15 320-333 disease:C0006142 denotes breast cancer
T16 298-301 gene:5617 denotes PRL
T17 320-333 disease:C0678222 denotes breast cancer
T18 427-430 gene:5617 denotes PRL
T19 252-265 disease:C1458155 denotes breast tumors
R1 T0 T1 associated_with prolactin,breast tumors
R2 T2 T3 associated_with prolactin,breast cancer
R3 T4 T5 associated_with prolactin,breast cancer
R4 T6 T7 associated_with PRL,breast tumors
R5 T8 T9 associated_with PRL,breast cancer
R6 T10 T11 associated_with PRL,breast cancer
R7 T12 T13 associated_with PRL,breast tumors
R8 T14 T15 associated_with PRL,breast cancer
R9 T16 T17 associated_with PRL,breast cancer
R10 T18 T19 associated_with PRL,breast tumors