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PubMed:15314219 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-95 Sentence denotes Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling.
TextSentencer_T2 96-242 Sentence denotes Prostate cancer is the most common solid tumor in men, and it shares with all cancers the hallmark of elevated, nonhomeostatic cell proliferation.
TextSentencer_T3 243-363 Sentence denotes Here we have tested the hypothesis that the SONIC HEDGEHOG (SHH)-GLI signaling pathway is implicated in prostate cancer.
TextSentencer_T4 364-518 Sentence denotes We report expression of SHH-GLI pathway components in adult human prostate cancer, often with enhanced levels in tumors versus normal prostatic epithelia.
TextSentencer_T5 519-653 Sentence denotes Blocking the pathway with cyclopamine or anti-SHH antibodies inhibits the proliferation of GLI1+/PSA+ primary prostate tumor cultures.
TextSentencer_T6 654-777 Sentence denotes Inversely, SHH can potentiate tumor cell proliferation, suggesting that autocrine signaling may often sustain tumor growth.
TextSentencer_T7 778-1068 Sentence denotes In addition, pathway blockade in three metastatic prostate cancer cell lines with cyclopamine or through GLI1 RNA interference leads to inhibition of cell proliferation, suggesting cell-autonomous pathway activation at different levels and showing an essential role for GLI1 in human cells.
TextSentencer_T8 1069-1185 Sentence denotes Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach.
T1 0-95 Sentence denotes Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling.
T2 96-242 Sentence denotes Prostate cancer is the most common solid tumor in men, and it shares with all cancers the hallmark of elevated, nonhomeostatic cell proliferation.
T3 243-363 Sentence denotes Here we have tested the hypothesis that the SONIC HEDGEHOG (SHH)-GLI signaling pathway is implicated in prostate cancer.
T4 364-518 Sentence denotes We report expression of SHH-GLI pathway components in adult human prostate cancer, often with enhanced levels in tumors versus normal prostatic epithelia.
T5 519-653 Sentence denotes Blocking the pathway with cyclopamine or anti-SHH antibodies inhibits the proliferation of GLI1+/PSA+ primary prostate tumor cultures.
T6 654-777 Sentence denotes Inversely, SHH can potentiate tumor cell proliferation, suggesting that autocrine signaling may often sustain tumor growth.
T7 778-1068 Sentence denotes In addition, pathway blockade in three metastatic prostate cancer cell lines with cyclopamine or through GLI1 RNA interference leads to inhibition of cell proliferation, suggesting cell-autonomous pathway activation at different levels and showing an essential role for GLI1 in human cells.
T8 1069-1185 Sentence denotes Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15314219-0#65#79#gene6469 65-79 gene6469 denotes SONIC HEDGEHOG
15314219-0#14#29#diseaseC0376358 14-29 diseaseC0376358 denotes prostate cancer
15314219-0#14#29#diseaseC0600139 14-29 diseaseC0600139 denotes prostate cancer
15314219-3#28#31#gene2735 392-395 gene2735 denotes GLI
15314219-3#66#81#diseaseC0376358 430-445 diseaseC0376358 denotes prostate cancer
15314219-3#66#81#diseaseC0600139 430-445 diseaseC0600139 denotes prostate cancer
15314219-4#97#100#gene354 616-619 gene354 denotes PSA
15314219-4#97#100#gene9520 616-619 gene9520 denotes PSA
15314219-4#97#100#gene5324 616-619 gene5324 denotes PSA
15314219-4#97#100#gene5627 616-619 gene5627 denotes PSA
15314219-4#97#100#gene29968 616-619 gene29968 denotes PSA
15314219-4#110#124#diseaseC0033578 629-643 diseaseC0033578 denotes prostate tumor
15314219-6#105#109#gene2735 883-887 gene2735 denotes GLI1
15314219-6#270#274#gene2735 1048-1052 gene2735 denotes GLI1
15314219-6#39#65#diseaseC0936223 817-843 diseaseC0936223 denotes metastatic prostate cancer
15314219-6#39#65#diseaseC1282496 817-843 diseaseC1282496 denotes metastatic prostate cancer
15314219-6#39#65#diseaseC0936223 817-843 diseaseC0936223 denotes metastatic prostate cancer
15314219-6#39#65#diseaseC1282496 817-843 diseaseC1282496 denotes metastatic prostate cancer
65#79#gene646914#29#diseaseC0376358 15314219-0#65#79#gene6469 15314219-0#14#29#diseaseC0376358 associated_with SONIC HEDGEHOG,prostate cancer
65#79#gene646914#29#diseaseC0600139 15314219-0#65#79#gene6469 15314219-0#14#29#diseaseC0600139 associated_with SONIC HEDGEHOG,prostate cancer
28#31#gene273566#81#diseaseC0376358 15314219-3#28#31#gene2735 15314219-3#66#81#diseaseC0376358 associated_with GLI,prostate cancer
28#31#gene273566#81#diseaseC0600139 15314219-3#28#31#gene2735 15314219-3#66#81#diseaseC0600139 associated_with GLI,prostate cancer
97#100#gene354110#124#diseaseC0033578 15314219-4#97#100#gene354 15314219-4#110#124#diseaseC0033578 associated_with PSA,prostate tumor
97#100#gene9520110#124#diseaseC0033578 15314219-4#97#100#gene9520 15314219-4#110#124#diseaseC0033578 associated_with PSA,prostate tumor
97#100#gene5324110#124#diseaseC0033578 15314219-4#97#100#gene5324 15314219-4#110#124#diseaseC0033578 associated_with PSA,prostate tumor
97#100#gene5627110#124#diseaseC0033578 15314219-4#97#100#gene5627 15314219-4#110#124#diseaseC0033578 associated_with PSA,prostate tumor
97#100#gene29968110#124#diseaseC0033578 15314219-4#97#100#gene29968 15314219-4#110#124#diseaseC0033578 associated_with PSA,prostate tumor
105#109#gene273539#65#diseaseC0936223 15314219-6#105#109#gene2735 15314219-6#39#65#diseaseC0936223 associated_with GLI1,metastatic prostate cancer
105#109#gene273539#65#diseaseC1282496 15314219-6#105#109#gene2735 15314219-6#39#65#diseaseC1282496 associated_with GLI1,metastatic prostate cancer
105#109#gene273539#65#diseaseC0936223 15314219-6#105#109#gene2735 15314219-6#39#65#diseaseC0936223 associated_with GLI1,metastatic prostate cancer
105#109#gene273539#65#diseaseC1282496 15314219-6#105#109#gene2735 15314219-6#39#65#diseaseC1282496 associated_with GLI1,metastatic prostate cancer
270#274#gene273539#65#diseaseC0936223 15314219-6#270#274#gene2735 15314219-6#39#65#diseaseC0936223 associated_with GLI1,metastatic prostate cancer
270#274#gene273539#65#diseaseC1282496 15314219-6#270#274#gene2735 15314219-6#39#65#diseaseC1282496 associated_with GLI1,metastatic prostate cancer
270#274#gene273539#65#diseaseC0936223 15314219-6#270#274#gene2735 15314219-6#39#65#diseaseC0936223 associated_with GLI1,metastatic prostate cancer
270#274#gene273539#65#diseaseC1282496 15314219-6#270#274#gene2735 15314219-6#39#65#diseaseC1282496 associated_with GLI1,metastatic prostate cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2358 65-79 gene:6469 denotes SONIC HEDGEHOG
T2359 14-29 disease:C0376358 denotes prostate cancer
T2360 392-395 gene:2735 denotes GLI
T2361 430-445 disease:C0376358 denotes prostate cancer
T2362 616-619 gene:354 denotes PSA
T2363 629-643 disease:C0033578 denotes prostate tumor
T2364 883-887 gene:2735 denotes GLI1
T2365 817-843 disease:C0936223 denotes metastatic prostate cancer
T2366 1048-1052 gene:2735 denotes GLI1
R1 T2358 T2359 associated_with SONIC HEDGEHOG,prostate cancer
R2 T2358 T2359 associated_with SONIC HEDGEHOG,prostate cancer
R3 T2360 T2361 associated_with GLI,prostate cancer
R4 T2360 T2361 associated_with GLI,prostate cancer
R5 T2362 T2363 associated_with PSA,prostate tumor
R6 T2362 T2363 associated_with PSA,prostate tumor
R7 T2362 T2363 associated_with PSA,prostate tumor
R8 T2362 T2363 associated_with PSA,prostate tumor
R9 T2362 T2363 associated_with PSA,prostate tumor
R10 T2364 T2365 associated_with GLI1,metastatic prostate cancer
R11 T2364 T2365 associated_with GLI1,metastatic prostate cancer
R12 T2366 T2365 associated_with GLI1,metastatic prostate cancer
R13 T2366 T2365 associated_with GLI1,metastatic prostate cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 65-79 gene:6469 denotes SONIC HEDGEHOG
T1 14-29 disease:C0376358 denotes prostate cancer
T2 65-79 gene:6469 denotes SONIC HEDGEHOG
T3 14-29 disease:C0600139 denotes prostate cancer
R1 T0 T1 associated_with SONIC HEDGEHOG,prostate cancer
R2 T2 T3 associated_with SONIC HEDGEHOG,prostate cancer