PubMed:15292179 / 664-1812
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7 | 61-180 | Sentence | denotes | In contrast, hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposure. |
| T8 | 181-389 | Sentence | denotes | Consistent with these observations, gel shift and reporter analyses demonstrated a correlation between the hyperoxia-enhanced ARE DNA-binding activity of Nrf2 and an up-regulation of ARE-driven transcription. |
| T9 | 390-512 | Sentence | denotes | Inhibition of NADPH oxidase with diphenyleneiodonium (DPI) blocked both Nrf2 translocation and ARE-mediated transcription. |
| T10 | 513-571 | Sentence | denotes | Inhibition of the MEK/ERK pathway caused a similar effect. |
| T11 | 572-715 | Sentence | denotes | Consistent with this finding, hyperoxia stimulated ERK-1 and ERK-2 phosphorylation, whereas DPI or N-acetyl-l-cysteine blocked such activation. |
| T12 | 716-882 | Sentence | denotes | Hyperoxia stimulated the phosphorylation of endogenous Nrf2, but not in the presence of U0126, suggesting a critical role for ERK signaling in the activation of Nrf2. |
| T13 | 883-1001 | Sentence | denotes | Consistent with this notion, hyperoxia did not stimulate the phosphorylation of Nrf2 in fibroblasts lacking the ERK-1. |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 74-179 | path(MESHD:Hyperoxia) increases tloc(p(MGI:Nfe2l2),GOCCID:0005737,GOCCID:0005634) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposure |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000586 | 602-654 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk1)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylation |
| BEL:20000590 | 602-654 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk3)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylation |
| BEL:20000598 | 74-179 | path(MESHD:Hyperoxia) increases tloc(p(MGI:Nfe2l2),GOCCID:0005737,GOCCID:0005634) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposure |
| BEL:20000586 | 602-653 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk1)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylatio |
| BEL:20000590 | 602-653 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk3)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylatio |
| BEL:20040036 | 74-178 | path(MESHD:Hyperoxia) increases tloc(p(MGI:Nfe2l2),GOCCID:0005737,GOCCID:0005634) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposur |
| BEL:20040038 | 74-178 | path(MESHD:Hyperoxia) increases tscript(p(MGI:Nfe2l2)) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposur |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T4 | 126-135 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T5 | 143-150 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
| T7 | 971-982 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T4 | 971-982 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |