PubMed:15292179 / 0-1601
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-124 | Sentence | denotes | NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells. |
| T2 | 125-200 | Sentence | denotes | Oxidative stress plays a major role in hyperoxia-induced acute lung injury. |
| T3 | 201-311 | Sentence | denotes | We have shown previously that mice lacking the Nrf2 are more susceptible to hyperoxia than are wild-type mice. |
| T4 | 312-441 | Sentence | denotes | Nrf2 activates antioxidant response element (ARE)-mediated gene expression involved in cellular protection against toxic insults. |
| T5 | 442-616 | Sentence | denotes | The present study was designed to investigate the mechanisms that control the activation of Nrf2 by hyperoxia using a non-malignant murine alveolar epithelial cell line, C10. |
| T6 | 617-724 | Sentence | denotes | No significant alteration in the levels of Nrf2 mRNA and protein was found following exposure to hyperoxia. |
| T7 | 725-844 | Sentence | denotes | In contrast, hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposure. |
| T8 | 845-1053 | Sentence | denotes | Consistent with these observations, gel shift and reporter analyses demonstrated a correlation between the hyperoxia-enhanced ARE DNA-binding activity of Nrf2 and an up-regulation of ARE-driven transcription. |
| T9 | 1054-1176 | Sentence | denotes | Inhibition of NADPH oxidase with diphenyleneiodonium (DPI) blocked both Nrf2 translocation and ARE-mediated transcription. |
| T10 | 1177-1235 | Sentence | denotes | Inhibition of the MEK/ERK pathway caused a similar effect. |
| T11 | 1236-1379 | Sentence | denotes | Consistent with this finding, hyperoxia stimulated ERK-1 and ERK-2 phosphorylation, whereas DPI or N-acetyl-l-cysteine blocked such activation. |
| T12 | 1380-1546 | Sentence | denotes | Hyperoxia stimulated the phosphorylation of endogenous Nrf2, but not in the presence of U0126, suggesting a critical role for ERK signaling in the activation of Nrf2. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 188-192 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 738-843 | path(MESHD:Hyperoxia) increases tloc(p(MGI:Nfe2l2),GOCCID:0005737,GOCCID:0005634) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposure |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000586 | 1266-1318 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk1)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylation |
| BEL:20000590 | 1266-1318 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk3)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylation |
| BEL:20000598 | 738-843 | path(MESHD:Hyperoxia) increases tloc(p(MGI:Nfe2l2),GOCCID:0005737,GOCCID:0005634) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposure |
| BEL:20000586 | 1266-1317 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk1)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylatio |
| BEL:20000590 | 1266-1317 | path(MESHD:Hyperoxia) increases kin(p(MGI:Mapk3)) | denotes | hyperoxia stimulated ERK-1 and ERK-2 phosphorylatio |
| BEL:20040036 | 738-842 | path(MESHD:Hyperoxia) increases tloc(p(MGI:Nfe2l2),GOCCID:0005737,GOCCID:0005634) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposur |
| BEL:20040038 | 738-842 | path(MESHD:Hyperoxia) increases tscript(p(MGI:Nfe2l2)) | denotes | hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposur |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 182-199 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 188-192 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 125-141 | Phenotype | denotes | Oxidative stress | HP:0025464 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 231-235 | OrganismTaxon | denotes | mice | 10088 |
| T2 | 306-310 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 107-123 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T2 | 188-192 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T3 | 581-605 | Body_part | denotes | alveolar epithelial cell | http://purl.obolibrary.org/obo/CL_0000322 |
| T4 | 790-799 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T5 | 807-814 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 107-123 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T2 | 581-605 | Cell | denotes | alveolar epithelial cell | http://purl.obolibrary.org/obo/CL:0000322 |
| T3 | 590-605 | Cell | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL:0000066 |