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PubMed:15266215 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
984 15-31 GeneOrGeneProduct denotes cyclooxygenase-2 NCBIGene:5743
985 51-61 ChemicalEntity denotes valdecoxib MESH:C406224
986 69-105 ChemicalEntity denotes nonsteroidal antiinflammatory agents MESH:D000894
987 136-146 DiseaseOrPhenotypicFeature denotes thrombotic MESH:D013927
988 157-165 OrganismTaxon denotes patients NCBITaxon:9606
989 171-180 DiseaseOrPhenotypicFeature denotes arthritis MESH:D001168
990 239-249 DiseaseOrPhenotypicFeature denotes thrombotic MESH:D013927
991 276-298 GeneOrGeneProduct denotes cyclooxygenase (COX)-2 NCBIGene:5743
992 337-372 ChemicalEntity denotes nonsteroidal antiinflammatory drugs MESH:D000894
993 374-380 ChemicalEntity denotes NSAIDs MESH:D000894
994 426-436 ChemicalEntity denotes valdecoxib MESH:C406224
995 444-449 GeneOrGeneProduct denotes COX-2 NCBIGene:5743
996 491-499 OrganismTaxon denotes patients NCBITaxon:9606
997 505-519 DiseaseOrPhenotypicFeature denotes osteoarthritis MESH:D010003
998 524-544 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis MESH:D001172
999 632-642 DiseaseOrPhenotypicFeature denotes thrombotic MESH:D013927
1000 713-723 DiseaseOrPhenotypicFeature denotes thrombotic MESH:D013927
1001 760-770 ChemicalEntity denotes valdecoxib MESH:C406224
1002 802-807 ChemicalEntity denotes NSAID MESH:D000894
1003 809-819 ChemicalEntity denotes diclofenac MESH:D004008
1004 831-840 ChemicalEntity denotes ibuprofen MESH:D007052
1005 856-864 ChemicalEntity denotes naproxen MESH:D009288
1006 913-927 DiseaseOrPhenotypicFeature denotes osteoarthritis MESH:D010003
1007 932-952 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis MESH:D001172
1008 1047-1055 OrganismTaxon denotes patients NCBITaxon:9606
1009 1113-1120 ChemicalEntity denotes aspirin MESH:D001241
1010 1148-1155 ChemicalEntity denotes aspirin MESH:D001241
1011 1210-1220 DiseaseOrPhenotypicFeature denotes thrombotic MESH:D013927
1012 1245-1255 ChemicalEntity denotes valdecoxib MESH:C406224
1013 1257-1263 ChemicalEntity denotes NSAIDs MESH:D000894
1014 1298-1308 DiseaseOrPhenotypicFeature denotes thrombotic MESH:D013927
1015 1342-1352 ChemicalEntity denotes valdecoxib MESH:C406224
1016 1359-1369 DiseaseOrPhenotypicFeature denotes Thrombotic MESH:D013927
1017 1412-1419 ChemicalEntity denotes aspirin MESH:D001241
1018 1443-1450 ChemicalEntity denotes aspirin MESH:D001241
1019 1474-1484 ChemicalEntity denotes valdecoxib MESH:C406224
1020 1501-1507 ChemicalEntity denotes NSAIDs MESH:D000894
1021 1557-1564 ChemicalEntity denotes aspirin MESH:D001241
1022 1616-1626 ChemicalEntity denotes valdecoxib MESH:C406224
1023 1751-1761 ChemicalEntity denotes valdecoxib MESH:C406224
1024 1818-1828 DiseaseOrPhenotypicFeature denotes thrombotic MESH:D013927
1025 1861-1867 ChemicalEntity denotes NSAIDs MESH:D000894
1026 1882-1896 DiseaseOrPhenotypicFeature denotes osteoarthritis MESH:D010003
1027 1901-1921 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis MESH:D001172
1028 1922-1930 OrganismTaxon denotes patients NCBITaxon:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-181 Sentence denotes Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis.
T2 182-382 Sentence denotes There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhibitors than nonselective nonsteroidal antiinflammatory drugs (NSAIDs).
T3 383-599 Sentence denotes We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients with osteoarthritis and rheumatoid arthritis treated with this agent in randomized clinical trials.
T4 600-993 Sentence denotes The incidence of cardiovascular thrombotic events (cardiac, cerebrovascular and peripheral vascular, or arterial thrombotic) was determined by analyzing pooled valdecoxib (10-80 mg daily), nonselective NSAID (diclofenac 75 mg bid, ibuprofen 800 mg tid, or naproxen 500 mg bid) and placebo data from 10 randomized osteoarthritis and rheumatoid arthritis trials that were 6-52 weeks in duration.
T5 994-1167 Sentence denotes The incidence rates of events were determined in all patients (n = 7934) and in users of low-dose (< or =325 mg daily) aspirin (n = 1051) and nonusers of aspirin (n = 6883).
T6 1168-1277 Sentence denotes Crude and exposure-adjusted incidences of thrombotic events were similar for valdecoxib, NSAIDs, and placebo.
T7 1278-1358 Sentence denotes The risk of serious thrombotic events was also similar for each valdecoxib dose.
T8 1359-1524 Sentence denotes Thrombotic risk was consistently higher for users of aspirin users than nonusers of aspirin (placebo, 1.4% vs. 0%; valdecoxib, 1.7% vs. 0.2%; NSAIDs, 1.9% vs. 0.5%).
T9 1525-1633 Sentence denotes The rates of events in users of aspirin were similar for all 3 treatment groups and across valdecoxib doses.
T10 1634-1961 Sentence denotes Short- and intermediate-term treatment with therapeutic (10 or 20 mg daily) and supratherapeutic (40 or 80 mg daily) valdecoxib doses was not associated with an increased incidence of thrombotic events relative to nonselective NSAIDs or placebo in osteoarthritis and rheumatoid arthritis patients in controlled clinical trials.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 505-519 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178
T2 524-544 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T3 913-927 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178
T4 932-952 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T5 1882-1896 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178
T6 1901-1921 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 15-31 GeneOrGeneProduct denotes cyclooxygenase-2
T2 41-50 GeneOrGeneProduct denotes inhibitor
T3 276-290 GeneOrGeneProduct denotes cyclooxygenase
T4 291-298 GeneOrGeneProduct denotes (COX)-2
T5 292-295 GeneOrGeneProduct denotes COX
T6 308-318 GeneOrGeneProduct denotes inhibitors
T7 444-449 GeneOrGeneProduct denotes COX-2
T8 444-447 GeneOrGeneProduct denotes COX
T9 459-468 GeneOrGeneProduct denotes inhibitor
T10 472-485 GeneOrGeneProduct denotes approximately
T11 729-739 GeneOrGeneProduct denotes determined
T12 778-780 GeneOrGeneProduct denotes mg
T13 823-825 GeneOrGeneProduct denotes mg
T14 845-847 GeneOrGeneProduct denotes mg
T15 869-871 GeneOrGeneProduct denotes mg
T16 1029-1039 GeneOrGeneProduct denotes determined
T17 1043-1046 GeneOrGeneProduct denotes all
T18 1103-1105 GeneOrGeneProduct denotes mg
T19 1233-1240 GeneOrGeneProduct denotes similar
T20 1325-1332 GeneOrGeneProduct denotes similar
T21 1570-1577 GeneOrGeneProduct denotes similar
T22 1582-1587 GeneOrGeneProduct denotes all 3
T23 1658-1662 GeneOrGeneProduct denotes term
T24 1691-1696 GeneOrGeneProduct denotes 10 or
T25 1700-1702 GeneOrGeneProduct denotes mg
T26 1732-1737 GeneOrGeneProduct denotes 40 or
T27 1741-1743 GeneOrGeneProduct denotes mg

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 15-31 GeneOrGeneProduct denotes cyclooxygenase-2
T2 41-50 GeneOrGeneProduct denotes inhibitor
T3 276-290 GeneOrGeneProduct denotes cyclooxygenase
T4 292-295 GeneOrGeneProduct denotes COX
T5 308-318 GeneOrGeneProduct denotes inhibitors
T6 444-449 GeneOrGeneProduct denotes COX-2
T7 444-447 GeneOrGeneProduct denotes COX
T8 459-468 GeneOrGeneProduct denotes inhibitor
T9 1233-1240 GeneOrGeneProduct denotes similar
T10 1325-1332 GeneOrGeneProduct denotes similar
T11 1570-1577 GeneOrGeneProduct denotes similar
T12 1658-1662 GeneOrGeneProduct denotes term

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 171-180 DiseaseOrPhenotypicFeature denotes arthritis D001168
T2 505-519 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T3 524-544 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T4 913-927 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T5 932-952 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T6 1882-1896 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T7 1901-1921 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 171-180 DiseaseOrPhenotypicFeature denotes arthritis 0005578
T2 505-519 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178
T3 524-544 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T4 913-927 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178
T5 932-952 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T6 1882-1896 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178
T7 1901-1921 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 136-146 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T2 171-180 DiseaseOrPhenotypicFeature denotes arthritis D001168
T3 239-249 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T4 505-519 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T5 524-544 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T6 632-642 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T7 713-723 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T8 913-927 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T9 932-952 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T10 1210-1220 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T11 1298-1308 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T12 1359-1369 DiseaseOrPhenotypicFeature denotes Thrombotic DISEASE
T13 1818-1828 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T14 1882-1896 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T15 1901-1921 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 157-165 OrganismTaxon denotes patients
T2 491-499 OrganismTaxon denotes patients
T3 1047-1055 OrganismTaxon denotes patients
T4 1922-1930 OrganismTaxon denotes patients

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 136-146 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T2 171-180 DiseaseOrPhenotypicFeature denotes arthritis D001168
T3 239-249 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T4 505-519 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T5 524-544 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T6 632-642 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T7 713-723 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T8 913-927 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T9 932-952 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T10 1210-1220 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T11 1298-1308 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T12 1359-1369 DiseaseOrPhenotypicFeature denotes Thrombotic DISEASE
T13 1818-1828 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T14 1882-1896 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T15 1901-1921 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 15-31 ChemicalEntity denotes cyclooxygenase-2 D051546
T2 51-61 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T4 69-105 ChemicalEntity denotes nonsteroidal antiinflammatory agents ChemicalEntity
T5 276-290 ChemicalEntity denotes cyclooxygenase D011451
T6 292-295 ChemicalEntity denotes COX D011451
T7 337-372 ChemicalEntity denotes nonsteroidal antiinflammatory drugs ChemicalEntity
T8 374-380 ChemicalEntity denotes NSAIDs ChemicalEntity
T9 426-436 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T11 444-447 ChemicalEntity denotes COX D011451
T12 760-770 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T14 802-807 ChemicalEntity denotes NSAID ChemicalEntity
T15 809-819 ChemicalEntity denotes diclofenac D004008|http://purl.obolibrary.org/obo/CHEBI_47381
T17 831-840 ChemicalEntity denotes ibuprofen D007052|http://purl.obolibrary.org/obo/CHEBI_5855|http://purl.obolibrary.org/obo/CHEBI_132922
T20 856-864 ChemicalEntity denotes naproxen D009288|http://purl.obolibrary.org/obo/CHEBI_7476|http://purl.obolibrary.org/obo/CHEBI_59527
T23 1113-1120 ChemicalEntity denotes aspirin D001241
T24 1148-1155 ChemicalEntity denotes aspirin D001241
T25 1245-1255 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T27 1257-1263 ChemicalEntity denotes NSAIDs ChemicalEntity
T28 1342-1352 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T30 1412-1419 ChemicalEntity denotes aspirin D001241
T31 1443-1450 ChemicalEntity denotes aspirin D001241
T32 1474-1484 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T34 1501-1507 ChemicalEntity denotes NSAIDs ChemicalEntity
T35 1557-1564 ChemicalEntity denotes aspirin D001241
T36 1616-1626 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T38 1751-1761 ChemicalEntity denotes valdecoxib C406224|http://purl.obolibrary.org/obo/CHEBI_63634
T40 1861-1867 ChemicalEntity denotes NSAIDs ChemicalEntity

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 15-31 GeneOrGeneProduct denotes cyclooxygenase-2
T2 276-290 GeneOrGeneProduct denotes cyclooxygenase
T3 292-295 GeneOrGeneProduct denotes COX
T4 444-449 GeneOrGeneProduct denotes COX-2

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T40 1861-1867 ChemicalEntity denotes NSAIDs ChemicalEntity
T38 1751-1761 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T36 1616-1626 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T30 1412-1419 ChemicalEntity denotes aspirin D001241
T35 1557-1564 ChemicalEntity denotes aspirin D001241
T34 1501-1507 ChemicalEntity denotes NSAIDs ChemicalEntity
T32 1474-1484 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T31 1443-1450 ChemicalEntity denotes aspirin D001241
T28 1342-1352 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T27 1257-1263 ChemicalEntity denotes NSAIDs ChemicalEntity
T25 1245-1255 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T24 1148-1155 ChemicalEntity denotes aspirin D001241
T23 1113-1120 ChemicalEntity denotes aspirin D001241
T20 856-864 ChemicalEntity denotes naproxen http://purl.obolibrary.org/obo/CHEBI_59527|http://purl.obolibrary.org/obo/CHEBI_7476|D009288
T17 831-840 ChemicalEntity denotes ibuprofen http://purl.obolibrary.org/obo/CHEBI_132922|http://purl.obolibrary.org/obo/CHEBI_5855|D007052
T15 809-819 ChemicalEntity denotes diclofenac http://purl.obolibrary.org/obo/CHEBI_47381|D004008
T14 802-807 ChemicalEntity denotes NSAID ChemicalEntity
T12 760-770 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T11 444-447 ChemicalEntity denotes COX D011451
T9 426-436 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T8 374-380 ChemicalEntity denotes NSAIDs ChemicalEntity
T7 337-372 ChemicalEntity denotes nonsteroidal antiinflammatory drugs ChemicalEntity
T6 292-295 ChemicalEntity denotes COX D011451
T5 276-290 ChemicalEntity denotes cyclooxygenase D011451
T4 69-105 ChemicalEntity denotes nonsteroidal antiinflammatory agents ChemicalEntity
T2 51-61 ChemicalEntity denotes valdecoxib http://purl.obolibrary.org/obo/CHEBI_63634|C406224
T1 15-31 ChemicalEntity denotes cyclooxygenase-2 D051546
T73175 444-449 GeneOrGeneProduct denotes COX-2
T3 292-295 GeneOrGeneProduct denotes COX
T30945 276-290 GeneOrGeneProduct denotes cyclooxygenase
T47917 15-31 GeneOrGeneProduct denotes cyclooxygenase-2
T54125 1901-1921 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T51976 1882-1896 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T13 1818-1828 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T26500 1359-1369 DiseaseOrPhenotypicFeature denotes Thrombotic DISEASE
T5103 1298-1308 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T10 1210-1220 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T55066 932-952 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T15545 913-927 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T87915 713-723 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T12107 632-642 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T78457 524-544 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T79048 505-519 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T3351 239-249 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T61052 171-180 DiseaseOrPhenotypicFeature denotes arthritis D001168
T88372 136-146 DiseaseOrPhenotypicFeature denotes thrombotic DISEASE
T38613 1922-1930 OrganismTaxon denotes patients
T75388 1047-1055 OrganismTaxon denotes patients
T97510 491-499 OrganismTaxon denotes patients
T660 157-165 OrganismTaxon denotes patients