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PubMed:15254034 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism.
T2 89-219 Sentence denotes NADPH is an essential cofactor for many enzymatic reactions including glutathione metabolism and fat and cholesterol biosynthesis.
T3 220-440 Sentence denotes We have reported recently an important role for mitochondrial NADP(+)-dependent isocitrate dehydrogenase in cellular defense against oxidative damage by providing NADPH needed for the regeneration of reduced glutathione.
T4 441-539 Sentence denotes However, the role of cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDPc) is still unclear.
T5 540-642 Sentence denotes We report here for the first time that IDPc plays a critical role in fat and cholesterol biosynthesis.
T6 643-792 Sentence denotes During differentiation of 3T3-L1 adipocytes, both IDPc enzyme activity and its protein content were increased in parallel in a time-dependent manner.
T7 793-999 Sentence denotes Increased expression of IDPc by stable transfection of IDPc cDNA positively correlated with adipogenesis of 3T3-L1 cells, whereas decreased IDPc expression by an antisense IDPc vector retarded adipogenesis.
T8 1000-1104 Sentence denotes Furthermore, transgenic mice with overexpressed IDPc exhibited fatty liver, hyperlipidemia, and obesity.
T9 1105-1282 Sentence denotes In the epididymal fat pads of the transgenic mice, the expressions of adipocyte-specific genes including peroxisome proliferator-activated receptor gamma were markedly elevated.
T10 1283-1712 Sentence denotes The hepatic and epididymal fat pad contents of acetyl-CoA and malonyl-CoA in the transgenic mice were significantly lower, whereas the total triglyceride and cholesterol contents were markedly higher in the liver and serum of transgenic mice compared with those measured in wild type mice, suggesting that the consumption rate of those lipogenic precursors needed for fat biosynthesis must be increased by elevated IDPc activity.
T11 1713-1845 Sentence denotes Taken together, our findings strongly indicate that IDPc would be a major NADPH producer required for fat and cholesterol synthesis.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1069-1074 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1490-1495 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1069-1074 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 1490-1495 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1063-1074 Phenotype denotes fatty liver HP:0001397
T2 1076-1090 Phenotype denotes hyperlipidemia HP:0003077
T3 1096-1103 Phenotype denotes obesity HP:0001513

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1063-1074 Disease denotes fatty liver http://purl.obolibrary.org/obo/MONDO_0004790
T2 1076-1090 Disease denotes hyperlipidemia http://purl.obolibrary.org/obo/MONDO_0021187
T3 1096-1103 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T4 1112-1122 Disease denotes epididymal http://purl.obolibrary.org/obo/MONDO_0004779
T5 1299-1309 Disease denotes epididymal http://purl.obolibrary.org/obo/MONDO_0004779
T6 1314-1317 Disease denotes pad http://purl.obolibrary.org/obo/MONDO_0005386

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1024-1028 OrganismTaxon denotes mice 10088
T2 1150-1154 OrganismTaxon denotes mice 10088
T3 1375-1379 OrganismTaxon denotes mice 10088
T4 1520-1524 OrganismTaxon denotes mice 10088
T5 1567-1571 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 186-189 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013
T2 609-612 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013
T3 676-686 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T4 1069-1074 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T5 1112-1131 Body_part denotes epididymal fat pads http://purl.obolibrary.org/obo/UBERON_0010412
T6 1175-1184 Body_part denotes adipocyte http://purl.obolibrary.org/obo/CL_0000136
T7 1299-1317 Body_part denotes epididymal fat pad http://purl.obolibrary.org/obo/UBERON_0010412
T8 1490-1495 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T9 1651-1654 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013
T10 1815-1818 Body_part denotes fat http://purl.obolibrary.org/obo/UBERON_0001013

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 676-686 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T2 1175-1184 Cell denotes adipocyte http://purl.obolibrary.org/obo/CL:0000136