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PubMed:15241482 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
960 0-13 GeneOrGeneProduct denotes Paraoxonase 1 NCBIGene:5444
961 65-78 GeneOrGeneProduct denotes paraoxonase 1 NCBIGene:5444
962 80-84 GeneOrGeneProduct denotes PON1 NCBIGene:5444
963 145-167 DiseaseOrPhenotypicFeature denotes coronary heart disease MESH:D003327
964 169-172 DiseaseOrPhenotypicFeature denotes CHD MESH:D003327
965 201-206 DiseaseOrPhenotypicFeature denotes death MESH:D003643
966 255-260 SequenceVariant denotes 55M/L p|SUB|M|55|L
967 265-271 SequenceVariant denotes 192Q/R p|SUB|Q|192|R
968 297-304 SequenceVariant denotes -107C/T c|SUB|C|-107|T
969 369-372 DiseaseOrPhenotypicFeature denotes CHD MESH:D003327
970 843-848 SequenceVariant denotes 192RR p|Allele|R|192
971 1148-1153 OrganismTaxon denotes women NCBITaxon:9606
972 1183-1205 DiseaseOrPhenotypicFeature denotes ischemic heart disease MESH:D017202
973 1236-1239 GeneOrGeneProduct denotes PON NCBIGene:5444
974 1240-1246 SequenceVariant denotes 192Q/R p|SUB|Q|192|R
975 1281-1284 DiseaseOrPhenotypicFeature denotes CHD MESH:D003327
976 1326-1331 SequenceVariant denotes 192RR p|Allele|R|192
977 1348-1353 OrganismTaxon denotes women NCBITaxon:9606
978 1407-1411 GeneOrGeneProduct denotes PON1 NCBIGene:5444
979 1412-1417 SequenceVariant denotes 192RR p|Allele|R|192
980 1473-1478 OrganismTaxon denotes women NCBITaxon:9606
981 1563-1566 DiseaseOrPhenotypicFeature denotes CHD MESH:D003327
982 1595-1598 DiseaseOrPhenotypicFeature denotes CHD MESH:D003327
983 1644-1647 DiseaseOrPhenotypicFeature denotes CHD MESH:D003327

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-41 Sentence denotes Paraoxonase 1 polymorphisms and survival.
T2 42-228 Sentence denotes The antioxidant enzyme paraoxonase 1 (PON1) has previously been suggested to confer protection against coronary heart disease (CHD), one of the main causes of death in the Western world.
T3 229-373 Sentence denotes Two coding polymorphisms, 55M/L and 192Q/R, and a promoter variant, -107C/T, has been extensively studied with respect to susceptibility to CHD.
T4 374-565 Sentence denotes In this study, we have investigated the impact of these three polymorphisms on mortality using a sample of 1932 Danish individuals aged 47-93 years, previously used in gene-longevity studies.
T5 566-756 Sentence denotes A cross-sectional study comparing the genotype distribution of the three polymorphisms separately as well as the haplotype distribution in different age groups did not reveal any difference.
T6 757-924 Sentence denotes However, a longitudinal follow-up study on survival in the same sample indicated that 192RR homozygotes have a poorer survival compared to QQ homozygotes (hazard rate:
T7 925-941 Sentence denotes 1.38, P = 0.04).
T8 942-1079 Sentence denotes We hereafter used an independent sample of 541 Danish individuals from the oldest cohort and confirmed the initial findings (hazard rate:
T9 1080-1096 Sentence denotes 1.38, P = 0.09).
T10 1097-1154 Sentence denotes In both samples, the effect was most pronounced in women.
T11 1155-1374 Sentence denotes Using self-reported data on ischemic heart disease to evaluate the impact of the PON 192Q/R polymorphism on susceptibility to CHD, we found only a nonsignificant trend of 192RR homozygosity in women being a risk factor.
T12 1375-1648 Sentence denotes Our results thus indicates that PON1 192RR homozygosity is associated with increased mortality in women in the second half of life and that this increased mortality is possibly related to CHD severity and survival after CHD rather than susceptibility to development of CHD.

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 255-258 SequenceVariant denotes 55M
T2 265-269 SequenceVariant denotes 192Q
T3 298-302 SequenceVariant denotes 107C
T4 843-848 SequenceVariant denotes 192RR
T5 1240-1244 SequenceVariant denotes 192Q
T6 1326-1331 SequenceVariant denotes 192RR
T7 1412-1417 SequenceVariant denotes 192RR

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 154-167 DiseaseOrPhenotypicFeature denotes heart disease 0005267
T2 1192-1205 DiseaseOrPhenotypicFeature denotes heart disease 0005267

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-11 GeneOrGeneProduct denotes Paraoxonase
T2 58-64 GeneOrGeneProduct denotes enzyme
T3 65-78 GeneOrGeneProduct denotes paraoxonase 1
T4 80-84 GeneOrGeneProduct denotes PON1
T5 154-159 GeneOrGeneProduct denotes heart
T6 186-190 GeneOrGeneProduct denotes main
T7 315-326 GeneOrGeneProduct denotes extensively
T8 414-420 GeneOrGeneProduct denotes impact
T9 516-521 GeneOrGeneProduct denotes years
T10 547-556 GeneOrGeneProduct denotes longevity
T11 653-663 GeneOrGeneProduct denotes separately
T12 1049-1056 GeneOrGeneProduct denotes initial
T13 1057-1065 GeneOrGeneProduct denotes findings
T14 1192-1197 GeneOrGeneProduct denotes heart
T15 1222-1228 GeneOrGeneProduct denotes impact
T16 1367-1373 GeneOrGeneProduct denotes factor
T17 1407-1411 GeneOrGeneProduct denotes PON1
T18 1493-1505 GeneOrGeneProduct denotes half of life

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-11 GeneOrGeneProduct denotes Paraoxonase
T2 58-64 GeneOrGeneProduct denotes enzyme
T3 65-78 GeneOrGeneProduct denotes paraoxonase 1
T4 80-84 GeneOrGeneProduct denotes PON1
T5 154-159 GeneOrGeneProduct denotes heart
T6 414-420 GeneOrGeneProduct denotes impact
T7 547-556 GeneOrGeneProduct denotes longevity
T8 1192-1197 GeneOrGeneProduct denotes heart
T9 1222-1228 GeneOrGeneProduct denotes impact
T10 1367-1373 GeneOrGeneProduct denotes factor
T11 1407-1411 GeneOrGeneProduct denotes PON1

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 145-167 DiseaseOrPhenotypicFeature denotes coronary heart disease D003327
T2 169-172 DiseaseOrPhenotypicFeature denotes CHD D003327
T3 201-206 DiseaseOrPhenotypicFeature denotes death D003643
T4 369-372 DiseaseOrPhenotypicFeature denotes CHD D003327
T5 1183-1205 DiseaseOrPhenotypicFeature denotes ischemic heart disease D017202
T6 1281-1284 DiseaseOrPhenotypicFeature denotes CHD D003327
T7 1563-1566 DiseaseOrPhenotypicFeature denotes CHD D003327
T8 1595-1598 DiseaseOrPhenotypicFeature denotes CHD D003327
T9 1644-1647 DiseaseOrPhenotypicFeature denotes CHD D003327

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-11 GeneOrGeneProduct denotes Paraoxonase
T2 65-78 GeneOrGeneProduct denotes paraoxonase 1
T3 80-84 GeneOrGeneProduct denotes PON1
T4 547-556 GeneOrGeneProduct denotes longevity
T5 1407-1411 GeneOrGeneProduct denotes PON1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 145-167 DiseaseOrPhenotypicFeature denotes coronary heart disease 0005010
T2 169-172 DiseaseOrPhenotypicFeature denotes CHD 0005010
T3 369-372 DiseaseOrPhenotypicFeature denotes CHD 0005010
T4 1183-1205 DiseaseOrPhenotypicFeature denotes ischemic heart disease 0024644
T5 1281-1284 DiseaseOrPhenotypicFeature denotes CHD 0005010
T6 1563-1566 DiseaseOrPhenotypicFeature denotes CHD 0005010
T7 1595-1598 DiseaseOrPhenotypicFeature denotes CHD 0005010
T8 1644-1647 DiseaseOrPhenotypicFeature denotes CHD 0005010

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 145-167 DiseaseOrPhenotypicFeature denotes coronary heart disease D003327
T2 169-172 DiseaseOrPhenotypicFeature denotes CHD D003327
T3 201-206 DiseaseOrPhenotypicFeature denotes death D003643
T4 369-372 DiseaseOrPhenotypicFeature denotes CHD D003327
T5 1183-1205 DiseaseOrPhenotypicFeature denotes ischemic heart disease D017202
T6 1281-1284 DiseaseOrPhenotypicFeature denotes CHD D003327
T7 1563-1566 DiseaseOrPhenotypicFeature denotes CHD D003327
T8 1595-1598 DiseaseOrPhenotypicFeature denotes CHD D003327
T9 1644-1647 DiseaseOrPhenotypicFeature denotes CHD D003327

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 145-167 DiseaseOrPhenotypicFeature denotes coronary heart disease D003327
T2 169-172 DiseaseOrPhenotypicFeature denotes CHD D003327
T3 369-372 DiseaseOrPhenotypicFeature denotes CHD D003327
T4 1183-1205 DiseaseOrPhenotypicFeature denotes ischemic heart disease D017202
T5 1281-1284 DiseaseOrPhenotypicFeature denotes CHD D003327
T6 1563-1566 DiseaseOrPhenotypicFeature denotes CHD D003327
T7 1595-1598 DiseaseOrPhenotypicFeature denotes CHD D003327
T8 1644-1647 DiseaseOrPhenotypicFeature denotes CHD D003327

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 1148-1153 OrganismTaxon denotes women
T2 1348-1353 OrganismTaxon denotes women
T3 1473-1478 OrganismTaxon denotes women

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-13 ChemicalEntity denotes Paraoxonase 1 D043303
T2 46-57 ChemicalEntity denotes antioxidant ChemicalEntity
T3 65-78 ChemicalEntity denotes paraoxonase 1 D043303
T4 80-84 ChemicalEntity denotes PON1 D043303
T5 1407-1411 ChemicalEntity denotes PON1 D043303

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T5 1407-1411 ChemicalEntity denotes PON1 D043303
T4 80-84 ChemicalEntity denotes PON1 D043303
T3 65-78 ChemicalEntity denotes paraoxonase 1 D043303
T2 46-57 ChemicalEntity denotes antioxidant ChemicalEntity
T1 0-13 ChemicalEntity denotes Paraoxonase 1 D043303
T57557 1407-1411 GeneOrGeneProduct denotes PON1
T92179 547-556 GeneOrGeneProduct denotes longevity
T8620 80-84 GeneOrGeneProduct denotes PON1
T30924 65-78 GeneOrGeneProduct denotes paraoxonase 1
T32133 0-11 GeneOrGeneProduct denotes Paraoxonase
T8 1644-1647 DiseaseOrPhenotypicFeature denotes CHD D003327
T7 1595-1598 DiseaseOrPhenotypicFeature denotes CHD D003327
T6 1563-1566 DiseaseOrPhenotypicFeature denotes CHD D003327
T58725 1281-1284 DiseaseOrPhenotypicFeature denotes CHD D003327
T70338 1183-1205 DiseaseOrPhenotypicFeature denotes ischemic heart disease D017202
T78486 369-372 DiseaseOrPhenotypicFeature denotes CHD D003327
T89682 169-172 DiseaseOrPhenotypicFeature denotes CHD D003327
T7184 145-167 DiseaseOrPhenotypicFeature denotes coronary heart disease D003327
T36026 1473-1478 OrganismTaxon denotes women
T7219 1348-1353 OrganismTaxon denotes women
T19778 1148-1153 OrganismTaxon denotes women
T13030 1412-1417 SequenceVariant denotes 192RR
T10408 1326-1331 SequenceVariant denotes 192RR
T90651 1240-1244 SequenceVariant denotes 192Q
T81293 843-848 SequenceVariant denotes 192RR
T36969 298-302 SequenceVariant denotes 107C
T25380 265-269 SequenceVariant denotes 192Q
T73731 255-258 SequenceVariant denotes 55M

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
15241482-2#26#31#geners854560 255-260 geners854560 denotes 55M/L
15241482-2#140#143#diseaseC0010068 369-372 diseaseC0010068 denotes CHD
15241482-8#85#91#geners662 1240-1246 geners662 denotes 192Q/R
15241482-8#28#50#diseaseC0151744 1183-1205 diseaseC0151744 denotes ischemic heart disease
15241482-8#126#129#diseaseC0010068 1281-1284 diseaseC0010068 denotes CHD
26#31#geners854560140#143#diseaseC0010068 15241482-2#26#31#geners854560 15241482-2#140#143#diseaseC0010068 associated_with 55M/L,CHD
85#91#geners66228#50#diseaseC0151744 15241482-8#85#91#geners662 15241482-8#28#50#diseaseC0151744 associated_with 192Q/R,ischemic heart disease
85#91#geners662126#129#diseaseC0010068 15241482-8#85#91#geners662 15241482-8#126#129#diseaseC0010068 associated_with 192Q/R,CHD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15241482-8#81#84#gene5444 1236-1239 gene5444 denotes PON
15241482-8#28#50#diseaseC0151744 1183-1205 diseaseC0151744 denotes ischemic heart disease
15241482-9#32#36#gene5444 1407-1411 gene5444 denotes PON1
15241482-9#188#191#diseaseC0010068 1563-1566 diseaseC0010068 denotes CHD
15241482-9#220#223#diseaseC0010068 1595-1598 diseaseC0010068 denotes CHD
15241482-9#269#272#diseaseC0010068 1644-1647 diseaseC0010068 denotes CHD
81#84#gene544428#50#diseaseC0151744 15241482-8#81#84#gene5444 15241482-8#28#50#diseaseC0151744 associated_with PON,ischemic heart disease
32#36#gene5444188#191#diseaseC0010068 15241482-9#32#36#gene5444 15241482-9#188#191#diseaseC0010068 associated_with PON1,CHD
32#36#gene5444220#223#diseaseC0010068 15241482-9#32#36#gene5444 15241482-9#220#223#diseaseC0010068 associated_with PON1,CHD
32#36#gene5444269#272#diseaseC0010068 15241482-9#32#36#gene5444 15241482-9#269#272#diseaseC0010068 associated_with PON1,CHD

DisGeNET

Id Subject Object Predicate Lexical cue
T0 65-78 gene:5444 denotes paraoxonase 1
T1 145-167 disease:C0010068 denotes coronary heart disease
T2 65-78 gene:5444 denotes paraoxonase 1
T3 169-172 disease:C0010068 denotes CHD
T4 80-84 gene:5444 denotes PON1
T5 145-167 disease:C0010068 denotes coronary heart disease
T6 80-84 gene:5444 denotes PON1
T7 169-172 disease:C0010068 denotes CHD
R1 T0 T1 associated_with paraoxonase 1,coronary heart disease
R2 T2 T3 associated_with paraoxonase 1,CHD
R3 T4 T5 associated_with PON1,coronary heart disease
R4 T6 T7 associated_with PON1,CHD